{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T17:51:46Z","timestamp":1775929906655,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s00417-025-06864-z","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T07:55:09Z","timestamp":1755590109000},"page":"3105-3112","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of predominant peripheral lesions with retinal microvasculature and risk of vitreous hemorrhage in proliferative diabetic retinopathy"],"prefix":"10.1007","volume":"263","author":[{"given":"Jenny","family":"Gan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioanna","family":"Ploumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Romano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine M.","family":"Overbey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio D.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itika","family":"Garg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippos","family":"Vingopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Stettler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Finn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peyman","family":"Razavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelyn M.","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cade F.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimesh A.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo A.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deeba","family":"Husain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demetrios G.","family":"Vavvas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John B.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"issue":"4","key":"6864_CR1","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1111\/ceo.12696","volume":"44","author":"DSW Ting","year":"2016","unstructured":"Ting DSW, Cheung GCM, Wong TY (2016) Diabetic retinopathy: global prevalence, major risk factors, screening practices and public health challenges: a review. Clin Exp Ophthalmol 44(4):260\u2013277. https:\/\/doi.org\/10.1111\/ceo.12696","journal-title":"Clin Exp Ophthalmol"},{"issue":"suppl1","key":"6864_CR2","doi-asserted-by":"publisher","first-page":"s84","DOI":"10.2337\/diacare.27.2007.S84","volume":"27","author":"DS Fong","year":"2004","unstructured":"Fong DS, Aiello L, Gardner TW et al (2004) Retinopathy in diabetes. Diabetes Care 27(suppl1):s84\u2013s87. https:\/\/doi.org\/10.2337\/diacare.27.2007.S84","journal-title":"Diabetes Care"},{"key":"6864_CR3","unstructured":"Home, Resources, diabetes L with, et al. IDF Diabetes Atlas 2021\u00a0| IDF Diabetes Atlas. Accessed February 3, 2024. https:\/\/diabetesatlas.org\/atlas\/tenth-edition\/"},{"key":"6864_CR4","doi-asserted-by":"publisher","unstructured":"Schaal KB, Munk MR, Wyssmueller I, Berger LE, Zinkernagel MS, Wolf S (2019) Vascular abnormalities in diabetic retinopathy assessed with swept-source optical coherence tomography angiography widefield imaging. Retina 39(1):79. https:\/\/doi.org\/10.1097\/IAE.0000000000001938","DOI":"10.1097\/IAE.0000000000001938"},{"key":"6864_CR5","doi-asserted-by":"publisher","first-page":"2156273","DOI":"10.1155\/2016\/2156273","volume":"2016","author":"P Romero-Aroca","year":"2016","unstructured":"Romero-Aroca P, Baget-Bernaldiz M, Pareja-Rios A, Lopez-Galvez M, Navarro-Gil R, Verges R (2016) Diabetic macular edema pathophysiology: vasogenic versus inflammatory. J Diabetes Res 2016:2156273. https:\/\/doi.org\/10.1155\/2016\/2156273","journal-title":"J Diabetes Res"},{"issue":"4","key":"6864_CR6","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/S2213-8587(19)30411-5","volume":"8","author":"S Vujosevic","year":"2020","unstructured":"Vujosevic S, Aldington SJ, Silva P et al (2020) Screening for diabetic retinopathy: new perspectives and challenges. Lancet Diabetes Endocrinol 8(4):337\u2013347. https:\/\/doi.org\/10.1016\/S2213-8587(19)30411-5","journal-title":"Lancet Diabetes Endocrinol"},{"key":"6864_CR7","doi-asserted-by":"crossref","unstructured":"Grading diabetic retinopathy from stereoscopic color fundus photographs\u2013an extension of the modified Airlie House classification (1991) ETDRS report number 10. Early treatment diabetic retinopathy study research group. Ophthalmology 98(5 Suppl):786\u2013806","DOI":"10.1016\/S0161-6420(13)38012-9"},{"issue":"10","key":"6864_CR8","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1136\/bjo-2022-321297","volume":"107","author":"X Zhuang","year":"2023","unstructured":"Zhuang X, Chen R, Liang A et al (2023) Multimodal imaging analysis for the impact of retinal peripheral lesions on central neurovascular structure and retinal function in type 2 diabetes with diabetic retinopathy. Br J Ophthalmol 107(10):1496\u20131501. https:\/\/doi.org\/10.1136\/bjo-2022-321297","journal-title":"Br J Ophthalmol"},{"issue":"2","key":"6864_CR9","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.joco.2016.04.001","volume":"28","author":"K Ghasemi Falavarjani","year":"2016","unstructured":"Ghasemi Falavarjani K, Wang K, Khadamy J, Sadda SR (2016) Ultra-wide-field imaging in diabetic retinopathy; an overview. J Curr Ophthalmol 28(2):57\u201360. https:\/\/doi.org\/10.1016\/j.joco.2016.04.001","journal-title":"J Curr Ophthalmol"},{"issue":"4","key":"6864_CR10","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1159\/000501372","volume":"62","author":"SD Solomon","year":"2019","unstructured":"Solomon SD, Goldberg MF (2019) ETDRS grading of diabetic retinopathy: still the gold standard?? Ophthalmic Res 62(4):190\u2013195. https:\/\/doi.org\/10.1159\/000501372","journal-title":"Ophthalmic Res"},{"issue":"2","key":"6864_CR11","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1177\/2474126419893829","volume":"4","author":"Y Yonekawa","year":"2020","unstructured":"Yonekawa Y, Modi YS, Kim LA, Skondra D, Kim JE, Wykoff CC (2020) American society of retina specialists clinical practice guidelines: management of nonproliferative and proliferative diabetic retinopathy without diabetic macular edema. J Vitreoretin Dis 4(2):125\u2013135. https:\/\/doi.org\/10.1177\/2474126419893829","journal-title":"J Vitreoretin Dis"},{"key":"6864_CR12","doi-asserted-by":"publisher","unstructured":"Duh EJ, Sun JK, Stitt AW. Diabetic retinopathy: current understanding, mechanisms, and treatment strategies. JCI Insight 2(14):e93751. https:\/\/doi.org\/10.1172\/jci.insight.93751","DOI":"10.1172\/jci.insight.93751"},{"issue":"9","key":"6864_CR13","first-page":"4772","volume":"60","author":"PS Silva","year":"2019","unstructured":"Silva PS, Stanton RC, Elmasry MA et al (2019) Association of systemic comorbities with predominantly peripheral diabetic retinopathy lesions (PPL) identified on ultrawide field (UWF) retinal imaging. Investig Ophthalmol Vis Sci 60(9):4772","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"10","key":"6864_CR14","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1001\/jamaophthalmol.2022.3131","volume":"140","author":"DM Marcus","year":"2022","unstructured":"Marcus DM, Silva PS, Liu D et al (2022) Association of predominantly peripheral lesions on ultra-widefield imaging and the risk of diabetic retinopathy worsening over time. JAMA Ophthalmol 140(10):946. https:\/\/doi.org\/10.1001\/jamaophthalmol.2022.3131","journal-title":"JAMA Ophthalmol"},{"issue":"4","key":"6864_CR15","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s00417-020-04607-w","volume":"258","author":"A Verma","year":"2020","unstructured":"Verma A, Alagorie AR, Ramasamy K et al (2020) Distribution of peripheral lesions identified by mydriatic ultra-wide field fundus imaging in diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 258(4):725\u2013733. https:\/\/doi.org\/10.1007\/s00417-020-04607-w","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"9","key":"6864_CR16","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1016\/j.ophtha.2021.02.020","volume":"128","author":"Y Cui","year":"2021","unstructured":"Cui Y, Zhu Y, Lu ES et al (2021) Widefield Swept-source OCT angiography metrics associated with the development of diabetic vitreous hemorrhage. Ophthalmology 128(9):1312\u20131324. https:\/\/doi.org\/10.1016\/j.ophtha.2021.02.020","journal-title":"Ophthalmology"},{"key":"6864_CR17","doi-asserted-by":"publisher","unstructured":"Romano F, Ding X, Miller JB (2024) Expanded field: filling the gap between macula and widefield. Eye (Lond). Published Online Febr 21. https:\/\/doi.org\/10.1038\/s41433-024-02978-6","DOI":"10.1038\/s41433-024-02978-6"},{"issue":"10","key":"6864_CR18","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1016\/j.ophtha.2018.04.007","volume":"125","author":"TY Wong","year":"2018","unstructured":"Wong TY, Sun J, Kawasaki R et al (2018) Guidelines on diabetic eye care: the international council of ophthalmology recommendations for screening, follow-up, referral, and treatment based on resource settings. Ophthalmology 125(10):1608\u20131622. https:\/\/doi.org\/10.1016\/j.ophtha.2018.04.007","journal-title":"Ophthalmology"},{"issue":"9","key":"6864_CR19","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1016\/S0161-6420(03)00475-5","volume":"110","author":"CP Wilkinson","year":"2003","unstructured":"Wilkinson CP, Ferris FL, Klein RE et al (2003) Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology 110(9):1677\u20131682. https:\/\/doi.org\/10.1016\/S0161-6420(03)00475-5","journal-title":"Ophthalmology"},{"issue":"12","key":"6864_CR20","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1016\/j.ophtha.2013.05.004","volume":"120","author":"PS Silva","year":"2013","unstructured":"Silva PS, Cavallerano JD, Sun JK, Soliman AZ, Aiello LM, Aiello LP (2013) Peripheral lesions identified by mydriatic ultrawide field imaging: distribution and potential impact on diabetic retinopathy severity. Ophthalmology 120(12):2587\u20132595. https:\/\/doi.org\/10.1016\/j.ophtha.2013.05.004","journal-title":"Ophthalmology"},{"issue":"6","key":"6864_CR21","doi-asserted-by":"publisher","first-page":"3688","DOI":"10.21037\/qims-21-1175","volume":"13","author":"I Garg","year":"2023","unstructured":"Garg I, Miller JB (2023) Semi-automated algorithm using directional filter for the precise quantification of non-perfusion area on widefield swept-source optical coherence tomography angiograms. Quant Imaging Med Surg 13(6):3688\u20133702. https:\/\/doi.org\/10.21037\/qims-21-1175","journal-title":"Quant Imaging Med Surg"},{"issue":"5","key":"6864_CR22","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/j.ophtha.2015.01.008","volume":"122","author":"PS Silva","year":"2015","unstructured":"Silva PS, Cavallerano JD, Haddad NMN et al (2015) Peripheral lesions identified on ultrawide field imaging predict increased risk of diabetic retinopathy progression over 4 years. Ophthalmology 122(5):949\u2013956. https:\/\/doi.org\/10.1016\/j.ophtha.2015.01.008","journal-title":"Ophthalmology"},{"issue":"1","key":"6864_CR23","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1001\/jamaophthalmol.2018.4982","volume":"137","author":"LP Aiello","year":"2019","unstructured":"Aiello LP, Odia I, Glassman AR et al (2019) Comparison of early treatment diabetic retinopathy study standard 7-field imaging with ultrawide-field imaging for determining severity of diabetic retinopathy. JAMA Ophthalmol 137(1):65\u201373. https:\/\/doi.org\/10.1001\/jamaophthalmol.2018.4982","journal-title":"JAMA Ophthalmol"},{"issue":"12","key":"6864_CR24","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1016\/j.oret.2023.07.020","volume":"7","author":"H Stino","year":"2023","unstructured":"Stino H, Huber KL, Niederleithner M et al (2023) Association of diabetic lesions and retinal nonperfusion using widefield multimodal imaging. Ophthalmol Retina 7(12):1042\u20131050. https:\/\/doi.org\/10.1016\/j.oret.2023.07.020","journal-title":"Ophthalmol Retina"},{"issue":"12","key":"6864_CR25","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1016\/j.ophtha.2015.07.034","volume":"122","author":"PS Silva","year":"2015","unstructured":"Silva PS, Dela Cruz AJ, Ledesma MG et al (2015) Diabetic retinopathy severity and peripheral lesions are associated with nonperfusion on ultrawide field angiography. Ophthalmology 122(12):2465\u20132472. https:\/\/doi.org\/10.1016\/j.ophtha.2015.07.034","journal-title":"Ophthalmology"},{"key":"6864_CR26","doi-asserted-by":"publisher","unstructured":"Hafner J, Pollreisz A, Egner B, Pablik E, Schmidt-Erfurth U\u00a0(2020) Presence of peripheral lesions, and correlation to macular perfusion, oxygenation and neurodegeneration in early type II diabetic retinal disease.\u00a0Retina 40(10):1964\u20131971. https:\/\/doi.org\/10.1097\/IAE.0000000000002704","DOI":"10.1097\/IAE.0000000000002704"},{"issue":"1","key":"6864_CR27","doi-asserted-by":"publisher","first-page":"e001616","DOI":"10.1136\/bmjdrc-2020-001616","volume":"8","author":"YJ Kim","year":"2020","unstructured":"Kim YJ, Yeo JH, Son G et al (2020) Efficacy of intravitreal AFlibercept injection for improvement of retinal nonperfusion in diabetic retinopathy (AFFINITY study). BMJ Open Diabetes Res Care 8(1):e001616. https:\/\/doi.org\/10.1136\/bmjdrc-2020-001616","journal-title":"BMJ Open Diabetes Res Care"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-025-06864-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-025-06864-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-025-06864-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T03:50:34Z","timestamp":1764820234000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-025-06864-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,19]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["6864"],"URL":"https:\/\/doi.org\/10.1007\/s00417-025-06864-z","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,19]]},"assertion":[{"value":"4 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the tenets set forth in the Declaration of Helsinki, and all necessary authorizations were obtained from the MEE Institutional Review Board (Protocol #: 2019P001863). Written informed consent was obtained from all participants prior to their inclusion in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"1. JBM is a consultant for Alcon, Allergan, Carl Zeiss, Sumitomo, Topcon, and Genentech.2. DGV is a consultant for Olix Pharma, Valitor, TwentyTwenty, Sumitomo, Cambridge Polymer Group; and has received financial support from National Eye Institute, Research to Prevent Blindness, Loefflers Family Foundation, Yeatts Family Foundation, and Alcon Research Institute. (None relevant to this work).3. DH is a consultant for Allergan, Genentech, Omeicos Therapeutics; and has received financial support from National Eye Institute, Lions Vision Gift, Commonwealth Grant, Lions International, Syneos LLC, and the Macular Society.4. NAP is a consultant for Alimera Sciences, Alcon, Allergan, Genentech, Eyepoint, Lifesciences Guidepoint and GLG.5. LAK has received research support from National Eye Institute and CureVac AG; and has a financial arrangement with Pykus Therapeutics.6. JG, XD, IP, FR, KMO, MDG, IG, FV, IS, JMR, MJF, PR, CFB have no relevant financial disclosures.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Financial disclosures"}},{"value":"No conflicting relationship exists for any author.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}