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KG, Alcon, Sanoculis; Wild PS: received outside the submitted work, consulting fees from Astra Zeneca, research funding from Bayer AG, research funding, consulting and lecturing fees from Bayer Health Care, lecturing fees from Bristol Myers Squibb, research funding and consulting fees from Boehringer Ingelheim, research funding and consulting fees from Daiichi Sankyo Europe, consulting fees and non-financial support from Diasorin, non-financial research support from I.E.M., research funding and consulting fees from Novartis Pharma, lecturing fees from Pfizer Pharma, non-financial grants from Philips Medical Systems, research funding and consulting fees from Sanofi-Aventis; S.V. Konstantinides reports institutional grants and personal lecture\/consultant fees from Bayer AG, Daiichi-Sankyo, Inari Medical, Penumbra Inc. and Boston Scientific, all outside the submitted work. 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