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Optical coherence tomography scanning was done at 9 a.m., 1 p.m., and 3 p.m. Between the first and second scanning, the patients were instructed to stay upright, whereas they were positioned recumbent thereafter. Automated mean retinal thickness measurements were derived from the ETDRS grid for the central, parafoveal, and perifoveal subfields. Mean ocular perfusion pressure (MOPP) was calculated for all time points. Primary endpoints were changes in MH-related oedema from 9 a.m.\u22121 p.m., and from 1 p.m.\u22123 p.m.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n In upright position from 9 a.m.\u22121 p.m., the mean parafoveal retinal thickness decreased from 362\u00a0\u03bcm (SD\u2009=\u200956) to 350\u00a0\u03bcm (SD\u2009=\u200951) (P<\/jats:italic>\u2009<\u20090.001). The reduction of MH-related oedema when upright was positively correlated with a reduction in MOPP. Eyes with vitreomacular traction (VMT) exhibited significantly less reduction in MH-related oedema compared to eyes without VMT. In recumbent position from 1 p.m.\u22123 p.m., the mean parafoveal retinal thickness increased to 356\u00a0\u03bcm (SD\u2009=\u200952) (P<\/jats:italic>\u2009=\u20090.002).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n MH-related oedema belongs to the non-vasogenic cystoid maculopathies. The decrease in MH-related oedema when upright and its positive correlation to a reduction in MOPP is therefore unexpected. In recumbent position, the situation is reversed, and the oedema increases. This may be related to subtle leakage from the retinal capillaries. The presence of VMT seems to counteract the resolution of the oedema. In a clinical setting, upright positioning after MH surgery facilitates absorption of the oedema which is beneficial for MH closure.<\/jats:p>\n <\/jats:sec>\n \n Key messages<\/jats:title>\n \n \n What is known<\/jats:italic>\n <\/jats:bold>:\n \n Macular hole formation is associated with cystoid macular oedema, possibly due to hydration of the outer retinal layers exposed to the hypotonic vitreous fluid. This oedema promotes the elevation of the hole edges from the retinal pigment epithelium.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n \n \n What is new<\/jats:italic>\n <\/jats:bold>:\n \n Macular hole-related oedema decreases when the patients are upright and increases, in parallel with an increase in mean minimum macular hole diameter, when they are recumbent. <\/jats:p>\n <\/jats:list-item>\n \n The reduction of macular oedema is correlated with a reduction in mean ocular perfusion pressure, indicating that the oedema is influenced by subtle leakage from retinal capillaries.<\/jats:p>\n <\/jats:list-item>\n \n The results suggest that upright positioning might be beneficial in the early postoperative period of macular hole surgery.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1007\/s00417-025-06757-1","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T21:15:18Z","timestamp":1738703718000},"page":"1249-1257","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Upright positioning facilitates the absorption of macular hole-related oedema"],"prefix":"10.1007","volume":"263","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5797-4207","authenticated-orcid":false,"given":"Vegard A.","family":"Forsaa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birger","family":"Lindtj\u00f8rn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian","family":"Dahl\u00f8","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia","family":"Ushakova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rgen","family":"Krohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"6757_CR1","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1111\/aos.13618","volume":"96","author":"VA Forsaa","year":"2017","unstructured":"Forsaa VA, Lindtjorn B, Kvaloy JT, Froystein T, Krohn J (2017) Epidemiology and morphology of full-thickness macular holes. 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