{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:55:59Z","timestamp":1780080959497,"version":"3.54.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005967","name":"Linnaeus University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005967","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>The aim of this study was to assess perceived stress levels in patients with nAMD undergoing treatment with anti-VEGF injections, and to investigate psychosocial and visual factors that can be associated with perceived stress among these patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We recruited 202 patients diagnosed with nAMD (mean age of 78 years) who had received three or more anti-VEGF injections and had been scheduled for further treatments. To measure perceived stress, participants completed the Perceived Stress Scale-10 (PSS10). For the associated factors, the participants also completed the National Eye Institute Visual Function Questionnaire-25 and Multidimensional Perceived Social Support. Participants completed the questionnaires at home before an upcoming treatment scheduled at the hospital. Best corrected visual acuity was measured at the hospital before the treatment. Factors associated with PSS10 scores were examined using multiple regression models.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Participants with near vision impairment perceived higher stress levels than those without near vision impairment (<jats:italic>p<\/jats:italic>\u2009=\u20090.034). Younger age (\u03b2 = -0.15, <jats:italic>p<\/jats:italic>\u2009=\u20090.003), better visual acuity (\u03b2 = -4.20, <jats:italic>p<\/jats:italic>\u2009=\u20090.036), poorer perceived social support (\u03b2 = -1.21, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and poorer self-reported visual function (\u03b2 = -0.16, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were significantly associated with increased levels of perceived stress.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our study highlighted factors potentially associated with increased perceived stress in nAMD patients undergoing anti-VEGF treatment. Self-reported visual function, in particular near-vision, and perceived social support are factors that can be addressed to reduce the levels of stress and risk of mental health disorders in this patient group.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00417-025-06883-w","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T01:21:03Z","timestamp":1751073663000},"page":"2523-2531","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Perceived stress levels among patients treated for neovascular age-related macular degeneration with anti-VEGF injections"],"prefix":"10.1007","volume":"263","author":[{"given":"Ida","family":"Nilsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Senra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3745-0035","authenticated-orcid":false,"given":"Karthikeyan","family":"Baskaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Mohlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3436-2010","authenticated-orcid":false,"given":"Antonio Filipe","family":"Macedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,28]]},"reference":[{"issue":"2","key":"6883_CR1","doi-asserted-by":"publisher","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","volume":"2","author":"WL Wong","year":"2014","unstructured":"Wong WL, Su X, Li X, Cheung CM, Klein R, Cheng CY, Wong TY (2014) Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health 2(2):e106\u2013e116","journal-title":"Lancet Glob Health"},{"issue":"9","key":"6883_CR2","doi-asserted-by":"publisher","first-page":"e056995","DOI":"10.1136\/bmjopen-2021-056995","volume":"12","author":"PL Ramos","year":"2022","unstructured":"Ramos PL, Santana R, Marques AP, Sousa I, Rocha-Sousa A, Macedo AF (2022) Cross-sectional study investigating the prevalence and causes of vision impairment in northwest Portugal using capture-recapture. BMJ Open 12(9):e056995","journal-title":"BMJ Open"},{"issue":"3","key":"6883_CR3","first-page":"Cd005139","volume":"3","author":"SD Solomon","year":"2019","unstructured":"Solomon SD, Lindsley K, Vedula SS, Krzystolik MG, Hawkins BS (2019) Anti-vascular endothelial growth factor for neovascular age-related macular degeneration. Cochrane Database Syst Rev 3(3):Cd005139","journal-title":"Cochrane Database Syst Rev"},{"issue":"11","key":"6883_CR4","doi-asserted-by":"publisher","first-page":"e009006","DOI":"10.1136\/bmjopen-2015-009006","volume":"5","author":"AP Marques","year":"2015","unstructured":"Marques AP, Macedo AF, Perelman J, Aguiar P, Rocha-Sousa A, Santana R (2015) Diffusion of anti-VEGF injections in the Portuguese national health system. BMJ Open 5(11):e009006","journal-title":"BMJ Open"},{"issue":"4","key":"6883_CR5","doi-asserted-by":"publisher","first-page":"e055478","DOI":"10.1136\/bmjopen-2021-055478","volume":"12","author":"JV Rocha","year":"2022","unstructured":"Rocha JV, Marques AP, Macedo AF, Afonso-Silva M, Laires P, Almeida AS, Fernandes J, Pardal M, Santana R (2022) Trends, geographical variation and factors associated with the use of anti-VEGF intravitreal injections in Portugal (2013\u20132018): a retrospective analysis of administrative data. BMJ Open 12(4):e055478","journal-title":"BMJ Open"},{"issue":"5","key":"6883_CR6","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1007\/s00417-012-2177-3","volume":"251","author":"KM Droege","year":"2013","unstructured":"Droege KM, Muether PS, Hermann MM, Caramoy A, Viebahn U, Kirchhof B, Fauser S (2013) Adherence to Ranibizumab treatment for neovascular age-related macular degeneration in real life. Graefes Arch Clin Exp Ophthalmol 251(5):1281\u20131284","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"10","key":"6883_CR7","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1007\/s00417-016-3384-0","volume":"254","author":"H Senra","year":"2016","unstructured":"Senra H, Ali Z, Balaskas K, Aslam T (2016) Psychological impact of anti-VEGF treatments for wet macular degeneration-a review. Graefes Arch Clin Exp Ophthalmol 254(10):1873\u20131880","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"6883_CR8","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.ajo.2017.03.005","volume":"177","author":"H Senra","year":"2017","unstructured":"Senra H, Balaskas K, Mahmoodi N, Aslam T (2017) Experience of Anti-VEGF treatment and clinical levels of depression and anxiety in patients with wet age-related macular degeneration. Am J Ophthalmol 177:213\u2013224","journal-title":"Am J Ophthalmol"},{"issue":"12","key":"6883_CR9","doi-asserted-by":"publisher","first-page":"3649","DOI":"10.1007\/s00417-021-05324-8","volume":"259","author":"U Kellner","year":"2021","unstructured":"Kellner U, Bedar MS, Weinitz S, Farmand G, S\u00fcr\u00fcl EN, Weide SM, Schick T (2021) Treatment contentment and preference of patients undergoing intravitreal anti-VEGF therapy. Graefes Arch Clin Exp Ophthalmol 259(12):3649\u20133654","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"6883_CR10","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/1471-2415-14-78","volume":"14","author":"SR Dawson","year":"2014","unstructured":"Dawson SR, Mallen CD, Gouldstone MB, Yarham R, Mansell G (2014) The prevalence of anxiety and depression in people with age-related macular degeneration: a systematic review of observational study data. BMC Ophthalmol 14:78","journal-title":"BMC Ophthalmol"},{"issue":"5","key":"6883_CR11","doi-asserted-by":"publisher","first-page":"e152","DOI":"10.1192\/bjo.2022.558","volume":"8","author":"A Macnamara","year":"2022","unstructured":"Macnamara A, Coussens S, Chen C, Schinazi VR, Loetscher T (2022) The psychological impact of instrumental activities of daily living on people with simulated age-related macular degeneration. BJPsych Open 8(5):e152","journal-title":"BJPsych Open"},{"issue":"7","key":"6883_CR12","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1001\/jamaophthalmol.2021.1557","volume":"139","author":"M Parravano","year":"2021","unstructured":"Parravano M, Petri D, Maurutto E, Lucenteforte E, Menchini F, Lanzetta P, Varano M, van Nispen RMA (2021) Virgili, association between visual impairment and depression in patients attending eye clinics: a meta-analysis. JAMA Ophthalmol 139(7):753\u2013761","journal-title":"JAMA Ophthalmol"},{"issue":"4","key":"6883_CR13","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1111\/opo.12837","volume":"41","author":"HP van der Aa","year":"2021","unstructured":"van der Aa HP, van Rens GH, Verbraak FD, Bosscha M, Comijs HC, van Nispen RM (2021) Anxiety and depression in patients who receive anti-VEGF treatment and the usability and feasibility of e-mental health support: the E-PsEYE pilot study. Ophthalmic Physiol Opt 41(4):808\u2013819","journal-title":"Ophthalmic Physiol Opt"},{"issue":"1","key":"6883_CR14","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1038\/s41598-022-06252-1","volume":"12","author":"H Senra","year":"2022","unstructured":"Senra H, Hernandez-Moreno L, Moreno N, Macedo AF (2022) Anxiety levels moderate the association between visual acuity and health-related quality of life in chronic eye disease patients. Sci Rep 12(1):2313","journal-title":"Sci Rep"},{"issue":"9","key":"6883_CR15","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1177\/0269215521997991","volume":"35","author":"L Hern\u00e1ndez-Moreno","year":"2021","unstructured":"Hern\u00e1ndez-Moreno L, Senra H, Moreno N, Macedo AF (2021) Is perceived social support more important than visual acuity for clinical depression and anxiety in patients with age-related macular degeneration and diabetic retinopathy? Clin Rehabil 35(9):1341\u20131347","journal-title":"Clin Rehabil"},{"issue":"3","key":"6883_CR16","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1080\/13548506.2014.936886","volume":"20","author":"J Boyle","year":"2015","unstructured":"Boyle J, Vukicevic M, Koklanis K, Itsiopoulos C (2015) Experiences of patients undergoing anti-VEGF treatment for neovascular age-related macular degeneration: a systematic review. Psychol Health Med 20(3):296\u2013310","journal-title":"Psychol Health Med"},{"issue":"4","key":"6883_CR17","doi-asserted-by":"publisher","first-page":"385","DOI":"10.2307\/2136404","volume":"24","author":"S Cohen","year":"1983","unstructured":"Cohen S, Kamarck T, Mermelstein R (1983) A global measure of perceived stress. J Health Soc Behav 24(4):385\u2013396","journal-title":"J Health Soc Behav"},{"key":"6883_CR18","first-page":"31","volume-title":"Perceived stress in a probability sample of the united states, the social psychology of health","author":"S Cohen","year":"1988","unstructured":"Cohen S (1988) Perceived stress in a probability sample of the united states, the social psychology of health. Sage Publications, Inc, Thousand Oaks, pp 31\u201367"},{"issue":"6","key":"6883_CR19","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1111\/sjop.12071","volume":"54","author":"M Nordin","year":"2013","unstructured":"Nordin M, Nordin S (2013) Psychometric evaluation and normative data of the Swedish version of the 10-item perceived stress scale. Scand J Psychol 54(6):502\u2013507","journal-title":"Scand J Psychol"},{"issue":"3","key":"6883_CR20","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1097\/OPX.0000000000001055","volume":"94","author":"BE Dougherty","year":"2017","unstructured":"Dougherty BE, Cooley SL, Davidorf FH (2017) Measurement of perceived stress in age-related macular degeneration. Optom Vis Sci 94(3):290\u2013296","journal-title":"Optom Vis Sci"},{"issue":"2","key":"6883_CR21","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1001\/jamaophthalmol.2018.5893","volume":"137","author":"EJ Berlinberg","year":"2019","unstructured":"Berlinberg EJ, Gonzales JA, Doan T, Acharya NR (2019) Association between noninfectious uveitis and psychological stress. JAMA Ophthalmol 137(2):199\u2013205","journal-title":"JAMA Ophthalmol"},{"issue":"5","key":"6883_CR22","doi-asserted-by":"publisher","first-page":"443","DOI":"10.3341\/kjo.2022.0049","volume":"36","author":"M Ji","year":"2022","unstructured":"Ji M, Kim JS, Baek SU, Kim YK, Nam KT, Lee JY, Lee HJ, Jeong J, Ha A (2022) Perceived stress levels and associated factors in adult patients with primary open-angle glaucoma: a prospective survey study. Korean J Ophthalmol 36(5):443\u2013451","journal-title":"Korean J Ophthalmol"},{"issue":"5","key":"6883_CR23","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1111\/j.1755-3768.2010.02092.x","volume":"90","author":"M Rasmussen","year":"2012","unstructured":"Rasmussen M, Ekholm O, Prause JU, Toft PB (2012) Quality of life of eye amputated patients. Acta Ophthalmol 90(5):435\u2013440","journal-title":"Acta Ophthalmol"},{"issue":"1","key":"6883_CR24","doi-asserted-by":"publisher","first-page":"7079","DOI":"10.1038\/s41598-022-11271-z","volume":"12","author":"N Tananuvat","year":"2022","unstructured":"Tananuvat N, Tansanguan S, Wongpakaran N, Wongpakaran T (2022) Role of neuroticism and perceived stress on quality of life among patients with dry eye disease. Sci Rep 12(1):7079","journal-title":"Sci Rep"},{"issue":"2","key":"6883_CR25","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1001\/archopht.116.2.227","volume":"116","author":"CM Mangione","year":"1998","unstructured":"Mangione CM, Berry S, Spritzer K, Janz NK, Klein R, Owsley C, Lee PP (1998) Identifying the content area for the 51-item national eye institute visual function questionnaire: results from focus groups with visually impaired persons. Arch Ophthalmol 116(2):227\u2013233","journal-title":"Arch Ophthalmol"},{"issue":"1","key":"6883_CR26","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1207\/s15327752jpa5201_2","volume":"52","author":"GD Zimet","year":"1988","unstructured":"Zimet GD, Dahlem NW, Zimet SG, Farley GK (1988) The multidimensional scale of perceived social support. J Pers Assess 52(1):30\u201341","journal-title":"J Pers Assess"},{"key":"6883_CR27","doi-asserted-by":"publisher","first-page":"21","DOI":"10.2147\/CLEP.S282475","volume":"13","author":"JF Ludvigsson","year":"2021","unstructured":"Ludvigsson JF, Appelros P, Askling J, Byberg L, Carrero JJ, Ekstr\u00f6m AM, Ekstr\u00f6m M, Smedby KE, Hagstr\u00f6m H, James S, J\u00e4rvholm B, Michaelsson K, Pedersen NL, Sundelin H, Sundquist K, Sundstr\u00f6m J (2021) Adaptation of the Charlson comorbidity index for register-based research in Sweden. Clin Epidemiol 13:21\u201341","journal-title":"Clin Epidemiol"},{"issue":"5","key":"6883_CR28","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","volume":"40","author":"ME Charlson","year":"1987","unstructured":"Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40(5):373\u2013383","journal-title":"J Chronic Dis"},{"key":"6883_CR29","unstructured":"WHO, Classification of visual impairment according to International Classification of Diseases Eleventh Revision (ICD-11), 2019\/2021. https:\/\/icd.who.int\/browse11\/l-m\/en. Accessed 2022-09-26"},{"issue":"3","key":"6883_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v045.i03","volume":"45","author":"S van Buuren","year":"2011","unstructured":"van Buuren S (2011) Groothuis-Oudshoorn, mice: multivariate imputation by chained equations in R. J Stat Softw 45(3):1\u201367","journal-title":"J Stat Softw"},{"issue":"5","key":"6883_CR31","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1080\/09638288.2020.1775901","volume":"44","author":"A Thier","year":"2022","unstructured":"Thier A, Holmberg C (2022) The patients\u2019 view: age-related macular degeneration and its effects - a meta-synthesis. Disabil Rehabil 44(5):661\u2013671","journal-title":"Disabil Rehabil"},{"issue":"9","key":"6883_CR32","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1016\/j.ophtha.2005.03.028","volume":"112","author":"LG Hyman","year":"2005","unstructured":"Hyman LG, Komaroff E, Heijl A, Bengtsson B, Leske MC (2005) Treatment and vision-related quality of life in the early manifest glaucoma trial. Ophthalmology 112(9):1505\u20131513","journal-title":"Ophthalmology"},{"issue":"3\u20134","key":"6883_CR33","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1177\/01640275211027304","volume":"44","author":"M Wettstein","year":"2022","unstructured":"Wettstein M, Wahl HW, Heyl V (2022) Perceived stress predicts subsequent self-reported problems with vision and hearing: longitudinal findings from the German ageing survey. Res Aging 44(3\u20134):286\u2013300","journal-title":"Res Aging"},{"issue":"1","key":"6883_CR34","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.jad.2013.05.071","volume":"151","author":"I Carri\u00e8re","year":"2013","unstructured":"Carri\u00e8re I, Delcourt C, Daien V, P\u00e9r\u00e8s K, F\u00e9art C, Berr C, Ancelin ML, Ritchie K (2013) A prospective study of the bi-directional association between vision loss and depression in the elderly. J Affect Disord 151(1):164\u2013170","journal-title":"J Affect Disord"},{"issue":"7","key":"6883_CR35","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1001\/jamaophthalmol.2019.1085","volume":"137","author":"CR Frank","year":"2019","unstructured":"Frank CR, Xiang X, Stagg BC, Ehrlich JR (2019) Longitudinal associations of self-reported vision impairment with symptoms of anxiety and depression among older adults in the united States. JAMA Ophthalmol 137(7):793\u2013800","journal-title":"JAMA Ophthalmol"},{"issue":"1","key":"6883_CR36","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s40123-022-00600-0","volume":"12","author":"L Hern\u00e1ndez-Moreno","year":"2023","unstructured":"Hern\u00e1ndez-Moreno L, Senra H, Marques AP, Perdomo NM, Macedo AF (2023) The basic VRS-effect study: clinical trial outcomes and cost-effectiveness of low vision rehabilitation in Portugal. Ophthalmol Ther 12(1):307\u2013323","journal-title":"Ophthalmol Ther"},{"issue":"7","key":"6883_CR37","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1001\/jamaophthalmol.2015.0693","volume":"133","author":"JE Goldstein","year":"2015","unstructured":"Goldstein JE, Jackson ML, Fox SM, Deremeik JT, Massof RW (2015) Clinically meaningful rehabilitation outcomes of low vision patients served by outpatient clinical centers. JAMA Ophthalmol 133(7):762\u2013769","journal-title":"JAMA Ophthalmol"},{"issue":"1","key":"6883_CR38","first-page":"Cd006543","volume":"1","author":"RM van Nispen","year":"2020","unstructured":"van Nispen RM, Virgili G, Hoeben M, Langelaan M, Klevering J, Keunen JE, van Rens GH (2020) Low vision rehabilitation for better quality of life in visually impaired adults. Cochrane Database Syst Rev 1(1):Cd006543","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"6883_CR39","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/opo.12779","volume":"41","author":"L Dillon","year":"2021","unstructured":"Dillon L, Gandhi S, Tang D, Liew G, Hackett M, Craig A, Mitchell P, Keay L, Gopinath B (2021) Perspectives of people with late age-related macular degeneration on mental health and mental wellbeing programmes: a qualitative study. Ophthalmic Physiol Opt 41(2):255\u2013265","journal-title":"Ophthalmic Physiol Opt"},{"issue":"1","key":"6883_CR40","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s40123-020-00325-y","volume":"10","author":"NM Schultz","year":"2021","unstructured":"Schultz NM, Braunack-Mayer L, Schwartz J, Gaspar L (2021) The patient experience: symptoms and impact of dry age-related macular degeneration. Ophthalmol Ther 10(1):151\u2013164","journal-title":"Ophthalmol Ther"},{"issue":"6","key":"6883_CR41","doi-asserted-by":"publisher","first-page":"2891","DOI":"10.1167\/iovs.09-5080","volume":"51","author":"G Rees","year":"2010","unstructured":"Rees G, Tee HW, Marella M, Fenwick E, Dirani M, Lamoureux EL (2010) Vision-specific distress and depressive symptoms in people with vision impairment. Invest Ophthalmol Vis Sci 51(6):2891\u20132896","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6883_CR42","doi-asserted-by":"publisher","first-page":"101036","DOI":"10.1016\/j.jaging.2022.101036","volume":"61","author":"A Siren","year":"2022","unstructured":"Siren A, R\u00f8geskov M, Amilon A (2022) Negotiations of vulnerability in aging with vision impairment. J Aging Stud 61:101036","journal-title":"J Aging Stud"},{"issue":"5","key":"6883_CR43","first-page":"35","volume":"4","author":"F Ozbay","year":"2007","unstructured":"Ozbay F, Johnson DC, Dimoulas E, Morgan CA, Charney D, Southwick S (2007) Social support and resilience to stress: from neurobiology to clinical practice. Psychiatry (Edgmont) 4(5):35\u201340","journal-title":"Psychiatry (Edgmont)"},{"issue":"8","key":"6883_CR44","doi-asserted-by":"publisher","first-page":"3287","DOI":"10.3390\/ijerph8083287","volume":"8","author":"E Andreou","year":"2011","unstructured":"Andreou E, Alexopoulos EC, Lionis C, Varvogli L, Gnardellis C, Chrousos GP, Darviri C (2011) Perceived stress scale: reliability and validity study in Greece. Int J Environ Res Public Health 8(8):3287\u20133298","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"6883_CR45","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1017\/S1138741600006004","volume":"9","author":"E Remor","year":"2006","unstructured":"Remor E (2006) Psychometric properties of a European Spanish version of the perceived stress scale (PSS). Span J Psychol 9(1):86\u201393","journal-title":"Span J Psychol"},{"key":"6883_CR46","doi-asserted-by":"publisher","unstructured":"Gale RP, Finger RP, Eldem B, Aslam T, Barratt J, Daien V, Kodjikian L, Loewenstein A, Okada M, Wong TY, Sylvanowicz M, Rodr\u00edguez FJ (2022) The management of neovascular age-related macular degeneration: a systematic literature review of patient-reported outcomes, patient mental health and caregiver burden. Acta Ophthalmol\u00a0101:e26\u2013e42.\u00a0https:\/\/doi.org\/10.1111\/aos.15201","DOI":"10.1111\/aos.15201"},{"issue":"3","key":"6883_CR47","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1097\/01.icu.0000120710.35941.3f","volume":"15","author":"RJ Casten","year":"2004","unstructured":"Casten RJ, Rovner BW, Tasman W (2004) Age-related macular degeneration and depression: a review of recent research. Curr Opin Ophthalmol 15(3):181\u2013183","journal-title":"Curr Opin Ophthalmol"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-025-06883-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-025-06883-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-025-06883-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T07:04:00Z","timestamp":1760079840000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-025-06883-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,28]]},"references-count":47,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["6883"],"URL":"https:\/\/doi.org\/10.1007\/s00417-025-06883-w","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,28]]},"assertion":[{"value":"29 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the Swedish Ethics Review Authority (Dnr 2020\/04083) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers\u2019 bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}