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Therefore, this study aimed to evaluate the 10-years long-term efficacy and safety of the XEN63 implant (63\u00b5m inner diameter, Aquesys Inc.\/AbbVie Plc).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, monocentric longitudinal study included 28 eyes of 26 patients with open angle glaucoma. Implantation of the XEN63 implant was performed at a tertiary study center either as solo procedure or combined with cataract surgery. Notably, neither Mitomycin C nor primary needling was used. Annual examinations of intraocular pressure (IOP), number of IOP-lowering-medications, best-corrected visual acuity (BCVA), visual field mean deviation (VF-MD), complications, surgical success and secondary procedures were analyzed over the first 10 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The preoperative mean IOP of 23.3\u00b14.3mmHg and mean number of IOP-lowering-medications of 3.1\u00b11.1 significantly reduced to 12.8\u00b12.7mmHg and 1.1\u00b11.2, respectively, at 10 years (n=8, p&lt;0.001). 50% (14\/28) of all eyes dropped out due to secondary IOP-lowering surgery or explantation until 10 years follow-up. Overall surgical success was achieved in 42% after 8 years and 36% after 10 years, apparently at the expense of 88% (7\/8) eyes that required an average of 3.7\u00b12.4 needlings. VF-MD remained stable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>XEN63 implantation significantly reduced IOP (-45%) and the number of IOP-lowering-medications (-65%) at the 10 years follow-up. However, limitations must be taken into account here with regard to a potentially attrition effect. A comparison of the results of our early learning curve study population with those reported in the literature on conventional trabeculectomy suggests lower surgical success rates; however, this was accompanied by a comparable need for medications but higher needling rates, while at the same time fewer complications occurred.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00417-026-07446-3","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T04:03:44Z","timestamp":1786161824000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The efficacy and safety of the XEN63 glaucoma gel stent without Mitomycin C over the first 10 years"],"prefix":"10.1007","author":[{"given":"Anna","family":"Bermayer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melchior","family":"Hohensinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veit","family":"Steiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kistermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Hitzl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Trost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne M.","family":"Brunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Preishuber-Pfl\u00fcgl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Koller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Weissensteiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert A.","family":"Reitsamer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5299-7330","authenticated-orcid":false,"given":"Markus","family":"Lenzhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,8]]},"reference":[{"key":"7446_CR1","doi-asserted-by":"publisher","first-page":"e1221","DOI":"10.1016\/S2214-109X(17)30393-5","volume":"5","author":"SR Flaxman","year":"2017","unstructured":"Flaxman SR, Bourne RRA, Resnikoff S, Ackland P, Braithwaite T, Cicinelli MV, Das A, Jonas JB, Keeffe J, Kempen JH, Leasher J, Limburg H, Naidoo K, Pesudovs K, Silvester A, Stevens GA, Tahhan N, Wong TY, Taylor HR, Study VLEGotGBoD (2017) Global causes of blindness and distance vision impairment 1990\u20132020: a systematic review and meta-analysis. 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