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The consortium collects, de-identifies, and harmonizes longitudinal optical coherence tomography (OCT) data, as well as associated clinical metadata, from multiple international clinical centers using a cloud-based infrastructure. Imaging data is converted and stored in DICOM format, and associated clinical data is mapped to the OMOP Common Data Model. All analyses are conducted within a secure cloud environment, supporting both built-in and member-contributed artificial intelligence (AI) tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>As of the time of reporting, the Consortium has ingested over 100,000 OCT volumes from more than 5,000 subjects across 7 global cohorts spanning 4 continents and 3 major OCT platforms. Based on information provided by the data providers, the dataset encompasses a wide range of AMD stages, from normal aging to late-stage neovascular or atrophic AMD, with longitudinal follow-up extending beyond 15 years for some subjects. A data harmonization pipeline has been established to convert all ingested OCT data to the DICOM standard and is thus ready for automated analysis to gain disease-related insights.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The RIMR AMD Consortium represents a novel model for global collaboration in AMD research, enabling the pooling and analysis of heterogeneous imaging data while addressing privacy, regulatory, and interoperability challenges. This framework may serve as a model for similar initiatives in other ocular diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00417-025-07081-4","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T05:17:04Z","timestamp":1766985424000},"page":"935-943","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Initiation of a global consortium to study the progression of age-related macular degeneration: RIMR AMD consortium report # 1"],"prefix":"10.1007","volume":"264","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4939-3306","authenticated-orcid":false,"given":"Srinivas R.","family":"Sadda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles C.","family":"Wykoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itay","family":"Chowers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Francois","family":"Korobelnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raja","family":"Narayana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajeev R.","family":"Pappuru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank G.","family":"Holz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn","family":"Guymer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chui Ming Gemmy","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Boyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Ip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiko G.","family":"Niessen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Holenkamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Durbin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Magazzeni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Marie","family":"Cairns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Ciller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasa","family":"Jovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Blair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"De Zanet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron Y.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"7081_CR1","doi-asserted-by":"publisher","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","volume":"2","author":"WL Wong","year":"2014","unstructured":"Wong WL, Su X, Li X, Cheung CM, Klein R, Cheng CY, Wong TY (2014) Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. 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Each respective institution providing data obtained appropriate approvals from their institutional review boards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants"}},{"value":"The following financial disclosures are provided for each of the co-authors:SRS: Consultant: Boerhinger Ingelheim, Roche, Optos, Topcon, Zeiss, Ikerian, 4DMT, Abbvie, Alexion, Allergan Inc., Alnylam Pharmaceuticals, Amgen Inc., Apellis Pharmaceuticals, Inc., Astellas, Bayer Healthcare Pharmaceuticals, Biogen MA Inc., Catalyst Pharmaceuticals Inc., Centervue Inc., GENENTECH, Gyroscope Therapeutics, Heidelberg Engineering, Iveric Bio, iCare, Janssen Pharmaceuticals Inc., Nanoscope, Notal Vision Inc., Novartis Pharma AG, Oxurion\/Thrombogenics, Oyster Point Pharma, Regeneron Pharmaceuticals Inc., Samsung Bioepis, Topcon Medical Systems Inc. Research instruments from: Carl Zeiss Meditec, Heidelberg Engineering, Nidek Incorporated, Novartis Pharma AG, Topcon Medical Systems Inc.CCW: Consultant: 4DMT, AbbVie, ADARx, Adverum, Alcon, Alimera, Alkeus, Annexon, Apellis, Aviceda, Bausch + Lomb, Bayer, Biocryst, Boehringer Ingelheim, Chengdu Kanghong, Curacle, EyeBiotech, EyePoint, Genentech, InGel, Janssen, Kiora, Kodiak, Nanonscope, Neurotech, Novartis, Oak Bay Bio, Ocular Therapeutix, Ollin, ONL, Opthea, Opus, Osanni, Perceive Bio, Perfuse, Regeneron, RegenXBio, RetinAI, Roche, Sanofi, Santen, Skyline, Stealth, Sylentis, Visgenx, Vitranu, Zeiss. Recipient: 4DMT, AbbVie, Adverum, Alexion, Alimera, Allgenesis, Annexon, Apellis, Ascidian, Astellas, Aviceda, Bayer, Boehringer Ingelheim, Clearside, Curacle, EyeBiotech, EyePoint, Genentech, Janssen, Kodiak, Nanoscope, Neurotech, Novartis, Ocular Therapeutix, Opthea, Perceive Bio, Regeneron, RegenXBio, Roche, Skyline, Stealth. SO: InGel, Ollin, ONL, Osanni, Perceive Bio, Visgenx.IC: Stock and stock options: Sensinject, Orsight Pharma. Consultant: Remepy, Tarsier Pharma, Ocutrack, Roche, Xoltar.JFK: Consultant: Abbvie, Adverum, Apellis, Bayer, Boehringer-Ingelheim, Eyepoint Pharma, Ocular Therapeutix, Roche, SeaBeLife, Thea, Carl Zeiss Meditec. Member of DSMB: Alexion, Novonordisk and Opthea.FGH: Grants: Acucela, Allergan, Apellis, Bayer, Belite Bio, Bioeq, Centervue, Geuder, Roche\/Genentech, Heidelberg Engineering, IvericBio\/Astellas, NightStarx, Novartis, Optos, Science, Zeiss. Consultant: Acucela, Alcon, Alexion, Alzheon, Apellis, Bayer, Boehringer-Ingelheim, Genentech\/Roche, Grayburg Vision, Heidelberg Engineering, IvericBio\/Astellas, Lin Bioscience, Janssen, Novartis, Oculis, Opthea, Oxurion, Science, Stealth Biotherapeutics, Zeiss.RHG: Advisory boards: Apellis, Roche\/Genentech, Bayer, Novartis, Regeneron, Zeiss. Research Support: Adverum, Apellis, Astellas, Aviceda, Biogen, Belite Bio, Boehringer Ingelheim, Genentech, Lineage Cell Therapeutics, ONL Therapeutics, Regeneron, Regenexbio, SpliceBio, 4DMT Pharmaceuticals, Character Bioscience, Janssen, AbbVie, Astellas, RetinAI, Sitala, Kriya, Ocular Therapeutix, Complement therapeutics, Pulse sight, i2vision.HGN: Employee of Boehringer Ingelheim, Clearside Biomedical, Pharma GmbH & Co. KG, Biberach, Germany.NH: Employee: F. Hoffmann LaRoche, Basel Switzerland. Stock and Stock options: Roche, Notal Vision, Nacuity.CMGC: Grants: Bayer, Boehringer-Ingelheim, Roche, Zeiss. Consulting fee: Astellas, Bayer, Boehringer-Ingelheim, Janssen, Roche\/Genentech, Novartis, Opthea, Topcon, Zeiss, 4DMT.DSB: 4DT: AdArx: Adverum Biotechnologies: Aerpio: Alcon Laboratories, Inc.: Alkahest: Alkeus: Allergan, Inc: Allegro: Allgenesis: Amgen Inc: Annexon: Apellis Pharmaceuticals, Inc.: AsclepiX Therapeutics: AshvatthaBausch + Lomb: Bayer Healthcare Pharmaceuticals: Biogen International Gmbh: BioMotiv: BioTime Inc.: Boehringer Ingelheim: : Chengdu Kanghong Biotec: Clearside Biomedical, Inc.: Duet: EyePoint Pharmaceuticals: Galimedix Therapeutics, Inc.: GENENTECH: GenSight Biologics: Glaukos Corporation: Iconic Therapeutics Inc: InflammX: Consultant\/Advisor, Stock Options: Interface Biologics, Inc.Ionis: Iveric Bio: Jcyte: Kala Pharmaceuticals, Inc.: Lumithera: Nanoscope: Consultant\/Advisor Neurotech USA: NGM: NGM : Notal Vision, Inc.: Novartis Pharma AG: Novartis Pharmaceuticals: :Ocugen, Inc: Consultant\/Advisor, Stock Options: Ocular Therapeutix:, Grant Support Ocuphire Pharma Inc: Opthea: Optos, Inc.: Consultant\/Advisor Ora, Inc: Oxurion: Ray Vision, Inc.: RecensMedical Inc: Regeneron Pharmaceuticals, Inc.: REGENXBIO: Regulus Therapeutics: Sanofi:LLC: Consultant\/Advisor Santen, Inc: Semathera: Smilebiotek: Stealth Biotherapeutics: Sun Pharmaceutical Industries: THEA: Unity:MI: Consulting: Alimera, Allergan, Amgen, Apellis, Astellas.CC, SA, SDZ, JB, NJ: Employees: Ikerian AG; Stock and Stock options: Ikerian AGAY: Consultant (personal fees): Genentech, Johnson and Johnson, Apellis, Boehringer Ingelheim, Gyroscope. Grant support from Santen, Topcon, Carl Zeiss Meditec, Amazon, Regeneron, Meta. Non-financial support from iCareWorld, Optomed, Heidelberg, Microsoft.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Conflicts of interests"}}]}}