{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:59:17Z","timestamp":1793026757713,"version":"4.5.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to evaluate changes in choriocapillaris (CC) perfusion in patients with chronic central serous chorioretinopathy (cCSC) following treatment with half-dose photodynamic therapy (PDT), using swept-source optical coherence tomography angiography (SS-OCTA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This pilot study included patients diagnosed with cCSC who underwent half-dose PDT using the Visulas 690s PDT Laser System (Carl Zeiss Meditec, Inc., Jena, Germany; 689-nm wavelength, 50J\/cm\u00b2, 83s). Fovea-centered OCTA scans (6\u2009\u00d7\u20096mm) were obtained using the Zeiss Plex Elite 9000 SS-OCT system. OCTA assessments were conducted at baseline prior to treatment and 6 months post-treatment. The primary outcome was the percentage of choriocapillaris flow deficits (FD%) on OCTA. Secondary outcomes included best-corrected visual acuity (BCVA), central macular thickness (CMT), and subfoveal choroidal thickness (SFCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 23 eyes from 23 patients with cCSC, with a mean age of 46.3\u2009\u00b1\u20092.1 years, of which 16 out of 23 were men. Significant improvements were observed in all parameters at 6 months. The FD% decreased significantly from 28.9\u2009\u00b1\u20092.2% at baseline to 26.4\u2009\u00b1\u20091.9% after 6 months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023). BCVA improved from 0.28\u2009\u00b1\u20090.13 LogMAR to 0.22\u2009\u00b1\u20090.11 LogMAR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025). Both CMT and SFCT showed significant reductions (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). After 6-months, SRF was resolved in 21 out of 23 eyes (91.3%) included in the analysis, while the remaining two eyes showed a reduction of SRF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Half-dose PDT was effective in improving CC perfusion and other morpho-functional parameters in eyes with cCSC. These findings provide valuable insights into the potential mechanisms through which PDT may influence the progression of cCSC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00417-025-06957-9","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T09:39:37Z","timestamp":1760089177000},"page":"65-71","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of choriocapillaris perfusion changes in chronic central serous chorioretinopathy following Half-Dose photodynamic therapy"],"prefix":"10.1007","volume":"264","author":[{"given":"Giacomo","family":"Boscia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Viggiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Corradetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba Chiara","family":"Termite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Savastano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Quarta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Feo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceren","family":"Soylu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Mastropasqua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Toto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Boscia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4939-3306","authenticated-orcid":false,"given":"SriniVas R.","family":"Sadda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"6957_CR1","doi-asserted-by":"publisher","first-page":"100770","DOI":"10.1016\/j.preteyeres.2019.07.003","volume":"73","author":"TJ Rijssen","year":"2019","unstructured":"Rijssen TJ, Van DEHC, Van, Yzer S et al (2019) Progress in retinal and eye research central serous chorioretinopathy: towards an evidence-based treatment guideline. 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