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This study aimed to describe the histological findings of bleb fibrosis after XEN and Preserflo surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This retrospective study included patients with different types of glaucoma who underwent revision surgery after XEN or Preserflo implantation. The available clinical information and histological samples of removed fibrotic tissue were analyzed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Thirty-six patients were included. Revision surgery was performed at a median of 195 (range\u2009=\u200931\u20131264) days after primary surgery. The mean intraocular pressure changed from 29.1 (\u00b1\u200910.3) mmHg at baseline to 18.3 (\u00b1\u20098.7) mmHg (\u2212\u200937%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and 16.2 (\u00b1\u20094.2) mmHg (\u2212\u200945%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) after 6 and 12\u00a0months, respectively. Histological analysis revealed an increase in activated fibroblasts and macrophages in all specimens and a parallel orientation of fibroblasts in a minor part of the probe in 60% of the specimens. No pronounced inflammatory reaction in the form of lymphocytic or granulocytic infiltration was observed. The comparison of specimens from uveitic glaucoma and primary open-angle glaucoma patients revealed no significant differences.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The histological analysis of fibrotic blebs from the XEN and Preserflo implants did not show any pronounced immune or foreign-body reaction and revealed a similar histological pattern of failed blebs after trabeculectomy.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00417-024-06479-w","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T11:14:15Z","timestamp":1713266055000},"page":"2977-2984","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Histopathological findings of failed blebs after microinvasive bleb surgery with the XEN Gel Stent and Preserflo MicroShunt"],"prefix":"10.1007","volume":"262","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4120-534X","authenticated-orcid":false,"given":"Jonas","family":"Neubauer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Suesskind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline J.","family":"Gassel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil","family":"Nasyrov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogomil","family":"Voykov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"6479_CR1","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1016\/s0161-6420(95)30796-8","volume":"102","author":"K Nouri-Mahdavi","year":"1995","unstructured":"Nouri-Mahdavi K, Brigatti L, Weitzman M, Caprioli J (1995) Outcomes of trabeculectomy for primary open-angle glaucoma. 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BV has received speaker honoraria and advisory board compensation fees from AbbVie Deutschland GmbH and Santen GmbH.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study adhered to the tenets of the Declaration of Helsinki and was approved by the Institutional Ethics Committee of the University of Tuebingen (Project Number 489\/2022BO2). Patient consent was waived due to the retrospective nature of the study and because only anonymous clinical data was analyzed.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}