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Main outcome parameters were the mean arterial (A-SO<jats:sub>2<\/jats:sub>; %), venular (V-SO<jats:sub>2<\/jats:sub>; %) oxygen saturation, and their difference (A-V SO<jats:sub>2<\/jats:sub>; %) recorded with the oxygen saturation tool of the Retinal Vessel Analyzer (IMEDOS Systems UG, Germany). Statistical analyses were performed with linear mixed-effects models.<\/jats:p>\n            <\/jats:sec><jats:sec>\n              <jats:title>Results<\/jats:title>\n              <jats:p>Eyes suffering from CHM differed significantly from both RP and control eyes, when the retinal oxygen metabolic parameters were taken into account. While RP showed significantly higher A-SO<jats:sub>2<\/jats:sub> and V-SO<jats:sub>2<\/jats:sub> values when compared to controls, CHM showed opposite findings with significantly lower values when compared to both RP and controls (P\u2009&lt;\u20090.001). The A-V SO<jats:sub>2<\/jats:sub>, which represents the retinal oxygen metabolic consumption, showed significantly lower values in CHM compared to controls.<\/jats:p>\n            <\/jats:sec><jats:sec>\n              <jats:title>Conclusion<\/jats:title>\n              <jats:p>The retina in CHM is a relatively hypoxic environment. The decrease in oxygen levels may be due to the profound choroidal degeneration, leading to decreased oxygen flux to the retina. RO measurements may help understand the pathogenesis of CHM and RP. These findings may provide useful details to inform the planning of clinical trials of emerging therapies for CHM.<\/jats:p>\n            <\/jats:sec><jats:sec>\n              <jats:title>Key messages<\/jats:title>\n              <jats:p><jats:bold><jats:italic>What was known before?<\/jats:italic><\/jats:bold><jats:list list-type=\"bullet\">\n                <jats:list-item>\n                  <jats:p>Retinal oxygen metabolic function measured with retinal oximetry (RO) shows significant alterations in patients with retinitis pigmentosa.<\/jats:p>\n                <\/jats:list-item>\n              <\/jats:list><\/jats:p>\n              <jats:p><jats:bold><jats:italic>What this study adds:<\/jats:italic><\/jats:bold><jats:list list-type=\"bullet\">\n                <jats:list-item>\n                  <jats:p>RO function in choroideremia is significantly altered when compared to controls.<\/jats:p>\n                <\/jats:list-item>\n                <jats:list-item>\n                  <jats:p>Furthermore, RO in choroideremia shows opposing findings within different oxygen metabolic parameters to those that were so far known for retinitis pigmentosa.<\/jats:p>\n                <\/jats:list-item>\n                <jats:list-item>\n                  <jats:p>By providing insights into the retinal oxygen metabolic mechanisms, RO can help understand the underlying pathophysiology in choroideremia.<\/jats:p>\n                <\/jats:list-item>\n              <\/jats:list><\/jats:p>\n            <\/jats:sec>","DOI":"10.1007\/s00417-024-06659-8","type":"journal-article","created":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:01:50Z","timestamp":1728691310000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Retinal oxygen metabolic function in choroideremia and retinitis pigmentosa"],"prefix":"10.1007","author":[{"given":"Dominique","family":"Pr\u00e9tot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"della Volpe Waizel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Kaminska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Valmaggia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Placidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetto","family":"Falsini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian N.","family":"Fries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00f3ra","family":"Szentm\u00e1ry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Rivolta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik P. 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Ethical Approval was provided by Ethics Commission of Central and Northern Switzerland (EKNZ Basel Switzerland) with a positive vote for a prospective observational study (trial number EKNZ BASEC 2020\u201300122).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Dr. della Volpe Waizel is member of the Scientific Advisory Board of backlight therapeutics Switzerland.Dr. Valmaggia discloses personal compensation from Heidelberg Engineering and Roche.Dr. Scholl is member of the Scientific Advisory Board of: Boehringer Ingelheim Pharma GmbH & Co; Droia NV; Eluminex Biosciences; Janssen Research & Development, LLC (Johnson & Johnson); Okuvision GmbH; ReVision Therapeutics Inc.; and Saliogen Therapeutics Inc. Dr. Scholl is a consultant of: Alnylam Pharmaceuticals Inc.; Gerson Lehrman Group Inc.; Guidepoint Global, LLC; and Tenpoint Therapeutics.Dr. Scholl is member of the Data Monitoring and Safety Board\/Committee of Belite Bio (DRAGON trial, NCT05244304; LBS-008-CT02, NCT05266014), F. Hoffmann-La Roche Ltd (VELODROME trial, NCT04657289; DIAGRID trial, NCT05126966; HUTONG trial), ViGeneron (protocol number VG901-2021-A) and member of the Steering Committee of Novo Nordisk (FOCUS trial; NCT03811561).Individual investigators who participate in the sponsored project(s) are not directly compensated by the sponsor but may receive salary or other support from the institution to support their effort on the project(s).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}