{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:04:07Z","timestamp":1784631847674,"version":"3.55.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005639","name":"Universidade De S\u00e3o Paulo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005639","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the structure-structure correspondence between circumpapillary retinal nerve fiber layer (cpRNFL) thickness and Bruch\u2019s Membrane Opening Minimum Rim Width (BMO-MRW) in primary open-angle glaucoma (POAG) and controls, and to assess the impact of manual realignment to the clinically visible optic nerve head (ONH) margin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cross-sectional study, spectral-domain optical coherence tomography measured BMO-MRW at 48 radial positions and the 3.5-mm cpRNFL thickness. The Spectralis normative database was used to confirm sectoral MRW and cpRNFL correlation in a large, independent dataset within Garway-Heath sectors. An internal anatomical reference curve of MRW\u2013cpRNFL differences was constructed from 36 eyes with concordant automated and clinically adjusted ONH margins. Subsequently, 116 eyes (72 control, 44 POAG) with margin discordance were analyzed to determine whether manual realignment by two examiners improved correspondence with the reference curve, using squared Spearman correlation (rho\u00b2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Automated BMO-MRW and cpRNFL showed significant sectoral correlation (maximum\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.44, inferotemporal;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with excellent interobserver agreement (ICC 0.99 controls, 0.96 POAG). In controls, automated curves were closer to the reference than manual realignment (9.9\u2009\u00b1\u20099.8\u00a0\u03bcm vs. 27.7\u2009\u00b1\u200916.1\u00a0\u03bcm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001; rho\u00b2=0.96 vs. 0.91). In POAG, manual realignment reduced mean deviation from the reference (\u2212\u200999.7\u2009\u00b1\u200937.7\u00a0\u03bcm vs.\u2009\u2212\u2009124.3\u2009\u00b1\u200930.4\u00a0\u03bcm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Nevertheless, automated segmentation retained stronger monotonic association (rho\u00b2=0.82 vs. 0.57), indicating better structural correspondence. Realignment offered minimal benefit in inferotemporal sectors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Automated BMO-based segmentation demonstrates consistent structure-structure correspondence with cpRNFL in healthy and glaucomatous eyes. Manual realignment yields limited benefit in relatively preserved rim sectors and adds little value in routine glaucoma assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00417-026-07398-8","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:11:25Z","timestamp":1784628685000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Robustness of automated Bruch\u2019s membrane opening minimum rim width and retinal nerve fiber layer thickness without clinical disc margin adjustment in glaucoma"],"prefix":"10.1007","author":[{"given":"Valeria Batista Boreck","family":"Seki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George Cunha","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato Antunes Schiave","family":"Germano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zane Zenon","family":"Zemborain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Jord\u00e3o L.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Gustavo","family":"De Moraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8111-3810","authenticated-orcid":false,"given":"Jayter Silva","family":"Paula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"issue":"18","key":"7398_CR1","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1001\/jama.2014.3192","volume":"311","author":"RN Weinreb","year":"2014","unstructured":"Weinreb RN, Aung T, Medeiros FA (2014) The pathophysiology and treatment of glaucoma: a review. 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Silva certify that they have no affiliations with or involvement in any organization or entity with any financial interest, or non-financial interest in the subject matter or materials discussed in this manuscript. Potential Conflicts: Carlos Gustavo de Moraes: Code C (Consultant\/Contractor): Carl Zeiss, Novartis, Perfuse Therapeutics, Thea Pharma, Galimedix; Code R (Research): Topcon, Carl Zeiss, RPB, CDC, NIH; Code E (Employment): Ora Clinical. Jayter Silva Paula: Code C (Consultant\/Contractor): Abbvie Inc.; Code R (Research): The S\u00e3o Paulo Research Foundation: FAPESP.","order":3,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}