{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:15:28Z","timestamp":1762161328065,"version":"build-2065373602"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Key Research and Development Plan Project of Xianyang City","award":["L2024-ZDYF-ZDYF-SF-0029"],"award-info":[{"award-number":["L2024-ZDYF-ZDYF-SF-0029"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s00417-025-06911-9","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T12:23:59Z","timestamp":1753100639000},"page":"2779-2787","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The influence of different types of collateral vessels on the recurrence of macular edema in branch retinal vein occlusion"],"prefix":"10.1007","volume":"263","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9149-6149","authenticated-orcid":false,"given":"Yi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9265-177X","authenticated-orcid":false,"given":"Weidong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8374-5924","authenticated-orcid":false,"given":"Yidan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5522-8681","authenticated-orcid":false,"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4745-3894","authenticated-orcid":false,"given":"Aiyi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"6911_CR1","doi-asserted-by":"publisher","first-page":"010427","DOI":"10.7189\/jogh.09.010427","volume":"9","author":"P Song","year":"2019","unstructured":"Song P, Xu Y, Zha M, Zhang Y, Rudan I (2019) Global epidemiology of retinal vein occlusion: a systematic review and meta-analysis of prevalence, incidence, and risk factors. J Glob Health 9:010427. https:\/\/doi.org\/10.7189\/jogh.09.010427","journal-title":"J Glob Health"},{"key":"6911_CR2","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1159\/000502041","volume":"242","author":"U Schmidt-Erfurth","year":"2019","unstructured":"Schmidt-Erfurth U, Garcia-Arumi J, Gerendas BS et al (2019) Guidelines for the management of retinal vein occlusion by the European society of retina specialists (EURETINA). Ophthalmologica 242:123\u2013162. https:\/\/doi.org\/10.1159\/000502041","journal-title":"Ophthalmologica"},{"key":"6911_CR3","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/0306-9877(95)90079-9","volume":"44","author":"RP Danis","year":"1995","unstructured":"Danis RP, Moorthy RS, Savage J (1995) Microhemodynamics of retinal collateral vessel formation. Med Hypotheses 44:103\u2013109. https:\/\/doi.org\/10.1016\/0306-9877(95)90079-9","journal-title":"Med Hypotheses"},{"key":"6911_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1167\/iovs.62.14.1","volume":"62","author":"A Arrigo","year":"2021","unstructured":"Arrigo A, Aragona E, Lattanzio R, Scalia G, Bandello F, Parodi MB (2021) Collateral vessel development in central and branch retinal vein occlusions are associated with worse visual and anatomic outcomes. Invest Ophthalmol Vis Sci 62:1. https:\/\/doi.org\/10.1167\/iovs.62.14.1","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6911_CR5","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1136\/bjophthalmol-2018-313322","volume":"103","author":"N Suzuki","year":"2019","unstructured":"Suzuki N, Hirano Y, Tomiyasu T et al (2019) Collateral vessels on optical coherence tomography angiography in eyes with branch retinal vein occlusion. Br J Ophthalmol 103:1373\u20131379. https:\/\/doi.org\/10.1136\/bjophthalmol-2018-313322","journal-title":"Br J Ophthalmol"},{"key":"6911_CR6","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.oret.2019.04.015","volume":"3","author":"K Tsuboi","year":"2019","unstructured":"Tsuboi K, Sasajima H, Kamei M (2019) Collateral vessels in branch retinal vein occlusion: anatomic and functional analyses by OCT angiography. Ophthalmol Retina 3:767\u2013776. https:\/\/doi.org\/10.1016\/j.oret.2019.04.015","journal-title":"Ophthalmol Retina"},{"key":"6911_CR7","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1001\/jamaophthalmol.2018.3586","volume":"136","author":"KB Freund","year":"2018","unstructured":"Freund KB, Sarraf D, Leong BCS, Garrity ST, Vupparaboina KK, Dansingani KK (2018) Association of optical coherence tomography angiography of collaterals in retinal vein occlusion with major venous outflow through the deep vascular complex. JAMA Ophthalmol 136:1262\u20131270. https:\/\/doi.org\/10.1001\/jamaophthalmol.2018.3586","journal-title":"JAMA Ophthalmol"},{"key":"6911_CR8","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3341\/kjo.2002.16.2.82","volume":"16","author":"CY Im","year":"2002","unstructured":"Im CY, Lee SY, Kwon OW (2002) Collateral vessels in branch retinal vein occlusion. Korean J Ophthalmol 16:82\u201387. https:\/\/doi.org\/10.3341\/kjo.2002.16.2.82","journal-title":"Korean J Ophthalmol"},{"key":"6911_CR9","doi-asserted-by":"publisher","first-page":"e0215790","DOI":"10.1371\/journal.pone.0215790","volume":"14","author":"HE Lee","year":"2019","unstructured":"Lee HE, Wang Y, Fayed AE, Fawzi AA (2019) Exploring the relationship between collaterals and vessel density in retinal vein occlusions using optical coherence tomography angiography. PLoS ONE 14:e0215790. https:\/\/doi.org\/10.1371\/journal.pone.0215790","journal-title":"PLoS ONE"},{"key":"6911_CR10","doi-asserted-by":"publisher","first-page":"Oct486","DOI":"10.1167\/iovs.15-18907","volume":"57","author":"M Adhi","year":"2016","unstructured":"Adhi M, Filho MA, Louzada RN et al (2016) Retinal capillary network and foveal avascular zone in eyes with vein occlusion and fellow eyes analyzed with optical coherence tomography angiography. Invest Ophthalmol Vis Sci 57:Oct486\u2013494. https:\/\/doi.org\/10.1167\/iovs.15-18907","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6911_CR11","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1136\/bjo-2021-320356","volume":"107","author":"ND Rudnick","year":"2023","unstructured":"Rudnick ND, Vingopoulos F, Wang JC et al (2023) Characterising collateral vessels in eyes with branch retinal vein occlusions using widefield swept-source optical coherence tomography angiography. Br J Ophthalmol 107:1887\u20131891. https:\/\/doi.org\/10.1136\/bjo-2021-320356","journal-title":"Br J Ophthalmol"},{"key":"6911_CR12","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3390\/jcm10030405","volume":"10","author":"Y Hirano","year":"2021","unstructured":"Hirano Y, Suzuki N, Tomiyasu T et al (2021) Multimodal imaging of microvascular abnormalities in retinal vein occlusion. J Clin Med 10:405. https:\/\/doi.org\/10.3390\/jcm10030405","journal-title":"J Clin Med"},{"key":"6911_CR13","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1097\/IAE.0000000000001158","volume":"36","author":"RF Spaide","year":"2016","unstructured":"Spaide RF (2016) Retinal vascular cystoid macular edema: review and new theory. Retina 36:1823\u20131842. https:\/\/doi.org\/10.1097\/IAE.0000000000001158","journal-title":"Retina"},{"key":"6911_CR14","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.ajo.2015.10.008","volume":"161","author":"F Coscas","year":"2016","unstructured":"Coscas F, Glacet-Bernard A, Miere A et al (2016) Optical coherence tomography angiography in retinal vein occlusion: evaluation of superficial and deep capillary plexa. Am J Ophthalmol 161:160\u2013171. https:\/\/doi.org\/10.1016\/j.ajo.2015.10.008","journal-title":"Am J Ophthalmol"},{"key":"6911_CR15","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.ajo.2016.03.033","volume":"166","author":"WA Samara","year":"2016","unstructured":"Samara WA, Shahlaee A, Sridhar J, Khan MA, Ho AC, Hsu J (2016) Quantitative optical coherence tomography angiography features and visual function in eyes with branch retinal vein occlusion. Am J Ophthalmol 166:76\u201383. https:\/\/doi.org\/10.1016\/j.ajo.2016.03.033","journal-title":"Am J Ophthalmol"},{"key":"6911_CR16","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1167\/iovs.16-21208","volume":"58","author":"T Wakabayashi","year":"2017","unstructured":"Wakabayashi T, Sato T, Hara-Ueno C et al (2017) Retinal microvasculature and visual acuity in eyes with branch retinal vein occlusion: imaging analysis by optical coherence tomography angiography. Invest Ophthalmol Vis Sci 58:2087\u20132094. https:\/\/doi.org\/10.1167\/iovs.16-21208","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6911_CR17","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4137\/OED.S7264","volume":"4","author":"R Gallego-Pinazo","year":"2012","unstructured":"Gallego-Pinazo R, Dolz-Marco R, Mar\u00edn-Lamb\u00edes C, D\u00edaz-Llopis M (2012) Safety and efficacy of Ranibizumab in macular edema following retinal vein occlusion. Ophthalmol Eye Dis 4:15\u201321. https:\/\/doi.org\/10.4137\/OED.S7264","journal-title":"Ophthalmol Eye Dis"},{"key":"6911_CR18","doi-asserted-by":"publisher","first-page":"3858","DOI":"10.1167\/iovs.18-24710","volume":"59","author":"PL Nesper","year":"2018","unstructured":"Nesper PL, Fawzi AA (2018) Human parafoveal capillary vascular anatomy and connectivity revealed by optical coherence tomography angiography. Invest Ophthalmol Vis Sci 59:3858\u20133867. https:\/\/doi.org\/10.1167\/iovs.18-24710","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6911_CR19","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1177\/11206721211008354","volume":"32","author":"M Kaya","year":"2021","unstructured":"Kaya M, Ozturk T, Atas F, Akbulut Yagci B, Oner H (2021) Effect of intravitreal dexamethasone implant versus Ranibizumab on vessel density in branch retinal vein occlusion. Eur J Ophthalmol 32:1073\u20131079. https:\/\/doi.org\/10.1177\/11206721211008354","journal-title":"Eur J Ophthalmol"},{"key":"6911_CR20","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1097\/IAE.0000000000001674","volume":"38","author":"BG Moon","year":"2018","unstructured":"Moon BG, Cho AR, Kim YN, Kim JG (2018) Predictors of refractory macular edema after branch retinal vein occlusion following intravitreal bevacizumab. Retina 38:1166\u20131174. https:\/\/doi.org\/10.1097\/IAE.0000000000001674","journal-title":"Retina"},{"key":"6911_CR21","doi-asserted-by":"publisher","first-page":"29445","DOI":"10.1038\/srep29445","volume":"6","author":"T Tomiyasu","year":"2016","unstructured":"Tomiyasu T, Hirano Y, Yoshida M et al (2016) Microaneurysms cause refractory macular edema in branch retinal vein occlusion. Sci Rep 6:29445. https:\/\/doi.org\/10.1038\/srep29445","journal-title":"Sci Rep"},{"key":"6911_CR22","doi-asserted-by":"publisher","first-page":"858","DOI":"10.18240\/ijo.2016.06.12","volume":"9","author":"K Abri Aghdam","year":"2016","unstructured":"Abri Aghdam K, Reznicek L, Soltan Sanjari M et al (2016) Peripheral retinal non-perfusion and treatment response in branch retinal vein occlusion. Int J Ophthalmol 9:858\u2013862. https:\/\/doi.org\/10.18240\/ijo.2016.06.12","journal-title":"Int J Ophthalmol"},{"key":"6911_CR23","doi-asserted-by":"publisher","first-page":"e0278968","DOI":"10.1371\/journal.pone.0278968","volume":"18","author":"S Kawakami","year":"2023","unstructured":"Kawakami S, Wakabayashi Y, Watanabe Y, Umazume K, Yamamoto K, Goto H (2023) Healing rate of macular edema secondary to branch retinal vein occlusion in two years after initiation of intravitreal Ranibizumab later combined with other treatment as needed and characteristics of refractory cases. PLoS ONE 18:e0278968. https:\/\/doi.org\/10.1371\/journal.pone.0278968","journal-title":"PLoS ONE"},{"key":"6911_CR24","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1097\/IAE.0b013e318263d106","volume":"33","author":"DV Weinberg","year":"2013","unstructured":"Weinberg DV, Wahle AE, Ip MS, Scott IU, VanVeldhuisen PC, Blodi BA (2013) Score study report 12: development of venous collaterals in the score study. Retina 33:287\u2013295. https:\/\/doi.org\/10.1097\/IAE.0b013e318263d106","journal-title":"Retina"},{"key":"6911_CR25","doi-asserted-by":"publisher","first-page":"40763","DOI":"10.1038\/srep40763","volume":"7","author":"R Mastropasqua","year":"2017","unstructured":"Mastropasqua R, Toto L, Di Antonio L et al (2017) Optical coherence tomography angiography microvascular findings in macular edema due to central and branch retinal vein occlusions. Sci Rep 7:40763. https:\/\/doi.org\/10.1038\/srep40763","journal-title":"Sci Rep"},{"key":"6911_CR26","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.2147\/opth.S258958","volume":"14","author":"Y Esaki","year":"2020","unstructured":"Esaki Y, Hirano Y, Kurobe R et al (2020) Morphologic classifications and locations of microaneurysms and clinical relevance in branch retinal vein occlusion. Clin Ophthalmol 14:1909\u20131919. https:\/\/doi.org\/10.2147\/opth.S258958","journal-title":"Clin Ophthalmol"},{"key":"6911_CR27","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.ajo.2015.09.038","volume":"161","author":"N Suzuki","year":"2016","unstructured":"Suzuki N, Hirano Y, Yoshida M, Tomiyasu T, Uemura A, Yasukawa T, Ogura Y (2016) Microvascular abnormalities on optical coherence tomography angiography in macular edema associated with branch retinal vein occlusion. Am J Ophthalmol 161:126\u2013132. https:\/\/doi.org\/10.1016\/j.ajo.2015.09.038","journal-title":"Am J Ophthalmol"},{"key":"6911_CR28","doi-asserted-by":"publisher","first-page":"e443","DOI":"10.1016\/j.jcjo.2024.08.007","volume":"60","author":"J Kreminger","year":"2024","unstructured":"Kreminger J, Iby J, Rokitansky S et al (2024) Association of microaneurysms with retinal vascular alterations in patients with retinal vein occlusion. Can J Ophthalmol 60:e443\u2013e450. https:\/\/doi.org\/10.1016\/j.jcjo.2024.08.007","journal-title":"Can J Ophthalmol"},{"key":"6911_CR29","doi-asserted-by":"publisher","first-page":"5728","DOI":"10.1167\/iovs.12-10017","volume":"53","author":"PE Tan","year":"2012","unstructured":"Tan PE, Yu PK, Balaratnasingam C et al (2012) Quantitative confocal imaging of the retinal microvasculature in the human retina. Invest Ophthalmol Vis Sci 53:5728\u20135736. https:\/\/doi.org\/10.1167\/iovs.12-10017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6911_CR30","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.2147\/opth.S170698","volume":"12","author":"M Kawamura","year":"2018","unstructured":"Kawamura M, Hirano Y, Yoshida M et al (2018) Six-month results of intravitreal Ranibizumab for macular edema after branch retinal vein occlusion in a single-center prospective study: visual outcomes and microaneurysm formation. Clin Ophthalmol 12:1487\u20131494. https:\/\/doi.org\/10.2147\/opth.S170698","journal-title":"Clin Ophthalmol"},{"key":"6911_CR31","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.atherosclerosis.2011.04.040","volume":"218","author":"T Nakamura","year":"2011","unstructured":"Nakamura T, Obata JE, Hirano M et al (2011) Predictive value of remnant lipoprotein for cardiovascular events in patients with coronary artery disease after achievement of LDL-cholesterol goals. Atherosclerosis 218:163\u2013167. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2011.04.040","journal-title":"Atherosclerosis"},{"key":"6911_CR32","doi-asserted-by":"publisher","first-page":"4105","DOI":"10.1007\/s10792-023-02811-1","volume":"43","author":"D Gildea","year":"2023","unstructured":"Gildea D, Tang B, Baily C, Ryan A (2023) Real-world outcomes of intravitreal bevacizumab treat-and-extend for cystoid macular oedema secondary to central retinal vein occlusion. Int Ophthalmol 43:4105\u20134110. https:\/\/doi.org\/10.1007\/s10792-023-02811-1","journal-title":"Int Ophthalmol"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-025-06911-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-025-06911-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-025-06911-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:00:56Z","timestamp":1762160456000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-025-06911-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,21]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["6911"],"URL":"https:\/\/doi.org\/10.1007\/s00417-025-06911-9","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"type":"print","value":"0721-832X"},{"type":"electronic","value":"1435-702X"}],"subject":[],"published":{"date-parts":[[2025,7,21]]},"assertion":[{"value":"11 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Approval was obtained from the Ethics Committee of the Second Affiliated Hospital of Xi\u2019an Jiaotong University (No. 2024249). The procedures used in this study adhere to the tenets of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The Ethics Committee of the Second Affiliated Hospital of Xi\u2019an Jiaotong University waived the need for informed consent, considering the use of de-identifed patient data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors have no proprietary or commercial interest in any materials discussed in this article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}