{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T16:27:25Z","timestamp":1793896045748,"version":"4.8.0"},"reference-count":88,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100018623","name":"Quanzhou City Science and Technology Program","doi-asserted-by":"publisher","award":["No. 2025QZNY110"],"award-info":[{"award-number":["No. 2025QZNY110"]}],"id":[{"id":"10.13039\/501100018623","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1007\/s00417-026-07445-4","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T03:52:37Z","timestamp":1786161157000},"page":"3373-3385","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immunological drivers of oxidative stress in glaucoma: implications for antioxidant therapy"],"prefix":"10.1007","volume":"264","author":[{"given":"Bin","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-kan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,8]]},"reference":[{"key":"7445_CR1","doi-asserted-by":"publisher","unstructured":"Caceres-Velez PR, Hui F, Hercus J, Bui B, Jusuf PR (2022) Restoring the oxidative balance in age-related diseases - An approach in glaucoma. Ageing Res Rev 75:101572. https:\/\/doi.org\/10.1016\/j.arr.2022.101572. eng. Epub 2022\/01\/23","DOI":"10.1016\/j.arr.2022.101572"},{"key":"7445_CR2","doi-asserted-by":"publisher","first-page":"1660401","DOI":"10.3389\/fphar.2025.1660401","volume":"16","author":"B Lin","year":"2025","unstructured":"Lin B, Shi P, Li DK (2025) Intravitreal drug injection for glaucoma: mechanisms, clinical efficacy, and future horizons. Front Pharmacol 16:1660401 eng. Epub 2025\/08\/29 20:45. https:\/\/doi.org\/10.3389\/fphar.2025.1660401","journal-title":"Front Pharmacol"},{"key":"7445_CR3","doi-asserted-by":"publisher","unstructured":"Lin B, Li DK (2025) From tumor microenvironment to ocular hypertension: unraveling the pathogenesis and therapeutic strategies of cancer-related glaucoma. Front Med (Lausanne) 12:1628325. https:\/\/doi.org\/10.3389\/fmed.2025.1628325.\u00a0eng. Epub\u00a02025\/09\/02 22:34","DOI":"10.3389\/fmed.2025.1628325"},{"issue":"1","key":"7445_CR4","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s12974-024-03075-x","volume":"21","author":"X Shi","year":"2024","unstructured":"Shi X, Li P, Herb M, Liu H, Wang M, Wang X, Feng Y, van Beers T, Xia N, Li H, Prokosch V (2024) Pathological high intraocular pressure induces glial cell reactive proliferation contributing to neuroinflammation of the blood-retinal barrier via the NOX2\/ET-1 axis-controlled ERK1\/2 pathway. J Neuroinflammation 21(1):105. https:\/\/doi.org\/10.1186\/s12974-024-03075-x. eng. Epub 2024\/04\/23. Cited in: Pubmed; PMID 38649885","journal-title":"J Neuroinflammation"},{"key":"7445_CR5","doi-asserted-by":"publisher","unstructured":"Liao J, Peng B, Huang G, Diao C, Qin Y, Hong Y, Lin J, Lin Y, Jiang L, Tang N, Tang F, Liang J, Zhang J, Yan Y, Chen Q, Zhou Z, Shen C, Huang W, Huang K, Lan Q, Cui L, Zhong H, Xu F, Li M, Wei Y, Lu P, Zhang M (2023) Inhibition of NOX4 with GLX351322 alleviates acute ocular hypertension-induced retinal inflammation and injury by suppressing ROS mediated redox-sensitive factors activation. Biomed Pharmacother 165:115052. https:\/\/doi.org\/10.1016\/j.biopha.2023.115052. eng. Epub 2023\/07\/04","DOI":"10.1016\/j.biopha.2023.115052"},{"key":"7445_CR6","doi-asserted-by":"publisher","unstructured":"Yu H, Zhang Y, Zhong H, Zhang Y, He S, Zhang Y, Wang Y, Chen J, Guo Y, Shen X, Wang Y, Huang S, Zhong Y (2026) Superoxide-responsive mitochondria-targeting peptide-persulfide donor conjugate for retinal ganglion cells protection in glaucoma. Biomaterials 330:124054. https:\/\/doi.org\/10.1016\/j.biomaterials.2026.124054. eng. Epub 2026\/02\/14","DOI":"10.1016\/j.biomaterials.2026.124054"},{"key":"7445_CR7","doi-asserted-by":"publisher","DOI":"10.1097\/js9.0000000000004146","author":"Y Liu","year":"2025","unstructured":"Liu Y, You M, Wang J, Liu J, Zhou X, Kenny J, Rong R, Xia X (2025) 3-n-Butylphthalide exerts mitochondria-mediated retinal ganglion cell protection and modulates eye-brain axis-related emotional disturbances in glaucoma. Int J Surg. Dec 4. eng. Epub 2025\/12\/04 https:\/\/doi.org\/10.1097\/js9.0000000000004146","journal-title":"Int J Surg"},{"key":"7445_CR8","doi-asserted-by":"publisher","unstructured":"Callaghan B, Vallabh NA, Willoughby CE (2023) Deuterated polyunsaturated fatty acids provided protection against oxidative stress in ocular fibroblasts derived from glaucoma patients. Mech Ageing Dev 211:111778. https:\/\/doi.org\/10.1016\/j.mad.2023.111778. eng. Epub 2023\/01\/31","DOI":"10.1016\/j.mad.2023.111778"},{"key":"7445_CR9","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8063651","author":"C He","year":"2022","unstructured":"He C, Zhang G, Fu J, Zhang R, Li A, Liu D, Li B, Chen Y, Deng B, Chen Y, Shuai P, Lu F (2022) Clinical Significance of Albumin- and Bilirubin-Based Biomarkers in Glaucoma: A Retrospective Case-Control Study. Oxid Med Cell Longev. 2022:8063651. eng. Epub 2022\/03\/15 https:\/\/doi.org\/10.1155\/2022\/8063651","journal-title":"Oxid Med Cell Longev"},{"issue":"10","key":"7445_CR10","doi-asserted-by":"publisher","first-page":"e0204263","DOI":"10.1371\/journal.pone.0204263","volume":"13","author":"JB Jonas","year":"2018","unstructured":"Jonas JB, Wei WB, Xu L, Wang YX (2018) Systemic inflammation and eye diseases. The Beijing Eye Study. PLoS ONE 13(10):e0204263 Epub 2018\/10\/04. https:\/\/doi.org\/10.1371\/journal.pone.0204263","journal-title":"PLoS ONE"},{"key":"7445_CR11","doi-asserted-by":"publisher","unstructured":"Mrugacz M, Bryl A, Falkowski M, Zorena K (2021) Integrins: An important link between angiogenesis, inflammation and eye diseases. Cells 10(7). https:\/\/doi.org\/10.3390\/cells10071703. Epub 2021\/08\/08","DOI":"10.3390\/cells10071703"},{"issue":"8","key":"7445_CR12","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/j.ophtha.2021.01.019","volume":"128","author":"N Nezu","year":"2021","unstructured":"Nezu N, Usui Y, Saito A, Shimizu H, Asakage M, Yamakawa N, Tsubota K, Wakabayashi Y, Narimatsu A, Umazume K, Maruyama K, Sugimoto M, Kuroda M, Goto H (2021) Machine Learning Approach for Intraocular Disease Prediction Based on Aqueous Humor Immune Mediator Profiles. Ophthalmology 128(8):1197\u20131208 Epub 2021\/01\/24. https:\/\/doi.org\/10.1016\/j.ophtha.2021.01.019","journal-title":"Ophthalmology"},{"issue":"6","key":"7445_CR13","doi-asserted-by":"publisher","first-page":"e22945","DOI":"10.1096\/fj.202202056RR","volume":"37","author":"J Chen","year":"2023","unstructured":"Chen J, Zhong H, Yu H, Sun J, Shen B, Xu X, Huang S, Huang P, Zhong Y (2023) Interleukin-17A modulates retinal inflammation by regulating microglial activation via the p38 MAPK pathway in experimental glaucoma neuropathy. FASEB J 37(6):e22945 Epub 2023\/05\/05. https:\/\/doi.org\/10.1096\/fj.202202056RR","journal-title":"FASEB J"},{"key":"7445_CR14","doi-asserted-by":"publisher","unstructured":"Dziedziak J, Kasarello K, Cudnoch-Jedrzejewska A (2021) Dietary Antioxidants in age-related macular degeneration and glaucoma. Antioxid (Basel) 10(11). https:\/\/doi.org\/10.3390\/antiox10111743. eng. Epub 2021\/11\/28","DOI":"10.3390\/antiox10111743"},{"key":"7445_CR15","doi-asserted-by":"publisher","unstructured":"Ng TK, Chu KO, Wang CC, Pang CP (2023) Green tea catechins as therapeutic antioxidants for glaucoma treatment. Antioxid (Basel) 12(7). https:\/\/doi.org\/10.3390\/antiox12071320. eng. Epub 2023\/07\/29","DOI":"10.3390\/antiox12071320"},{"issue":"11","key":"7445_CR16","doi-asserted-by":"publisher","first-page":"e2303817","DOI":"10.1002\/adhm.202303817","volume":"13","author":"B Hu","year":"2024","unstructured":"Hu B, Ouyang Y, Zhao T, Wang Z, Yan Q, Qian Q, Wang W, Wang S (2024) Antioxidant Hydrogels: Antioxidant Mechanisms, Design Strategies, and Applications in the Treatment of Oxidative Stress-Related Diseases. Adv Healthc Mater 13(11):e2303817. https:\/\/doi.org\/10.1002\/adhm.202303817. eng. Epub 2024\/01\/03. Cited in: Pubmed; PMID 38166174","journal-title":"Adv Healthc Mater"},{"issue":"33","key":"7445_CR17","doi-asserted-by":"publisher","first-page":"39126","DOI":"10.1021\/acsami.1c12176","volume":"13","author":"P Yang","year":"2021","unstructured":"Yang P, Zhang J, Xiang S, Jin Z, Zhu F, Wang T, Duan G, Liu X, Gu Z, Li Y (2021) Green Nanoparticle Scavengers against Oxidative Stress. ACS Appl Mater Interfaces 13(33):39126\u201339134 eng. Epub 2021\/08\/13. https:\/\/doi.org\/10.1021\/acsami.1c12176","journal-title":"ACS Appl Mater Interfaces"},{"key":"7445_CR18","doi-asserted-by":"publisher","unstructured":"Luo L, Yang G, Zhang P, Tang F, Luo P, Ding L, Ma X, Gao C, Lin J, Lin J, Wu A, Chen T (2026) Cerium-Based Materials for Theranostics: Building a Bridge Across the Divide From Antioxidant Therapy to Diagnostic Signals. Wiley Interdiscip Rev Nanomed Nanobiotechnol 18(2):e70055. https:\/\/doi.org\/10.1002\/wnan.70055. eng. Epub 2026\/03\/08","DOI":"10.1002\/wnan.70055"},{"key":"7445_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2025.118833","author":"S Makhijani","year":"2026","unstructured":"Makhijani S, Khobragade D, Beyond IOP (2026) Neuroprotection and neuroregeneration as important therapeutic strategies for glaucoma. Biomed Pharmacother. 194:118833. eng. Epub 2026\/01\/07 https:\/\/doi.org\/10.1016\/j.biopha.2025.118833","journal-title":"Biomed Pharmacother"},{"key":"7445_CR20","doi-asserted-by":"publisher","unstructured":"Chaudhry S, Dunn H, Carnt N, White A (2022) Nutritional supplementation in the prevention and treatment of glaucoma. Surv Ophthalmol 67(4):1081-1098. eng. Epub 2021\/12\/14. https:\/\/doi.org\/10.1016\/j.survophthal.2021.12.001. Cited in: Pubmed; PMID 34896192","DOI":"10.1016\/j.survophthal.2021.12.001"},{"issue":"44","key":"7445_CR21","doi-asserted-by":"publisher","first-page":"30361","DOI":"10.1021\/jacs.4c10457","volume":"146","author":"X Chen","year":"2024","unstructured":"Chen X, Liu J, Chen M, Zhou J, Zhang Y, Hu X, Geng W, Mao Q, Kitagishi H, Chen J, Qian X, Yang Y, Lei Y, Luo X (2024) Green-Light-Triggered and Self-Calibrated Cascade Release of Nitric Oxide and Carbon Monoxide for Synergistic Glaucoma Therapy. J Am Chem Soc 146(44):30361\u201330371 eng. Epub 2024\/10\/18. https:\/\/doi.org\/10.1021\/jacs.4c10457","journal-title":"J Am Chem Soc"},{"key":"7445_CR22","doi-asserted-by":"publisher","unstructured":"Ahmed CM, Johnson HM, Lewin AS (2024) Corneal application of SOCS1\/3 peptides for the treatment of eye diseases mediated by inflammation and oxidative stress. Front Immunol 15 :1416181. https:\/\/doi.org\/10.3389\/fimmu.2024.1416181. eng. Epub 2024\/08\/06","DOI":"10.3389\/fimmu.2024.1416181"},{"key":"7445_CR23","doi-asserted-by":"publisher","unstructured":"Lin B, Li DK, Xu M, Shi P, Liang W (2025) Letter to the Editor: Wipe-out phenomenon after gonioscopy-assisted transluminal trabeculotomy. J Glaucoma. https:\/\/doi.org\/10.1097\/IJG.0000000000002655. Epub 2025\/12\/16","DOI":"10.1097\/IJG.0000000000002655"},{"key":"7445_CR24","doi-asserted-by":"publisher","first-page":"1667097","DOI":"10.3389\/fimmu.2025.1667097","volume":"16","author":"Z Wang","year":"2025","unstructured":"Wang Z, Chen Y, Wang J, Xiu W, Zhang G, Gao Y, Li A, Long P, Deng B, He C, Lu F (2025) Pro-inflammatory S100A9 contributes to retinal ganglion cell degeneration in glaucoma. Front Immunol 16:1667097. https:\/\/doi.org\/10.3389\/fimmu.2025.1667097. eng. Epub 2025\/10\/13. Cited in: Pubmed; PMID 41080559","journal-title":"Front Immunol"},{"key":"7445_CR25","doi-asserted-by":"publisher","unstructured":"Mandell JT, de Rivero Vaccari JP, Sabater AL, Galor A (2023) The inflammasome pathway: A key player in ocular surface and anterior segment diseases. Surv Ophthalmol 68(2):280\u2013289. https:\/\/doi.org\/10.1016\/j.survophthal.2022.06.003. eng. Epub 2022\/07\/08","DOI":"10.1016\/j.survophthal.2022.06.003"},{"issue":"9","key":"7445_CR26","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1038\/s41423-021-00740-6","volume":"18","author":"Y Huang","year":"2021","unstructured":"Huang Y, Xu W, Zhou R (2021) NLRP3 inflammasome activation and cell death. Cell Mol Immunol 18(9):2114\u20132127 eng. Epub 2021\/07\/30. https:\/\/doi.org\/10.1038\/s41423-021-00740-6","journal-title":"Cell Mol Immunol"},{"issue":"7","key":"7445_CR27","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1002\/glia.24174","volume":"70","author":"S Drinkall","year":"2022","unstructured":"Drinkall S, Lawrence CB, Ossola B, Russell S, Bender C, Brice NB, Dawson LA, Harte M, Brough D (2022) The two pore potassium channel THIK-1 regulates NLRP3 inflammasome activation. Glia 70(7):1301\u20131316 eng. Epub 2022\/03\/31. https:\/\/doi.org\/10.1002\/glia.24174","journal-title":"Glia"},{"key":"7445_CR28","doi-asserted-by":"publisher","unstructured":"Liu M, Li H, Yang R, Ji D, Xia X (2022) GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis through inhibition of RIP1\/RIP3\/MLKL pathway in glutamate-induced retinal excitotoxic model of glaucoma. J Neuroinflammation 19(1):262. https:\/\/doi.org\/10.1186\/s12974-022-02626-4. eng. Epub 2022\/10\/28","DOI":"10.1186\/s12974-022-02626-4"},{"key":"7445_CR29","doi-asserted-by":"publisher","unstructured":"Coyle S, Khan MN, Chemaly M, Callaghan B, Doyle C, Willoughby CE, Atkinson SD, Gregory-Ksander M, McGilligan V (2021) Targeting the NLRP3 Inflammasome in Glaucoma. Biomolecules 11(8). https:\/\/doi.org\/10.3390\/biom11081239. Epub 2021\/08\/28","DOI":"10.3390\/biom11081239"},{"issue":"3","key":"7445_CR30","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.exphem.2014.11.003","volume":"43","author":"KK Thakur","year":"2015","unstructured":"Thakur KK, Bolshette NB, Trandafir C, Jamdade VS, Istrate A, Gogoi R, Cucuianu A (2015) Role of toll-like receptors in multiple myeloma and recent advances. Exp Hematol 43(3):158\u2013167 Cited in: Pubmed; PMID 25462020","journal-title":"Exp Hematol"},{"issue":"1","key":"7445_CR31","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1007\/s00018-024-05533-4","volume":"82","author":"Y Huang","year":"2025","unstructured":"Huang Y, Zhang G, Li S, Feng J, Zhang Z (2025) Innate and adaptive immunity in neurodegenerative disease. Cell Mol Life Sci 82(1):68 Epub 2025\/02\/03. https:\/\/doi.org\/10.1007\/s00018-024-05533-4","journal-title":"Cell Mol Life Sci"},{"key":"7445_CR32","doi-asserted-by":"publisher","unstructured":"Hoppe C, Mukai R, Refaian N, Karg M, Shirahama S, Shrestha M, Guo Y, Nwogu A, Krasniqi-Vanmeter D, Malechka VV, Ksander BR, Connor K, Gregory-Ksander M (2025) The alternative complement pathway drives neuroinflammation and neurodegeneration in mouse models of glaucoma and optic nerve injury. Neurobiol Dis 216:107119. https:\/\/doi.org\/10.1016\/j.nbd.2025.107119. eng. Epub 2025\/09\/27","DOI":"10.1016\/j.nbd.2025.107119"},{"issue":"1","key":"7445_CR33","doi-asserted-by":"publisher","first-page":"115","DOI":"10.14336\/ad.2024.0129","volume":"16","author":"S He","year":"2024","unstructured":"He S, Liu C, Ren C, Zhao H, Zhang X (2024) Immunological Landscape of Retinal Ischemia-Reperfusion Injury: Insights into Resident and Peripheral Immune Cell Responses. Aging Dis 16(1):115\u2013136 eng. Epub 2024\/03\/19. https:\/\/doi.org\/10.14336\/ad.2024.0129","journal-title":"Aging Dis"},{"key":"7445_CR34","doi-asserted-by":"publisher","unstructured":"He J, Xiong S, Zhou W, Qiu H, Rao Y, Liu Y, Shen G, Zhao P, Chen G, Li J (2024) Long-term polystyrene nanoparticles exposure reduces electroretinal responses and exacerbates retinal degeneration induced by light exposure. J Hazard Mater 473:134586. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.134586. eng. Epub 2024\/05\/23","DOI":"10.1016\/j.jhazmat.2024.134586"},{"key":"7445_CR35","doi-asserted-by":"publisher","unstructured":"Kulshrestha P, Goel P, Murthy S, Tyagi M, Basu S, Gogri P, Kaur I (2023) Exploring the involvement of the alternative complement pathway in non-infectious uveitis pathogenesis. Front Immunol 14:1222998. https:\/\/doi.org\/10.3389\/fimmu.2023.1222998. eng. Epub 2024\/01\/08","DOI":"10.3389\/fimmu.2023.1222998"},{"issue":"1","key":"7445_CR36","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1038\/s41419-025-08104-y","volume":"16","author":"AJ Ortega","year":"2025","unstructured":"Ortega AJ, Daniel S, Renwick M, Kambhampati P, Thompson KN, Collier GE, Baker EL, Zaki H, Hulleman JD (2025) Genetic removal of Nlrp3 protects against age-related and R345W Efemp1-induced basal laminar deposit formation. Cell Death Dis 16(1):803. https:\/\/doi.org\/10.1038\/s41419-025-08104-y. eng. Epub 2025\/11\/07. Cited in: Pubmed; PMID 41198612","journal-title":"Cell Death Dis"},{"key":"7445_CR37","doi-asserted-by":"publisher","unstructured":"Yu N, Wu X, Zhang C, Qin Q, Gu Y, Ke W, Liu X, Zhang Q, Liu Z, Chen M, Wang K (2024) NADPH and NAC synergistically inhibits chronic ocular hypertension-induced neurodegeneration and neuroinflammation through regulating p38\/MAPK pathway and peroxidation. Biomed Pharmacother 175 :116711. https:\/\/doi.org\/10.1016\/j.biopha.2024.116711. eng. Epub 2024\/05\/13","DOI":"10.1016\/j.biopha.2024.116711"},{"issue":"1","key":"7445_CR38","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s40478-023-01663-1","volume":"11","author":"S Naguib","year":"2023","unstructured":"Naguib S, Backstrom JR, Artis E, Ghose P, Stahl A, Hardin R, Haider AA, Ang J, Calkins DJ, Rex TS (2023) NRF2\/ARE mediated antioxidant response to glaucoma: role of glia and retinal ganglion cells. Acta Neuropathol Commun 11(1):171. https:\/\/doi.org\/10.1186\/s40478-023-01663-1. eng. Epub 2023\/10\/25. Cited in: Pubmed; PMID 37875948","journal-title":"Acta Neuropathol Commun"},{"key":"7445_CR39","doi-asserted-by":"publisher","unstructured":"Xing YY, Zheng YK, Yang S, Zhang LH, Guo SW, Shi LL, Xu YQ, Jin X, Yan SM, Shi BL (2021) Artemisia ordosica Polysaccharide Alleviated Lipopolysaccharide-induced Oxidative Stress of Broilers via Nrf2\/Keap1 and TLR4\/NF-kappaB Pathway. Ecotoxicol Environ Saf 223:112566. https:\/\/doi.org\/10.1016\/j.ecoenv.2021.112566. eng. Epub 2021\/08\/03","DOI":"10.1016\/j.ecoenv.2021.112566"},{"key":"7445_CR40","doi-asserted-by":"publisher","unstructured":"Roberson JK, Bauer AN, Lopez-Ramirez A, Jenness DB, Cruz Zayas S, Cooke Bailey JN, Woodlief TL (2026) Environmental exposures and oxidative stress in retinal and optic nerve diseases: Mechanisms, consequences, and therapeutic opportunities. Antioxid (Basel) 15(3). https:\/\/doi.org\/10.3390\/antiox15030281. eng. Epub 2026\/03\/28","DOI":"10.3390\/antiox15030281"},{"key":"7445_CR41","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1497813","author":"Q Yang","year":"2022","unstructured":"Yang Q, Cai W, Jin H, Shen T, Yu J (2022) Downregulation of Inflammatory Response via Nrf2\/Trx1\/TXNIP Axis in Oxidative Stress-Induced ARPE-19 Cells and Mouse Model of AMD. Oxid Med Cell Longev. 2022:1497813. eng. Epub 2022\/08\/23 https:\/\/doi.org\/10.1155\/2022\/1497813","journal-title":"Oxid Med Cell Longev"},{"key":"7445_CR42","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.freeradbiomed.2022.04.005","volume":"184","author":"W Zhao","year":"2022","unstructured":"Zhao W, Deng Z, Barkema HW, Xu M, Gao J, Liu G, Lin Y, Kastelic JP, Han B (2022) Nrf2 and NF-kappaB\/NLRP3 inflammasome pathways are involved in Prototheca bovis infections of mouse mammary gland tissue and mammary epithelial cells. Free Radic Biol Med 184:148\u2013157 eng. Epub 2022\/04\/14. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.04.005","journal-title":"Free Radic Biol Med"},{"key":"7445_CR43","doi-asserted-by":"publisher","first-page":"tkad062","DOI":"10.1093\/burnst\/tkad062","volume":"12","author":"L Xu","year":"2024","unstructured":"Xu L, An T, Jia B, Wu Q, Shen J, Jin J, Liu J, Li C (2024) Histone deacetylase 3-specific inhibitor RGFP966 attenuates oxidative stress and inflammation after traumatic brain injury by activating the Nrf2 pathway. Burns Trauma 12:tkad062. https:\/\/doi.org\/10.1093\/burnst\/tkad062. eng. Epub 2024\/05\/06. Cited in: Pubmed; PMID 38708192","journal-title":"Burns Trauma"},{"issue":"1","key":"7445_CR44","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/s10495-025-02248-0","volume":"31","author":"J Deng","year":"2026","unstructured":"Deng J, Kang W, Wang A, Yang J, Wang K, Quan L, Pan H, Song W, Xu P, Lin D (2026) Phillyrin promotes flap survival by mitigating pyroptosis through the TLR4\/NF-kappaB\/NLRP3 signaling pathway. Apoptosis 31(1):36. https:\/\/doi.org\/10.1007\/s10495-025-02248-0. eng. Epub 2026\/01\/10 22:40. Cited in: Pubmed; PMID 41518527","journal-title":"Apoptosis"},{"key":"7445_CR45","doi-asserted-by":"publisher","unstructured":"Xu P, Wang A, Xiao Z, Song W, Pan H, Yang J, Deng J, Wang K, Lin D (2026) Osthole promotes skin flap survival by inhibiting ferroptosis and alleviating pyroptosis. J Ethnopharmacol 358:121058. https:\/\/doi.org\/10.1016\/j.jep.2025.121058. eng. Epub 2025\/12\/17","DOI":"10.1016\/j.jep.2025.121058"},{"key":"7445_CR46","doi-asserted-by":"publisher","unstructured":"van der Horst D, Carter-Timofte ME, van Grevenynghe J, Laguette N, Dinkova-Kostova AT, Olagnier D (2022) Regulation of innate immunity by Nrf2. Curr Opin Immunol 78:102247. https:\/\/doi.org\/10.1016\/j.coi.2022.102247. eng. Epub 2022\/09\/30","DOI":"10.1016\/j.coi.2022.102247"},{"issue":"11","key":"7445_CR47","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1038\/s41374-022-00813-8","volume":"102","author":"DD Wang","year":"2022","unstructured":"Wang DD, Gao FJ, Zhang XJ, Hu FY, Xu P, Wu JH (2022) Nobiletin protects retinal ganglion cells in models of ocular hypertension in vivo and hypoxia in vitro. Lab Invest 102(11):1225\u20131235 eng. Epub 2022\/07\/09. https:\/\/doi.org\/10.1038\/s41374-022-00813-8","journal-title":"Lab Invest"},{"key":"7445_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102308","author":"D Wei","year":"2024","unstructured":"Wei D, Qu C, Zhao N, Li S, Pu N, Song Z, Tao Y (2024) The significance of precisely regulating heme oxygenase-1 expression: Another avenue for treating age-related ocular disease? Ageing Res Rev. 97:102308. eng. Epub 2024\/04\/15 https:\/\/doi.org\/10.1016\/j.arr.2024.102308","journal-title":"Ageing Res Rev"},{"issue":"1","key":"7445_CR49","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41418-022-01046-4","volume":"30","author":"F Yao","year":"2023","unstructured":"Yao F, Peng J, Zhang E, Ji D, Gao Z, Tang Y, Yao X, Xia X (2023) Pathologically high intraocular pressure disturbs normal iron homeostasis and leads to retinal ganglion cell ferroptosis in glaucoma. Cell Death Differ 30(1):69\u201381 eng. Epub 2022\/08\/07. https:\/\/doi.org\/10.1038\/s41418-022-01046-4","journal-title":"Cell Death Differ"},{"issue":"4","key":"7445_CR50","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1016\/j.ymthe.2025.12.057","volume":"34","author":"M Yang","year":"2026","unstructured":"Yang M, Bian F, Feng X, Li L, Huang H, Liu L, Dalal R, Yang H, Jiang H, Lin Y, Suraparaju PV, Cao F, Ong P, Luo A, Liu D, Hu Y (2026) GPX4 promotes optic nerve regeneration and retinal ganglion cell neuroprotection. Mol Ther 34(4):1938\u20131944 eng. Epub 2026\/01\/04. https:\/\/doi.org\/10.1016\/j.ymthe.2025.12.057","journal-title":"Mol Ther"},{"key":"7445_CR51","doi-asserted-by":"publisher","unstructured":"Guo M, Zhu Y, Shi Y, Meng X, Dong X, Zhang H, Wang X, Du M, Yan H (2022) Inhibition of ferroptosis promotes retina ganglion cell survival in experimental optic neuropathies. Redox Biol 58:102541. https:\/\/doi.org\/10.1016\/j.redox.2022.102541. eng. Epub 2022\/11\/23","DOI":"10.1016\/j.redox.2022.102541"},{"key":"7445_CR52","doi-asserted-by":"publisher","first-page":"10175","DOI":"10.2147\/dddt.S556831","volume":"19","author":"F Latib","year":"2025","unstructured":"Latib F, Zafendi MAI, Mohd Lazaldin MA (2025) Therapeutic Potential of Tocopherol and Tocotrienol in Glaucoma Management. Drug Des Devel Ther 19:10175\u201310194 eng. Epub 2025\/11\/26. https:\/\/doi.org\/10.2147\/dddt.S556831","journal-title":"Drug Des Devel Ther"},{"key":"7445_CR53","doi-asserted-by":"publisher","unstructured":"Matamoros JA, Rubio-Casado S, Fernandez-Albarral JA, Martinez-Lopez MA, Salobrar-Garcia E, Marco EM, Paleo-Garcia V, de Hoz R, Lopez-Cuenca I, Elvira-Hurtado L, Sanchez-Puebla L, Ramirez JM, Salazar JJ, Lopez-Gallardo M, Ramirez AI (2024) Neuroprotective effect of the combination of citicoline and CoQ10 in a mouse model of ocular hypertension. Antioxid (Basel) 14(1). https:\/\/doi.org\/10.3390\/antiox14010004. eng. Epub 2025\/01\/25","DOI":"10.3390\/antiox14010004"},{"issue":"26","key":"7445_CR54","doi-asserted-by":"publisher","first-page":"9672","DOI":"10.1080\/10408398.2023.2215865","volume":"64","author":"Y Semenova","year":"2024","unstructured":"Semenova Y, Bjorklund G (2024) Antioxidants and neurodegenerative eye disease. Crit Rev Food Sci Nutr 64(26):9672\u20139690 eng. Epub 2023\/06\/14. https:\/\/doi.org\/10.1080\/10408398.2023.2215865","journal-title":"Crit Rev Food Sci Nutr"},{"key":"7445_CR55","doi-asserted-by":"publisher","unstructured":"Nakano-Kobayashi A, Canela A, Yoshihara T, Hagiwara M (2023) Astrocyte-targeting therapy rescues cognitive impairment caused by neuroinflammation via the Nrf2 pathway. Proc Natl Acad Sci U S A 120(33):e2303809120. https:\/\/doi.org\/10.1073\/pnas.2303809120. eng. Epub 2023\/08\/07","DOI":"10.1073\/pnas.2303809120"},{"key":"7445_CR56","doi-asserted-by":"publisher","unstructured":"Campos J, Gleitze S, Hidalgo C, Nunez MT (2024) IP(3)R-Mediated calcium release promotes ferroptotic death in SH-SY5Y neuroblastoma cells. Antioxid (Basel) 13(2). https:\/\/doi.org\/10.3390\/antiox13020196. eng. Epub 2024\/02\/24","DOI":"10.3390\/antiox13020196"},{"issue":"6","key":"7445_CR57","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1681\/asn.0000001011","volume":"37","author":"FC Chang","year":"2026","unstructured":"Chang FC, Enya T, Souma T (2026) Ferroptosis and Its Survivors in Kidney Injury and Repair. J Am Soc Nephrol 37(6):1304\u20131318 eng. Epub 2026\/01\/22. https:\/\/doi.org\/10.1681\/asn.0000001011","journal-title":"J Am Soc Nephrol"},{"key":"7445_CR58","doi-asserted-by":"publisher","first-page":"1555518","DOI":"10.3389\/fimmu.2025.1555518","volume":"16","author":"M Ding","year":"2025","unstructured":"Ding M, Huo K, Chen X, Wang W, Xiang Z, Song Y, Chen P, Liu L (2025) The role of non-coding RNA in ferroptosis of liver cancer and its impact on lipid peroxidation. Front Immunol 16:1555518. https:\/\/doi.org\/10.3389\/fimmu.2025.1555518. eng. Epub 2025\/04\/10. Cited in: Pubmed; PMID 40207231","journal-title":"Front Immunol"},{"key":"7445_CR59","doi-asserted-by":"publisher","unstructured":"Rossino MG, Amato R, Amadio M, Rosini M, Basagni F, Cammalleri M, Dal Monte M, Casini G (2021) A NATURE-INspired Nrf2 activator protects retinal explants from oxidative stress and neurodegeneration. Antioxid (Basel) 10(8). https:\/\/doi.org\/10.3390\/antiox10081296. eng. Epub 2021\/08\/28","DOI":"10.3390\/antiox10081296"},{"key":"7445_CR60","doi-asserted-by":"publisher","unstructured":"Wang J, Liang Y, Qi W, Li W, He D, Ding L, Wu L, Wu M, Sun Y, Zeng Y, Liu X, Huang Y, Liu J, Zhang X (2026) Biomimetic beta-lapachone and hemin nanoassembly for intracellular oxidation cascade amplified ferroptosis in hepatocellular carcinoma therapy. J Nanobiotechnol 24(1). https:\/\/doi.org\/10.1186\/s12951-026-04486-z. eng. Epub 2026\/04\/29","DOI":"10.1186\/s12951-026-04486-z"},{"key":"7445_CR61","doi-asserted-by":"publisher","unstructured":"Xu J, Chen C, Yuan HY, Zhang YY, Wang CR, Xi X, Pan H, Li DH, Lu Y (2026) Reappraising heme oxygenase-1 as a ferroptosis modulator in atherosclerosis: a mechanism-focused review. Front Immunol 17:1737751. https:\/\/doi.org\/10.3389\/fimmu.2026.1737751. eng. Epub 2026\/02\/20","DOI":"10.3389\/fimmu.2026.1737751"},{"key":"7445_CR62","doi-asserted-by":"publisher","unstructured":"Naguib S, DeJulius CR, Backstrom JR, Haider AA, Ang JM, Boal AM, Calkins DJ, Duvall CL, Rex TS (2023) Intraocular sustained release of EPO-R76E mitigates glaucoma pathogenesis by activating the NRF2\/ARE pathway. Antioxid (Basel) 12(3). https:\/\/doi.org\/10.3390\/antiox12030556. eng. Epub 2023\/03\/30","DOI":"10.3390\/antiox12030556"},{"key":"7445_CR63","doi-asserted-by":"publisher","unstructured":"Schnell MR, Zhai T, Ragwan ER, Jung H, Zhang J, Lagalante AF, Kung Y, Kraut DA, Huang Z, Eggler AL (2025) KEAP1 C151 active site catalysis drives electrophilic signaling to upregulate cytoprotective enzyme expression. Redox Biol 88:103906. https:\/\/doi.org\/10.1016\/j.redox.2025.103906. eng. Epub 2025\/11\/05","DOI":"10.1016\/j.redox.2025.103906"},{"key":"7445_CR64","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.bbi.2025.06.037","volume":"129","author":"AK Singh","year":"2025","unstructured":"Singh AK, Ruiz D, Pandey VK, Ur Rasheed MS, Turner DJL, Avery TD, Abell AD, Grace PM (2025) Targeted activation of Nrf2 at sites of oxidative stress reverses doxorubicin-induced cognitive impairments in mice. Brain Behav Immun 129:547\u2013556 eng. Epub 2025\/07\/02. https:\/\/doi.org\/10.1016\/j.bbi.2025.06.037","journal-title":"Brain Behav Immun"},{"key":"7445_CR65","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.semcancer.2021.06.003","volume":"76","author":"J Sivinski","year":"2021","unstructured":"Sivinski J, Zhang DD, Chapman E (2021) Targeting NRF2 to treat cancer. Semin Cancer Biol 76:61\u201373 eng. Epub 2021\/06\/09. https:\/\/doi.org\/10.1016\/j.semcancer.2021.06.003","journal-title":"Semin Cancer Biol"},{"issue":"7","key":"7445_CR66","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1007\/s13346-024-01739-y","volume":"15","author":"S Signorini","year":"2025","unstructured":"Signorini S, Pescina S, Ricci C, Del Favero E, Vivero-Lopez M, Alvarez-Lorenzo C, Santi P, Padula C, Nicoli S (2025) Innovative formulations for the ocular delivery of coenzyme Q10. Drug Deliv Transl Res 15(7):2415\u20132430. https:\/\/doi.org\/10.1007\/s13346-024-01739-y. eng. Epub 2024\/12\/08. Cited in: Pubmed; PMID 39645537","journal-title":"Drug Deliv Transl Res"},{"key":"7445_CR67","doi-asserted-by":"publisher","unstructured":"Hurley DJ, Irnaten M, O\u2019Brien C (2021) Metformin and glaucoma-review of anti-fibrotic processes and bioenergetics. Cells 10(8). https:\/\/doi.org\/10.3390\/cells10082131. eng. Epub 2021\/08\/28","DOI":"10.3390\/cells10082131"},{"key":"7445_CR68","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.bioactmat.2022.10.019","volume":"23","author":"J Sun","year":"2023","unstructured":"Sun J, Yang F, Wang L, Yu H, Yang Z, Wei J, Vasilev K, Zhang X, Liu X, Zhao Y (2023) Delivery of coenzyme Q10 loaded micelle targets mitochondrial ROS and enhances efficiency of mesenchymal stem cell therapy in intervertebral disc degeneration. Bioact Mater 23:247\u2013260 eng. Epub 2022\/11\/29. https:\/\/doi.org\/10.1016\/j.bioactmat.2022.10.019","journal-title":"Bioact Mater"},{"key":"7445_CR69","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-026-02098-6","author":"M Juhascik","year":"2026","unstructured":"Juhascik M, Fiala F, Cozikova D, Vagnerova H, Kulhanek J, Kocurkova A, Simek M, Stranska A, Kubala L, Ondreas F (2026) Oleyl-hyaluronate nanoparticles for enhanced peroral bioavailability of encapsulated Coenzyme Q10. Drug Deliv Transl Res. Apr 7. eng. Epub 2026\/04\/08 https:\/\/doi.org\/10.1007\/s13346-026-02098-6","journal-title":"Drug Deliv Transl Res"},{"issue":"29","key":"7445_CR70","doi-asserted-by":"publisher","first-page":"11180","DOI":"10.1021\/acs.jafc.3c02322","volume":"71","author":"X Luo","year":"2023","unstructured":"Luo X, Ao S, Wu H, McClements DJ, Fang L, Huang M, Zhou Y, Yin X, Xi M, Cai T, Zhu K (2023) Hyaluronic Acid Poly(glyceryl)(10)-Stearate Derivatives: Novel Emulsifiers for Improving the Gastrointestinal Stability and Bioaccessibility of Coenzyme Q10 Nanoemulsions. J Agric Food Chem 71(29):11180\u201311194 eng. Epub 2023\/07\/12. https:\/\/doi.org\/10.1021\/acs.jafc.3c02322","journal-title":"J Agric Food Chem"},{"key":"7445_CR71","doi-asserted-by":"publisher","unstructured":"Mantle D, Heaton RA, Hargreaves IP (2021) Coenzyme Q10, ageing and the nervous system: An overview. Antioxid (Basel) 11(1). https:\/\/doi.org\/10.3390\/antiox11010002. eng. Epub 2022\/01\/22","DOI":"10.3390\/antiox11010002"},{"issue":"8","key":"7445_CR72","doi-asserted-by":"publisher","first-page":"3470","DOI":"10.1093\/brain\/awac453","volume":"146","author":"A Jacquier","year":"2023","unstructured":"Jacquier A, Theuriet J, Fontaine F, Mosbach V, Lacoste N, Ribault S, Risson V, Carras J, Coudert L, Simonet T, Latour P, Stojkovic T, Piard J, Cosson A, Lesca G, Bouhour F, Allouche S, Puccio H, Pegat A, Schaeffer L (2023) Homozygous COQ7 mutation: a new cause of potentially treatable distal hereditary motor neuropathy. Brain 146(8):3470\u20133483 eng. Epub 2022\/12\/02. https:\/\/doi.org\/10.1093\/brain\/awac453","journal-title":"Brain"},{"key":"7445_CR73","doi-asserted-by":"publisher","first-page":"495","DOI":"10.2147\/IJN.S30725","volume":"8","author":"M Honda","year":"2013","unstructured":"Honda M, Asai T, Oku N, Araki Y, Tanaka M, Ebihara N (2013) Liposomes and nanotechnology in drug development: focus on ocular targets. Int J Nanomed 8:495\u2013503 Epub 2013\/02\/27. https:\/\/doi.org\/10.2147\/IJN.S30725","journal-title":"Int J Nanomed"},{"key":"7445_CR74","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.brainres.2008.06.026","volume":"1226","author":"Y Nakajima","year":"2008","unstructured":"Nakajima Y, Inokuchi Y, Nishi M, Shimazawa M, Otsubo K, Hara H (2008) Coenzyme Q10 protects retinal cells against oxidative stress in vitro and in vivo. Brain Res 1226:226\u2013233. https:\/\/doi.org\/10.1016\/j.brainres.2008.06.026. Epub 2008\/07\/05. Cited in: Pubmed; PMID 18598676","journal-title":"Brain Res"},{"issue":"4","key":"7445_CR75","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1177\/1120672119833271","volume":"30","author":"S Ekicier Acar","year":"2020","unstructured":"Ekicier Acar S, Saricaoglu MS, Colak A, Aktas Z, Sepici Dincel A (2020) Neuroprotective effects of topical coenzyme Q10\u2009+\u2009vitamin E in mechanic optic nerve injury model. Eur J Ophthalmol 30(4):714\u2013722 Epub 2019\/03\/12. https:\/\/doi.org\/10.1177\/1120672119833271","journal-title":"Eur J Ophthalmol"},{"key":"7445_CR76","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.freeradbiomed.2021.10.027","volume":"177","author":"M Tanito","year":"2021","unstructured":"Tanito M (2021) Reported evidence of vitamin E protection against cataract and glaucoma. Free Radic Biol Med 177:100\u2013119 Epub 2021\/10\/26. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2021.10.027","journal-title":"Free Radic Biol Med"},{"key":"7445_CR77","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2022.109236","author":"RS Kapuganti","year":"2022","unstructured":"Kapuganti RS, Mohanty PP, Alone DP (2022) Quantitative analysis of circulating levels of vimentin, clusterin and fibulin-5 in patients with pseudoexfoliation syndrome and glaucoma. Exp Eye Res. 224:109236. Epub 2022\/09\/03 https:\/\/doi.org\/10.1016\/j.exer.2022.109236","journal-title":"Exp Eye Res"},{"issue":"4","key":"7445_CR78","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1159\/000455152","volume":"57","author":"CY Wang","year":"2017","unstructured":"Wang CY, Liang CY, Feng SC, Lin KH, Lee HN, Shen YC, Wei LC, Chang CJ, Hsu MY, Yang YY, Chiu CH, Wang CY (2017) Analysis of the Interleukin-6 (-174) Locus Polymorphism and Serum IL-6 Levels with the Severity of Normal Tension Glaucoma. Ophthalmic Res 57(4):224\u2013229 Epub 2017\/02\/09. https:\/\/doi.org\/10.1159\/000455152","journal-title":"Ophthalmic Res"},{"key":"7445_CR79","doi-asserted-by":"publisher","unstructured":"Wu T, Ji Q, Liao Y, Zhao X, Hong Y (2025) Aqueous humor cytokines levels and illuminated microcatheter-assisted circumferential trabeculotomy outcome in open-angle glaucoma patients: a 24-month prospective study. Front Immunol 16:1575909. https:\/\/doi.org\/10.3389\/fimmu.2025.1575909. eng. Epub 2025\/06\/04","DOI":"10.3389\/fimmu.2025.1575909"},{"issue":"9","key":"7445_CR80","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1016\/j.immuni.2022.07.014","volume":"55","author":"MA Margeta","year":"2022","unstructured":"Margeta MA, Yin Z, Madore C, Pitts KM, Letcher SM, Tang J, Jiang S, Gauthier CD, Silveira SR, Schroeder CM, Lad EM, Proia AD, Tanzi RE, Holtzman DM, Krasemann S, Chen DF, Butovsky O (2022) Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma. Immunity 55(9):1627\u20131644 e7. eng. Epub 2022\/08\/18. https:\/\/doi.org\/10.1016\/j.immuni.2022.07.014","journal-title":"Immunity"},{"issue":"4","key":"7445_CR81","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.14336\/ad.2023.0312-1","volume":"14","author":"M Abyadeh","year":"2023","unstructured":"Abyadeh M, Gupta V, Paulo JA, Sheriff S, Shadfar S, Fitzhenry M, Amirkhani A, Gupta V, Salekdeh GH, Haynes PA, Graham SL, Mirzaei M (2023) Apolipoprotein epsilon in Brain and Retinal Neurodegenerative Diseases. Aging Dis 14(4):1311\u20131330 eng. Epub 2023\/05\/18. https:\/\/doi.org\/10.14336\/ad.2023.0312-1","journal-title":"Aging Dis"},{"key":"7445_CR82","doi-asserted-by":"publisher","unstructured":"Lin B, Li D (2025) The pivotal role of inflammatory factors in glaucoma: a systematic review. Front Immunol 16:1577200. https:\/\/doi.org\/10.3389\/fimmu.2025.1577200. eng. Epub 2025\/06\/09","DOI":"10.3389\/fimmu.2025.1577200"},{"key":"7445_CR83","doi-asserted-by":"publisher","unstructured":"Wang J, Sun Y, Liu X, Kang Y, Cao W, Ye J, Gao C (2024) An antibacterial and anti-oxidant hydrogel containing hyperbranched poly-l-lysine and tea polyphenols accelerates healing of infected wound. Biomater Adv 157:213755. https:\/\/doi.org\/10.1016\/j.bioadv.2023.213755. eng. Epub 2024\/01\/04","DOI":"10.1016\/j.bioadv.2023.213755"},{"issue":"5","key":"7445_CR84","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.14336\/ad.2024.0128","volume":"15","author":"RVS Rajala","year":"2024","unstructured":"Rajala RVS, Rajala A (2024) From Insight to Eyesight: Unveiling the Secrets of the Insulin-Like Growth Factor Axis in Retinal Health. Aging Dis 15(5):1994\u20132002 eng. Epub 2024\/02\/01. https:\/\/doi.org\/10.14336\/ad.2024.0128","journal-title":"Aging Dis"},{"key":"7445_CR85","doi-asserted-by":"publisher","unstructured":"Amankwa CE, Gondi SR, Dibas A, Weston C, Funk A, Nguyen T, Nguyen KT, Ellis DZ, Acharya S (2021) Novel thiol containing hybrid antioxidant-nitric oxide donor small molecules for treatment of glaucoma. Antioxid (Basel) 10(4). https:\/\/doi.org\/10.3390\/antiox10040575. eng. Epub 2021\/05\/01","DOI":"10.3390\/antiox10040575"},{"key":"7445_CR86","doi-asserted-by":"publisher","unstructured":"Wei G, Zhang W, Li Y, Wang D, Chai Y, Wang Y, Xu Z, Hu S, Shi J, Zhao X, Huang A (2025) Novel exopolysaccharide from Limosilactobacillus fermentum A10: Biosynthesis, physicochemical properties and antioxidant activity. Int J Biol Macromol 312:144051. https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.144051. eng. Epub 2025\/05\/11","DOI":"10.1016\/j.ijbiomac.2025.144051"},{"key":"7445_CR87","doi-asserted-by":"publisher","unstructured":"Yang M, Bian F, Feng X, Li L, Huang H, Liu L, Dalal R, Yang H, Jiang H, Lin Y, Suraparaju PV, Cao F, Ong P, Luo A, Liu D, Hu Y (2026) GPX4 promotes optic nerve regeneration and retinal ganglion cell neuroprotection. Mol Ther. https:\/\/doi.org\/10.1016\/j.ymthe.2025.12.057. eng. Epub 2026\/01\/04.","DOI":"10.1016\/j.ymthe.2025.12.057"},{"key":"7445_CR88","doi-asserted-by":"publisher","unstructured":"Ren Y, Liang H, Xie M, Zhang M (2024) Natural plant medications for the treatment of retinal diseases: The blood-retinal barrier as a clue. Phytomedicine 130:155568. https:\/\/doi.org\/10.1016\/j.phymed.2024.155568. eng. Epub 2024\/05\/26","DOI":"10.1016\/j.phymed.2024.155568"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-026-07445-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-026-07445-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-026-07445-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T16:03:23Z","timestamp":1793894603000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-026-07445-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,8]]},"references-count":88,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["7445"],"URL":"https:\/\/doi.org\/10.1007\/s00417-026-07445-4","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,8]]},"assertion":[{"value":"20 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"N\/A.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors agree to publish their findings in this journal.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}