{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T08:13:10Z","timestamp":1771575190057,"version":"3.50.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s00417-025-06986-4","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T08:16:24Z","timestamp":1763367384000},"page":"465-471","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of subretinal hyperreflective material and short-term visual acuity in patients with neovascular age related macular degeneration after loading dose with antiangiogenics"],"prefix":"10.1007","volume":"264","author":[{"given":"Willy Carpio","family":"Rosso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usha","family":"Chakravarthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8636-6298","authenticated-orcid":false,"given":"Said Eduardo Meneses","family":"Girado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley","family":"Rosenstiehl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tunde","family":"Peto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J.","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"issue":"10153","key":"6986_CR1","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/S0140-6736(18)31550-2","volume":"392","author":"P Mitchell","year":"2018","unstructured":"Mitchell P, Liew G, Gopinath B, Wong TY (2018) Age-related macular degeneration. Lancet 392(10153):1147\u20131159","journal-title":"Lancet"},{"issue":"5","key":"6986_CR2","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.oret.2017.08.019","volume":"2","author":"G Casalino","year":"2018","unstructured":"Casalino G, Stevenson MR, Bandello F, Chakravarthy U (2018) Tomographic biomarkers predicting progression to fibrosis in treated neovascular Age-Related macular degeneration: a multimodal imaging study. Ophthalmol Retina 2(5):451\u2013461","journal-title":"Ophthalmol Retina"},{"key":"6986_CR3","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.ajo.2018.04.007","volume":"191","author":"H Lee","year":"2018","unstructured":"Lee H, Kang KE, Chung H, Kim HC (2018) Automated segmentation of lesions including subretinal hyperreflective material in neovascular age-related macular degeneration. Am J Ophthalmol 191:64\u201375","journal-title":"Am J Ophthalmol"},{"issue":"8","key":"6986_CR4","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1038\/eye.2013.93","volume":"27","author":"G Menon","year":"2013","unstructured":"Menon G, Chandran M, Sivaprasad S, Chavan R, Narendran N, Yang Y (2013) Is it necessary to use three mandatory loading doses when commencing therapy for neovascular age-related macular degeneration using bevacizumab? (BeMOc trial). Eye 27(8):959\u2013963","journal-title":"Eye"},{"key":"6986_CR5","doi-asserted-by":"crossref","unstructured":"Sagkriotis A, Chakravarthy U, Griner R, Doyle O, Wintermantel T, Clemens A (2021) Application of machine learning methods to Bridge the gap between non-interventional studies and randomized controlled trials in ophthalmic patients with neovascular age-related macular degeneration. Contemp Clin Trials. ;104","DOI":"10.1016\/j.cct.2021.106364"},{"issue":"1","key":"6986_CR6","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1159\/000354551","volume":"231","author":"T Ristau","year":"2014","unstructured":"Ristau T, Keane PA, Walsh AC, Engin A, Mokwa N, Kirchhof B et al (2014) Relationship between visual acuity and spectral domain optical coherence tomography retinal parameters in neovascular age-related macular degeneration. Ophthalmologica 231(1):37\u201344","journal-title":"Ophthalmologica"},{"issue":"1","key":"6986_CR7","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1177\/11206721211001716","volume":"32","author":"B Pina Mar\u00edn","year":"2022","unstructured":"Pina Mar\u00edn B, Gajate Paniagua NM, G\u00f3mez-Bald\u00f3 L, Gallego-Pinazo R (2022) Burden of disease assessment in patients with neovascular age-related macular degeneration in Spain: results of the AMD-MANAGE study. Eur J Ophthalmol 32(1):385\u2013394","journal-title":"Eur J Ophthalmol"},{"issue":"8","key":"6986_CR8","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1097\/IAE.0000000000001748","volume":"38","author":"R Pokroy","year":"2018","unstructured":"Pokroy R, Mimouni M, Barayev E, Segev F, Geffen N, Nemet AY et al (2018) Prognostic value of subretinal hyperreflective material in neovascular age-related macular degeneration treated with bevacizumab. Retina 38(8):1485\u20131491","journal-title":"Retina"},{"key":"6986_CR9","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.ajo.2017.06.015","volume":"181","author":"Y Kawashima","year":"2017","unstructured":"Kawashima Y, Hata M, Oishi A, Ooto S, Yamashiro K, Tamura H et al (2017) Association of vascular versus avascular subretinal hyperreflective material with Aflibercept response in age-related macular degeneration. Am J Ophthalmol 181:61\u201370","journal-title":"Am J Ophthalmol"},{"issue":"11","key":"6986_CR10","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1007\/s00417-018-4121-7","volume":"256","author":"M Maruyama-Inoue","year":"2018","unstructured":"Maruyama-Inoue M, Sato S, Yamane S, Kadonosono K (2018) Variable response of subretinal hyperreflective material to anti-vascular endothelial growth factor classified with optical coherence tomography angiography. Graefes Arch Clin Exp Ophthalmol 256(11):2089\u20132096","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"6986_CR11","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.ajo.2016.06.031","volume":"169","author":"KK Dansingani","year":"2016","unstructured":"Dansingani KK, Tan ACS, Gilani F, Phasukkijwatana N, Novais E, Querques L et al (2016) Subretinal hyperreflective material imaged with optical coherence tomography angiography. Am J Ophthalmol 169:235\u2013248","journal-title":"Am J Ophthalmol"},{"issue":"7","key":"6986_CR12","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.4103\/ijo.IJO_3156_20","volume":"69","author":"D Alex","year":"2021","unstructured":"Alex D, Giridhar A, Gopalakrishnan M, Indurkhya S, Madan S (2021) Subretinal hyperreflective material morphology in neovascular age-related macular degeneration: a case control study. Indian J Ophthalmol 69(7):1862","journal-title":"Indian J Ophthalmol"},{"issue":"9","key":"6986_CR13","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1016\/j.ophtha.2015.05.042","volume":"122","author":"AS Willoughby","year":"2015","unstructured":"Willoughby AS, Ying G, shuang, Toth CA, Maguire MG, Burns RE, Grunwald JE et al (2015) Subretinal hyperreflective material in the comparison of Age-Related macular degeneration treatments trials. Ophthalmology 122(9):1846\u20131853e5","journal-title":"Ophthalmology"},{"issue":"2","key":"6986_CR14","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.ajo.2014.04.025","volume":"158","author":"R Ores","year":"2014","unstructured":"Ores R, Puche N, Querques G, Blanco-Garavito R, Merle B, Coscas G et al (2014) Gray hyper-reflective subretinal exudative lesions in exudative age-related macular degeneration. Am J Ophthalmol 158(2):354\u2013361","journal-title":"Am J Ophthalmol"},{"issue":"9","key":"6986_CR15","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18753","volume":"57","author":"G Casalino","year":"2016","unstructured":"Casalino G, Bandello F, Chakravarthy U (2016) Changes in neovascular lesion hyperreflectivity after anti-VEGF treatment in Age-Related macular degeneration: an integrated multimodal imaging analysis. Invest Ophthalmol Vis Sci 57(9):OCT288","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"6986_CR16","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1167\/iovs.18-25189","volume":"60","author":"PK Roberts","year":"2019","unstructured":"Roberts PK, Zotter S, Montuoro A, Pircher M, Baumann B, Ritter M et al (2019) Identification and quantification of the angiofibrotic switch in neovascular AMD. Invest Ophthalmol Vis Sci 60(1):304","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"0","key":"6986_CR17","first-page":"1","volume":"0","author":"R Pokroy","year":"2017","unstructured":"Pokroy R, Mimouni M, Barayev E, Segev F, Geffen N, Nemet A et al (2017) Prognostic value of subretinal hyperreflective material in neovascular age-related macular degeneration treated with bevacizumab. Retina 0(0):1\u20137","journal-title":"Retina"},{"key":"6986_CR18","doi-asserted-by":"crossref","unstructured":"Willoughby AS, Ying GS, Toth CA, Maguire MG, Burns RE, Grunwald JE et al (2015) Subretinal hyperreflective material in the comparison of Age-Related macular degeneration treatments trials. Ophthalmology. ;1\u20138","DOI":"10.1016\/j.ophtha.2015.05.042"},{"issue":"9","key":"6986_CR19","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1167\/iovs.15-18753","volume":"57","author":"G Casalino","year":"2016","unstructured":"Casalino G, Bandello F, Chakravarthy U (2016) Changes in neovascular lesion hyperreflectivity after anti-VEGF treatment in age-related macular degeneration: an integrated multimodal imaging analysis. Invest Ophthalmol Vis Sci 57(9):288\u2013298","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"6986_CR20","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1097\/IAE.0000000000002552","volume":"40","author":"JB Kumar","year":"2020","unstructured":"Kumar JB, Stinnett S, Han JIL, Jaffe GJ, CORRELATION OF SUBRETINAL HYPERREFLECTIVE, MATERIAL MORPHOLOGY AND VISUAL ACUITY IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION (2020) Retina 40(5):845\u2013856","journal-title":"Retina"},{"issue":"5","key":"6986_CR21","doi-asserted-by":"publisher","first-page":"523","DOI":"10.3928\/23258160-20150521-03","volume":"46","author":"W Charafeddin","year":"2015","unstructured":"Charafeddin W, Nittala MG, Oregon A, Sadda SR (2015) Relationship between subretinal hyperreflective material reflectivity and volume in patients with neovascular age-related macular degeneration following anti-vascular endothelial growth factor treatment. Ophthalmic Surg Lasers Imaging Retina 46(5):523\u2013530","journal-title":"Ophthalmic Surg Lasers Imaging Retina"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-025-06986-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-025-06986-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-025-06986-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T07:43:24Z","timestamp":1771573404000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-025-06986-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,17]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["6986"],"URL":"https:\/\/doi.org\/10.1007\/s00417-025-06986-4","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,17]]},"assertion":[{"value":"24 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the Fundaci\u00f3n Oftalmol\u00f3gica Nacional Institutional Review Board (IRB) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Due to the retrospective nature of the study, the requirement for informed consent was waived by the Institutional Review Board.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers\u2019 bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}