{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T02:59:34Z","timestamp":1781146774288,"version":"3.54.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science, Japan","doi-asserted-by":"crossref","award":["22K09824"],"award-info":[{"award-number":["22K09824"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science, Japan","doi-asserted-by":"crossref","award":["24K12754"],"award-info":[{"award-number":["24K12754"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science, Japan","doi-asserted-by":"crossref","award":["JP24K12815"],"award-info":[{"award-number":["JP24K12815"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"DOI":"10.1007\/s00417-026-07306-0","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T02:42:19Z","timestamp":1781145739000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["FECD-like histopathological features of descemet\u2019s membrane in bullous keratopathy associated with primary angle closure"],"prefix":"10.1007","author":[{"given":"Ami","family":"Igarashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Nishihata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyohei","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naruki","family":"Higashise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sora","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Yamagami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Koizumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2275-5263","authenticated-orcid":false,"given":"Naoki","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8704-680X","authenticated-orcid":false,"given":"Takahiko","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"7306_CR1","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1097\/ICU.0b013e32833a8cc9","volume":"21","author":"N Ghaznawi","year":"2010","unstructured":"Ghaznawi N, Chen ES (2010) Descemet\u2019s stripping automated endothelial keratoplasty: innovations in surgical technique. Curr Opin Ophthalmol 21:283\u2013287. https:\/\/doi.org\/10.1097\/ICU.0b013e32833a8cc9","journal-title":"Curr Opin Ophthalmol"},{"key":"7306_CR2","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1097\/ICU.0b013e32832b8d18","volume":"20","author":"I Dapena","year":"2009","unstructured":"Dapena I, Ham L, Melles GRJ (2009) Endothelial keratoplasty: DSEK\/DSAEK or DMEK\u2014the thinner the better? Curr Opin Ophthalmol 20:299\u2013307. https:\/\/doi.org\/10.1097\/ICU.0b013e32832b8d18","journal-title":"Curr Opin Ophthalmol"},{"key":"7306_CR3","doi-asserted-by":"publisher","first-page":"100768","DOI":"10.1016\/j.preteyeres.2019.07.001","volume":"73","author":"D Hos","year":"2019","unstructured":"Hos D, Matthaei M, Bock F, Maruyama K, Notara M, Clahsen T, Hou Y, Le VNH, Salabarria A-C, Horstmann J, Bachmann BO, Cursiefen C (2019) Immune reactions after modern lamellar (DALK, DSAEK, DMEK) versus conventional penetrating corneal transplantation. Prog Retin Eye Res 73:100768. https:\/\/doi.org\/10.1016\/j.preteyeres.2019.07.001","journal-title":"Prog Retin Eye Res"},{"key":"7306_CR4","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1097\/ICO.0000000000001606","volume":"37","author":"T Hayashi","year":"2018","unstructured":"Hayashi T, Kobayashi A (2018) Double-bubble technique in Descemet membrane endothelial keratoplasty for vitrectomized eyes: A case series. Cornea 37:1185\u20131188. https:\/\/doi.org\/10.1097\/ICO.0000000000001606","journal-title":"Cornea"},{"key":"7306_CR5","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1097\/ICO.0000000000003630","volume":"43","author":"D Romano","year":"2024","unstructured":"Romano D, Shimizu T, Kobayashi A, Yamagami S, Romano V, Hayashi T (2024) Descemet membrane endothelial keratoplasty in aphakic, aniridic, and vitrectomized eyes: A review. Cornea 43:1448\u20131455. https:\/\/doi.org\/10.1097\/ICO.0000000000003630","journal-title":"Cornea"},{"key":"7306_CR6","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1007\/s10384-021-00849-1","volume":"65","author":"A Takahashi","year":"2021","unstructured":"Takahashi A, Yamaguchi T, Tomida D, Nishisako S, Sasaki C, Shimazaki J (2021) Trends in surgical procedures and indications for corneal transplantation over 27 years in a tertiary hospital in Japan. Jpn J Ophthalmol 65:608\u2013615. https:\/\/doi.org\/10.1007\/s10384-021-00849-1","journal-title":"Jpn J Ophthalmol"},{"key":"7306_CR7","doi-asserted-by":"publisher","unstructured":"Snyder AJ, Bauer AJ, Straiko MD, Terry MA, Chen J (2025) Long-term outcomes of Descemet stripping automated endothelial keratoplasty versus Descemet membrane endothelial keratoplasty under failed a penetrating keratoplasty graft. https:\/\/doi.org\/10.1097\/ICO.0000000000003828. Cornea","DOI":"10.1097\/ICO.0000000000003828"},{"key":"7306_CR8","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.ajo.2018.01.018","volume":"188","author":"E Flockerzi","year":"2018","unstructured":"Flockerzi E, Maier P, B\u00f6hringer D, Reinshagen H, Kruse F, Cursiefen C, Reinhard T, Geerling G, Torun N, Seitz B, all German Keratoplasty Registry Contributors (2018) Trends in corneal transplantation from 2001 to 2016 in Germany: A report of the DOG-section cornea and its keratoplasty registry. Am J Ophthalmol 188:91\u201398. https:\/\/doi.org\/10.1016\/j.ajo.2018.01.018","journal-title":"Am J Ophthalmol"},{"key":"7306_CR9","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1097\/ICO.0b013e31802c9e19","volume":"26","author":"J Shimazaki","year":"2007","unstructured":"Shimazaki J, Amano S, Uno T, Maeda N, Yokoi N, Japan Bullous Keratopathy Study Group (2007) National survey on bullous keratopathy in Japan. Cornea 26:274\u2013278. https:\/\/doi.org\/10.1097\/ICO.0b013e31802c9e19","journal-title":"Cornea"},{"key":"7306_CR10","doi-asserted-by":"publisher","unstructured":"Shimazaki J, Soma T, Yamada K, Kobayashi A, Usui T, Inatomi T (2025) National survey on corneal transplantation in Japan. https:\/\/doi.org\/10.1097\/ICO.0000000000003807. Japan Corneal Transplantation Study GroupCornea","DOI":"10.1097\/ICO.0000000000003807"},{"key":"7306_CR11","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s12886-019-1130-1","volume":"19","author":"S Tase","year":"2019","unstructured":"Tase S, Shimizu T, Hayashi T, Tabuchi H, Niimi K, Mizuki N, Kato N (2019) Descemet\u2019s membrane endothelial keratoplasty for pseudoexfoliation syndrome: a case series. BMC Ophthalmol 19:119. https:\/\/doi.org\/10.1186\/s12886-019-1130-1","journal-title":"BMC Ophthalmol"},{"key":"7306_CR12","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1097\/ICO.0000000000001797","volume":"38","author":"A Basilious","year":"2019","unstructured":"Basilious A, Chew HF (2019) Topical ganciclovir for prophylaxis of Cytomegalovirus endotheliitis in endothelial keratoplasty. Cornea 38:120\u2013122. https:\/\/doi.org\/10.1097\/ICO.0000000000001797","journal-title":"Cornea"},{"key":"7306_CR13","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1136\/bjo.2007.120261","volume":"91","author":"LPK Ang","year":"2007","unstructured":"Ang LPK, Higashihara H, Sotozono C, Shanmuganathan VA, Dua H, Tan DTH, Kinoshita S (2007) Argon laser iridotomy-induced bullous keratopathy a growing problem in Japan. Br J Ophthalmol 91:1613\u20131615. https:\/\/doi.org\/10.1136\/bjo.2007.120261","journal-title":"Br J Ophthalmol"},{"key":"7306_CR14","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.2147\/OPTH.S170263","volume":"12","author":"T Nishino","year":"2018","unstructured":"Nishino T, Kobayashi A, Yokogawa H, Mori N, Masaki T, Sugiyama K (2018) A 10-year review of underlying diseases for endothelial keratoplasty (DSAEK\/DMEK) in a tertiary referral hospital in Japan. Clin Ophthalmol 12:1359\u20131365","journal-title":"Clin Ophthalmol"},{"key":"7306_CR15","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1097\/ICO.0000000000003603","volume":"44","author":"E Roy-Chowdhury","year":"2024","unstructured":"Roy-Chowdhury E, Angerer MPM, Schl\u00f6tzer-Schrehardt U, Tourtas T, Kruse FE, Weller JM (2024) Descemet membrane endothelial keratoplasty for endothelial failure in primary angle closure suspects. Cornea 44:740\u2013749. https:\/\/doi.org\/10.1097\/ICO.0000000000003603","journal-title":"Cornea"},{"key":"7306_CR16","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1007\/s10384-018-0598-1","volume":"62","author":"N Okumura","year":"2018","unstructured":"Okumura N, Kusakabe A, Koizumi N, Wakimasu K, Kayukawa K, Kondo M, Mori K, Sotozono C, Kinoshita S (2018) Endothelial cell loss and graft survival after penetrating keratoplasty for laser iridotomy-induced bullous keratopathy. Jpn J Ophthalmol 62:438\u2013442. https:\/\/doi.org\/10.1007\/s10384-018-0598-1","journal-title":"Jpn J Ophthalmol"},{"key":"7306_CR17","doi-asserted-by":"publisher","unstructured":"Narayanaswamy A, Kumar RS, Aung T, Foster PJ (2009) Argon laser iridotomy-induced bullous keratopathy. Br J Ophthalmol 93 :842; author reply 842-3. https:\/\/doi.org\/10.1136\/bjo.2008.142786","DOI":"10.1136\/bjo.2008.142786"},{"key":"7306_CR18","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1097\/01.ico.0000248385.16896.34","volume":"25","author":"GRJ Melles","year":"2006","unstructured":"Melles GRJ, Ong TS, Ververs B, van der Wees J (2006) Descemet membrane endothelial keratoplasty (DMEK). Cornea 25:987\u2013990. https:\/\/doi.org\/10.1097\/01.ico.0000248385.16896.34","journal-title":"Cornea"},{"key":"7306_CR19","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1097\/ICO.0000000000001093","volume":"36","author":"T Hayashi","year":"2017","unstructured":"Hayashi T, Oyakawa I, Kato N (2017) Techniques for learning Descemet membrane endothelial keratoplasty for eyes of Asian patients with shallow anterior chamber. Cornea 36:390\u2013393. https:\/\/doi.org\/10.1097\/ICO.0000000000001093","journal-title":"Cornea"},{"key":"7306_CR20","doi-asserted-by":"publisher","unstructured":"Kobayashi A, Yokogawa H, Sugiyama K (2008) Descemet stripping with automated endothelial keratoplasty for bullous keratopathies secondary to argon laser iridotomy\u2014preliminary results and usefulness of double-glide donor insertion technique. Cornea 27 Suppl 1S62\u2013S69. https:\/\/doi.org\/10.1097\/ICO.0b013e31817f38e9","DOI":"10.1097\/ICO.0b013e31817f38e9"},{"key":"7306_CR21","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-025-01261-9","author":"M Niwa","year":"2025","unstructured":"Niwa M, Yoshii K, Okumura N (2025) Clinical characteristics and risk factors for corneal guttae in Japanese cataract patients. Jpn J Ophthalmol. https:\/\/doi.org\/10.1007\/s10384-025-01261-9","journal-title":"Jpn J Ophthalmol"},{"key":"7306_CR22","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.ophtha.2005.12.014","volume":"113","author":"GM Zoega","year":"2006","unstructured":"Zoega GM, Fujisawa A, Sasaki H, Kubota A, Sasaki K, Kitagawa K, Jonasson F (2006) Prevalence and risk factors for cornea guttata in the Reykjavik Eye Study. Ophthalmology 113:565\u2013569. https:\/\/doi.org\/10.1016\/j.ophtha.2005.12.014","journal-title":"Ophthalmology"},{"key":"7306_CR23","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1001\/archophthalmol.2010.372","volume":"129","author":"A Higa","year":"2011","unstructured":"Higa A, Sakai H, Sawaguchi S, Iwase A, Tomidokoro A, Amano S, Araie M (2011) Prevalence of and risk factors for cornea guttata in a population-based study in a southwestern island of Japan: the Kumejima study: The kumejima study. Arch Ophthalmol 129:332\u2013336. https:\/\/doi.org\/10.1001\/archophthalmol.2010.372","journal-title":"Arch Ophthalmol"},{"key":"7306_CR24","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1159\/000063656","volume":"34","author":"K Kitagawa","year":"2002","unstructured":"Kitagawa K, Kojima M, Sasaki H, Shui Y-B, Chew SJ, Cheng H-M, Ono M, Morikawa Y, Sasaki K (2002) Prevalence of primary cornea guttata and morphology of corneal endothelium in aging Japanese and Singaporean subjects. Ophthalmic Res 34:135\u2013138. https:\/\/doi.org\/10.1159\/000063656","journal-title":"Ophthalmic Res"},{"issue":"Pt 6","key":"7306_CR25","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/eye.1999.219","volume":"13","author":"AJ Jackson","year":"1999","unstructured":"Jackson AJ, Robinson FO, Frazer DG, Archer DB (1999) Corneal guttata: a comparative clinical and specular micrographic study. Eye (Lond) 13(Pt 6):737\u2013743. https:\/\/doi.org\/10.1038\/eye.1999.219","journal-title":"Eye (Lond)"},{"key":"7306_CR26","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1167\/tvst.11.9.33","volume":"11","author":"S Yamagami","year":"2022","unstructured":"Yamagami S, Yokoo S (2022) Role of monocytes\/macrophages in the etiology of bullous keratopathy after argon laser iridotomy. Transl Vis Sci Technol 11:33. https:\/\/doi.org\/10.1167\/tvst.11.9.33","journal-title":"Transl Vis Sci Technol"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-026-07306-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-026-07306-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-026-07306-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T02:42:21Z","timestamp":1781145741000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-026-07306-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,11]]},"references-count":26,"alternative-id":["7306"],"URL":"https:\/\/doi.org\/10.1007\/s00417-026-07306-0","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,11]]},"assertion":[{"value":"26 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study adhered to the tenets of the Declaration of Helsinki. The entire research protocol\u2014including the procurement of surgical specimens at Nihon University Hospital and Kikuna Yuda Eye Clinic and all subsequent laboratory analyses performed at Doshisha University\u2014was reviewed and approved under a single umbrella approval by the Institutional Review Board of Nihon University Hospital (reference number: RK-240409-1).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All patients provided informed consent in the form of opt-out on the website. Patients who declined to participate were excluded.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}