{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T06:55:40Z","timestamp":1757314540394,"version":"3.37.3"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["22K09773"],"award-info":[{"award-number":["22K09773"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"DOI":"10.1007\/s00417-024-06667-8","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T09:29:07Z","timestamp":1730107747000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Immunohistochemical expression of Fibrillin-1 in idiopathic epiretinal membranes"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7044-4857","authenticated-orcid":false,"given":"Luu Viet","family":"Tien","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizuki","family":"Tagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiko","family":"Misawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0632-997X","authenticated-orcid":false,"given":"Shigeru","family":"Honda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"6667_CR1","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/s0161-6420(02)01443-4","volume":"110","author":"S Fraser-Bell","year":"2003","unstructured":"Fraser-Bell S, Guzowski M, Rochtchina E, Wang JJ, Mitchell P (2003) Five-year cumulative incidence and progression of epiretinal membranes: the blue mountains eye study. Ophthalmology 110:34\u201340. https:\/\/doi.org\/10.1016\/s0161-6420(02)01443-4","journal-title":"Ophthalmology"},{"key":"6667_CR2","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/j.ophtha.2014.10.014","volume":"122","author":"SM Meuer","year":"2015","unstructured":"Meuer SM, Myers CE, Klein BE, Swift MK, Huang Y, Gangaputra S, Pak JW, Danis RP, Klein R (2015) The epidemiology of vitreoretinal interface abnormalities as detected by spectral-domain optical coherence tomography: the beaver dam eye study. Ophthalmology 122:787\u2013795. https:\/\/doi.org\/10.1016\/j.ophtha.2014.10.014","journal-title":"Ophthalmology"},{"key":"6667_CR3","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/s41433-021-01681-0","volume":"36","author":"PY Chua","year":"2022","unstructured":"Chua PY, Sandinha MT, Steel DH (2022) Idiopathic epiretinal membrane: progression and timing of surgery. Eye 36:495\u2013503. https:\/\/doi.org\/10.1038\/s41433-021-01681-0","journal-title":"Eye"},{"key":"6667_CR4","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1097\/IAE.0000000000001559","volume":"38","author":"SM Lee","year":"2018","unstructured":"Lee SM, Pak KY, Kwon HJ, Park SW, Lee JE, Byon IS (2018) Association between tangential contraction and early vision loss in idiopathic epiretinal membrane. Retina 38:541\u2013549","journal-title":"Retina"},{"key":"6667_CR5","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1007\/s00417-021-05492-7","volume":"260","author":"RA da Silva","year":"2022","unstructured":"da Silva RA, Roda VM, Matsuda M, Siqueira PV, Lustoza-Costa GJ, Wu DC, Hamassaki DE (2022) Cellular components of the idiopathic epiretinal membrane. Graefes Arch Clin Exp Ophthalmol 260:1435\u20131444. https:\/\/doi.org\/10.1007\/s00417-021-05492-7","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"6667_CR6","doi-asserted-by":"publisher","first-page":"107722","DOI":"10.1016\/j.exer.2019.107722","volume":"186","author":"C Christakopoulos","year":"2019","unstructured":"Christakopoulos C, Cehofski LJ, Christensen SR, Vorum H, Honor\u00e9 B (2019) Proteomics reveals a set of highly enriched proteins in epiretinal membrane compared with inner limiting membrane. Exp Eye Res 186:107722. https:\/\/doi.org\/10.1016\/j.exer.2019.107722","journal-title":"Exp Eye Res"},{"key":"6667_CR7","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.3390\/cells11162531","volume":"11","author":"L Bianchi","year":"2022","unstructured":"Bianchi L, Altera A, Barone V, Bonente D, Bacci T, De Benedetto E, Bini L, Tosi GM, Galvagni F, Bertelli E (2022) Untangling the extracellular matrix of idiopathic epiretinal membrane: a path winding among structure, interactomics and translational medicine. Cells 11:2531. https:\/\/doi.org\/10.3390\/cells11162531","journal-title":"Cells"},{"key":"6667_CR8","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1038\/s41594-023-00950-8","volume":"30","author":"ARF Godwin","year":"2023","unstructured":"Godwin ARF, Dajani R, Zhang X, Thomson J, Holmes DF, Adamo CS, Sengle G, Sherratt MJ, Roseman AM, Baldock C (2023) Fibrillin microfibril structure identifies long-range effects of inherited pathogenic mutations affecting a key regulatory latent TGF\u03b2-binding site. Nat Struct Mol Biol 30:608\u2013618. https:\/\/doi.org\/10.1038\/s41594-023-00950-8","journal-title":"Nat Struct Mol Biol"},{"key":"6667_CR9","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/s41572-021-00298-7","volume":"7","author":"DM Milewicz","year":"2021","unstructured":"Milewicz DM, Braverman AC, De Backer J, Morris SA, Boileau C, Maumenee IH, Jondeau G, Evangelista A, Pyeritz RE (2021) Marfan syndrome. Nat Reviews Disease Primers 7:64. https:\/\/doi.org\/10.1038\/s41572-021-00298-7","journal-title":"Nat Reviews Disease Primers"},{"key":"6667_CR10","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1007\/s00018-015-2110-0","volume":"73","author":"IA Darby","year":"2016","unstructured":"Darby IA, Zakuan N, Billet F, Desmouli\u00e8re A (2016) The myofibroblast, a key cell in normal and pathological tissue repair. Cell Mol Life Sci 73:1145\u20131157. https:\/\/doi.org\/10.1007\/s00018-015-2110-0","journal-title":"Cell Mol Life Sci"},{"key":"6667_CR11","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.preteyeres.2017.08.001","volume":"60","author":"DY Shu","year":"2017","unstructured":"Shu DY, Lovicu FJ (2017) Myofibroblast transdifferentiation: the dark force in ocular wound healing and fibrosis. Prog Retin Eye Res 60:44\u201365. https:\/\/doi.org\/10.1016\/j.preteyeres.2017.08.001","journal-title":"Prog Retin Eye Res"},{"key":"6667_CR12","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1097\/iae.0000000000000013","volume":"34","author":"SC Bu","year":"2014","unstructured":"Bu SC, Kuijer R, van der Worp RJ, Huiskamp EA, Renardel de Lavalette VW, Li XR, Hooymans JM, Los LI (2014) Glial cells and collagens in epiretinal membranes associated with idiopathic macular holes. Retina (Philadelphia Pa) 34:897\u2013906. https:\/\/doi.org\/10.1097\/iae.0000000000000013","journal-title":"Retina (Philadelphia Pa)"},{"key":"6667_CR13","doi-asserted-by":"publisher","first-page":"6506","DOI":"10.1167\/iovs.14-15971","volume":"56","author":"SC Bu","year":"2015","unstructured":"Bu SC, Kuijer R, van der Worp RJ, Postma G, De Lavalette VW, Li XR, Hooymans JM, Los LI (2015) Immunohistochemical evaluation of idiopathic epiretinal membranes and in vitro studies on the effect of TGF-\u03b2 on M\u00fcller cells. Investig Ophthalmol Vis Sci 56:6506\u201314. https:\/\/doi.org\/10.1167\/iovs.14-15971","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"6667_CR14","doi-asserted-by":"publisher","first-page":"7934","DOI":"10.1167\/iovs.14-15453","volume":"55","author":"D Hubmacher","year":"2014","unstructured":"Hubmacher D, Reinhardt DP, Plesec T, Schenke-Layland K, Apte SS (2014) Human eye development is characterized by coordinated expression of fibrillin isoforms. Investig Ophthalmol Vis Sci 55:7934\u20137944. https:\/\/doi.org\/10.1167\/iovs.14-15453","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"6667_CR15","doi-asserted-by":"publisher","first-page":"1121270","DOI":"10.3389\/fmed.2023.1121270","volume":"10","author":"MK O\u017c\u00f3g","year":"2023","unstructured":"O\u017c\u00f3g MK, Nowak-W\u0105s M, Rokicki W (2023) Pathophysiology and clinical aspects of epiretinal membrane - review. Front Med 10:1121270. https:\/\/doi.org\/10.3389\/fmed.2023.1121270","journal-title":"Front Med"},{"key":"6667_CR16","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1083\/jcb.103.6.2499","volume":"103","author":"LY Sakai","year":"1986","unstructured":"Sakai LY, Keene DR, Engvall E (1986) Fibrillin, a new 350-kD glycoprotein, is a component of extracellular microfibrils. J Cell Biol 103:2499\u20132509. https:\/\/doi.org\/10.1083\/jcb.103.6.2499","journal-title":"J Cell Biol"},{"key":"6667_CR17","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1083\/jcb.201402006","volume":"207","author":"F Klingberg","year":"2014","unstructured":"Klingberg F, Chow ML, Koehler A, Boo S, Buscemi L, Quinn TM, Costell M, Alman BA, Genot E, Hinz B (2014) Prestress in the extracellular matrix sensitizes latent TGF-\u03b21 for activation. J Cell Biol 207:283\u2013297. https:\/\/doi.org\/10.1083\/jcb.201402006","journal-title":"J Cell Biol"},{"key":"6667_CR18","doi-asserted-by":"publisher","first-page":"3000","DOI":"10.1002\/art.10621","volume":"46","author":"EY Kissin","year":"2002","unstructured":"Kissin EY, Lemaire R, Korn JH, Lafyatis R (2002) Transforming growth factor beta induces fibroblast fibrillin-1 matrix formation. Arthritis Rheum 46:3000\u20133009. https:\/\/doi.org\/10.1002\/art.10621","journal-title":"Arthritis Rheum"},{"key":"6667_CR19","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/s0161-6420(83)34521-8","volume":"90","author":"PS Lindsey","year":"1983","unstructured":"Lindsey PS, Michels RG, Luckenbach M, Green WR (1983) Ultrastructure of epiretinal membrane causing retinal starfold. Ophthalmology 90:578\u2013583. https:\/\/doi.org\/10.1016\/s0161-6420(83)34521-8","journal-title":"Ophthalmology"},{"key":"6667_CR20","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1136\/bjo.68.10.708","volume":"68","author":"PS Hiscott","year":"1984","unstructured":"Hiscott PS, Grierson I, McLeod D (1984) Retinal pigment epithelial cells in epiretinal membranes: an immunohistochemical study. Br J Ophthalmol 68:708\u2013715. https:\/\/doi.org\/10.1136\/bjo.68.10.708","journal-title":"Br J Ophthalmol"},{"key":"6667_CR21","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/s0161-6420(89)32811-9","volume":"96","author":"WE Smiddy","year":"1989","unstructured":"Smiddy WE, Maguire AM, Green WR, Michels RG, de la Cruz Z, Enger C, Jaeger M, Rice TA (1989) Idiopathic epiretinal membranes. Ultrastructural characteristics and clinicopathologic correlation. Ophthalmology 96:811\u2013820. https:\/\/doi.org\/10.1016\/s0161-6420(89)32811-9","journal-title":"Ophthalmology"},{"key":"6667_CR22","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1038\/eye.2008.36","volume":"22","author":"DR Snead","year":"2008","unstructured":"Snead DR, James S, Snead MP (2008) Pathological changes in the vitreoretinal junction 1: epiretinal membrane formation. Eye 22:1310\u20131317. https:\/\/doi.org\/10.1038\/eye.2008.36","journal-title":"Eye"},{"key":"6667_CR23","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1007\/s10384-017-0542-9","volume":"62","author":"R Yokota","year":"2018","unstructured":"Yokota R, Hirakata A, Hayashi N, Hirota K, Rii T, Itoh Y, Orihara T, Inoue M (2018) Ultrastructural analyses of internal limiting membrane excised from highly myopic eyes with myopic traction maculopathy. Jpn J Ophthalmol 62:84\u201391. https:\/\/doi.org\/10.1007\/s10384-017-0542-9","journal-title":"Jpn J Ophthalmol"},{"key":"6667_CR24","first-page":"3636","volume":"62","author":"S Tamiya","year":"2021","unstructured":"Tamiya S, Jagatheesan G, Ueda S (2021) Rho is involved in regulation of myocardin-related transcription factor and myofibroblast transdifferentiation of RPE cells. Investig Ophthalmol Vis Sci 62:3636\u20133636","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"6667_CR25","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.exer.2005.12.007","volume":"83","author":"MA Gamulescu","year":"2006","unstructured":"Gamulescu MA, Chen Y, He S, Spee C, Jin M, Ryan SJ, Hinton DR (2006) Transforming growth factor beta2-induced myofibroblastic differentiation of human retinal pigment epithelial cells: regulation by extracellular matrix proteins and hepatocyte growth factor. Exp Eye Res 83:212\u2013222. https:\/\/doi.org\/10.1016\/j.exer.2005.12.007","journal-title":"Exp Eye Res"},{"key":"6667_CR26","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1136\/bjo.2008.155069","volume":"93","author":"RI Kohno","year":"2009","unstructured":"Kohno RI, Hata Y, Kawahara S, Kita T, Arita R, Mochizuki Y, Aiello LP, Ishibashi T (2009) Possible contribution of hyalocytes to idiopathic epiretinal membrane formation and its contraction. Br J Ophthalmol 93:1020\u20131026. https:\/\/doi.org\/10.1136\/bjo.2008.155069","journal-title":"Br J Ophthalmol"},{"key":"6667_CR27","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1167\/iovs.08-2475","volume":"50","author":"C Guidry","year":"2009","unstructured":"Guidry C, King JL, Mason JO (2009) Fibrocontractive Muller cell phenotypes in proliferative diabetic retinopathy. Investig Ophthalmol Vis Sci 50:1929\u201339. https:\/\/doi.org\/10.1167\/iovs.08-2475","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"6667_CR28","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/s41598-018-36917-9","volume":"9","author":"A Kanda","year":"2019","unstructured":"Kanda A, Noda K, Hirose I, Ishida S (2019) TGF-\u03b2-SNAIL axis induces M\u00fcller glial-mesenchymal transition in the pathogenesis of idiopathic epiretinal membrane. Sci Rep 9:673. https:\/\/doi.org\/10.1038\/s41598-018-36917-9","journal-title":"Sci Rep"},{"key":"6667_CR29","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1038\/s41467-020-15326-5","volume":"11","author":"A Plaza Reyes","year":"2020","unstructured":"Plaza Reyes A, Petrus-Reurer S, Padrell S\u00e1nchez S, Kumar P, Douagi I, Bartuma H, Aronsson M, Westman S, Lardner E, Andr\u00e9 H, Falk A, Nandrot EF, Kvanta A, Lanner F (2020) Identification of cell surface markers and establishment of monolayer differentiation to retinal pigment epithelial cells. Nat Commun 11:1609. https:\/\/doi.org\/10.1038\/s41467-020-15326-5","journal-title":"Nat Commun"},{"key":"6667_CR30","doi-asserted-by":"publisher","first-page":"7085","DOI":"10.1167\/iovs.14-16246","volume":"56","author":"TA Blenkinsop","year":"2015","unstructured":"Blenkinsop TA, Saini JS, Maminishkis A, Bharti K, Wan Q, Banzon T, Lotfi M, Davis J, Singh D, Rizzolo LJ, Miller S (2015) Human adult retinal pigment epithelial stem cell\u2013derived RPE monolayers exhibit key physiological characteristics of native tissue. Investig Ophthalmol Vis Sci 56:7085\u20137099. https:\/\/doi.org\/10.1167\/iovs.14-16246","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"6667_CR31","doi-asserted-by":"publisher","first-page":"109336","DOI":"10.1016\/j.exer.2022.109336","volume":"226","author":"RA da Silva","year":"2023","unstructured":"da Silva RA, Roda VMP, Akamine PS, da Silva DS, Siqueira PV, Matsuda M, Hamassaki DE (2023) Blockade of the TGF-\u03b2 pathway by galunisertib inhibits the glial-mesenchymal transition in M\u00fcller glial cells. Exp Eye Res 226:109336. https:\/\/doi.org\/10.1016\/j.exer.2022.109336","journal-title":"Exp Eye Res"},{"key":"6667_CR32","doi-asserted-by":"publisher","first-page":"192582","DOI":"10.1155\/2013\/192582","volume":"2013","author":"M Joshi","year":"2013","unstructured":"Joshi M, Agrawal S, Christoforidis JB (2013) Inflammatory mechanisms of idiopathic epiretinal membrane formation. Mediat Inflamm 2013:192582","journal-title":"Mediat Inflamm"},{"key":"6667_CR33","doi-asserted-by":"publisher","first-page":"5786","DOI":"10.1167\/iovs.10-7116","volume":"52","author":"L Iannetti","year":"2011","unstructured":"Iannetti L, Accorinti M, Malagola R, Bozzoni-Pantaleoni F, Da Dalt S, Nicoletti F, Gradini R, Traficante A, Campanella M, Pivetti-Pezzi P (2011) Role of the intravitreal growth factors in the pathogenesis of idiopathic epiretinal membrane. Investig Ophthalmol Vis Sci 52:5786\u20135789. https:\/\/doi.org\/10.1167\/iovs.10-7116","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"6667_CR34","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1083\/jcb.200608167","volume":"176","author":"SS Chaudhry","year":"2007","unstructured":"Chaudhry SS, Cain SA, Morgan A, Dallas SL, Shuttleworth CA, Kielty CM (2007) Fibrillin-1 regulates the bioavailability of TGFbeta1. J Cell Biol 176:355\u2013367. https:\/\/doi.org\/10.1083\/jcb.200608167","journal-title":"J Cell Biol"},{"key":"6667_CR35","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/nature10152","volume":"474","author":"M Shi","year":"2011","unstructured":"Shi M, Zhu J, Wang R, Chen X, Mi L, Walz T, Springer TA (2011) Latent TGF-\u03b2 structure and activation. Nature 474:343\u2013349. https:\/\/doi.org\/10.1038\/nature10152","journal-title":"Nature"},{"key":"6667_CR36","doi-asserted-by":"publisher","first-page":"5965","DOI":"10.1167\/iovs.09-3621","volume":"50","author":"SK Parapuram","year":"2009","unstructured":"Parapuram SK, Chang B, Li L, Hartung RA, Chalam KV, Nair-Menon JU, Hunt DM, Hunt RC (2009) Differential effects of TGFbeta and vitreous on the transformation of retinal pigment epithelial cells. Investig Ophthalmol Vis Sci 50:5965\u20135974. https:\/\/doi.org\/10.1167\/iovs.09-3621","journal-title":"Investig Ophthalmol Vis Sci"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-024-06667-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-024-06667-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-024-06667-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T18:03:18Z","timestamp":1730138598000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-024-06667-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,28]]},"references-count":36,"alternative-id":["6667"],"URL":"https:\/\/doi.org\/10.1007\/s00417-024-06667-8","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"type":"print","value":"0721-832X"},{"type":"electronic","value":"1435-702X"}],"subject":[],"published":{"date-parts":[[2024,10,28]]},"assertion":[{"value":"15 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers\u2019 bureaus; membership, employment, consultancies, stock ownership, or other equity interests; and expert testimony or patent-licensing arrangements) or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures involving human participants performed in this study were in accordance with the ethical standards of Osaka Metropolitan University (Japan) and the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study protocol was approved by the Institutional Ethics Committee of Osaka Metropolitan University (protocol 2020\u2009\u2212\u2009150, February 2, 2023).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}