{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T18:07:41Z","timestamp":1775844461470,"version":"3.50.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Ulm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate incidence and clinical course of microcystic macular edema (MME) in eyes with idiopathic epiretinal membranes (iERM) before and after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Of 1283 eyes that underwent vitrectomy with membrane peeling, 170 eyes were retrospectively analysed. All eyes had iERM and at least one postoperative control with retinal imaging. MME and cystoid macular edema (CME) were assessed by optical coherence tomography (OCT), along with demographic and clinical data. Correlations with functional outcomes were statistically significant at\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, 42 eyes (25%) had MME, 18 eyes (11%) had combined MME\u2009+\u2009CME and 110 eyes (64%) had no edema. The mean postoperative follow-up was 7.1\u2009\u00b1\u20095.9 months. All three groups showed significant improvement in visual acuity (VA), greatest in the no-edema group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Incidence of MME increased with ERM severity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033). At three months postoperatively, MME persisted in 32\/159 eyes, resolved in 25, newly developed in 20, and was absent in 82\/159 eyes, with a significant difference in VA between groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). After 12 months, persistent MME reduced to 4\/26 eyes, resolution of MME was seen in 6, new MME in 5 and 11\/26 eyes still had no edema, with no significant VA between the groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.206).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study demonstrates that visual recovery occurred irrespective of MME status. In advanced iERM stages, MME was more frequently observed and associated with delayed visual improvement, particularly when it developed or persisted after surgery. Despite its early effects, MME does not seem to significantly affect long-term visual outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00417-025-07006-1","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T07:54:29Z","timestamp":1762329269000},"page":"393-405","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Microcystic macular edema in eyes with idiopathic epiretinal gliosis: A retrospective analysis before and after vitreomacular surgery"],"prefix":"10.1007","volume":"264","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1032-6675","authenticated-orcid":false,"given":"Denise","family":"Vogt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Kilani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melih","family":"Parlak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricarda G.","family":"Schumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efstathios","family":"Vounotrypidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"7006_CR1","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.ajo.2024.12.027","volume":"272","author":"A Govetto","year":"2025","unstructured":"Govetto A, Francone A, Lucchini S, Garavaglia S, Carini E, Virgili G, Radice P, Vogt D, Edwards M, Spaide RF, Romano MR (2025) Microcystoid macular edema in epiretinal membrane: not a retrograde maculopathy. 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The study was conducted according to the tenets of the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Ethics approval"}},{"value":"None.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Denise Vogt: Travel reimbursements and speaker fees by AbbVie Germany GmbH & Co. KG, Novartis Pharma GmbH and Bayer Vital GmbH. Adnan Kilani: speaking fees, advisory board fees and travel reimbursement by Novartis Pharma GmbH, Bayer Pharma AG and Roche. Melih Parlak: speaking fees and travel reimbursement by Bayer Pharma AG. Ricarda G. Schumann: Research grant, travel reimbursement, personal fee and non-financial support by Novartis, Bayer, AbbVie, Roche and Zeiss. Armin Wolf: consulting or advisory, funding grants, speaking and lecture fees, and travel reimbursement by AbbVie, Boehringer Ingelheim Corp USA, Bayer Corporation, Alimera Sciences Inc., Novartis Pharmaceuticals Corporation, Oertli Instrumente AG, Sandoz and Roche. Consulting or advisory and travel reimbursement by Carl Zeiss AG.\u00a0","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Disclosure of potential conflicts of interest"}}]}}