{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:12:59Z","timestamp":1770970379017,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007109","name":"Universit\u00e0 degli Studi di Ferrara","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007109","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The aim of the study was to assess the outcomes of pars plana vitrectomy and macular peeling for vitreomacular interface disorders in eyes with coexisting nonexudative age-related macular degeneration (AMD), and to compare the rate of AMD progression in operated and fellow eyes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This retrospective comparative study included patients with bilateral nonexudative AMD and unilateral vitreomacular interface disorder who underwent pars plana vitrectomy with internal limiting membrane peeling. Controlateral unoperated eyes were used as a control group. Cox proportional hazards regression analysis was used to compare the incidence of macular neovascularization, geographic atrophy and progression to late AMD in operated eyes and fellow eyes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>142 eyes of 71 patients were included. The mean follow-up duration was 17.5\u2009\u00b1\u200915.5\u00a0months. Best corrected visual acuity significantly improved in operated eyes (from 0.47\u2009\u00b1\u20090.25 to 0.21\u2009\u00b1\u20090.18 logMAR; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), while no significant difference was observed in fellow eyes (from 0.18\u2009\u00b1\u20090.22 to 0.33\u2009\u00b1\u20090.56 logMAR; <jats:italic>p<\/jats:italic>\u2009=\u20090.055). Central retinal thickness improved in operated eyes (from 0402.9\u2009\u00b1\u200979.9 to 296.1\u2009\u00b1\u200948.4\u00a0\u00b5m; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), while no change in fellow eyes was observed (from 296.1\u2009\u00b1\u200948.4 to 312.7\u2009\u00b1\u2009110.6\u00a0\u00b5m; <jats:italic>p<\/jats:italic>\u2009=\u20090.205). Vitrectomy was not associated with the risk of developing macular neovascularization (hazard ratio [HR]\u2009=\u20090.30; 95% confidence intervals (CI)\u2009=\u20090.08\u20131.09; <jats:italic>p<\/jats:italic>\u2009=\u20090.068); geographic atrophy (HR\u2009=\u20091.01, 95% CI\u2009=\u20090.32\u20133.12; <jats:italic>p<\/jats:italic>\u2009=\u20090.990) nor progression to late AMD (HR\u2009=\u20090.64, 95% CI\u2009=\u20090.28\u20131.49; <jats:italic>p<\/jats:italic>\u2009=\u20090.307).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Pars plana vitrectomy with macular peeling for vitreomacular interface disorders in eyes with coexisting nonexudative AMD is associated with positive visual and functional outcomes, with no shot-term increased risk of AMD progression.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00417-025-06848-z","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T05:56:15Z","timestamp":1746078975000},"page":"2203-2208","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Vitrectomy with macular peeling in eyes with vitreomacular interface disorders and nonexudative age-related macular degeneration"],"prefix":"10.1007","volume":"263","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6419-6941","authenticated-orcid":false,"given":"Marco","family":"Pellegrini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ginevra Giovanna","family":"Adamo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Vivarelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Sarti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro Maria","family":"Talli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Nasini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Parmeggiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Mura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,1]]},"reference":[{"key":"6848_CR1","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1001\/archopht.122.4.477","volume":"122","author":"N Congdon","year":"2004","unstructured":"Congdon N, O\u2019Colmain B, Klaver CC et al (2004) Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol 122:477\u2013485","journal-title":"Arch Ophthalmol"},{"key":"6848_CR2","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1001\/archopht.122.4.564","volume":"122","author":"Eye Diseases Prevalence Research Group","year":"2004","unstructured":"Eye Diseases Prevalence Research Group (2004) Prevalence of agerelated macular degeneration in the United States. Arch Ophthalmol 122:564\u2013572","journal-title":"Arch Ophthalmol"},{"key":"6848_CR3","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.ajo.2003.11.069","volume":"137","author":"R Klein","year":"2004","unstructured":"Klein R, Peto T, Bird A, Vannewkirk MR (2004) The epidemiology of age-related macular degeneration. Am J Ophthalmol 137:486\u2013495","journal-title":"Am J Ophthalmol"},{"key":"6848_CR4","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1016\/j.ophtha.2009.11.007","volume":"117","author":"AB Roller","year":"2010","unstructured":"Roller AB, Mahajan VB, Boldt HC, Abramoff MD, Russell SR, Folk JC (2010) Effects of vitrectomy on age-related macular degeneration. Ophthalmology 117:1381\u20131386","journal-title":"Ophthalmology"},{"issue":"4","key":"6848_CR5","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1007\/s00417-020-04943-x","volume":"259","author":"IK Muftuoglu","year":"2021","unstructured":"Muftuoglu IK, Lin T, Bartsch DU, Freeman WR (2021) Influence of vitrectomy on the progression of dry age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 259(4):847\u2013853","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"5","key":"6848_CR6","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.ajo.2007.07.024","volume":"144","author":"I Krebs","year":"2007","unstructured":"Krebs I, Brannath W, Glittenberg C, Zeiler F, Sebag J, Binder S (2007) Posterior vitreomacular adhesion: a potential risk factor for exudative age-related macular degeneration? Am J Ophthalmol 144(5):741\u2013746","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"6848_CR7","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.ajo.2008.04.027","volume":"146","author":"F Mojana","year":"2008","unstructured":"Mojana F, Cheng L, Bartsch DU, Silva GA, Kozak I, Nigam N, Freeman WR (2008) The role of abnormal vitreomacular adhesion in age-related macular degeneration: spectral optical coherence tomography and surgical results. Am J Ophthalmol 146(2):218\u2013227","journal-title":"Am J Ophthalmol"},{"key":"6848_CR8","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1001\/archopht.120.1.29","volume":"120","author":"MS Ip","year":"2002","unstructured":"Ip MS, Baker BJ, Duker JS, Reichel E, Baumal CR, Gangnon R et al (2002) Anatomical outcomes of surgery for idiopathic macular hole as determined by optical coherence tomography. Arch Ophthalmol 120:29\u201335","journal-title":"Arch Ophthalmol"},{"key":"6848_CR9","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1046\/j.1442-9071.2000.00329.x","volume":"28","author":"HK Kang","year":"2000","unstructured":"Kang HK, Chang AA, Beaumont PE (2000) The macular hole: report of an Australian surgical series and meta-analysis of the literature. Clin Exp Ophthalmol 28:298\u2013308","journal-title":"Clin Exp Ophthalmol"},{"issue":"4","key":"6848_CR10","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.ophtha.2017.09.028","volume":"125","author":"SR Sadda","year":"2017","unstructured":"Sadda SR, Guymer R, Holz FG et al (2017) Consensus definition for atrophy associated with age-related macular degeneration onOCT: Classification of Atrophy report 3. Ophthalmology 125(4):537\u2013548","journal-title":"Ophthalmology"},{"key":"6848_CR11","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/j.ophtha.2010.09.001","volume":"118","author":"Y Nomura","year":"2011","unstructured":"Nomura Y, Ueta T, Iriyama A et al (2011) Vitreomacular interface in typical exudative age-related macular degeneration and polypoidal choroidal vasculopathy. Ophthalmology 118:853\u2013859","journal-title":"Ophthalmology"},{"issue":"3","key":"6848_CR12","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1097\/IAE.0b013e3182278b80","volume":"32","author":"SM Waldstein","year":"2012","unstructured":"Waldstein SM, Sponer U, Simader C, Sacu S, Schmidt-Erfurth U (2012) Influence of vitreomacular adhesion on the development of exudative age-related macular degeneration: 4-year results of a longitudinal study. Retina 32(3):424\u2013433","journal-title":"Retina"},{"issue":"5","key":"6848_CR13","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.ophtha.2017.01.018","volume":"124","author":"E Maggio","year":"2017","unstructured":"Maggio E, Polito A, Guerriero M, Prigione G, Parolini B, Pertile G (2017) Vitreomacular Adhesion and the Risk of Neovascular Age-Related Macular Degeneration. Ophthalmology 124(5):657\u2013666","journal-title":"Ophthalmology"},{"issue":"4","key":"6848_CR14","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.ajo.2008.10.003","volume":"147","author":"SJ Lee","year":"2009","unstructured":"Lee SJ, Lee CS, Koh HJ (2009) Posterior vitreomacular adhesion and risk of exudative age-related macular degeneration: paired eye study. Am J Ophthalmol 147(4):621\u2013626.e1","journal-title":"Am J Ophthalmol"},{"key":"6848_CR15","doi-asserted-by":"crossref","unstructured":"Lee EK, Lee S-Y, Yu HG. Epiretinal membrane in nonexudative age-related macular degeneration: anatomical features, visual outcomes and prognostic factors. Retina. 2016;36:1557e1565.","DOI":"10.1097\/IAE.0000000000000953"},{"issue":"8","key":"6848_CR16","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/j.oret.2018.01.004","volume":"2","author":"A Obeid","year":"2018","unstructured":"Obeid A, Ali FS, Deaner JD, Gao X, Hsu J, Chiang A (2018) Outcomes of Pars Plana Vitrectomy for Epiretinal Membrane in Eyes With Coexisting Dry Age-related Macular Degeneration. Ophthalmol Retina 2(8):765\u2013770","journal-title":"Ophthalmol Retina"},{"issue":"14","key":"6848_CR17","doi-asserted-by":"publisher","first-page":"389","DOI":"10.2147\/OPTH.S240480","volume":"11","author":"O Furashova","year":"2020","unstructured":"Furashova O, Engelmann K (2020) To Peel or Not to Peel: Pars plana vitrectomy with macular membrane peel in eyes with abnormalities of vitreomacular interface and coexisting dry age-related macular degeneration. Clin Ophthalmol 11(14):389\u2013396","journal-title":"Clin Ophthalmol"},{"key":"6848_CR18","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/j.exer.2004.01.003","volume":"78","author":"IA Barbazetto","year":"2004","unstructured":"Barbazetto IA, Liang J, Chang S et al (2004) Oxygen tension in the rabbit lens and vitreous before and after vitrectomy. Exp Eye Res 78:917\u2013924. https:\/\/doi.org\/10.1016\/j.exer.2004.01.003","journal-title":"Exp Eye Res"},{"key":"6848_CR19","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.ajo.2004.09.046","volume":"139","author":"NM Holekamp","year":"2005","unstructured":"Holekamp NM, Shui YB, Beebe DC (2005) Vitrectomy surgery increases oxygen exposure to the lens: a possible mechanism for nuclear cataract formation. Am J Ophthalmol 139:302\u2013310","journal-title":"Am J Ophthalmol"},{"issue":"12","key":"6848_CR20","doi-asserted-by":"publisher","first-page":"2620","DOI":"10.1016\/j.ophtha.2013.05.032","volume":"120","author":"U Mayr-Sponer","year":"2013","unstructured":"Mayr-Sponer U, Waldstein SM, Kundi M, Ritter M, Golbaz I, Heiling U, Papp A, Simader C, Schmidt-Erfurth U (2013) Influence of the vitreomacular interface on outcomes of ranibizumab therapy in neovascular age-related macular degeneration. Ophthalmology 120(12):2620\u20132629","journal-title":"Ophthalmology"},{"key":"6848_CR21","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1016\/j.ophtha.2015.02.031","volume":"122","author":"TA Ciulla","year":"2015","unstructured":"Ciulla TA, Ying GS, Maguire MG et al (2015) Influence of the vitreomacular interface on treatment outcomes in the comparison of age-related macular degeneration treatments trials. Ophthalmology 122:1203\u20131211","journal-title":"Ophthalmology"},{"issue":"8","key":"6848_CR22","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1097\/IAE.0000000000000531","volume":"35","author":"EE Karaca","year":"2015","unstructured":"Karaca EE, Kepez Yldz B, \u00c7ubuk M\u00d6, \u00d6zdek \u015e (2015) EPIRETINAL MEMBRANES IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: Effect on Outcomes of Anti-vascular Endothelial Growth Factor Therapy. Retina 35(8):1540\u20131546","journal-title":"Retina"},{"issue":"4","key":"6848_CR23","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1167\/iovs.09-3582","volume":"51","author":"SS Lee","year":"2010","unstructured":"Lee SS, Ghosn C, Yu Z, Zacharias LC, Kao H, Lanni C, Abdelfattah N, Kuppermann B, Csaky KG, D\u2019Argenio DZ, Burke JA, Hughes PM, Robinson MR (2010) Vitreous VEGF clearance is increased after vitrectomy. Invest Ophthalmol Vis Sci 51(4):2135\u20132138","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"6848_CR24","doi-asserted-by":"publisher","first-page":"6501","DOI":"10.1167\/iovs.15-17279","volume":"56","author":"Y Niwa","year":"2015","unstructured":"Niwa Y, Kakinoki M, Sawada T, Wang X, Ohji M (2015) Ranibizumab and aflibercept: intraocular pharmacokinetics and their effects on aqueous VEGF level in vitrectomized and nonvitrectomized macaque eyes. Invest Ophthalmol Visual Sci 56(11):6501\u20136505. https:\/\/doi.org\/10.1167\/iovs.15-17279","journal-title":"Invest Ophthalmol Visual Sci"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-025-06848-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-025-06848-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-025-06848-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T05:45:12Z","timestamp":1757137512000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-025-06848-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,1]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["6848"],"URL":"https:\/\/doi.org\/10.1007\/s00417-025-06848-z","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,1]]},"assertion":[{"value":"12 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the Comitato Etico di Area Vasta Emilia Centro della Regione Emilia-Romagna and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers\u2019 bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}