{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T06:21:09Z","timestamp":1783405269576,"version":"3.54.6"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100018916","name":"Suzhou Municipal Health Commission","doi-asserted-by":"publisher","award":["SZM 2021015"],"award-info":[{"award-number":["SZM 2021015"]}],"id":[{"id":"10.13039\/100018916","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018916","name":"Suzhou Municipal Health Commission","doi-asserted-by":"publisher","award":["LCZX202236"],"award-info":[{"award-number":["LCZX202236"]}],"id":[{"id":"10.13039\/100018916","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016803","name":"Natural Science Foundation of Suzhou Municipality","doi-asserted-by":"publisher","award":["2022YX-M04"],"award-info":[{"award-number":["2022YX-M04"]}],"id":[{"id":"10.13039\/100016803","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s00417-026-07158-8","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T05:21:32Z","timestamp":1773724892000},"page":"2047-2058","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated Radiomics-Enhanced machine learning models for accurate diagnosis and prediction of oGVHD-Related ocular complications"],"prefix":"10.1007","volume":"264","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Decai","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengtai","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0604-0532","authenticated-orcid":false,"given":"Xiaofeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"7158_CR1","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1146\/annurev-immunol-102119-073227","volume":"39","author":"GR Hill","year":"2021","unstructured":"Hill GR, Betts BC, Tkachev V, Kean LS, Blazar BR (2021) Current concepts and advances in graft-versus-host disease immunology. Annu Rev Immunol 39:19\u201349. https:\/\/doi.org\/10.1146\/annurev-immunol-102119-073227","journal-title":"Annu Rev Immunol"},{"key":"7158_CR2","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.ajo.2023.09.018","volume":"257","author":"PA Sepulveda-Beltran","year":"2024","unstructured":"Sepulveda-Beltran PA, Carletti P, Banda V et al (2024) Infectious and noninfectious corneal ulcers in ocular graft-versus-host disease: epidemiology, clinical characteristics, and outcomes. Am J Ophthalmol 257:236\u2013246. https:\/\/doi.org\/10.1016\/j.ajo.2023.09.018","journal-title":"Am J Ophthalmol"},{"key":"7158_CR3","doi-asserted-by":"publisher","first-page":"449","DOI":"10.3760\/cma.j.issn.0253-2727.2023.06.002","volume":"44","author":"Stem Cell Application Group CSoHCMA","year":"2023","unstructured":"Stem Cell Application Group CSoHCMA (2023) [Chinese expert consensus on ocular chronic graft-versus-host disease (2023)]. Zhonghua Xue Ye Xue Za Zhi 44:449\u2013457. https:\/\/doi.org\/10.3760\/cma.j.issn.0253-2727.2023.06.002","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"7158_CR4","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1097\/ICO.0000000000000340","volume":"34","author":"H Shikari","year":"2015","unstructured":"Shikari H, Amparo F, Saboo U, Dana R (2015) Onset of ocular graft-versus-host disease symptoms after allogeneic hematopoietic stem cell transplantation. Cornea 34:243\u2013247. https:\/\/doi.org\/10.1097\/ICO.0000000000000340","journal-title":"Cornea"},{"key":"7158_CR5","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1038\/bmt.2012.56","volume":"47","author":"R Jacobs","year":"2012","unstructured":"Jacobs R, Tran U, Chen H et al (2012) Prevalence and risk factors associated with development of ocular GVHD defined by NIH consensus criteria. Bone Marrow Transplant 47:1470\u20131473. https:\/\/doi.org\/10.1038\/bmt.2012.56","journal-title":"Bone Marrow Transplant"},{"key":"7158_CR6","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1080\/08164622.2021.1971047","volume":"105","author":"JM Kezic","year":"2022","unstructured":"Kezic JM, Wiffen S, Degli-Esposti M (2022) Keeping an \u2018eye\u2019 on ocular GVHD. Clin Exp Optom 105:135\u2013142. https:\/\/doi.org\/10.1080\/08164622.2021.1971047","journal-title":"Clin Exp Optom"},{"key":"7158_CR7","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1007\/s00417-019-04301-6","volume":"257","author":"G Giannaccare","year":"2019","unstructured":"Giannaccare G, Pellegrini M, Bernabei F, Scorcia V, Campos E (2019) Ocular surface system alterations in ocular graft-versus-host disease: all the pieces of the complex puzzle. Graefes Arch Clin Exp Ophthalmol 257:1341\u20131351. https:\/\/doi.org\/10.1007\/s00417-019-04301-6","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"7158_CR8","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6430953","volume":"2018","author":"Y Qiu","year":"2018","unstructured":"Qiu Y, Hong J, Peng R (2018) Manifestation of clinical categories of ocular graft-versus-host disease. J Ophthalmol 2018:6430953. https:\/\/doi.org\/10.1155\/2018\/6430953","journal-title":"J Ophthalmol"},{"key":"7158_CR9","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.jtos.2019.04.009","volume":"17","author":"HS Hwang","year":"2019","unstructured":"Hwang HS, Ha M, Kim HS, Na KS (2019) Longitudinal analysis of meibomian gland dropout in patients with ocular graft-versus-host disease. Ocul Surf 17:464\u2013469. https:\/\/doi.org\/10.1016\/j.jtos.2019.04.009","journal-title":"Ocul Surf"},{"key":"7158_CR10","doi-asserted-by":"publisher","first-page":"2692","DOI":"10.1167\/iovs.05-0040","volume":"46","author":"AS Hassan","year":"2005","unstructured":"Hassan AS, Clouthier SG, Ferrara JL et al (2005) Lacrimal gland involvement in graft-versus-host disease: a murine model. Invest Ophthalmol Vis Sci 46:2692\u20132697. https:\/\/doi.org\/10.1167\/iovs.05-0040","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"7158_CR11","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1167\/iovs.02-0699","volume":"44","author":"Y Ogawa","year":"2003","unstructured":"Ogawa Y, Kuwana M, Yamazaki K et al (2003) Periductal area as the primary site for T-cell activation in lacrimal gland chronic graft-versus-host disease. Invest Ophthalmol Vis Sci 44:1888\u20131896.https:\/\/doi.org\/10.1167\/iovs.02-0699","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"7158_CR12","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1016\/S0046-8177(81)80260-2","volume":"12","author":"GE Sale","year":"1981","unstructured":"Sale GE, Shulman HM, Schubert MM et al (1981) Oral and ophthalmic pathology of graft versus host disease in man: predictive value of the lip biopsy. Hum Pathol 12:1022\u20131030.https:\/\/doi.org\/10.1016\/s0046-8177(81)80260-2","journal-title":"Hum Pathol"},{"key":"7158_CR13","doi-asserted-by":"publisher","unstructured":"Bogani G, Chiappa V, Lopez S et al (2022) Radiomics and molecular classification in endometrial cancer (The ROME Study): A step forward to a simplified precision medicine. Healthcare (Basel) 1010.3390\/healthcare10122464 https:\/\/doi.org\/10.3390\/healthcare10122464","DOI":"10.3390\/healthcare10122464"},{"key":"7158_CR14","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1148\/radiol.2015151169","volume":"278","author":"RJ Gillies","year":"2016","unstructured":"Gillies RJ, Kinahan PE, Hricak H (2016) Radiomics: images are more than pictures, they are data. Radiology 278:563\u2013577. Doi\uff1a10.1148\/radiol.2015151169 https:\/\/doi.org\/10.1148\/radiol.2015151169","journal-title":"Radiology"},{"key":"7158_CR15","doi-asserted-by":"publisher","first-page":"5815","DOI":"10.1007\/s00330-020-06993-5","volume":"30","author":"L Qian","year":"2020","unstructured":"Qian L, Ren J, Liu A et al (2020) MR imaging of epithelial ovarian cancer: a combined model to predict histologic subtypes. Eur Radiol 30:5815\u20135825. https:\/\/doi.org\/10.1007\/s00330-020-06993-5","journal-title":"Eur Radiol"},{"key":"7158_CR16","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1177\/0284185120940258","volume":"62","author":"J Guo","year":"2021","unstructured":"Guo J, Li Z, Qu X, Xian J (2021) Value of MRI-based radiomics analysis for differentiation of benign and malignant epithelial neoplasms in the lacrimal gland: a retrospective study. Acta Radiol 62:743\u2013751. https:\/\/doi.org\/10.1177\/0284185120940258","journal-title":"Acta Radiol"},{"key":"7158_CR17","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.bbmt.2014.12.001","volume":"21","author":"MH Jagasia","year":"2015","unstructured":"Jagasia MH, Greinix HT, Arora M et al (2015) National institutes of health consensus development project on criteria for clinical trials in chronic Graft-versus-Host disease: I. The 2014 diagnosis and staging working group report. Biol Blood Marrow Transpl 21:389\u2013401e381. https:\/\/doi.org\/10.1016\/j.bbmt.2014.12.001","journal-title":"Biol Blood Marrow Transpl"},{"key":"7158_CR18","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1016\/j.ajo.2015.08.021","volume":"160","author":"J Rose-Nussbaumer","year":"2015","unstructured":"Rose-Nussbaumer J, Lietman TM, Shiboski CH et al (2015) Inter-grader agreement of the ocular staining score in the sjogren\u2019s international clinical collaborative alliance (SICCA) registry. Am J Ophthalmol 160:1150\u20131153e1153. https:\/\/doi.org\/10.1016\/j.ajo.2015.08.021","journal-title":"Am J Ophthalmol"},{"key":"7158_CR19","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.ajo.2016.06.025","volume":"169","author":"R Arita","year":"2016","unstructured":"Arita R, Minoura I, Morishige N et al (2016) Development of Definitive and Reliable Grading Scales for Meibomian Gland Dysfunction. Am J Ophthalmol 169:125\u2013137. https:\/\/doi.org\/10.1016\/j.ajo.2016.06.025","journal-title":"Am J Ophthalmol"},{"key":"7158_CR20","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1038\/sj.bmt.1704453","volume":"33","author":"MR Robinson","year":"2004","unstructured":"Robinson MR, Lee SS, Rubin BI et al (2004) Topical corticosteroid therapy for cicatricial conjunctivitis associated with chronic graft-versus-host disease. Bone Marrow Transplant 33:1031\u20131035. https:\/\/doi.org\/10.1038\/sj.bmt.1704453","journal-title":"Bone Marrow Transplant"},{"key":"7158_CR21","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.ophtha.2007.06.031","volume":"115","author":"R Arita","year":"2008","unstructured":"Arita R, Itoh K, Inoue K, Amano S (2008) Noncontact infrared meibography to document Age-Related changes of the meibomian glands in a normal population. Ophthalmology 115:911\u2013915. https:\/\/doi.org\/10.1016\/j.ophtha.2007.06.031","journal-title":"Ophthalmology"},{"key":"7158_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1133381","volume":"10","author":"C Tappeiner","year":"2023","unstructured":"Tappeiner C, Heiligenhaus A, Halter JP, Miserocchi E, Bandello F, Goldblum D (2023) Challenges and concepts in the diagnosis and management of ocular graft-versus-host disease. Front Med (Lausanne) 10:1133381. https:\/\/doi.org\/10.3389\/fmed.2023.1133381","journal-title":"Front Med (Lausanne)"},{"key":"7158_CR23","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1097\/ICO.0000000000001109","volume":"36","author":"Y Rapoport","year":"2017","unstructured":"Rapoport Y, Freeman T, Koyama T et al (2017) Validation of international chronic ocular Graft-Versus-Host disease (GVHD) group diagnostic criteria as a chronic ocular GVHD-specific metric. Cornea 36:258\u2013263. https:\/\/doi.org\/10.1097\/ICO.0000000000001109","journal-title":"Cornea"},{"key":"7158_CR24","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-021-01925-3","volume":"21","author":"H Ikarashi","year":"2021","unstructured":"Ikarashi H, Aketa N, Shimizu E et al (2021) Two case reports of continued progression of chronic ocular graft-versus-host disease without concurrent systemic comorbidities treated by amniotic membrane transplantation. BMC Ophthalmol 21:164. https:\/\/doi.org\/10.1186\/s12886-021-01925-3","journal-title":"BMC Ophthalmol"},{"key":"7158_CR25","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1136\/bjo.83.10.1125","volume":"83","author":"Y Ogawa","year":"1999","unstructured":"Ogawa Y, Okamoto S, Wakui M et al (1999) Dry eye after haematopoietic stem cell transplantation. Br J Ophthalmol 83:1125\u20131130. Doi:10.1136\/bjo.83.10.1125","journal-title":"Br J Ophthalmol"},{"key":"7158_CR26","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1097\/ICO.0000000000001487","volume":"37","author":"J He","year":"2018","unstructured":"He J, Yamane M, Shibata S et al (2018) Ocular surface and tear film characteristics in a sclerodermatous chronic Graft-Versus-Host disease mouse model. Cornea 37:486\u2013494.https:\/\/doi.org\/10.1097\/ICO.0000000000001487","journal-title":"Cornea"},{"key":"7158_CR27","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/s1542-0124(12)70207-0","volume":"3","author":"M Balaram","year":"2005","unstructured":"Balaram M, Rashid S, Dana R (2005) Chronic ocular surface disease after allogeneic bone marrow transplantation. Ocul Surf 3:203\u2013211. https:\/\/doi.org\/10.1016\/s1542-0124(12)70207-0","journal-title":"Ocul Surf"},{"key":"7158_CR28","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.2353\/ajpath.2009.090318","volume":"175","author":"Y Ogawa","year":"2009","unstructured":"Ogawa Y, Shimmura S, Kawakita T, Yoshida S, Kawakami Y, Tsubota K (2009) Epithelial mesenchymal transition in human ocular chronic graft-versus-host disease. Am J Pathol 175:2372\u20132381. https:\/\/doi.org\/10.2353\/ajpath.2009.090318","journal-title":"Am J Pathol"},{"key":"7158_CR29","first-page":"111","volume":"42","author":"Y Ogawa","year":"2001","unstructured":"Ogawa Y, Yamazaki K, Kuwana M et al (2001) A significant role of stromal fibroblasts in rapidly progressive dry eye in patients with chronic GVHD. Invest Ophth Vis Sci 42:111\u2013119. PMID: 11133855","journal-title":"Invest Ophth Vis Sci"},{"key":"7158_CR30","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1136\/ijgc-2023-004313","volume":"33","author":"V Di Donato","year":"2023","unstructured":"Di Donato V, Kontopantelis E, Cuccu I et al (2023) Magnetic resonance imaging-radiomics in endometrial cancer: a systematic review and meta-analysis. Int J Gynecol Cancer 33:1070\u20131076. https:\/\/doi.org\/10.1136\/ijgc-2023-004313","journal-title":"Int J Gynecol Cancer"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-026-07158-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-026-07158-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-026-07158-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:47:47Z","timestamp":1783403267000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-026-07158-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["7158"],"URL":"https:\/\/doi.org\/10.1007\/s00417-026-07158-8","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]},"assertion":[{"value":"22 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration"}},{"value":"All procedures performed in studies involving human participants were conducted in accordance with the ethical standards of the Ethics Committee of the Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou Municipal Hospital) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This study was approved by the Ethics Committee of the Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou Municipal Hospital) (K-2022-073-H01).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"No conflicts of interest. All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers\u2019 bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}