{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:35:04Z","timestamp":1793018104412,"version":"4.5.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsmedizin der Johannes Gutenberg-Universit\u00e4t Mainz","id":[{"id":"https:\/\/ror.org\/00q1fsf04","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To define preoperative thresholds of intraocular pressure (IOP) and the number of IOP-lowering eye drops that may predict surgical success following Kahook Dual Blade goniotomy combined with phacoemulsification (Phaco-KDB) in patients with glaucoma and cataract.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study analysed 307 eyes of 307 patients undergoing Phaco-KDB. Data on demographics, glaucoma type, IOP, number of IOP-lowering medications and complications were collected over 18 months of follow-up. Complete success was defined as IOP\u2009\u2264\u200921, 18, 15 or 12 mmHg without medications; qualified success allowed for ongoing topical IOP-lowering therapy. Logistic regression models were used to determine predictive thresholds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean baseline IOP was 18.6\u2009\u00b1\u20095.2 mmHg and decreased to 15.0\u2009\u00b1\u20094.4 mmHg at 18 months. The mean number of IOP-lowering medications was reduced from 2.2\u2009\u00b1\u20091.1 to 1.7\u2009\u00b1\u20091.4. For qualified success, the identified preoperative IOP thresholds were 27.2 mmHg for achieving\u2009\u2264\u200921 mmHg (AUC\u2009=\u20090.900,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), 25.1 mmHg for \u2264\u200918 mmHg (AUC\u2009=\u20090.8604,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), 19.8 mmHg for \u2264\u200915 mmHg (AUC\u2009=\u20090.7752,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and 13.5 mmHg for \u2264\u200912 mmHg (AUC\u2009=\u20090.7772,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0011). For complete success, the threshold IOP values were 20.6 mmHg for \u2264\u200921 mmHg (AUC\u2009=\u20090.7893,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), 18.1 mmHg for \u2264\u200918 mmHg (AUC\u2009=\u20090.7365,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and 15.0 mmHg for \u2264\u200915 mmHg (AUC\u2009=\u20090.5890,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0109). No significant association was found between the number of preoperative medications and surgical outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preoperative IOP is a significant predictor of Phaco-KDB success. Our findings suggest that Phaco-KDB primarily stabilizes IOP at preoperative levels while reducing the need for IOP-lowering therapy, rather than achieving substantial additional IOP reduction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00417-026-07485-w","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:14:49Z","timestamp":1792725289000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictive baseline thresholds for successful dual blade goniotomy combined with phacoemulsification in glaucoma patients"],"prefix":"10.1007","author":[{"given":"Julia","family":"Prinz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna K.","family":"Freyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Plange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Fuest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kuerten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Mercieca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Prokosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"issue":"1","key":"7485_CR1","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S1350-9462(98)00014-7","volume":"18","author":"HA Quigley","year":"1999","unstructured":"Quigley HA (1999) Neuronal death in glaucoma. 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She was not involved in the peer review or decision-making process for this manuscript. The authors declare that they have no other competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the University of Cologne, RWTH Aachen University and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","label":"Human ethics and consent to participate\u00a0declarations","group":{"name":"EthicsHeading","label":"Declarations"}}]}}