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Eyes were categorized postoperatively according to stent position within the anterior chamber angle (Grades 0\u20134). Stent position was evaluated 12 weeks postoperatively through automated gonioscopy (GS-1, Nidek). Aqueous humor outflow was assessed using a standardized non-invasive stress test. Primary outcome was the intraocular pressure (IOP) reduction during stress test. Secondary outcomes included IOP reduction from baseline to 12 weeks postoperatively, number of glaucoma medications, complications and need for additional interventions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean IOP decreased significantly after XEN\n                      <jats:sup>\u00ae<\/jats:sup>\n                      Gel Stent implantation from 22.2\u2009\u00b1\u20097.5 mmHg to 12.1\u2009\u00b1\u20095.1 mmHg 12 weeks postoperatively measured with Goldmann applanation tonometry (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, Z -5.6). Stress test induced IOP reduction increased from 14.8\u2009\u00b1\u200913.3% pre-implantation to 32.7\u2009\u00b1\u200919.7% at 12 weeks (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, CI -24.1 to -11.8). Eyes with stent placement within the scleral spur or ciliary body band (Grading 3\u2009+\u20094,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200934) had greater aqueous humor outflow improvement compared with eyes graded 0\u20132 (stent above scleral spur,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010, 95% CI -28.6 to -4.2). Postoperative transient hypotony occurred in 85.3% vs. 61.5% of eyes in Grading group 3\u2009+\u20094 vs. 0\u20132 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.08). 4 eyes were considered non-functional due to malposition (Grading x). Mean number of glaucoma medications decreased from 2.8\u2009\u00b1\u20091.3 preoperatively to 0.2\u2009\u00b1\u20090.9 postoperatively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The positioning of the XEN\n                      <jats:sup>\u00ae<\/jats:sup>\n                      Gel Stent within the scleral spur or ciliary body band (Grade 3\u2009+\u20094) was associated with greater pressure reduction during stress testing, suggesting an increased aqueous humor outflow in this study cohort. Such placement was associated with high treatment success and no increase in major complications, except the risk of misplacement, while transient hypotony was common.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00417-026-07351-9","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T04:25:51Z","timestamp":1782793551000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional assessment of the XEN\u00ae Gel Stent relative to the implant position using non-invasive stress testing and automated gonioscopy"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7446-5333","authenticated-orcid":false,"given":"Leonie","family":"Mahrenholtz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9119-9067","authenticated-orcid":false,"given":"Robin","family":"H\u00f6rle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8509-5149","authenticated-orcid":false,"given":"Sibylle","family":"Winterhalter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danai Sophia","family":"Kruse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Guthoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8095-0254","authenticated-orcid":false,"given":"Anna-Karina B.","family":"Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"7351_CR1","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","volume":"121","author":"Y-C Tham","year":"2014","unstructured":"Tham Y-C, Li X, Wong TY et al (2014) Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040. 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