{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:20:31Z","timestamp":1787595631520,"version":"build-2736575974"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"DOI":"10.1007\/s00417-026-07471-2","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T04:33:15Z","timestamp":1787545995000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Progression in familial exudative vitreoretinopathy: Long-term clinical course and baseline predictors"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1312-438X","authenticated-orcid":false,"given":"Ahmet Burak","family":"Acar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sengul","family":"Ozdek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Baran","family":"Ozdemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcls\u00fcm","family":"Kayhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Ali","family":"Ergun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Tuba","family":"Atalay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulya Yaylacioglu","family":"Tuncay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6khan","family":"G\u00fcrelik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"issue":"4","key":"7471_CR1","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/0002-9394(69)91237-9","volume":"68","author":"VG Criswick","year":"1969","unstructured":"Criswick VG, Schepens CL (1969) Familial exudative vitreoretinopathy. Am J Ophthalmol 68(4):578\u2013594","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"7471_CR2","first-page":"275","volume":"15","author":"RL Bergen","year":"1983","unstructured":"Bergen RL, Glassman R (1983) Familial exudative vitreoretinopathy. Ann Ophthalmol 15(3):275\u2013276","journal-title":"Ann Ophthalmol"},{"issue":"4","key":"7471_CR3","first-page":"323","volume":"51","author":"D Shukla","year":"2003","unstructured":"Shukla D, Singh J, Sudheer G et al (2003) Familial exudative vitreoretinopathy (FEVR). Clinical profile and management. Indian J Ophthalmol 51(4):323\u2013328","journal-title":"Indian J Ophthalmol"},{"key":"7471_CR4","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/978-3-031-14506-3_25","volume-title":"Pediatric Vitreoretinal Surgery","author":"K Agarwal","year":"2023","unstructured":"Agarwal K, Jalali S (2023) Familial exudative vitreo-retinopathy. In: Ozdek S, Berrocal A, Spandau U (eds) Pediatric Vitreoretinal Surgery. Springer, Cham, Switzerland, pp 343\u2013365. https:\/\/doi.org\/10.1007\/978-3-031-14506-3_25"},{"issue":"3","key":"7471_CR5","first-page":"176","volume":"7","author":"Z Tauqeer","year":"2018","unstructured":"Tauqeer Z, Yonekawa Y (2018) Familial exudative vitreoretinopathy: pathophysiology, diagnosis, and management. Asia Pac J Ophthalmol (Phila) 7(3):176\u2013182","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"issue":"11","key":"7471_CR6","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1016\/j.ophtha.2014.05.029","volume":"121","author":"AH Kashani","year":"2014","unstructured":"Kashani AH, Brown KT, Chang E et al (2014) Diversity of retinal vascular anomalies in patients with familial exudative vitreoretinopathy. Ophthalmology 121(11):2220\u20132227","journal-title":"Ophthalmology"},{"issue":"21","key":"7471_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/cells12212579","volume":"12","author":"V Le","year":"2023","unstructured":"Le V, Abdelmessih G, Dailey WA et al (2023) Mechanisms underlying rare inherited pediatric retinal vascular diseases: FEVR, Norrie disease, persistent fetal vascular syndrome. Cells 12(21):2579","journal-title":"Cells"},{"issue":"3","key":"7471_CR8","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1167\/iovs.14-16065","volume":"56","author":"J Salvo","year":"2015","unstructured":"Salvo J, Lyubasyuk V, Xu M et al (2015) Next-generation sequencing and novel variant determination in a cohort of 92 familial exudative vitreoretinopathy patients. Invest Ophthalmol Vis Sci 56(3):1937\u20131946","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"7471_CR9","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.tjo.2015.04.002","volume":"5","author":"H Kondo","year":"2015","unstructured":"Kondo H (2015) Complex genetics of familial exudative vitreoretinopathy and related pediatric retinal detachments. Taiwan J Ophthalmol 5(2):56\u201362","journal-title":"Taiwan J Ophthalmol"},{"issue":"Suppl","key":"7471_CR10","first-page":"120","volume":"20","author":"B Kaderli","year":"2012","unstructured":"Kaderli B (2012) Familial exudative vitreoretinopathy. Ret-Vit 20(Suppl):120\u2013124","journal-title":"Ret-Vit"},{"issue":"24","key":"7471_CR11","doi-asserted-by":"publisher","first-page":"9856","DOI":"10.1073\/pnas.1220864110","volume":"110","author":"RW Collin","year":"2013","unstructured":"Collin RW, Nikopoulos K, Dona M et al (2013) ZNF408 is mutated in familial exudative vitreoretinopathy and is crucial for the development of zebrafish retinal vasculature. Proc Natl Acad Sci U S A 110(24):9856\u20139861","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"7471_CR12","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1001\/jamaophthalmol.2014.2814","volume":"132","author":"JM Robitaille","year":"2014","unstructured":"Robitaille JM, Gillett RM, LeBlanc MA et al (2014) Phenotypic overlap between familial exudative vitreoretinopathy and microcephaly, lymphedema, and chorioretinal dysplasia caused by KIF11 mutations. JAMA Ophthalmol 132(12):1393\u20131399","journal-title":"JAMA Ophthalmol"},{"issue":"4","key":"7471_CR13","doi-asserted-by":"publisher","first-page":"468","DOI":"10.3109\/13816810.2015.1120318","volume":"37","author":"MW Dixon","year":"2016","unstructured":"Dixon MW, Stem MS, Schuette JL, Keegan CE, Besirli CG (2016) CTNNB1 mutation associated with familial exudative vitreoretinopathy (FEVR) phenotype. Ophthalmic Genet 37(4):468\u2013470","journal-title":"Ophthalmic Genet"},{"issue":"13","key":"7471_CR14","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1167\/iovs.61.13.2","volume":"61","author":"MF Shurygina","year":"2020","unstructured":"Shurygina MF, Simonett JM, Parker MA et al (2020) Genotype phenotype correlation and variability in microcephaly associated with chorioretinopathy or familial exudative vitreoretinopathy. Invest Ophthalmol Vis Sci 61(13):2","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"7471_CR15","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s10384-017-0547-4","volume":"62","author":"M Takahashi","year":"2018","unstructured":"Takahashi M, Yokoi T, Katagiri S, Yoshida-Uemura T, Nishina S, Azuma N (2018) Surgical treatments for fibrous tissue extending to the posterior retina in eyes with familial exudative vitreoretinopathy. Jpn J Ophthalmol 62(1):63\u201367","journal-title":"Jpn J Ophthalmol"},{"issue":"5","key":"7471_CR16","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/gim.2015.30","volume":"17","author":"S Richards","year":"2015","unstructured":"Richards S, Aziz N, Bale S, Bick D, Das S, Gastier-Foster J et al (2015) Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med 17(5):405\u2013424","journal-title":"Genet Med"},{"issue":"3","key":"7471_CR17","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1167\/iovs.05-0981","volume":"47","author":"K Schulze-Bonsel","year":"2006","unstructured":"Schulze-Bonsel K, Feltgen N, Burau H, Hansen L, Bach M (2006) Visual acuities hand motion and counting fingers can be quantified with the Freiburg visual acuity test. Invest Ophthalmol Vis Sci 47(3):1236\u20131240","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"7471_CR18","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1001\/archopht.1976.03910030189003","volume":"94","author":"RF Zipf","year":"1976","unstructured":"Zipf RF (1976) Binocular fixation pattern. Arch Ophthalmol 94(3):401\u2013405","journal-title":"Arch Ophthalmol"},{"issue":"6","key":"7471_CR19","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/S0161-6420(98)96002-X","volume":"105","author":"SD Pendergast","year":"1998","unstructured":"Pendergast SD, Trese MT (1998) Familial exudative vitreoretinopathy: results of surgical management. Ophthalmology 105(6):1015\u20131023","journal-title":"Ophthalmology"},{"key":"7471_CR20","first-page":"473","volume":"93","author":"WE Benson","year":"1995","unstructured":"Benson WE (1995) Familial exudative vitreoretinopathy. Trans Am Ophthalmol Soc 93:473\u2013521","journal-title":"Trans Am Ophthalmol Soc"},{"key":"7471_CR21","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.ajo.2020.07.013","volume":"223","author":"GB Hubbard","year":"2021","unstructured":"Hubbard GB, Li AL (2021) Analysis of predisposing clinical features for worsening traction after treatment of familial exudative vitreoretinopathy in children. Am J Ophthalmol 223:430\u2013445","journal-title":"Am J Ophthalmol"},{"issue":"9","key":"7471_CR22","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1097\/IAE.0000000000003122","volume":"41","author":"J Lyu","year":"2021","unstructured":"Lyu J, Zhang Q, Xu Y, Zhang X, Fei P, Zhao P (2021) Intravitreal ranibizumab treatment for advanced familial exudative vitreoretinopathy with high vascular activity. Retina 41(9):1976\u20131985","journal-title":"Retina"},{"issue":"11","key":"7471_CR23","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1001\/archopht.122.11.1717","volume":"122","author":"R Margolis","year":"2004","unstructured":"Margolis R, Couvillion SS, Mavrofrides EC, Hess D, Murray TG (2004) Progression of familial exudative vitreoretinopathy after laser treatment. Arch Ophthalmol 122(11):1717\u20131719","journal-title":"Arch Ophthalmol"},{"issue":"12","key":"7471_CR24","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1016\/S0161-6420(84)34119-7","volume":"91","author":"H Miyakubo","year":"1984","unstructured":"Miyakubo H, Hashimoto K, Miyakubo S (1984) Retinal vascular pattern in familial exudative vitreoretinopathy. Ophthalmology 91(12):1524\u20131530","journal-title":"Ophthalmology"},{"issue":"1","key":"7471_CR25","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1186\/s12886-022-02522-8","volume":"22","author":"C Chen","year":"2022","unstructured":"Chen C, Cheng Y, Zhang Z et al (2022) Long-term clinical prognosis of 335 infant single-gene positive FEVR cases. BMC Ophthalmol 22(1):329","journal-title":"BMC Ophthalmol"},{"issue":"1","key":"7471_CR26","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1136\/bjophthalmol-2019-315598","volume":"105","author":"S Wang","year":"2021","unstructured":"Wang S, Zhang X, Hu Y et al (2021) Clinical and genetical features of probands and affected family members with familial exudative vitreoretinopathy in a large Chinese cohort. Br J Ophthalmol 105(1):83\u201386","journal-title":"Br J Ophthalmol"},{"issue":"5","key":"7471_CR27","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1097\/IAE.0000000000004372","volume":"45","author":"H Chen","year":"2025","unstructured":"Chen H, Caldwell AS, Patnaik JL et al (2025) Long-term functional and clinical outcomes in familial exudative vitreoretinopathy. Retina 45(5):908\u2013914","journal-title":"Retina"},{"issue":"8","key":"7471_CR28","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1242\/dev.01732","volume":"132","author":"H West","year":"2005","unstructured":"West H, Richardson WD, Fruttiger M (2005) Stabilization of the retinal vascular network by reciprocal feedback between blood vessels and astrocytes. Development 132(8):1855\u20131862","journal-title":"Development"},{"issue":"2","key":"7471_CR29","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1172\/JCI25964","volume":"116","author":"A Uemura","year":"2006","unstructured":"Uemura A, Kusuhara S, Wiegand SJ, Yu RT, Nishikawa SI (2006) Tlx acts as a proangiogenic switch by regulating extracellular assembly of fibronectin matrices in retinal astrocytes. J Clin Invest 116(2):369\u2013377","journal-title":"J Clin Invest"},{"issue":"1","key":"7471_CR30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084736","volume":"9","author":"LJ Duan","year":"2014","unstructured":"Duan LJ, Takeda K, Fong GH (2014) Hypoxia inducible factor-2\u03b1 regulates the development of retinal astrocytic network by maintaining adequate supply of astrocyte progenitors. PLoS One 9(1):e84736","journal-title":"PLoS One"},{"key":"7471_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.11.001","volume":"63","author":"S Selvam","year":"2018","unstructured":"Selvam S, Kumar T, Fruttiger M (2018) Retinal vasculature development in health and disease. Prog Retin Eye Res 63:1\u201319","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"7471_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/eye.2014.70","volume":"29","author":"DF Gilmour","year":"2015","unstructured":"Gilmour DF (2015) Familial exudative vitreoretinopathy and related retinopathies. Eye (Lond) 29(1):1\u201314","journal-title":"Eye (Lond)"},{"key":"7471_CR33","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.exer.2014.10.021","volume":"133","author":"PN Bishop","year":"2015","unstructured":"Bishop PN (2015) The role of extracellular matrix in retinal vascular development and preretinal neovascularization. Exp Eye Res 133:30\u201336","journal-title":"Exp Eye Res"},{"issue":"7070","key":"7471_CR34","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1038\/nature04482","volume":"438","author":"RF Gariano","year":"2005","unstructured":"Gariano RF, Gardner TW (2005) Retinal angiogenesis in development and disease. Nature 438(7070):960\u2013966","journal-title":"Nature"},{"issue":"7 Suppl","key":"7471_CR35","doi-asserted-by":"publisher","first-page":"S38","DOI":"10.1097\/01.iae.0000244287.63757.5a","volume":"26","author":"MM Joshi","year":"2006","unstructured":"Joshi MM, Ciaccia S, Trese MT, Capone A Jr. (2006) Posterior hyaloid contracture in pediatric vitreoretinopathies. Retina 26(7 Suppl):S38\u2013S41","journal-title":"Retina"},{"issue":"11","key":"7471_CR36","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1016\/j.ophtha.2015.07.024","volume":"122","author":"Y Yonekawa","year":"2015","unstructured":"Yonekawa Y, Thomas BJ, Drenser KA, Trese MT, Capone A Jr (2015) Familial Exudative Vitreoretinopathy: Spectral-Domain Optical Coherence Tomography of the Vitreoretinal Interface, Retina, and Choroid. Ophthalmology 122(11):2270\u20132277","journal-title":"Ophthalmology"},{"issue":"1","key":"7471_CR37","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1097\/IAE.0000000000001930","volume":"39","author":"J Lee","year":"2019","unstructured":"Lee J, El-Dairi MA, Tran-Viet D et al (2019) Longitudinal changes in the optic nerve head and retina over time in very young children with familial exudative vitreoretinopathy. Retina 39(1):98\u2013110","journal-title":"Retina"},{"issue":"8","key":"7471_CR38","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1007\/s00417-020-04712-w","volume":"258","author":"S El-Khoury","year":"2020","unstructured":"El-Khoury S, Clement A, Chehaibou I et al (2020) Outcome and risk factors of vitreoretinal surgery in pediatric patients with familial exudative vitreoretinopathy. Graefes Arch Clin Exp Ophthalmol 258(8):1617\u20131623","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"8","key":"7471_CR39","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1007\/BF00947005","volume":"235","author":"A Shubert","year":"1997","unstructured":"Shubert A, Tasman W (1997) Familial exudative vitreoretinopathy: surgical intervention and visual acuity outcomes. Graefes Arch Clin Exp Ophthalmol 235(8):490\u2013493","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"3","key":"7471_CR40","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.jcjo.2019.11.001","volume":"55","author":"P Sen","year":"2020","unstructured":"Sen P, Singh N, Rishi E et al (2020) Outcomes of surgery in eyes with familial exudative vitreoretinopathy-associated retinal detachment. Can J Ophthalmol 55(3):253\u2013262","journal-title":"Can J Ophthalmol"},{"issue":"6","key":"7471_CR41","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1097\/IAE.0000000000002490","volume":"40","author":"J Zhang","year":"2020","unstructured":"Zhang J, Jiang C, Ruan L, Yang Q, Chang Q, Huang X (2020) Macular capillary dropout in familial exudative vitreoretinopathy and its relationship with visual acuity and disease progression. Retina 40(6):1140\u20131147","journal-title":"Retina"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-026-07471-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-026-07471-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-026-07471-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:21:34Z","timestamp":1787592094000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-026-07471-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,24]]},"references-count":41,"alternative-id":["7471"],"URL":"https:\/\/doi.org\/10.1007\/s00417-026-07471-2","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,24]]},"assertion":[{"value":"4 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}