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Correlations between the mean deviation (MD) and axial length were evaluated in these patients using the Pearson\u2019s correlation coefficient. Advanced POAG was defined as having an MD of less than \u201312 dB as measured by the Humphrey visual field analyzer (HFA). The cutoff values of the axial length and SER for the risk of developing advanced POAG were determined using Fisher\u2019s exact test and Youden\u2019s J statistic for HFA 24\u20132 and 10\u20132, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study included 741 eyes of 438 patients. In POAG, axial length was negatively correlated with the MDs of the HFA 24\u20132 and 10\u20132. However, in secondary glaucoma, axial length did not significantly correlate with the MDs of the HFA. The cutoff axial length for the HFA 24\u20132 was 27.7 mm. For HFA 10\u20132, two peaks for the Youden\u2019s J statistic were observed, at 27.67 mm and 25.51 mm. No significant association was found between SER and severity of visual field changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Axial length measurement was clinically significant in assessing risk of severe or central visual field defects in young patients with POAG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00417-025-06827-4","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T13:07:22Z","timestamp":1744636042000},"page":"2631-2639","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploration of the cutoff values of axial length that is susceptible to develop advanced primary open angle glaucoma in patients aged less than 50 years"],"prefix":"10.1007","volume":"263","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1636-0898","authenticated-orcid":false,"given":"Kenji","family":"Suda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Miyake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadamichi","family":"Akagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanako Ohashi","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Kameda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Numa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akitaka","family":"Tsujikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"6827_CR1","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/519276A","volume":"519","author":"E Dolgin","year":"2015","unstructured":"Dolgin E (2015) The myopia boom. 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