{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T16:57:03Z","timestamp":1785603423179,"version":"3.56.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"NIH"},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the quantitative changes in the number and spatial distribution of corneal guttae in subjects with Fuchs endothelial corneal dystrophy (FECD) following a single intracameral injection of allogeneic magnetic human corneal endothelial cells (EO2002).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective analysis included participants from a Phase 1 U.S. multicenter study who received an intracameral injection of EO2002 without concurrent endothelial polishing (endobrushing) or Descemet membrane stripping. High-resolution retroillumination images of the central cornea were captured at pre-injection (baseline), 3 months, and 6 months post-treatment. Corneal guttae were meticulously quantified by two independent, masked graders using a standardized protocol involving a 7-zone concentric circular grid overlaid on the images. Inter-grader reliability was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four participants who met the inclusion criteria were analyzed. A significant reduction in central corneal guttae was observed. The mean percentage decrease in guttae count compared to pre-injection in the central analytical zones was 53% \u00b1 28% (standard deviation) at 3 months, progressing to 70% \u00b1 16% at 6 months. The reduction was most pronounced in the central and paracentral zones, corresponding to the primary targeted delivery area of the magnetically guided cells, with a diminishing effect towards the periphery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides the first quantitative evidence of visible guttae reduction per retroillumination photography in FECD following endothelial cell therapy, without endo-polishing, Descemet membrane stripping or surgical manipulation. Our findings suggest that magnetically guided allogeneic CEC therapy may alter the Descemet membrane-endothelial complex in FECD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00417-026-07423-w","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:07:54Z","timestamp":1785557274000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Guttae modifying effect following intracameral injection of magnetically delivered human corneal endothelial cells in Fuchs endothelial corneal dystrophy"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5016-2775","authenticated-orcid":false,"given":"Ellen H.","family":"Koo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Pajek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Santiago-Leon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen O.","family":"Eghrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Stanfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia J.","family":"Kunzevitzky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina J.","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather S.","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger A.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,1]]},"reference":[{"key":"7423_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100863","volume":"80","author":"S Ong Tone","year":"2021","unstructured":"Ong Tone S, Kocaba V, B\u00f6hm M, Wylegala A, White TL, Jurkunas UV (2021) Fuchs endothelial corneal dystrophy: the vicious cycle of Fuchs pathogenesis. Prog Retin Eye Res 80:100863. https:\/\/doi.org\/10.1016\/j.preteyeres.2020.100863","journal-title":"Prog Retin Eye Res"},{"key":"7423_CR2","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1146\/annurev-vision-091718-014852","volume":"5","author":"M Matthaei","year":"2019","unstructured":"Matthaei M, Hribek A, Clahsen T, Bachmann B, Cursiefen C, Jun AS (2019) Fuchs endothelial corneal dystrophy: clinical, genetic, pathophysiologic, and therapeutic aspects. Annu Rev Vis Sci 5:151\u2013175. https:\/\/doi.org\/10.1146\/annurev-vision-091718-014852","journal-title":"Annu Rev Vis Sci"},{"key":"7423_CR3","doi-asserted-by":"publisher","unstructured":"Price FW Jr., Price MO (2013) Evolution of endothelial keratoplasty. Cornea 32(Suppl 1):S28\u2013S32. https:\/\/doi.org\/10.1097\/ICO.0b013e3182a0a307","DOI":"10.1097\/ICO.0b013e3182a0a307"},{"key":"7423_CR4","doi-asserted-by":"publisher","unstructured":"Price MO, Gupta P, Lass J, Price FW Jr. (2017) EK (DLEK, DSEK, DMEK): new frontier in cornea surgery. Annu Rev Vis Sci 3:69\u201390. https:\/\/doi.org\/10.1146\/annurev-vision-102016-061400","DOI":"10.1146\/annurev-vision-102016-061400"},{"key":"7423_CR5","doi-asserted-by":"publisher","unstructured":"Price MO, Kanapka L, Kollman C, Lass JH, Price FW Jr. (2024) Descemet membrane endothelial keratoplasty: 10-year cell loss and failure rate compared with Descemet stripping endothelial keratoplasty and penetrating keratoplasty. Cornea 43(11):1403\u20131409. https:\/\/doi.org\/10.1097\/ICO.0000000000003446","DOI":"10.1097\/ICO.0000000000003446"},{"issue":"8","key":"7423_CR6","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1097\/ICO.0000000000003421","volume":"43","author":"FE Hakim","year":"2024","unstructured":"Hakim FE, Nagra AK, Dhaliwal DK (2024) Descemet Stripping Only: Long-Term Outcomes. Cornea 43(8):994\u2013998. https:\/\/doi.org\/10.1097\/ICO.0000000000003421","journal-title":"Cornea"},{"issue":"2","key":"7423_CR7","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.ophtha.2017.08.015","volume":"125","author":"SX Deng","year":"2018","unstructured":"Deng SX, Lee WB, Hammersmith KM et al (2018) Descemet membrane endothelial keratoplasty: safety and outcomes. Ophthalmology 125(2):295\u2013310. https:\/\/doi.org\/10.1016\/j.ophtha.2017.08.015","journal-title":"Ophthalmology"},{"issue":"4","key":"7423_CR8","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.ophtha.2010.08.012","volume":"118","author":"MO Price","year":"2011","unstructured":"Price MO, Fairchild KM, Price DA, Price FW Jr (2011) Descemet\u2019s stripping endothelial keratoplasty: five-year graft survival and endothelial cell loss. Ophthalmology 118(4):725\u2013729. https:\/\/doi.org\/10.1016\/j.ophtha.2010.08.012","journal-title":"Ophthalmology"},{"issue":"2","key":"7423_CR9","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1097\/ICO.0000000000003310","volume":"43","author":"L Fu","year":"2024","unstructured":"Fu L, Hollick EJ (2024) Comparison of long-term outcomes of DSEK and DMEK in Fuchs endothelial dystrophy. Cornea 43(2):184\u2013189. https:\/\/doi.org\/10.1097\/ICO.0000000000003310","journal-title":"Cornea"},{"issue":"11","key":"7423_CR10","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1056\/NEJMoa1712770","volume":"378","author":"S Kinoshita","year":"2018","unstructured":"Kinoshita S, Koizumi N, Ueno M et al (2018) Injection of cultured cells with a Rho kinase inhibitor for bullous keratopathy. N Engl J Med 378(11):995\u20131003. https:\/\/doi.org\/10.1056\/NEJMoa1712770","journal-title":"N Engl J Med"},{"issue":"8","key":"7423_CR11","doi-asserted-by":"publisher","first-page":"3680","DOI":"10.1167\/iovs.08-2634","volume":"50","author":"N Okumura","year":"2009","unstructured":"Okumura N, Ueno M, Koizumi N et al (2009) Enhancement of primate corneal endothelial cell survival in vitro by a ROCK inhibitor. Invest Ophthalmol Vis Sci 50(8):3680\u20133687. https:\/\/doi.org\/10.1167\/iovs.08-2634","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"7423_CR12","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.nano.2014.12.002","volume":"11","author":"SN Moysidis","year":"2015","unstructured":"Moysidis SN, Alvarez-Delfin K, Peschansky VJ et al (2015) Magnetic field-guided cell delivery with nanoparticle-loaded human corneal endothelial cells. Nanomedicine 11(3):499\u2013509. https:\/\/doi.org\/10.1016\/j.nano.2014.12.002","journal-title":"Nanomedicine"},{"issue":"4","key":"7423_CR13","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1097\/ICU.0000000000001050","volume":"35","author":"EH Koo","year":"2024","unstructured":"Koo EH (2024) Current state of endothelial cell therapy. Curr Opin Ophthalmol 35(4):304\u2013308. https:\/\/doi.org\/10.1097\/ICU.0000000000001050","journal-title":"Curr Opin Ophthalmol"},{"issue":"4","key":"7423_CR14","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.ophtha.2020.09.002","volume":"128","author":"K Numa","year":"2021","unstructured":"Numa K, Imai K, Ueno M et al (2021) Five-year follow-up of first 11 patients undergoing injection of cultured corneal endothelial cells for corneal endothelial failure. Ophthalmology 128(4):504\u2013514. https:\/\/doi.org\/10.1016\/j.ophtha.2020.09.002","journal-title":"Ophthalmology"},{"issue":"3","key":"7423_CR15","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1167\/iovs.17-23637","volume":"59","author":"A Bartakova","year":"2018","unstructured":"Bartakova A, Kuzmenko O, Alvarez-Delfin K, Kunzevitzky NJ, Goldberg JL (2018) A cell culture approach to optimized human corneal endothelial cell function. Invest Ophthalmol Vis Sci 59(3):1617\u20131629. https:\/\/doi.org\/10.1167\/iovs.17-23637","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"7423_CR16","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3727\/096368913X675719","volume":"24","author":"GS Peh","year":"2015","unstructured":"Peh GS, Chng Z, Ang HP et al (2015) Propagation of human corneal endothelial cells: a novel dual media approach. Cell Transpl 24(2):287\u2013304. https:\/\/doi.org\/10.3727\/096368913X675719","journal-title":"Cell Transpl"},{"issue":"4","key":"7423_CR17","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1097\/01.ICO.0000178726.11693.14","volume":"25","author":"JD Gottsch","year":"2006","unstructured":"Gottsch JD, Sundin OH, Rencs EV et al (2006) Analysis and documentation of progression of Fuchs corneal dystrophy with retroillumination photography. Cornea 25(4):485\u2013489. https:\/\/doi.org\/10.1097\/01.ICO.0000178726.11693.14","journal-title":"Cornea"},{"issue":"12","key":"7423_CR18","doi-asserted-by":"publisher","first-page":"5662","DOI":"10.1167\/iovs.09-3568","volume":"50","author":"DN Meadows","year":"2009","unstructured":"Meadows DN, Eghrari AO, Riazuddin SA, Emmert DG, Katsanis N, Gottsch JD (2009) Progression of Fuchs corneal dystrophy in a family linked to the FCD1 locus. Invest Ophthalmol Vis Sci 50(12):5662\u20135666. https:\/\/doi.org\/10.1167\/iovs.09-3568","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"7423_CR19","volume-title":"Foundations of Clinical Research: Applications to Practice","author":"LG Portney","year":"2015","unstructured":"Portney LG, Watkins MP (2015) Foundations of Clinical Research: Applications to Practice, 3rd ed. Pearson","edition":"3rd ed"},{"issue":"7","key":"7423_CR20","doi-asserted-by":"publisher","first-page":"073701","DOI":"10.1103\/PhysRevFluids.10.073701","volume":"10","author":"P Rassolov","year":"2025","unstructured":"Rassolov P, Ali J, Siegrist T, Humayun M, Mohammadigoushki H (2025) Magnetophoresis of paramagnetic nanoparticles in suspensions under magnetic field gradients. Phys Rev Fluids 10(7):073701. https:\/\/doi.org\/10.1103\/PhysRevFluids.10.073701","journal-title":"Phys Rev Fluids"},{"issue":"12","key":"7423_CR21","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1097\/ICO.0000000000000656","volume":"34","author":"AOM Eghrari","year":"2015","unstructured":"Eghrari AOM, Garrett BSB, Mumtaz AAB et al (2015) Retroillumination photography analysis enhances clinical definition of severe Fuchs corneal dystrophy. Cornea 34(12):1623\u20131626","journal-title":"Cornea"},{"issue":"6","key":"7423_CR22","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1097\/00003226-200308000-00005","volume":"22","author":"M Hara","year":"2003","unstructured":"Hara M, Morishige N, Chikama T, Nishida T (2003) Comparison of confocal biomicroscopy and noncontact specular microscopy for evaluation of the corneal endothelium. Cornea 22(6):512\u2013515","journal-title":"Cornea"},{"issue":"4","key":"7423_CR23","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1080\/08820538.2019.1632355","volume":"34","author":"S Ong Tone","year":"2019","unstructured":"Ong Tone S, Jurkunas U (2019) Imaging the Corneal Endothelium in Fuchs Corneal Endothelial Dystrophy. Semin Ophthalmol 34(4):340\u2013346. https:\/\/doi.org\/10.1080\/08820538.2019.1632355","journal-title":"Semin Ophthalmol"},{"issue":"3","key":"7423_CR24","doi-asserted-by":"publisher","first-page":"517","DOI":"10.4103\/ijo.IJO_574_20","volume":"69","author":"S Chaurasia","year":"2021","unstructured":"Chaurasia S, Vanathi M (2021) Specular microscopy in clinical practice. Indian J Ophthalmol 69(3):517\u2013524. https:\/\/doi.org\/10.4103\/ijo.IJO_574_20","journal-title":"Indian J Ophthalmol"},{"key":"7423_CR25","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1001\/jamaophthalmol.2024.2718","volume":"142","author":"Y Tomioka","year":"2024","unstructured":"Tomioka Y, Ueno M, Yamamoto A et al (2024) Guttae Morphology After Cultured Corneal Endothelial Cell Transplant in Fuchs Endothelial Corneal Dystrophy. JAMA Ophthalmol 142:818\u2013826","journal-title":"JAMA Ophthalmol"},{"key":"7423_CR26","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.exer.2016.09.004","volume":"152","author":"M Ali","year":"2016","unstructured":"Ali M, Raghunathan V, Li JY, Murphy CJ, Thomasy SM (2016) Biomechanical relationships between the corneal endothelium and Descemet\u2019s membrane. Exp Eye Res 152:57\u201370. https:\/\/doi.org\/10.1016\/j.exer.2016.09.004","journal-title":"Exp Eye Res"},{"issue":"1","key":"7423_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-91850-y","volume":"15","author":"S Inagaki","year":"2025","unstructured":"Inagaki S, Vaitinadapoule H, Yuasa T et al (2025) Comprehensive identification of dysregulated extracellular matrix molecules in the corneal endothelium of patients with Fuchs endothelial corneal dystrophy. Sci Rep 15(1):14654. https:\/\/doi.org\/10.1038\/s41598-025-91850-y","journal-title":"Sci Rep"},{"issue":"4","key":"7423_CR28","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1167\/iovs.65.4.38","volume":"65","author":"A Tchatchouang","year":"2024","unstructured":"Tchatchouang A, Brunette I, Rochette PJ, Proulx S (2024) Expression and impact of fibronectin, tenascin-C, osteopontin, and type XIV collagen in Fuchs endothelial corneal dystrophy. Invest Ophthalmol Vis Sci 65(4):38. https:\/\/doi.org\/10.1167\/iovs.65.4.38","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"7423_CR29","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1167\/iovs.08-2525","volume":"50","author":"UV Jurkunas","year":"2009","unstructured":"Jurkunas UV, Bitar M, Rawe I et al (2009) Colocalization of increased transforming growth factor-\u03b2-induced protein (TGFBIp) and clusterin in Fuchs endothelial corneal dystrophy. Invest Ophthalmol Vis Sci 50(3):1129\u20131136. https:\/\/doi.org\/10.1167\/iovs.08-2525","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"7423_CR30","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1097\/ICO.0000000000003504","volume":"43","author":"JM Weller","year":"2024","unstructured":"Weller JM, Bennemann M, Tourtas T, Kruse FE, Schl\u00f6tzer-Schrehardt U (2024) Differences in Guttae Ultramorphology in Relation to Visual Function in Fuchs Endothelial Corneal Dystrophy. Cornea 43(11):1348\u20131354. https:\/\/doi.org\/10.1097\/ICO.0000000000003504","journal-title":"Cornea"},{"issue":"6","key":"7423_CR31","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.1167\/iovs.15-18826","volume":"57","author":"A Bartakova","year":"2016","unstructured":"Bartakova A, Alvarez-Delfin K, Weisman AD et al (2016) Novel identity and functional markers for human corneal endothelial cells. Invest Ophthalmol Vis Sci 57(6):2749\u20132762. https:\/\/doi.org\/10.1167\/iovs.15-18826","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"7423_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2021.108500","volume":"205","author":"I Xu","year":"2021","unstructured":"Xu I, Th\u00e9riault M, Brunette I, Rochette PJ, Proulx S (2021) Matrix metalloproteinases and their inhibitors in Fuchs endothelial corneal dystrophy. Exp Eye Res 205:108500. https:\/\/doi.org\/10.1016\/j.exer.2021.108500","journal-title":"Exp Eye Res"},{"key":"7423_CR33","doi-asserted-by":"publisher","unstructured":"Kocaba V, Katikireddy KR, Gipson I, Price MO, Price FW Jr, Jurkunas UV (2018) Association of the gutta-induced microenvironment with corneal endothelial cell behavior and demise in Fuchs endothelial corneal dystrophy. JAMA Ophthalmol 136(8):886\u2013892. https:\/\/doi.org\/10.1001\/jamaophthalmol.2018.2031","DOI":"10.1001\/jamaophthalmol.2018.2031"},{"issue":"1","key":"7423_CR34","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-30383-8","volume":"13","author":"S M\u00e9thot","year":"2023","unstructured":"M\u00e9thot S, Proulx S, Brunette I, Rochette PJ (2023) Rescuing cellular function in Fuchs endothelial corneal dystrophy by healthy exogenous mitochondrial internalization. Sci Rep 13(1):3380. https:\/\/doi.org\/10.1038\/s41598-023-30383-8","journal-title":"Sci Rep"},{"issue":"6","key":"7423_CR35","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1097\/ICO.0000000000002762","volume":"41","author":"K Shah","year":"2022","unstructured":"Shah K, Eghrari AO, Vanner EA, O\u2019Brien TP, Koo EH (2022) Scheimpflug corneal densitometry values and severity of guttae in relation to visual acuity in Fuchs endothelial corneal dystrophy. Cornea 41(6):692\u2013698. https:\/\/doi.org\/10.1097\/ICO.0000000000002762","journal-title":"Cornea"},{"issue":"8","key":"7423_CR36","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1016\/j.ophtha.2015.05.005","volume":"122","author":"K Wacker","year":"2015","unstructured":"Wacker K, McLaren JW, Amin SR, Baratz KH, Patel SV (2015) Corneal high-order aberrations and backscatter in Fuchs\u2019 endothelial corneal dystrophy. Ophthalmology 122(8):1645\u20131652. https:\/\/doi.org\/10.1016\/j.ophtha.2015.05.005","journal-title":"Ophthalmology"},{"issue":"6","key":"7423_CR37","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1016\/j.ophtha.2009.10.027","volume":"117","author":"MA Shousha","year":"2010","unstructured":"Shousha MA, Perez VL, Wang J et al (2010) Use of ultra-high-resolution optical coherence tomography to detect in vivo characteristics of Descemet\u2019s membrane in Fuchs\u2019 dystrophy. Ophthalmology 117(6):1220\u20131227. https:\/\/doi.org\/10.1016\/j.ophtha.2009.10.027","journal-title":"Ophthalmology"},{"issue":"10","key":"7423_CR38","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.3390\/jcm11102815","volume":"11","author":"O \u00d6zer","year":"2022","unstructured":"\u00d6zer O, Mestanoglu M, Howaldt A, Clahsen T, Schiller P, Siebelmann S, Reinking N, Cursiefen C, Bachmann B, Matthaei M (2022) Correlation of Clinical Fibrillar Layer Detection and Corneal Thickness in Advanced Fuchs Endothelial Corneal Dystrophy. J Clin Med 11(10):2815. https:\/\/doi.org\/10.3390\/jcm11102815 PMID: 35628952; PMCID: PMC9144691","journal-title":"J Clin Med"},{"key":"7423_CR39","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.ajo.2020.09.030","volume":"222","author":"A Hribek","year":"2021","unstructured":"Hribek A, Clahsen T, Horstmann J, Siebelmann S, Loreck N, Heindl LM, Bachmann BO, Cursiefen C, Matthaei M (2021) Fibrillar layer as a marker for areas of pronounced corneal endothelial cell loss in advanced Fuchs endothelial corneal dystrophy. Am J Ophthalmol 222:292\u2013301. https:\/\/doi.org\/10.1016\/j.ajo.2020.09.030","journal-title":"Am J Ophthalmol"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-026-07423-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-026-07423-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-026-07423-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T16:02:37Z","timestamp":1785600157000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-026-07423-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,1]]},"references-count":39,"alternative-id":["7423"],"URL":"https:\/\/doi.org\/10.1007\/s00417-026-07423-w","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,1]]},"assertion":[{"value":"17 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"EHK receives research grants from Design Therapeutics, Emmecell and KOWA. NJK, CJF and HSE are employees of Emmecell. RAG and JLG are shareholders in Emmecell.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}