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Retinal microvasculature was evaluated by OCT-A in the superficial (SCP) and deep (DCP) plexuses, and peripheral microcirculation was assessed by NFC. Correlations between retinal microvascular parameters, disease duration, systemic involvement, and nailfold capillary density were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This cross-sectional study included 37 SSc patients without retinopathy and 37 healthy controls. The mean duration of disease was 10.5\u00b17.4 (1-30, median: 10.5 years). Central foveal thickness was significantly higher in the SSc group than in controls (p &lt; 0.001). The VD values of SSc patients in both plexuses were significantly lower compared to the healthy control group (p &lt; 0.05, for all). In subgroup analyses, SCP VD was significantly higher in the whole, parafoveal, and perifoveal areas in the SSc-&lt;10y group compared with the SSc-\u226510y group (p=0.03, p=0.025, p=0.005). NFC data revealed that the mean capillary number was significantly higher in SSc-&lt;10 y compared to SSc\u226510 y (p=0.043). Capillary density was positively correlated with SCP VD (whole; r = 0.606, p &lt; 0.001, parafovea; r=0.487 p=0.002, perifovea, r=0.603 p&lt;0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The study findings indicate that SCP-VD may serve as a surrogate quantitative marker of systemic vascular involvement during the progressive course of SSc. OCT-A holds promise as a robust, non-invasive modality for disease monitoring and prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00417-026-07123-5","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T05:19:53Z","timestamp":1771219193000},"page":"1863-1871","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microvascular markers in systemic sclerosis: a comparative OCT-angiography and nailfold videocapillaroscopy study"],"prefix":"10.1007","volume":"264","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5633-9036","authenticated-orcid":false,"given":"Puren","family":"Isik Eker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3237-0623","authenticated-orcid":false,"given":"Serife Seyda","family":"Zengin Acemoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7448-451X","authenticated-orcid":false,"given":"Ebru","family":"Esen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5192-9045","authenticated-orcid":false,"given":"Ipek","family":"Turk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Hacioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feyza Alara","family":"Celikten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8189-9246","authenticated-orcid":false,"given":"Nihal","family":"Demircan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0162-4574","authenticated-orcid":false,"given":"Hulya","family":"Binokay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"7123_CR1","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/s0140-6736(22)01692-0","volume":"401","author":"ER Volkmann","year":"2023","unstructured":"Volkmann ER, Andr\u00e9asson K, Smith V (2023) Systemic sclerosis. 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