{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:19:18Z","timestamp":1793945958618,"version":"4.8.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Unidade Local de Sa\u00fade de S\u00e3o Jos\u00e9"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To analyze clinical, laboratory, and Doppler vascular parameters in pediatric sickle cell disease (SCD) patients and identify correlations and predictive factors for sickle cell retinopathy (SCR) and proliferative SCR (PSR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study included pediatric SCD patients screened for SCR between December 2023 and August 2024. Systemic, transcranial-cervical Doppler, and ophthalmologic evaluations were performed. Correlation analyses explored relationships between clinical, laboratory, and ophthalmologic parameters and SCR. Logistic regression identified predictive factors for SCR and PSR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 172 eyes from 86 pediatric SCD patients (mean age: 11.1 years; 57% male). SCR was diagnosed in 20 patients (23.3%), including 15 with non-proliferative (NPSR) and 5 with PSR. SCR correlated significantly with higher vaso-occlusive crises (VOC) frequency (\u03c1\u2009=\u20090.379,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), lower fetal hemoglobin (HbF) (\u03c1 = -0.363,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), older age (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.295,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006), and glucose-6-phosphate dehydrogenase (G6PD) deficiency (\u03c1\u2009=\u20090.428,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Doppler evaluations showed reduced velocities associated with SCR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Logistic regression identified G6PD deficiency (OR\u2009=\u20098.34,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014), increased VOC (OR\u2009=\u20092.22,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011), older age (OR\u2009=\u20091.26,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), and lower HbF (OR\u2009=\u20090.89,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047) as predictors of SCR. An age cut-off of 11.5 years yielded 65% sensitivity and 64% specificity.\n                    <\/jats:p>\n                    <jats:p>\n                      For PSR, significant correlations included SC genotype (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.728,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and higher hemoglobin (Hb) (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.518,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019). Lower hydroxyurea doses were linked to PSR (\n                      <jats:italic>r<\/jats:italic>\n                      = -0.548,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012). Hb levels predicted PSR, with a 9.2\u00a0g\/dL cut-off (80% sensitivity, 86% specificity).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early detection of SCR is crucial in pediatric SCD patients. Key risk factors include older age (cut-off 11.5 years), higher VOC frequency, G6PD deficiency, and lower HbF for SCR, and SC genotype, reduced hydroxyurea doses, and higher Hb (cut-off 9.2\u00a0g\/dL) for PSR. Regular ophthalmologic screening and targeted management may help prevent vision loss and improve clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00417-025-06946-y","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T10:13:48Z","timestamp":1755944028000},"page":"3237-3245","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sickle cell retinopathy in pediatric patients: exploring correlations and predictive factors"],"prefix":"10.1007","volume":"263","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3329-1014","authenticated-orcid":false,"given":"Nuno","family":"Rodrigues Alves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Bar\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Barros Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas","family":"Ludovico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edvio","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Anjos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Serras Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,23]]},"reference":[{"key":"6946_CR1","doi-asserted-by":"publisher","first-page":"335","DOI":"10.2147\/JMDH.S90630","volume":"10","author":"F Menaa","year":"2017","unstructured":"Menaa F, Khan BA, Uzair B, Menaa A (2017) Sickle cell retinopathy: improving care with a multidisciplinary approach. 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The omitted authors has been added to the publication.","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2026","order":9,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":10,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00417-026-07154-y","URL":"https:\/\/doi.org\/10.1007\/s00417-026-07154-y","order":12,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers\u2019 bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the Hospital Dona Estef\u00e2nia Ethics Committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants and\/or their legal guardians included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}