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Study outcomes were median IOP change and the mean number of topical IOP-lowering medications at 3, 6 and 12 months after surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median IOP change in the iStent inject\n                      <jats:sup>\u00ae<\/jats:sup>\n                      W group at 3-, 6- and 12 months follow-up was \u2212\u20094 (-6 to -2) mmHg (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), -4 (-6 to -1) mmHg (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and \u2212\u20094 (-6.75 to -2) mmHg (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), respectively. The median IOP change in the control group at 3-, 6- and 12 months follow-up was 0 (-1.25 to 2) mmHg, 1 (-1 to 3) mmHg, and 0 (-2.5 to 3) mmHg, respectively. IOP reduction in the study group was statistically significantly larger than in the control group at all follow-ups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). We found a statistically significant difference between the mean number of topical IOP-lowering medications before and at 12 months in the combined surgery group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) as compared to the control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study shows a statistically significant IOP reduction at 3-, 6- and 12 months and reduction of topical IOP-lowering medications at 12 months after combined cataract surgery with iStent\n                      <jats:italic>inject<\/jats:italic>\n                      <jats:sup>\u00ae<\/jats:sup>\n                      W implantation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00417-025-06909-3","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:10:54Z","timestamp":1756285854000},"page":"3191-3198","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical outcomes of combined cataract surgery with iStent inject\u00ae W implantation versus cataract surgery alone in patients with open-angle glaucoma: real life data in a community-based outpatient setting"],"prefix":"10.1007","volume":"263","author":[{"given":"Fidan A.","family":"Aghayeva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelrahman","family":"Assaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakriiar","family":"Gurbanzade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2850-8976","authenticated-orcid":false,"given":"Ines M.","family":"Lanzl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"issue":"2","key":"6909_CR1","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/ceo.14028","volume":"50","author":"R Lim","year":"2022","unstructured":"Lim R (2022) The surgical management of glaucoma: A review. 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