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Adrenaline 0.05% was also injected intracamerally in five primary open-angle glaucoma patients undergoing iStent inject or MINIject surgery combined with phacoemulsification. All patients were assessed for ocular and systemic adverse reactions, including the effects on intraoperative pupil size, preoperative and postoperative visual acuity, intraocular pressure, and anterior segment OCT results.<\/jats:p>\n            <\/jats:sec><jats:sec>\n              <jats:title>Results<\/jats:title>\n              <jats:p>Adrenaline significantly reduced the contractility of TM cells in a dose-dependent manner (87.8%, 80.6%, 7.9% matrix contraction with adrenaline 0%, 0.0005%, 0.01%, respectively). Adrenaline did not exhibit any significant cytotoxicity even at high concentrations (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Adrenaline 0.01% significantly downregulated the expression of key cell cycle genes in the G2 and M phases, and also decreased the expression of <jats:italic>MRTFB<\/jats:italic> and <jats:italic>ACTA2<\/jats:italic> genes (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Intracameral injections of adrenaline 0.05% in the five MIGS patients did not result in any ocular or systemic adverse effects.<\/jats:p>\n            <\/jats:sec><jats:sec>\n              <jats:title>Conclusion<\/jats:title>\n              <jats:p>We recommend intracameral injections of adrenaline 0.05% as a cheap and safe drug to be used before MIGS insertion. Adrenaline decreases the risk of bleeding from the trabecular meshwork and also exhibits antifibrotic effects by arresting the cell cycle, thereby increasing the postoperative success rates in MIGS.<\/jats:p>\n            <\/jats:sec><jats:sec>\n              <jats:title>Key message<\/jats:title>\n              <jats:p><jats:bold><jats:italic>What is known<\/jats:italic><\/jats:bold><jats:list list-type=\"bullet\">\n                <jats:list-item>\n                  <jats:p>Fibrosis is the main cause of surgical failure in minimally invasive glaucoma surgery (MIGS). Mitomycin-C and 5-fluorouracil are too toxic to be used inside the eye.<\/jats:p>\n                <\/jats:list-item>\n              <\/jats:list><\/jats:p>\n              <jats:p><jats:bold><jats:italic>What is new<\/jats:italic><\/jats:bold><jats:list list-type=\"bullet\">\n                <jats:list-item>\n                  <jats:p>Adrenaline reduced the contractility of trabecular meshwork cells and inhibited the expression of key cell cycle genes and fibrosis genes, without significant cytotoxicity.<\/jats:p>\n                <\/jats:list-item>\n                <jats:list-item>\n                  <jats:p>Intracameral injection of adrenaline 0.05% did not result in any ocular or systemic adverse reactions in MIGS patients.<\/jats:p>\n                <\/jats:list-item>\n              <\/jats:list><\/jats:p>\n            <\/jats:sec>","DOI":"10.1007\/s00417-024-06642-3","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T05:01:54Z","timestamp":1727672514000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preliminary antifibrotic and vasoconstrictor effects of adrenaline in Schlemm\u2019s canal and suprachoroidal minimally invasive glaucoma surgery in primary open-angle glaucoma"],"prefix":"10.1007","author":[{"given":"Jinyuan","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Fajardo-Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengqi","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brihitejas","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karishma","family":"Mahtani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrietta","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4868-5187","authenticated-orcid":false,"given":"Cynthia","family":"Yu-Wai-Man","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"6642_CR1","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1001\/jama.2014.3192","volume":"311","author":"RN Weinreb","year":"2014","unstructured":"Weinreb RN, Aung T, Medeiros FA (2014) The pathophysiology and treatment of glaucoma: a review. 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