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Correlations between patients\u2019 demographic data, ophthalmic and non-ophthalmic conditions, outcomes and complications were evaluated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>171 patients were included. IOP and IOP-lowering eye drops were significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) reduced 18\u00a0months after TE, cCP, and mCP. At the 18-month follow-up, IOP and IOP-lowering eye drops were significantly lower following TE than cCP (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>p<\/jats:italic>\u2009=\u20090.010, respectively) and mCP (<jats:italic>p<\/jats:italic>\u2009=\u20090.010, <jats:italic>p<\/jats:italic>\u2009=\u20090.014). At the 18-month follow-up, complete success rates were significantly higher after TE compared to cCP and mCP for IOP\u2009\u2264\u200921, 18, and 16\u00a0mmHg (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Qualified success rates for IOP\u2009\u2264\u200916\u00a0mmHg were higher following TE than cCP and mCP (<jats:italic>p<\/jats:italic>\u2009=\u20090.023). In the TE group, clinical hypotony at any postoperative follow-up was positively correlated with previous intravitreal anti-vascular endothelial growth factor (VEGF)-therapy (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), leukaemia (<jats:italic>p<\/jats:italic>\u2009=\u20090.002), and a spherical equivalent\u2009&lt;\u2009-3 dioptres (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). There were no significant correlations in the cCP and mCP groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>TE, cCP, and mCP led to a significant reduction in IOP and IOP-lowering eye drops during 18\u00a0months of follow-up. At 18\u00a0months of follow-up, IOP and IOP-lowering eye drops were significantly lower following TE compared to cCP and mCP. Anti-VEGF-therapy, cystostatic therapy in leukaemia, and a spherical equivalent\u2009&lt;\u2009-3 dioptres were significantly correlated with postoperative hypotony, macular folds, and choroidal detachment in the TE group.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Key messages<\/jats:title>\n            <jats:p>\n              <jats:italic>What is known<\/jats:italic>\n            <\/jats:p>\n            <jats:p>\u2022 Trabeculectomy (TE) is considered the gold standard in the surgical management of glaucoma. However, TE involves extensive postoperative management and might be associated with severe surgery-related complications.<\/jats:p>\n            <jats:p>\n              <jats:italic>What is new<\/jats:italic>\n            <\/jats:p>\n            <jats:p>\u2022 In this study, intraocular pressure (IOP) and IOP-lowering eye drops were significantly lower following TE compared to conventional canaloplasty (cCP) and mitomycin C augmented canaloplasty (mCP) at a follow-up of 18\u00a0months.<\/jats:p>\n            <jats:p>\u2022 In patients undergoing TE, anti-VEGF-therapy, cystostatic therapy in leukaemia, and a spherical equivalent\u2009&lt;\u2009-3 dioptres were significantly correlated with postoperative hypotony, macular folds, and choroidal detachment.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00417-024-06656-x","type":"journal-article","created":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T14:02:02Z","timestamp":1729951322000},"page":"807-817","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Factors influencing the outcomes of trabeculectomy, conventional canaloplasty, and mitomycin C augmented canaloplasty"],"prefix":"10.1007","volume":"263","author":[{"given":"Julia","family":"Prinz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Fuest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kuerten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Cursiefen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Prokosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,26]]},"reference":[{"key":"6656_CR1","doi-asserted-by":"publisher","first-page":"e1221","DOI":"10.1016\/s2214-109x(17)30393-5","volume":"5","author":"SR Flaxman","year":"2017","unstructured":"Flaxman SR, Bourne RRA, Resnikoff S, Ackland P, Braithwaite T, Cicinelli MV, Das A, Jonas JB, Keeffe J, Kempen JH, Leasher J, Limburg H, Naidoo K, Pesudovs K, Silvester A, Stevens GA, Tahhan N, Wong TY, Taylor HR (2017) Global causes of blindness and distance vision impairment 1990\u20132020: a systematic review and meta-analysis. 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