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The aim of this review is to describe the different surgical approaches reported in the literature and compare the outcomes and complications between them.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed\/MEDLINE, Scopus and Web of Science for all articles that reported scleral decompressive surgical procedures for idiopathic and\/or nanophthalmic UES treatment, as well as publications reporting prophylactic surgeries for uveal effusion in nanophthalmic eyes. Risk of bias was assessed using the Cochrane proposed tool for randomized controlled trials\u2013 RoB2 and the JBI checklist for case series and for cohort studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty-eight articles were included and reviewed. Sclerectomies were the most frequently reported procedures, associated or not with sclerostomies or sclerotomies. Following in frequency were sclerostomies and sclerotomies alone, whereas vortex vein decompression (VVD) was the less frequently reported surgery. Overall, the articles demonstrated positive results in the resolution of uveal effusion and retinal\/choroidal detachment, as well as in the prevention of uveal effusion in nanophthalmic eyes. Improvement in visual acuity (VA) was reported by most authors, except in cases with long-term retinal detachments (RD), where retinal damage prevented an enhancement of VA even with good anatomical results. Moreover, three studies included the use of adjunctive treatment to the surgeries, particularly mitomycin C (MMC) and intravitreal anti-VEGF injections. Complications of scleral decompression surgeries were reported in only ten articles and the most frequent and serious ones included\n                      <jats:italic>phthisis bulbi<\/jats:italic>\n                      , retinal and suprachoroidal hemorrhage, and vortex vein incision, among others.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In general, scleral decompressive surgeries showed efficacy in treating and preventing UES. However, bigger studies would be necessary to minimize possible bias and to draw more solid conclusions regarding the benefit of surgical management of these patients, compared to a conservative one, and to better understand if adjunctive treatment can be, in fact, beneficial or not.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key messages<\/jats:title>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>What is known<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>The best treatment for idiopathic and nanophthalmic uveal effusion syndrome is not yet clear among ophthalmologists, particularly due to their rare incidence. Many surgical techniques have been proposed for the management of these conditions, but a bigger study on this topic has not yet been made.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>What is new<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>We performed a systematic review of all published literature on surgical approaches for idiopathic and nanophthalmic uveal effusion syndrome, including its prophylaxis in nanophthalmic eyes.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Most studies demonstrated good results with the use of scleral decompressive surgeries, particularly sclerectomies, sclerostomies and sclerotomies. Bigger studies with control groups are, however, necessary to create more robust evidence.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00417-025-06908-4","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T04:44:15Z","timestamp":1752554655000},"page":"2709-2722","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sclerectomies in nanophthalmos and idiopathic uveal effusion syndrome: a systematic review"],"prefix":"10.1007","volume":"263","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2797-0347","authenticated-orcid":false,"given":"Leonor","family":"Braga de Sousa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Barbosa-Breda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"6908_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/6578750","volume":"2020","author":"N Yang","year":"2020","unstructured":"Yang N, Jin S, Ma L et al (2020) The pathogenesis and treatment of complications in nanophthalmos. 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The ethics review board of ULS S\u00e3o Jo\u00e3o (Porto, Portugal) was consulted and waived the need for an ethics approval for the development of this systematic review as it comprises previously published studies without any patient identifying information.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors also confirm that informed consent was obtained from all individual participants reported in the included studies.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"All authors certify that there is not financial or non-financial conflict of interest to be disclosed.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}