{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:04:36Z","timestamp":1791389076531,"version":"4.3.3"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100019442","name":"Kirikkale University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100019442","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>We aimed to investigate the effect of retinal vein occlusion (RVO) on the posterior segment structures of the eye and its changes with intravitreal anti-Vascular Endothelial Growth Factor (VEGF) treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This prospective longitudinal study included 29 eyes of 29 patients with RVO (17 males and 12 females) followed for 6 months. The best corrected visual acuity (BCVA), macula, choroid ticknesses and choroidal vascularity index (CVI) obtained by spectral-domain optical coherence tomography were recorded at baseline and the first, third, and sixth months after the first injection. Results were compared with fellow eyes (non-affected eyes) and age- and sex-matched controls.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>BCVA increased significantly in the 6th month, more in the first month of injection (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 for each). Central macular tickness, subfoveal choroid tickness, stromal and total area of choroid decreased significantly after injection (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 for each). CVI values increased significantly, especially in the 1st month after injection (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 for each). In eyes with Branch RVO, there was a significant decrease in the macular thickness of the occlusive areas with treatment, while there was no statistically significant change in the non-occlusive macular thickness.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Observation of changes in choroidal structure may be useful to assess the activity of RVO and predict the efficacy of anti-VEGF therapy.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00417-024-06562-2","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T12:01:45Z","timestamp":1721649705000},"page":"3837-3845","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Investigation of choroidal structure changes after intravitreal anti-VEGF therapy for retinal vein occlusion"],"prefix":"10.1007","volume":"262","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4320-9336","authenticated-orcid":false,"given":"Erdem","family":"Dursun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6989-9873","authenticated-orcid":false,"given":"Baki","family":"Derhem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6349-7136","authenticated-orcid":false,"given":"Seval","family":"\u00c7obano\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0658-2286","authenticated-orcid":false,"given":"Tevfik","family":"O\u011furel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"6562_CR1","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.ophtha.2009.07.017","volume":"117","author":"S Rogers","year":"2010","unstructured":"Rogers S, McIntosh RL, Cheung N et al (2010) The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia, and Australia. Ophthalmology 117:313\u2013319","journal-title":"Ophthalmology"},{"key":"6562_CR2","doi-asserted-by":"crossref","unstructured":"S. Bearelly ve S. Fekrat. (2004) controversy in the management of retinal venous occlusive disease. Int Ophthalmol Clin 44: 85\u2013102","DOI":"10.1097\/00004397-200404440-00008"},{"issue":"4","key":"6562_CR3","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1001\/archopht.126.4.513","volume":"126","author":"R Klein","year":"2008","unstructured":"Klein R, Moss SE, Meuer SM, Klein BE (2008) The 15-year cumulative incidence of retinal vein occlusion: the Beaver Dam Eye Study. Arch Ophthalmol 126(4):513\u2013518","journal-title":"Arch Ophthalmol"},{"issue":"10","key":"6562_CR4","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1001\/archopht.1996.01100140443012","volume":"114","author":"P Mitchell","year":"1996","unstructured":"Mitchell P, Smith W, Chang A (1996) Prevalence and associations of retinal vein occlusion in Australia. The Blue mountains Eye Study. Arch Ophthalmol 114(10):1243\u20131247","journal-title":"Arch Ophthalmol"},{"issue":"3","key":"6562_CR5","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1136\/bjo.66.3.161","volume":"66","author":"PM Dodson","year":"1982","unstructured":"Dodson PM, Galton DJ, Hamilton AM, Blach RK (1982) Retinal vein occlusion and the prevalence of lipoprotein abnormalities. Br J Ophthalmol 66(3):161\u2013164","journal-title":"Br J Ophthalmol"},{"issue":"10","key":"6562_CR6","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1136\/bjo.44.10.583","volume":"44","author":"S VANNAS","year":"1960","unstructured":"VANNAS S, TARKKANEN A (1960) Retinal vein occlusion and glaucoma. Tonographic study of the incidence of glaucoma and of its prognostic significance. Br J Ophthalmol 44(10):583\u2013589","journal-title":"Br J Ophthalmol"},{"issue":"3","key":"6562_CR7","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1159\/000502041","volume":"242","author":"U Schmidt-Erfurth","year":"2019","unstructured":"Schmidt-Erfurth U, Garcia-Arumi J, Gerendas BS, Midena E, Sivaprasad S, Tadayoni R et al (2019) Guidelines for the management of retinal vein occlusion by the European Society of Retina Specialists (EURETINA). Ophthalmologica 242(3):123\u2013162","journal-title":"Ophthalmologica"},{"key":"6562_CR8","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ajo.2016.08.026","volume":"171","author":"N Rayess","year":"2016","unstructured":"Rayess N, Rahimy E, Ying GS, Pefkianaki M, Franklin J, Regillo CD, Ho AC, Hsu J (2016) Baseline Choroidal Thickness as a predictor for treatment outcomes in central retinal vein occlusion. Am J Ophthalmol 171:47\u201352","journal-title":"Am J Ophthalmol"},{"key":"6562_CR9","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s40942-018-0152-9","volume":"27","author":"A Khodabandeh","year":"2018","unstructured":"Khodabandeh A, Shahraki K, Roohipoor R, Riazi-Esfahani H, Yaseri M, Faghihi H, Bazvand F (2018) Quantitative measurement of vascular density and flow using optical coherence tomography angiography (OCTA) in patients with central retinal vein occlusion: can OCTA help in distinguishing ischemic from non-ischemic type? Int J Retina Vitreous 27:4:47","journal-title":"Int J Retina Vitreous"},{"issue":"18","key":"6562_CR10","doi-asserted-by":"publisher","first-page":"40763","DOI":"10.1038\/srep40763","volume":"7","author":"R Mastropasqua","year":"2017","unstructured":"Mastropasqua R, Toto L, Di Antonio L, Borrelli E, Senatore A, Di Nicola M, Di Martino G, Ciancaglini M, Carpineto P (2017) Optical coherence tomography angiography microvascular findings in macular edema due to central and branch retinal vein occlusions. Sci Rep 7(18):40763","journal-title":"Sci Rep"},{"issue":"1","key":"6562_CR11","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/s41598-017-18511-7","volume":"8","author":"M Kim","year":"2018","unstructured":"Kim M, Ha MJ, Choi SY, Park YH (2018) Choroidal vascularity index in type-2 diabetes analyzed by swept-source optical coherence tomography. Sci Rep 8(1):70","journal-title":"Sci Rep"},{"issue":"1","key":"6562_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00004397-200404410-00003","volume":"44","author":"A Sharma","year":"2004","unstructured":"Sharma A, D\u2019Amico DJ (2004) Medical and surgical management of central retinal vein occlusion. Int Ophthalmol Clin 44(1):1\u201316","journal-title":"Int Ophthalmol Clin"},{"key":"6562_CR13","doi-asserted-by":"crossref","unstructured":"Grassi P, Naclerio C (2020) Central Retinal Vein Prethrombosis Secondary to Retinal Vasculitis: Early Detection and Treatment. Middle East Afr J Ophthalmol. 20;27(2):131\u2013133","DOI":"10.4103\/meajo.MEAJO_270_18"},{"issue":"3","key":"6562_CR14","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1159\/000502041","volume":"242","author":"U Schmidt-Erfurth","year":"2019","unstructured":"Schmidt-Erfurth U, Garcia-Arumi J, Gerendas BS, Midena E, Sivaprasad S, Tadayoni R, Wolf S, Loewenstein A (2019) Guidelines for the management of retinal vein occlusion by the European Society of Retina Specialists (EURETINA). Ophthalmologica 242(3):123\u2013162","journal-title":"Ophthalmologica"},{"key":"6562_CR15","doi-asserted-by":"crossref","unstructured":"Agrawal R, Gupta P, Tan KA, Cheung CM, Wong TY, Cheng CY (2016) Choroidal vascularity index as a measure of vascular status of the choroid: Measurements in healthy eyes from a population-based study. Sci Rep. 12;6:21090","DOI":"10.1038\/srep21090"},{"issue":"11","key":"6562_CR16","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1136\/bjophthalmol-2014-306417","volume":"99","author":"EK Lee","year":"2015","unstructured":"Lee EK, Han JM, Hyon JY, Yu HG (2015) Changes in choroidal thickness after intravitreal dexamethasone implant injection in retinal vein occlusion. Br J Ophthalmol 99(11):1543\u20131549","journal-title":"Br J Ophthalmol"},{"issue":"12","key":"6562_CR17","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1097\/IAE.0000000000001099","volume":"36","author":"E Esen","year":"2016","unstructured":"Esen E, Sizmaz S, Demircan N (2016) Choro\u0131dal thickness changes after intravitreal dexamethasone implant injection for the treatment of macular edema due to retinal vein occlusion. Retina 36(12):2297\u20132303","journal-title":"Retina"},{"issue":"3","key":"6562_CR18","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.ajo.2013.04.008","volume":"156","author":"E Tsuiki","year":"2013","unstructured":"Tsuiki E, Suzuma K, Ueki R, Maekawa Y, Kitaoka T (2013) Enhanced depth imaging optical coherence tomography of the choroid in central retinal vein occlusion. Am J Ophthalmol 156(3):543\u2013547","journal-title":"Am J Ophthalmol"},{"issue":"12","key":"6562_CR19","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.1016\/j.ophtha.2013.08.031","volume":"120","author":"KF Du","year":"2013","unstructured":"Du KF, Xu L, Shao L, Chen CX, Zhou JQ, Wang YX, You QS, Jonas JB, Wei WB (2013) Subfoveal choroidal thickness in retinal vein occlusion. Ophthalmology 120(12):2749\u20132750","journal-title":"Ophthalmology"},{"issue":"5","key":"6562_CR20","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1136\/bjophthalmol-2020-316214","volume":"105","author":"Y Mitamura","year":"2021","unstructured":"Mitamura Y, Enkhmaa T, Sano H, Niki M, Murao F, Egawa M, Sonoda S, Sakamoto T (2021) Changes in choroidal structure following intravitreal aflibercept therapy for retinal vein occlusion. Br J Ophthalmol 105(5):704\u2013710","journal-title":"Br J Ophthalmol"},{"issue":"11","key":"6562_CR21","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1007\/s00417-020-04886-3","volume":"258","author":"YK Aribas","year":"2020","unstructured":"Aribas YK, Hondur AM, Tezel TH (2020) Choroidal vascularity index and choriocapillary changes in retinal vein occlusions. Graefes Arch Clin Exp Ophthalmol 258(11):2389\u20132397","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"10","key":"6562_CR22","doi-asserted-by":"publisher","first-page":"e0258728","DOI":"10.1371\/journal.pone.0258728","volume":"16","author":"BE Hwang","year":"2021","unstructured":"Hwang BE, Kim M, Park YH (2021) Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema. PLoS ONE 16(10):e0258728","journal-title":"PLoS ONE"},{"issue":"1","key":"6562_CR23","doi-asserted-by":"publisher","first-page":"16228","DOI":"10.1038\/s41598-019-52750-0","volume":"9","author":"T Kinoshita","year":"2019","unstructured":"Kinoshita T, Imaizumi H, Shimizu M, Mori J, Hatanaka A, Aoki S, Miyamoto H, Iwasaki M, Murao F, Niki M, Sano H, Sonoda S, Sakamoto T, Mitamura Y (2019) Systemic and ocular determinants of Choroidal structures on Optical Coherence Tomography of eyes with Diabetes and Diabetic Retinopathy. Sci Rep 9(1):16228","journal-title":"Sci Rep"},{"issue":"3","key":"6562_CR24","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1097\/IAE.0000000000001566","volume":"38","author":"M Okamoto","year":"2018","unstructured":"Okamoto M, Yamashita M, Sakamoto T, Ogata N, CHOROIDAL BLOOD FLOW AND THICKNESS AS PREDICTORS FOR RESPONSE TO ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY IN MACULAR EDEMA SECONDARY TO BRANCH RETINAL VEIN OCCLUSION (2018) Retina 38(3):550\u2013558","journal-title":"Retina"},{"issue":"6","key":"6562_CR25","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1136\/bjophthalmol-2013-304019","volume":"98","author":"S Julien","year":"2014","unstructured":"Julien S, Biesemeier A, Taubitz T, Schraermeyer U (2014) Different effects of intravitreally injected ranibizumab and aflibercept on retinal and choroidal tissues of monkey eyes. Br J Ophthalmol 98(6):813\u2013825","journal-title":"Br J Ophthalmol"},{"issue":"3","key":"6562_CR26","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s00417-004-1087-4","volume":"244","author":"H Noma","year":"2006","unstructured":"Noma H, Minamoto A, Funatsu H, Tsukamoto H, Nakano K, Yamashita H, Mishima HK (2006) Intravitreal levels of vascular endothelial growth factor and interleukin-6 are correlated with macular edema in branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 244(3):309\u2013315","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"1","key":"6562_CR27","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1136\/bjophthalmol-2018-311898","volume":"103","author":"N Rayess","year":"2019","unstructured":"Rayess N, Rahimy E, Ying GS, Pefkianaki M, Franklin J, Regillo CD, Ho AC, Hsu J (2019) Baseline choroidal thickness as a short-term predictor of visual acuity improvement following antivascular endothelial growth factor therapy in branch retinal vein occlusion. Br J Ophthalmol 103(1):55\u201359","journal-title":"Br J Ophthalmol"},{"issue":"2","key":"6562_CR28","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1159\/000437276","volume":"234","author":"KH Kim","year":"2015","unstructured":"Kim KH, Lee DH, Lee JJ, Park SW, Byon IS, Lee JE (2015) Regional Choroidal thickness changes in Branch Retinal vein occlusion with Macular Edema. Ophthalmologica 234(2):109\u2013118","journal-title":"Ophthalmologica"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-024-06562-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-024-06562-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-024-06562-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T09:02:58Z","timestamp":1732957378000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-024-06562-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,22]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["6562"],"URL":"https:\/\/doi.org\/10.1007\/s00417-024-06562-2","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,22]]},"assertion":[{"value":"13 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Ethical approval for the study was received from the K\u0131r\u0131kkale University Clinical Research Ethics Committee (Decision number: 2022.03\/01).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers\u2019 bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}