{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T14:36:17Z","timestamp":1787150177212,"version":"build-2736575974"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Shanghai \u201cRising Stars of Medical Talents\u201d Youth Development Program","award":["SHWSRS [2024] _70"],"award-info":[{"award-number":["SHWSRS [2024] _70"]}]},{"name":"Specialized Clinical Research Program of Shanghai Municipal Health Commission","award":["20244Y0021"],"award-info":[{"award-number":["20244Y0021"]}]},{"DOI":"10.13039\/501100008750","name":"Shanghai Municipal Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC12023116"],"award-info":[{"award-number":["SHDC12023116"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Lumitin Vision to Brightness Research Funding for the Young and Middle-aged Ophthalmologists","award":["BCF-KH-YK-20221123-11"],"award-info":[{"award-number":["BCF-KH-YK-20221123-11"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s00417-026-07179-3","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:50:26Z","timestamp":1774342226000},"page":"2427-2434","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti-VEGF therapy for symptomatic exudative retinal arterial macroaneurysms: functional and anatomic outcomes with OCTA findings"],"prefix":"10.1007","volume":"264","author":[{"given":"Wenyi","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gezhi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"7179_CR1","first-page":"OP55","volume":"77","author":"DM Robertson","year":"1973","unstructured":"Robertson DM (1973) Macroaneurysms of the retinal arteries. Trans Am Acad Ophthalmol Otolaryngol 77:OP55\u201367","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"7179_CR2","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1136\/bjo.71.11.817","volume":"71","author":"MJ Lavin","year":"1987","unstructured":"Lavin MJ, Marsh RJ, Peart S, Rehman A (1987) Retinal arterial macroaneurysms: a retrospective study of 40 patients. Br J Ophthalmol 71:817\u2013825. https:\/\/doi.org\/10.1136\/bjo.71.11.817","journal-title":"Br J Ophthalmol"},{"key":"7179_CR3","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1136\/bjo.74.10.595","volume":"74","author":"RW Panton","year":"1990","unstructured":"Panton RW, Goldberg MF, Farber MD (1990) Retinal arterial macroaneurysms: risk factors and natural history. Br J Ophthalmol 74:595\u2013600. https:\/\/doi.org\/10.1136\/bjo.74.10.595","journal-title":"Br J Ophthalmol"},{"key":"7179_CR4","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1136\/bjo.59.7.355","volume":"59","author":"PE Cleary","year":"1975","unstructured":"Cleary PE, Kohner EM, Hamilton AM, Bird AC (1975) Retinal macroaneurysms. Br J Ophthalmol 59:355\u2013361. https:\/\/doi.org\/10.1136\/bjo.59.7.355","journal-title":"Br J Ophthalmol"},{"key":"7179_CR5","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/0039-6257(88)90160-9","volume":"33","author":"MF Rabb","year":"1988","unstructured":"Rabb MF, Gagliano DA, Teske MP (1988) Retinal arterial macroaneurysms. Surv Ophthalmol 33:73\u201396. https:\/\/doi.org\/10.1016\/0039-6257(88)90160-9","journal-title":"Surv Ophthalmol"},{"key":"7179_CR6","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/0002-9394(87)90015-8","volume":"104","author":"SR Russell","year":"1987","unstructured":"Russell SR, Folk JC (1987) Branch retinal artery occlusion after dye yellow photocoagulation of an arterial macroaneurysm. Am J Ophthalmol 104:186\u2013187. https:\/\/doi.org\/10.1016\/0002-9394(87)90015-8","journal-title":"Am J Ophthalmol"},{"key":"7179_CR7","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1186\/s12886-022-02641-2","volume":"22","author":"Y Wang","year":"2022","unstructured":"Wang Y, Du H, Zhao X, Meng L, Chen Y (2022) Observation, laser photocoagulation or anti-VEGF therapy in the management of retinal arterial macroaneurysms. BMC Ophthalmol 22:417. https:\/\/doi.org\/10.1186\/s12886-022-02641-2","journal-title":"BMC Ophthalmol"},{"key":"7179_CR8","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1097\/IAE.0b013e3182111711","volume":"31","author":"EK Lee","year":"2011","unstructured":"Lee EK, Woo SJ, Ahn J, Park KH (2011) Morphologic characteristics of retinal arterial macroaneurysm and its regression pattern on spectral-domain optical coherence tomography. Retina 31:2095\u20132101. https:\/\/doi.org\/10.1097\/IAE.0b013e3182111711","journal-title":"Retina"},{"key":"7179_CR9","doi-asserted-by":"publisher","first-page":"OCT27","DOI":"10.1167\/iovs.15-19043","volume":"57","author":"SS Gao","year":"2016","unstructured":"Gao SS, Jia Y, Zhang M, Su JP, Liu G, Hwang TS, Bailey ST, Huang D (2016) Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci 57:OCT27\u201336. https:\/\/doi.org\/10.1167\/iovs.15-19043","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"7179_CR10","doi-asserted-by":"publisher","first-page":"5474903","DOI":"10.1155\/2018\/5474903","volume":"2018","author":"VS Chang Jr","year":"2018","unstructured":"Chang VS, Schwartz SG, Flynn HW Jr (2018) Optical coherence tomography angiography of retinal arterial macroaneurysm before and after treatment. Case Rep Ophthalmol Med 2018:5474903. https:\/\/doi.org\/10.1155\/2018\/5474903","journal-title":"Case Rep Ophthalmol Med"},{"key":"7179_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/ICB.0000000000000741","volume":"15","author":"P Astroz","year":"2021","unstructured":"Astroz P, Miere A, Cohen SY, Querques G, Souied EH (2021) Optical Coherence Tomography Angiography in the Diagnosis and Follow-up of Retinal Arterial Macroaneurysms. Retin Cases Brief Rep 15:1\u20134. https:\/\/doi.org\/10.1097\/ICB.0000000000000741","journal-title":"Retin Cases Brief Rep"},{"key":"7179_CR12","doi-asserted-by":"publisher","first-page":"3564","DOI":"10.4103\/ijo.IJO_612_21","volume":"69","author":"C Wang","year":"2021","unstructured":"Wang C, Cao G, Xu X, Wang J, Zhang S (2021) Outcomes of combined treatments in patients with retinal arterial macroaneurysm. Indian J Ophthalmol 69:3564\u20133569. https:\/\/doi.org\/10.4103\/ijo.IJO_612_21","journal-title":"Indian J Ophthalmol"},{"key":"7179_CR13","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1097\/IAE.0000000000003637","volume":"43","author":"L Hu","year":"2023","unstructured":"Hu L, Zhang L, Li Z, Liu J, Yu R, Wang L, Xing D, Li C, Yang Y, Li X (2023) Features of Vasculature in Patients with Retina Arterial Macroaneurysm Using Optical Coherence Tomography Angiography. Retina 43:130\u2013137. https:\/\/doi.org\/10.1097\/IAE.0000000000003637","journal-title":"Retina"},{"key":"7179_CR14","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1136\/bjophthalmol-2014-305884","volume":"99","author":"S Koinzer","year":"2015","unstructured":"Koinzer S, Heckmann J, Tode J, Roider J (2015) Long-term, therapy-related visual outcome of 49 cases with retinal arterial macroaneurysm: a case series and literature review. Br J Ophthalmol 99:1345\u20131353. https:\/\/doi.org\/10.1136\/bjophthalmol-2014-305884","journal-title":"Br J Ophthalmol"},{"key":"7179_CR15","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s40135-019-00202-3","volume":"7","author":"B Evan Goldhagen","year":"2019","unstructured":"Evan Goldhagen B, Goldhardt R (2019) Retinal Arterial Macroaneurysms: Updating your Memory on RAM Management. Curr Ophthalmol Rep 7:73\u201379. https:\/\/doi.org\/10.1007\/s40135-019-00202-3","journal-title":"Curr Ophthalmol Rep"},{"key":"7179_CR16","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.ajo.2012.12.003","volume":"155","author":"HJ Cho","year":"2013","unstructured":"Cho HJ, Rhee TK, Kim HS, Han JI, Lee DW, Cho SW, Kim JW (2013) Intravitreal bevacizumab for symptomatic retinal arterial macroaneurysm. Am J Ophthalmol 155:898\u2013904. https:\/\/doi.org\/10.1016\/j.ajo.2012.12.003","journal-title":"Am J Ophthalmol"},{"key":"7179_CR17","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ajo.2012.07.029","volume":"155","author":"F Pichi","year":"2013","unstructured":"Pichi F, Morara M, Torrazza C, Manzi G, Alkabes M, Balducci N, Vitale L, Lembo A, Ciardella AP, Nucci P (2013) Intravitreal bevacizumab for macular complications from retinal arterial macroaneurysms. Am J Ophthalmol 155:287\u2013294e281. https:\/\/doi.org\/10.1016\/j.ajo.2012.07.029","journal-title":"Am J Ophthalmol"},{"key":"7179_CR18","first-page":"11572","volume":"8","author":"MK Erol","year":"2015","unstructured":"Erol MK, Dogan B, Coban DT, Toslak D, Cengiz A, Ozel D (2015) Intravitreal ranibizumab therapy for retinal arterial macroaneurysm. Int J Clin Exp Med 8:11572\u201311578","journal-title":"Int J Clin Exp Med"},{"key":"7179_CR19","doi-asserted-by":"publisher","first-page":"e19077","DOI":"10.1097\/MD.0000000000019077","volume":"99","author":"WH Cho","year":"2020","unstructured":"Cho WH, Chiang WY, Chen CH, Kuo HK (2020) To treat or not to treat: a clinical series of retinal arterial macroaneurysms: A single-center retrospective study. Med (Baltim) 99:e19077. https:\/\/doi.org\/10.1097\/MD.0000000000019077","journal-title":"Med (Baltim)"},{"key":"7179_CR20","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1097\/IAE.0000000000002131","volume":"39","author":"AM Mansour","year":"2019","unstructured":"Mansour AM, Foster RE, Gallego-Pinazo R, Moschos MM, Sisk RA, Chhablani J, Rojanaporn D, Sujirakul T, Arevalo JF, Lima LH, Wu L, Charbaji A, Saatci AO, Mansour HA, Martinez-Rubio C, Patel Y, Gangakhedkar S (2019) Intravitreal Anti-Vascular Endothelial Growth Factor Injections for Exudative Retinal Arterial Macroaneurysms. Retina 39:1133\u20131141. https:\/\/doi.org\/10.1097\/IAE.0000000000002131","journal-title":"Retina"},{"key":"7179_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.11.003","volume":"64","author":"RF Spaide","year":"2018","unstructured":"Spaide RF, Fujimoto JG, Waheed NK, Sadda SR, Staurenghi G (2018) Optical coherence tomography angiography. Prog Retin Eye Res 64:1\u201355. https:\/\/doi.org\/10.1016\/j.preteyeres.2017.11.003","journal-title":"Prog Retin Eye Res"},{"key":"7179_CR22","doi-asserted-by":"publisher","first-page":"101292","DOI":"10.1016\/j.preteyeres.2024.101292","volume":"103","author":"J Chua","year":"2024","unstructured":"Chua J, Tan B, Wong D, Garhofer G, Liew XW, Popa-Cherecheanu A, Loong Chin CW, Milea D, Li-Hsian Chen C, Schmetterer L (2024) Optical coherence tomography angiography of the retina and choroid in systemic diseases. Prog Retin Eye Res 103:101292. https:\/\/doi.org\/10.1016\/j.preteyeres.2024.101292","journal-title":"Prog Retin Eye Res"},{"key":"7179_CR23","doi-asserted-by":"publisher","first-page":"4710","DOI":"10.1364\/OE.20.004710","volume":"20","author":"Y Jia","year":"2012","unstructured":"Jia Y, Tan O, Tokayer J, Potsaid B, Wang Y, Liu JJ, Kraus MF, Subhash H, Fujimoto JG, Hornegger J, Huang D (2012) Split-spectrum amplitude-decorrelation angiography with optical coherence tomography. Opt Express 20:4710\u20134725. https:\/\/doi.org\/10.1364\/OE.20.004710","journal-title":"Opt Express"},{"key":"7179_CR24","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1186\/s12886-023-03016-x","volume":"23","author":"Y Song","year":"2023","unstructured":"Song Y, Zhang W, Yu S, Gong Y (2023) Appearance of retinal arterial macroaneurysms in patients using swept-source optical coherence tomographic angiography. BMC Ophthalmol 23:280. https:\/\/doi.org\/10.1186\/s12886-023-03016-x","journal-title":"BMC Ophthalmol"},{"key":"7179_CR25","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.ajo.2023.01.004","volume":"249","author":"G Yiu","year":"2023","unstructured":"Yiu G, Huang D, Wang Y, Wang Z, Yang M, Haskova Z (2023) Predictors of As-Needed Ranibizumab Injection Frequency in Patients With Macular Edema Following Retinal Vein Occlusion. Am J Ophthalmol 249:74\u201381. https:\/\/doi.org\/10.1016\/j.ajo.2023.01.004","journal-title":"Am J Ophthalmol"},{"key":"7179_CR26","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1097\/IAE.0b013e3181a2f26a","volume":"29","author":"A Tsujikawa","year":"2009","unstructured":"Tsujikawa A, Sakamoto A, Ota M, Oh H, Miyamoto K, Kita M, Yoshimura N (2009) Retinal structural changes associated with retinal arterial macroaneurysm examined with optical coherence tomography. Retina 29:782\u2013792. https:\/\/doi.org\/10.1097\/IAE.0b013e3181a2f26a","journal-title":"Retina"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-026-07179-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-026-07179-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-026-07179-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T14:21:56Z","timestamp":1787149316000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-026-07179-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,24]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["7179"],"URL":"https:\/\/doi.org\/10.1007\/s00417-026-07179-3","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,24]]},"assertion":[{"value":"29 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"not applicable.","order":2,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}}]}}