{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:52:13Z","timestamp":1786481533167,"version":"build-2736575974"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1007\/s00417-024-06612-9","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T08:03:45Z","timestamp":1725005025000},"page":"87-95","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pachychoroid pigment epitheliopathy in keratoconic eyes"],"prefix":"10.1007","volume":"263","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2999-6782","authenticated-orcid":false,"given":"Alessandro","family":"Feo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Vinciguerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Antropoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianmaria","family":"Barone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Criscuolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Vinciguerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario R.","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"6612_CR1","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/0039-6257(84)90094-8","volume":"28","author":"JH Krachmer","year":"1984","unstructured":"Krachmer JH, Feder RS, Belin MW (1984) Keratoconus and related noninflammatory corneal thinning disorders. Surv Ophthalmol 28:293\u2013322. https:\/\/doi.org\/10.1016\/0039-6257(84)90094-8","journal-title":"Surv Ophthalmol"},{"key":"6612_CR2","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.jtos.2021.12.004","volume":"23","author":"H Hashemi","year":"2022","unstructured":"Hashemi H, Heirani M, Ambr\u00f3sio R et al (2022) The link between Keratoconus and posterior segment parameters: An updated, comprehensive review. Ocular Surface 23:116\u2013122","journal-title":"Ocular Surface"},{"key":"6612_CR3","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.ajo.2022.10.012","volume":"246","author":"L Pierro","year":"2023","unstructured":"Pierro L, Bianco L, Bertuzzi F et al (2023) New Findings in Early-Stage Keratoconus: Lamina Cribrosa Curvature, Retinal Nerve Fiber Layer Thickness, and Vascular Perfusion. Am J Ophthalmol 246:122\u2013129. https:\/\/doi.org\/10.1016\/j.ajo.2022.10.012","journal-title":"Am J Ophthalmol"},{"key":"6612_CR4","doi-asserted-by":"publisher","unstructured":"Pinheiro-Costa J, Viana Pinto J, Perestrelo S et al (2019) Increased choroidal thickness in keratoconus patients: Perspectives in the disease pathophysiology. J Ophthalmol 2019:2453931. https:\/\/doi.org\/10.1155\/2019\/2453931","DOI":"10.1155\/2019\/2453931"},{"key":"6612_CR5","doi-asserted-by":"publisher","unstructured":"Gutierrez-Bonet R, Ruiz-Medrano J, Pe\u00f1a-Garcia P et al (2018) Macular choroidal thickening in keratoconus patients: Swept-source optical coherence tomography study. Transl Vis Sci Technol 7(3):15 https:\/\/doi.org\/10.1167\/tvst.7.3.15","DOI":"10.1167\/tvst.7.3.15"},{"key":"6612_CR6","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s10792-019-01156-y","volume":"40","author":"B Bilgin","year":"2020","unstructured":"Bilgin B, Karadag AS (2020) Choroidal thickness in keratoconus. Int Ophthalmol 40:135\u2013140. https:\/\/doi.org\/10.1007\/s10792-019-01156-y","journal-title":"Int Ophthalmol"},{"key":"6612_CR7","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s10792-022-02391-6","volume":"43","author":"G Aksoy Aydemir","year":"2023","unstructured":"Aksoy Aydemir G, Ozkoyuncu Kocabas D, Aydemir E et al (2023) Alterations in the choroidal thickness and retinal vascular caliber in keratoconus. Int Ophthalmol 43:95\u2013103. https:\/\/doi.org\/10.1007\/s10792-022-02391-6","journal-title":"Int Ophthalmol"},{"key":"6612_CR8","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-022-02517-w","author":"A Ballesteros-S\u00e1nchez","year":"2022","unstructured":"Ballesteros-S\u00e1nchez A, De-Hita-Cantalejo C, S\u00e1nchez-Gonz\u00e1lez MC et al (2022) Choroidal thickness assessment in keratoconus patients treated with cross-linking compared to healthy population. Int Ophthalmol. https:\/\/doi.org\/10.1007\/s10792-022-02517-w","journal-title":"Int Ophthalmol"},{"key":"6612_CR9","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1097\/IAE.0b013e3182953df4","volume":"33","author":"DJ Warrow","year":"2013","unstructured":"Warrow DJ, Hoang QV, Freund KB (2013) Pachychoroid pigment epitheliopathy. Retina 33:1659\u20131672. https:\/\/doi.org\/10.1097\/IAE.0b013e3182953df4","journal-title":"Retina"},{"key":"6612_CR10","doi-asserted-by":"publisher","first-page":"e806","DOI":"10.1111\/aos.14683","volume":"99","author":"S Borooah","year":"2021","unstructured":"Borooah S, Sim PY, Phatak S et al (2021) Pachychoroid spectrum disease. Acta Ophthalmol 99:e806\u2013e822. https:\/\/doi.org\/10.1111\/aos.14683","journal-title":"Acta Ophthalmol"},{"key":"6612_CR11","doi-asserted-by":"publisher","first-page":"100201","DOI":"10.1016\/j.xops.2022.100201","volume":"2","author":"M Yagi","year":"2022","unstructured":"Yagi M, Miyake M, Mori Y et al (2022) Natural Course of Pachychoroid Pigment Epitheliopathy. Ophthalmol Sci 2:100201. https:\/\/doi.org\/10.1016\/j.xops.2022.100201","journal-title":"Ophthalmol Sci"},{"key":"6612_CR12","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1136\/bjophthalmol-2017-310724","volume":"102","author":"MG Ersoz","year":"2018","unstructured":"Ersoz MG, Karacorlu M, Arf S et al (2018) Pachychoroid pigment epitheliopathy in fellow eyes of patients with unilateral central serous chorioretinopathy. Br J Ophthalmol 102:473\u2013478. https:\/\/doi.org\/10.1136\/bjophthalmol-2017-310724","journal-title":"Br J Ophthalmol"},{"key":"6612_CR13","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1007\/s00417-018-4144-0","volume":"256","author":"M Karacorlu","year":"2018","unstructured":"Karacorlu M, Ersoz MG, Arf S et al (2018) Long-term follow-up of pachychoroid pigment epitheliopathy and lesion characteristics. Graefes Arch Clin Exp Ophthalmol 256:2319\u20132326. https:\/\/doi.org\/10.1007\/s00417-018-4144-0","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"6612_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/8816449","volume":"2020","author":"A Tsiogka","year":"2020","unstructured":"Tsiogka A, Gkartzonikas A, Markopoulos K et al (2020) Keratoconus with Central Serous Chorioretinopathy: A Rare Combination. Case Rep Ophthalmol Med 2020:1\u20136. https:\/\/doi.org\/10.1155\/2020\/8816449","journal-title":"Case Rep Ophthalmol Med"},{"key":"6612_CR15","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1097\/IAE.0b013e3180986299","volume":"28","author":"CM Eandi","year":"2008","unstructured":"Eandi CM, Del Priore LV, Bertelli E et al (2008) Central Serous Chorioretinopathy in Patients with Keratoconus. Retina 28:94\u201396. https:\/\/doi.org\/10.1097\/IAE.0b013e3180986299","journal-title":"Retina"},{"key":"6612_CR16","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1097\/ICO.0000000000000408","volume":"34","author":"JAP Gomes","year":"2015","unstructured":"Gomes JAP, Tan D, Rapuano CJ et al (2015) Global consensus on keratoconus and ectatic diseases. Cornea 34:359\u2013369. https:\/\/doi.org\/10.1097\/ICO.0000000000000408","journal-title":"Cornea"},{"key":"6612_CR17","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.ophtha.2011.07.002","volume":"119","author":"L Branchini","year":"2012","unstructured":"Branchini L, Regatieri CV, Flores-Moreno I et al (2012) Reproducibility of choroidal thickness measurements across three spectral domain optical coherence tomography systems. Ophthalmology 119:119\u2013123. https:\/\/doi.org\/10.1016\/j.ophtha.2011.07.002","journal-title":"Ophthalmology"},{"key":"6612_CR18","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.survophthal.2023.10.013","volume":"69","author":"A Feo","year":"2024","unstructured":"Feo A, Stradiotto E, Sacconi R et al (2024) Subretinal hyperreflective material in retinal and chorioretinal disorders: A comprehensive review. Surv Ophthalmol 69:362\u2013377. https:\/\/doi.org\/10.1016\/j.survophthal.2023.10.013","journal-title":"Surv Ophthalmol"},{"key":"6612_CR19","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1007\/s00417-021-05450-3","volume":"260","author":"TJMM Mazzeo","year":"2022","unstructured":"Mazzeo TJMM, Leber HM, da Silva AG et al (2022) Pachychoroid disease spectrum: review article. Graefes Arch Clin Exp Ophthalmol 260:723\u2013735. https:\/\/doi.org\/10.1007\/s00417-021-05450-3","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"6612_CR20","doi-asserted-by":"publisher","first-page":"2831","DOI":"10.4103\/ijo.IJO_2078_20","volume":"68","author":"MW Belin","year":"2020","unstructured":"Belin MW, Kundu G, Shetty N et al (2020) ABCD: A new classification for keratoconus. Indian J Ophthalmol 68:2831\u20132834. https:\/\/doi.org\/10.4103\/ijo.IJO_2078_20","journal-title":"Indian J Ophthalmol"},{"key":"6612_CR21","doi-asserted-by":"publisher","first-page":"664","DOI":"10.3928\/23258160-20180831-03","volume":"49","author":"S Akkaya","year":"2018","unstructured":"Akkaya S (2018) Macular and Peripapillary Choroidal Thickness in Patients With Keratoconus. Ophthalmic Surg Lasers Imaging Retina 49:664\u2013673. https:\/\/doi.org\/10.3928\/23258160-20180831-03","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"6612_CR22","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1097\/IAE.0000000000003311","volume":"42","author":"M Gerardy","year":"2022","unstructured":"Gerardy M, Yesilirmak N, Legras R et al (2022) CENTRAL SEROUS CHORIORETINOPATHY: High-Resolution Imaging of Asymptomatic Fellow Eyes Using Adaptive Optics Scanning Laser Ophthalmoscopy. Retina 42:375\u2013380. https:\/\/doi.org\/10.1097\/IAE.0000000000003311","journal-title":"Retina"},{"key":"6612_CR23","doi-asserted-by":"publisher","unstructured":"Tang J, Han X, Tang R et al (2022) Case series: pachychoroid pigment epitheliopathy transformed to polypoidal choroidal vasculopathy after long-term follow-up. BMC Ophthalmol 22. https:\/\/doi.org\/10.1186\/s12886-022-02487-8","DOI":"10.1186\/s12886-022-02487-8"},{"key":"6612_CR24","doi-asserted-by":"publisher","unstructured":"Pang CE, Freund KB (2015) Pachychoroid neovasculopathy. Retina 35(1):1-9.\u00a0https:\/\/doi.org\/10.1097\/IAE.0000000000000331","DOI":"10.1097\/IAE.0000000000000331"},{"key":"6612_CR25","doi-asserted-by":"publisher","unstructured":"Pinheiro-Costa J, Correia PJ, Pinto JV et al (2020) Increased choroidal thickness is not a disease progression marker in keratoconus. Sci Rep 10(1):19938. https:\/\/doi.org\/10.1038\/s41598-020-77122-x","DOI":"10.1038\/s41598-020-77122-x"},{"key":"6612_CR26","doi-asserted-by":"publisher","first-page":"e0271747","DOI":"10.1371\/journal.pone.0271747","volume":"17","author":"M Tagawa","year":"2022","unstructured":"Tagawa M, Ooto S, Yamashiro K et al (2022) Choriocapillaris flow deficit in a pachychoroid spectrum disease using en face optical coherence tomography angiography averaging. PLoS ONE 17:e0271747. https:\/\/doi.org\/10.1371\/journal.pone.0271747","journal-title":"PLoS ONE"},{"key":"6612_CR27","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1097\/IAE.0000000000002635","volume":"40","author":"Y Sakurada","year":"2020","unstructured":"Sakurada Y, Fragiotta S, Leong BCS et al (2020) Relationship Between Choroidal Vascular Hyperpermeability, Choriocapillaris Flow Density, and Choroidal Thickness in Eyes with Pachychoroid Pigment Epitheliopathy. Retina 40:657\u2013662. https:\/\/doi.org\/10.1097\/IAE.0000000000002635","journal-title":"Retina"},{"key":"6612_CR28","doi-asserted-by":"publisher","first-page":"6789081","DOI":"10.1155\/2016\/6789081","volume":"2016","author":"RM Robati","year":"2016","unstructured":"Robati RM, Einollahi B, Einollahi H et al (2016) Skin Biophysical Characteristics in Patients with Keratoconus: A Controlled Study. Scientifica (Cairo) 2016:6789081. https:\/\/doi.org\/10.1155\/2016\/6789081","journal-title":"Scientifica (Cairo)"},{"key":"6612_CR29","doi-asserted-by":"publisher","first-page":"402193","DOI":"10.1155\/2014\/402193","volume":"2014","author":"E Kalkan Akcay","year":"2014","unstructured":"Kalkan Akcay E, Akcay M, Uysal BS et al (2014) Impaired corneal biomechanical properties and the prevalence of keratoconus in mitral valve prolapse. J Ophthalmol 2014:402193. https:\/\/doi.org\/10.1155\/2014\/402193","journal-title":"J Ophthalmol"},{"key":"6612_CR30","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1136\/bjo.71.12.886","volume":"71","author":"M Rehnberg","year":"1987","unstructured":"Rehnberg M, Ammitzb\u00f6ll T, Tengroth B (1987) Collagen distribution in the lamina cribrosa and the trabecular meshwork of the human eye. Br J Ophthalmol 71:886\u2013892. https:\/\/doi.org\/10.1136\/bjo.71.12.886","journal-title":"Br J Ophthalmol"},{"key":"6612_CR31","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/0092-8674(84)90514-2","volume":"38","author":"J L\u00f6hler","year":"1984","unstructured":"L\u00f6hler J, Timpl R, Jaenisch R (1984) Embryonic lethal mutation in mouse collagen I gene causes rupture of blood vessels and is associated with erythropoietic and mesenchymal cell death. Cell 38:597\u2013607. https:\/\/doi.org\/10.1016\/0092-8674(84)90514-2","journal-title":"Cell"},{"key":"6612_CR32","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.preteyeres.2004.04.002","volume":"23","author":"T Ihanam\u00e4ki","year":"2004","unstructured":"Ihanam\u00e4ki T, Pelliniemi LJ, Vuorio E (2004) Collagens and collagen-related matrix components in the human and mouse eye. Prog Retin Eye Res 23:403\u2013434. https:\/\/doi.org\/10.1016\/j.preteyeres.2004.04.002","journal-title":"Prog Retin Eye Res"},{"key":"6612_CR33","doi-asserted-by":"publisher","unstructured":"Pouw AE, Greiner MA, Coussa RG, et al (2021) Cell-Matrix Interactions in the Eye: From Cornea to Choroid. Cells 10. https:\/\/doi.org\/10.3390\/cells10030687","DOI":"10.3390\/cells10030687"},{"key":"6612_CR34","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1111\/j.1755-3768.2007.01142.x","volume":"86","author":"S Akhtar","year":"2008","unstructured":"Akhtar S, Bron AJ, Salvi SM et al (2008) Ultrastructural analysis of collagen fibrils and proteoglycans in keratoconus. Acta Ophthalmol 86:764\u2013772. https:\/\/doi.org\/10.1111\/j.1755-3768.2007.01142.x","journal-title":"Acta Ophthalmol"},{"key":"6612_CR35","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.jprot.2013.05.023","volume":"87","author":"R Chaerkady","year":"2013","unstructured":"Chaerkady R, Shao H, Scott S-G et al (2013) The keratoconus corneal proteome: loss of epithelial integrity and stromal degeneration. J Proteomics 87:122\u2013131. https:\/\/doi.org\/10.1016\/j.jprot.2013.05.023","journal-title":"J Proteomics"},{"key":"6612_CR36","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1076\/ceyr.16.2.102.5086","volume":"16","author":"JA Vranka","year":"1997","unstructured":"Vranka JA, Johnson E, Zhu X et al (1997) Discrete expression and distribution pattern of TIMP-3 in the human retina and choroid. Curr Eye Res 16:102\u2013110. https:\/\/doi.org\/10.1076\/ceyr.16.2.102.5086","journal-title":"Curr Eye Res"},{"key":"6612_CR37","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/eye.2015.63","volume":"29","author":"V Galvis","year":"2015","unstructured":"Galvis V, Sherwin T, Tello A et al (2015) Keratoconus: an inflammatory disorder? Eye 29:843\u2013859. https:\/\/doi.org\/10.1038\/eye.2015.63","journal-title":"Eye"},{"key":"6612_CR38","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1177\/11206721221125013","volume":"33","author":"PAH Nichani","year":"2023","unstructured":"Nichani PAH, Solomon B, Trinh T et al (2023) Investigating the role of inflammation in keratoconus: A retrospective analysis of 551 eyes. Eur J Ophthalmol 33:35\u201343. https:\/\/doi.org\/10.1177\/11206721221125013","journal-title":"Eur J Ophthalmol"},{"key":"6612_CR39","doi-asserted-by":"publisher","first-page":"2658","DOI":"10.4103\/ijo.IJO_3403_20","volume":"69","author":"A Reyhan","year":"2021","unstructured":"Reyhan A, Karada\u011f A, \u00c7\u0131nar \u015e (2021) Assessing the role of systemic inflammation in the etiopathogenesis of advanced stage keratoconus. Indian J Ophthalmol 69:2658. https:\/\/doi.org\/10.4103\/ijo.IJO_3403_20","journal-title":"Indian J Ophthalmol"},{"key":"6612_CR40","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1136\/bjophthalmol-2021-318804","volume":"106","author":"JLJ Claessens","year":"2022","unstructured":"Claessens JLJ, Godefrooij DA, Vink G et al (2022) Nationwide epidemiological approach to identify associations between keratoconus and immune-mediated diseases. Br J Ophthalmol 106:1350\u20131354. https:\/\/doi.org\/10.1136\/bjophthalmol-2021-318804","journal-title":"Br J Ophthalmol"},{"key":"6612_CR41","doi-asserted-by":"publisher","first-page":"20891","DOI":"10.1038\/s41598-021-99805-9","volume":"11","author":"S D\u2019Souza","year":"2021","unstructured":"D\u2019Souza S, Nair AP, Sahu GR et al (2021) Keratoconus patients exhibit a distinct ocular surface immune cell and inflammatory profile. Sci Rep 11:20891. https:\/\/doi.org\/10.1038\/s41598-021-99805-9","journal-title":"Sci Rep"},{"key":"6612_CR42","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.4103\/ijo.IJO_233_17","volume":"65","author":"R Shetty","year":"2017","unstructured":"Shetty R, Deshmukh R, Ghosh A et al (2017) Altered tear inflammatory profile in Indian keratoconus patients - The 2015 Col Rangachari Award paper. Indian J Ophthalmol 65:1105\u20131108. https:\/\/doi.org\/10.4103\/ijo.IJO_233_17","journal-title":"Indian J Ophthalmol"},{"key":"6612_CR43","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/s10792-014-9971-3","volume":"35","author":"R Sorkhabi","year":"2015","unstructured":"Sorkhabi R, Ghorbanihaghjo A, Taheri N, Ahoor MH (2015) Tear film inflammatory mediators in patients with keratoconus. Int Ophthalmol 35:467\u2013472. https:\/\/doi.org\/10.1007\/s10792-014-9971-3","journal-title":"Int Ophthalmol"},{"key":"6612_CR44","doi-asserted-by":"publisher","first-page":"e16437","DOI":"10.1371\/journal.pone.0016437","volume":"6","author":"AS Jun","year":"2011","unstructured":"Jun AS, Cope L, Speck C et al (2011) Subnormal cytokine profile in the tear fluid of keratoconus patients. PLoS ONE 6:e16437. https:\/\/doi.org\/10.1371\/journal.pone.0016437","journal-title":"PLoS ONE"},{"key":"6612_CR45","doi-asserted-by":"publisher","first-page":"782709","DOI":"10.3389\/fgene.2022.782709","volume":"13","author":"X Sun","year":"2022","unstructured":"Sun X, Zhang H, Shan M et al (2022) Comprehensive Transcriptome Analysis of Patients With Keratoconus Highlights the Regulation of Immune Responses and Inflammatory Processes. Front Genet 13:782709. https:\/\/doi.org\/10.3389\/fgene.2022.782709","journal-title":"Front Genet"},{"key":"6612_CR46","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1177\/11206721211021300","volume":"32","author":"K Nasrollahi","year":"2022","unstructured":"Nasrollahi K, Razmjoo F, Naderan M, Peyman A (2022) Corneal cross-linking for keratoconus: Evaluation of the retina and choroid. Eur J Ophthalmol 32:1491\u20131495. https:\/\/doi.org\/10.1177\/11206721211021300","journal-title":"Eur J Ophthalmol"},{"key":"6612_CR47","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.ajo.2011.03.023","volume":"152","author":"JM Holopainen","year":"2011","unstructured":"Holopainen JM, Krootila K (2011) Transient corneal thinning in eyes undergoing corneal cross-linking. Am J Ophthalmol 152:533\u2013536. https:\/\/doi.org\/10.1016\/j.ajo.2011.03.023","journal-title":"Am J Ophthalmol"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-024-06612-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-024-06612-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-024-06612-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T05:51:11Z","timestamp":1738993871000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-024-06612-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,30]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["6612"],"URL":"https:\/\/doi.org\/10.1007\/s00417-024-06612-9","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,30]]},"assertion":[{"value":"13 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with animals performed by any of the authors. All procedures performed in studies involving human participants were in accordance with the ethical standards of the Humanitas University and University of Brescia and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Riccardo Vinciguerra is a consultant for OCULUS Optikger\u00e4te GmbH and Intelon Optics. Paolo Vinciguerra is a consultant for OCULUS Optikger\u00e4te GmbH and Schwind. The remaining authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers\u2019 bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}