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Swap samples from all children were taken. The alpha diversity of the ocular surface microbiota within each group were evaluated by using Shannon's, Simpson, and Chao index. Beta diversity was evaluated by Bray Curtis index.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Microbiological diversity was higher in the patient group than in the control group. According to Shannon's, Simpson, and Chao index, there were statistically difference between groups (p: 0.000013, p:000003 p: 0.00235, respectively). According to the Bray Curtis index, the healthy eye microbiome in the control group is observed to be highly similar, consistent with other analyses, and the overlapping cluster with the blepharitis eye microbiome is quite low (pco1: 40.93%). <jats:italic>Sphingoblump<\/jats:italic>\n              <jats:italic>, <\/jats:italic>\n              <jats:italic>Micrococus<\/jats:italic>, <jats:italic>Lacnospiracebacterium<\/jats:italic>\n              <jats:italic>, <\/jats:italic>\n              <jats:italic>Stenothermophilus<\/jats:italic>\n              <jats:italic>, <\/jats:italic>\n              <jats:italic>Aurelmonass<\/jats:italic>\n              <jats:italic>, <\/jats:italic>\n              <jats:italic>Micrococus<\/jats:italic>\n              <jats:italic>, <\/jats:italic>\n              <jats:italic>Blatiabeum<\/jats:italic>\n              <jats:italic>, <\/jats:italic>\n              <jats:italic>Delfiacdiovorans<\/jats:italic> and <jats:italic>Vellonella<\/jats:italic> densities were found to be higher in the patient group.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Both alpha and beta diversity analyses were significantly higher in pediatric age group patients with blepharitis. In addition, <jats:italic>Lacnospiracebacterium<\/jats:italic>\n              <jats:italic>, <\/jats:italic>\n              <jats:italic>Stenothermophilus<\/jats:italic>\n              <jats:italic>, <\/jats:italic>\n              <jats:italic>Aurelmonass<\/jats:italic>\n              <jats:italic>, <\/jats:italic>\n              <jats:italic>Micrococus<\/jats:italic>\n              <jats:italic>, <\/jats:italic>\n              <jats:italic>Blatiabeum<\/jats:italic>\n              <jats:italic>, <\/jats:italic>\n              <jats:italic>Delfiacdiovorans<\/jats:italic> and <jats:italic>Vellonella<\/jats:italic> densities were found to be higher, which may lead to future studies focused on diagnosis and treatment.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00417-025-06836-3","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T03:18:21Z","timestamp":1745378301000},"page":"2359-2367","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of ocular surface microbiota in children with blepharoconjunctivitis"],"prefix":"10.1007","volume":"263","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7816-0627","authenticated-orcid":false,"given":"Bur\u00e7in","family":"\u00c7ak\u0131r","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2113-8450","authenticated-orcid":false,"given":"B\u00fc\u015fra G\u00fcner","family":"S\u00f6nmezo\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8873-2884","authenticated-orcid":false,"given":"Elif \u00d6z\u00f6zen","family":"\u015eahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8101-1104","authenticated-orcid":false,"given":"Mehmet","family":"K\u00f6ro\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1107-9546","authenticated-orcid":false,"given":"Nilg\u00fcn \u00d6zkan","family":"Aksoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"issue":"2","key":"6836_CR1","doi-asserted-by":"publisher","first-page":"CD011965","DOI":"10.1002\/14651858.CD011965.)","volume":"2","author":"M O'Gallagher","year":"2017","unstructured":"O\u2019Gallagher M, Bunce C, Hingorani M, Larkin F, Tuft S, Dahlmann-Noor A (2017) Topical treatments for blepharokeratoconjunctivitis in children. 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The authors of this manuscript have no financial conflicts of interest to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}