{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T01:03:20Z","timestamp":1775869400976,"version":"3.50.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005743","name":"Universit\u00e0 Cattolica del Sacro Cuore","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005743","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare, using optical coherence tomography angiography (OCTA), the earliest changes and damages to macular and optic disc microcirculation after active-fluidics system (AFS) and gravity-fluidics system (GFS) procedures in uncomplicated cataract surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 42 eyes affected by uncomplicated cataracts and divided them into two groups: 21 eyes were randomly assigned to an AFS group and 21 eyes were randomly assigned to a GFS group. Expert examiners performed OCTA 30\u2009\u00b1\u200910\u00a0min before surgery (T0), 30\u2009\u00b1\u20098\u00a0min after surgery (T1), 24\u2009\u00b1\u20092\u00a0h after surgery (T2) and 7 days after surgery (T3).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant differences at T1 were detected between the groups. At T2, eyes in the GFS group exhibited a whole macula deep capillary plexus vessel density of 37.9\u2009\u00b1\u20095.8%, which was significantly lower than that of the eyes in the AFS group (42.2\u2009\u00b1\u20095.7%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.048). At T3, eyes in the GFS group exhibited a significantly higher retinal nerve fibre layer thickness in the nasal (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020) and inferior (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045) quadrant, and a significantly lower peripapillary vessel density in the inferior quadrant of the papilla (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036) compared with eyes in the AFS group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The AFS procedure appears to protect macular and optic disc microcirculation during phacoemulsification, and it may represent a more prudent approach, particularly in cases that require specific care to preserve residual peripapillary and macular vasculature (e.g., diabetic or glaucomatous eyes).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00417-025-06939-x","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T07:54:27Z","timestamp":1762329267000},"page":"149-157","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Active-fluidics versus gravity-fluidics in uncomplicated cataract surgery: using optical coherence tomography angiography to estimate early changes in macular and optic disc microcirculation"],"prefix":"10.1007","volume":"264","author":[{"given":"Alessandra","family":"Scampoli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9996-9871","authenticated-orcid":false,"given":"Emanuele","family":"Crincoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Governatori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Monaco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cosma Danilo","family":"Mancini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Giannuzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo Mario","family":"Carl\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Grieco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislao","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomaso","family":"Caporossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"issue":"1","key":"6939_CR1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/0002-9394(67)93340-5","volume":"64","author":"CD Kelman","year":"1967","unstructured":"Kelman CD (1967) Phaco-emulsification and aspiration: a new technique of cataract removal: a preliminary report. 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This article does not contain any studies with animals performed by any of the authors. Informed consent was obtained from all individual participants included in the study. The study protocol was approved by the IRB of the Fondazione Policlinico Universitario Agostino Gemelli.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}