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Patients with cCSCR and healthy controls underwent imaging with Spectralis High Magnification Module (HMM), structural OCT, and OCT-Angiography in the macular area. Regions of interest were selected and topographically superimposed across modalities. Retinal sensitivity was assessed using fundus microperimetry with a 4-2-1 automated staircase strategy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean photoreceptor density was significantly lower in cCSCR eyes than in healthy controls (6617.8 vs. 11162.3 cells\/mm\u00b2,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0004). Mean NR-PRL was 0.6 in cCSCR and 0.9 in controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0074), while NR-RPE was also significantly reduced in cCSCR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0465). Mean CC-VPD was 41.8% in cCSCR compared with 63.7% in controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0011). Mean retinal sensitivity was significantly decreased in cCSCR (10.74\u2009\u00b1\u20093.90 dB) versus controls (19.39\u2009\u00b1\u20093.90 dB;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0001) and strongly correlated with photoreceptor density. A strong correlation between NR-PRL and NR-RPE was observed in both controls (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.883,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014) and cCSCR eyes (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.884,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Photoreceptor mosaic integrity significantly correlates with retinal sensitivity in cCSCR. HMM represents a reliable and accessible in vivo tool for quantifying photoreceptor loss and its functional impact.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00417-026-07429-4","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T09:47:51Z","timestamp":1785491271000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photoreceptors integrity as surrogate of retinal sensitivity in chronic central serous chorioretinopathy: a multimodal imaging study"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6817-2488","authenticated-orcid":false,"given":"Marco","family":"Lupidi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Muzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Gregori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Fruttini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Mangoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice","family":"Cardillo Piccolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Chhablani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Mariotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"7429_CR1","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1111\/aos.12779","volume":"94","author":"KH Wong","year":"2016","unstructured":"Wong KH, Lau KP, Chhablani J et al (2016) Central serous chorioretinopathy: what we have learnt so far. 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