{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:52:00Z","timestamp":1791528720957,"version":"4.3.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"DOI":"10.1007\/s00417-026-07534-4","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:45:08Z","timestamp":1791528308000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Macular sub-ILM hemorrhage as a favorable prognostic factor in ruptured retinal arterial macroaneurysm"],"prefix":"10.1007","author":[{"given":"Yukako","family":"Oka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4346-4054","authenticated-orcid":false,"given":"Masaharu","family":"Ishikura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotaro","family":"Ooto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Ogino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"7534_CR1","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/aos.12210","volume":"92","author":"L Pitk\u00e4nen","year":"2014","unstructured":"Pitk\u00e4nen L, Tommila P, Kaarniranta K, J\u00e4\u00e4skel\u00e4inen JE, Kinnunen K (2014) Retinal arterial macroaneurysms. Acta Ophthalmol 92:101\u2013104. https:\/\/doi.org\/10.1111\/aos.12210","journal-title":"Acta Ophthalmol"},{"key":"7534_CR2","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/0039-6257(88)90160-9","volume":"33","author":"MF Rabb","year":"1988","unstructured":"Rabb MF, Gagliano DA, Teske MP (1988) Retinal arterial macroaneurysms. Surv Ophthalmol 33:73\u201396. https:\/\/doi.org\/10.1016\/0039-6257(88)90160-9","journal-title":"Surv Ophthalmol"},{"key":"7534_CR3","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1136\/bjo.2006.107342","volume":"91","author":"L Xu","year":"2007","unstructured":"Xu L, Wang Y, Jonas JB (2007) Frequency of retinal macroaneurysms in adult Chinese: the Beijing Eye Study. Br J Ophthalmol 91:840\u2013841. https:\/\/doi.org\/10.1136\/bjo.2006.107342","journal-title":"Br J Ophthalmol"},{"key":"7534_CR4","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1136\/bjo.71.11.817","volume":"71","author":"MJ Lavin","year":"1987","unstructured":"Lavin MJ, Marsh RJ, Peart S, Rehman A (1987) Retinal arterial macroaneurysms: a retrospective study of 40 patients. Br J Ophthalmol 71:817\u2013825. https:\/\/doi.org\/10.1136\/bjo.71.11.817","journal-title":"Br J Ophthalmol"},{"key":"7534_CR5","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s40135-019-00202-3","volume":"7","author":"BE Goldhagen","year":"2019","unstructured":"Goldhagen BE, Goldhardt R (2019) Retinal arterial macroaneurysms: updating your memory on RAM management. Curr Ophthalmol Rep 7:73\u201379. https:\/\/doi.org\/10.1007\/s40135-019-00202-3","journal-title":"Curr Ophthalmol Rep"},{"key":"7534_CR6","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1136\/bjophthalmol-2014-305884","volume":"99","author":"S Koinzer","year":"2015","unstructured":"Koinzer S, Heckmann J, Tode J, Roider J (2015) Long-term, therapy-related visual outcome of 49 cases with retinal arterial macroaneurysm: a case series and literature review. Br J Ophthalmol 99:1345\u20131353. https:\/\/doi.org\/10.1136\/bjophthalmol-2014-305884","journal-title":"Br J Ophthalmol"},{"key":"7534_CR7","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1097\/IAE.0000000000002131","volume":"39","author":"AM Mansour","year":"2019","unstructured":"Mansour AM, Foster RE, Gallego-Pinazo R, Moschos MM, Sisk RA, Chhablani J, Rojanaporn D, Sujirakul T, Arevalo JF, Lima LH, Wu L, Charbaji A, Saatci AO, Mansour HA, Martinez-Rubio C, Patel Y, Gangakhedkar S (2019) Intravitreal anti-vascular endothelial growth factor injections for exudative retinal arterial macroaneurysms. Retina 39:1133\u20131141. https:\/\/doi.org\/10.1097\/IAE.0000000000002131","journal-title":"Retina"},{"key":"7534_CR8","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.ajo.2012.12.003","volume":"155","author":"HJ Cho","year":"2013","unstructured":"Cho HJ, Rhee TK, Kim HS, Han JI, Lee DW, Cho SW, Kim JW (2013) Intravitreal bevacizumab for symptomatic retinal arterial macroaneurysm. Am J Ophthalmol 155:898\u2013904. https:\/\/doi.org\/10.1016\/j.ajo.2012.12.003","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"7534_CR9","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1177\/24741264231200734","volume":"7","author":"DH Lam","year":"2023","unstructured":"Lam DH, Carr-Brendel V, Ye D, Iyer SSR, Hou H, Lim JI (2023) Clinical outcomes of retinal arterial macroaneurysms with vitreous hemorrhage treated with observation, antivascular endothelial growth factor intravitreal injections, or pars plana vitrectomy. J Vitreoretin Dis 7(6):483\u2013489. https:\/\/doi.org\/10.1177\/24741264231200734","journal-title":"J Vitreoretin Dis"},{"key":"7534_CR10","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0002-9394(14)75575-8","volume":"109","author":"SR Bennett","year":"1990","unstructured":"Bennett SR, Folk JC, Blodi CF, Klugman M (1990) Factors prognostic of visual outcome in patients with subretinal hemorrhage. Am J Ophthalmol 109:33\u201337. https:\/\/doi.org\/10.1016\/S0002-9394(14)75575-8","journal-title":"Am J Ophthalmol"},{"key":"7534_CR11","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/S0002-9394(00)00734-0","volume":"131","author":"CL Haupert","year":"2001","unstructured":"Haupert CL, McCuen BW 2nd, Jaffe GJ, Steuer ER, Cox TA, Toth CA, Fekrat S, Postel EA (2001) Pars plana vitrectomy, subretinal injection of tissue plasminogen activator, and fluid-gas exchange for displacement of thick submacular hemorrhage in age-related macular degeneration. Am J Ophthalmol 131:208\u2013215. https:\/\/doi.org\/10.1016\/S0002-9394(00)00734-0","journal-title":"Am J Ophthalmol"},{"key":"7534_CR12","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1001\/archopht.116.10.1326","volume":"116","author":"M Ohji","year":"1998","unstructured":"Ohji M, Saito Y, Hayashi A, Lewis JM, Tano Y (1998) Pneumatic displacement of subretinal hemorrhage without tissue plasminogen activator. Arch Ophthalmol 116:1326\u20131332. https:\/\/doi.org\/10.1001\/archopht.116.10.1326","journal-title":"Arch Ophthalmol"},{"key":"7534_CR13","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1016\/S0161-6420(99)90399-8","volume":"106","author":"AS Hassan","year":"1999","unstructured":"Hassan AS, Johnson MW, Schneiderman TE, Regillo CD, Tornambe PE, Poliner LS, Blodi BA, Elner SG (1999) Management of submacular hemorrhage with intravitreous tissue plasminogen activator injection and pneumatic displacement. Ophthalmology 106:1900\u20131906. https:\/\/doi.org\/10.1016\/S0161-6420(99)90399-8","journal-title":"Ophthalmology"},{"key":"7534_CR14","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1007\/s00417-014-2861-6","volume":"253","author":"M Inoue","year":"2015","unstructured":"Inoue M, Shiraga F, Shirakata Y, Morizane Y, Kimura S, Hirakata A (2015) Subretinal injection of recombinant tissue plasminogen activator for submacular hemorrhage associated with ruptured retinal arterial macroaneurysm. Graefes Arch Clin Exp Ophthalmol 253:1663\u20131669. https:\/\/doi.org\/10.1007\/s00417-014-2861-6","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"7534_CR15","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.3390\/ijms27031336","volume":"27","author":"K Eder","year":"2026","unstructured":"Eder K, Langosz P, Danikiewicz-Zaga\u0142a M, Leszczy\u0144ski R, Wygl\u0119dowska-Promie\u0144ska D (2026) Sub-internal limiting membrane hemorrhage: molecular microenvironment and review of treatment modalities. Int J Mol Sci 27:1336. https:\/\/doi.org\/10.3390\/ijms27031336","journal-title":"Int J Mol Sci"},{"key":"7534_CR16","doi-asserted-by":"publisher","first-page":"3291","DOI":"10.3390\/jcm12093291","volume":"12","author":"A Kimura","year":"2023","unstructured":"Kimura A, Imai H, Iwane Y, Kishimoto M, Sotani Y, Yamada H, Matsumiya W, Miki A, Kusuhara S, Nakamura M (2023) Removal of sub-internal limiting membrane hemorrhage secondary to retinal arterial macroaneurysm rupture: internal limiting membrane non-peeling technique. J Clin Med 12:3291. https:\/\/doi.org\/10.3390\/jcm12093291","journal-title":"J Clin Med"},{"key":"7534_CR17","doi-asserted-by":"publisher","first-page":"16321","DOI":"10.1038\/s41598-022-20949-3","volume":"12","author":"R Hayamizu","year":"2022","unstructured":"Hayamizu R, Totsuka K, Azuma K, Sugimoto K, Toyama T, Araki F, Shiraya T, Ueta T (2022) Optical coherence tomography findings after surgery for sub-internal limiting membrane hemorrhage due to ruptured retinal arterial macroaneurysm. Sci Rep 12:16321. https:\/\/doi.org\/10.1038\/s41598-022-20949-3","journal-title":"Sci Rep"},{"key":"7534_CR18","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1167\/iovs.05-0981","volume":"47","author":"K Schulze-Bonsel","year":"2006","unstructured":"Schulze-Bonsel K, Feltgen N, Burau H, Hansen L, Bach M (2006) Visual acuities hand motion and counting fingers can be quantified with the Freiburg Visual Acuity Test. Invest Ophthalmol Vis Sci 47:1236\u20131240. https:\/\/doi.org\/10.1167\/iovs.05-0981","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"7534_CR19","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/0002-9394(82)90301-4","volume":"94","author":"H Glatt","year":"1982","unstructured":"Glatt H, Machemer R (1982) Experimental subretinal hemorrhage in rabbits. Am J Ophthalmol 94:762\u2013773. https:\/\/doi.org\/10.1016\/0002-9394(82)90301-4","journal-title":"Am J Ophthalmol"},{"key":"7534_CR20","doi-asserted-by":"publisher","first-page":"4071","DOI":"10.1167\/iovs.08-1892","volume":"49","author":"RB Bhisitkul","year":"2008","unstructured":"Bhisitkul RB, Winn BJ, Lee OT, Wong J, Pereira DS, Porco TC, He X, Hahn P, Dunaief JL (2008) Neuroprotective effect of intravitreal triamcinolone acetonide against photoreceptor apoptosis in a rabbit model of subretinal hemorrhage. Invest Ophthalmol Vis Sci 49:4071\u20134077. https:\/\/doi.org\/10.1167\/iovs.08-1892","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"7534_CR21","doi-asserted-by":"publisher","first-page":"e53338","DOI":"10.1371\/journal.pone.0053338","volume":"8","author":"S Notomi","year":"2013","unstructured":"Notomi S, Hisatomi T, Murakami Y, Terasaki H, Sonoda S, Asato R, Takeda A, Ikeda Y, Enaida H, Sakamoto T, Ishibashi T (2013) Dynamic increase in extracellular ATP accelerates photoreceptor cell apoptosis via ligation of P2RX7 in subretinal hemorrhage. PLoS ONE 8:e53338. https:\/\/doi.org\/10.1371\/journal.pone.0053338","journal-title":"PLoS ONE"},{"key":"7534_CR22","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/s0021-5155(03)00104-7","volume":"47","author":"T Tonotsuka","year":"2003","unstructured":"Tonotsuka T, Imai M, Saito K, Iijima H (2003) Visual prognosis for symptomatic retinal arterial macroaneurysm. Jpn J Ophthalmol 47:498\u2013502. https:\/\/doi.org\/10.1016\/s0021-5155(03)00104-7","journal-title":"Jpn J Ophthalmol"},{"key":"7534_CR23","doi-asserted-by":"publisher","first-page":"109","DOI":"10.22608\/APO.2017389","volume":"7","author":"P Kunavisarut","year":"2018","unstructured":"Kunavisarut P, Thithuan T, Patikulsila D, Choovuthayakorn J, Watanachai N, Chaikitmongkol V, Pathanapitoon K, Rothova A (2018) Submacular hemorrhage: visual outcomes and prognostic factors. Asia Pac J Ophthalmol (Phila) 7:109\u2013113. https:\/\/doi.org\/10.22608\/APO.2017389","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"key":"7534_CR24","doi-asserted-by":"publisher","first-page":"e0168474","DOI":"10.1371\/journal.pone.0168474","volume":"11","author":"K Bae","year":"2016","unstructured":"Bae K, Cho GE, Yoon JM, Kang SW (2016) Optical coherence tomographic features and prognosis of pneumatic displacement for submacular hemorrhage. PLoS ONE 11:e0168474. https:\/\/doi.org\/10.1371\/journal.pone.0168474","journal-title":"PLoS ONE"},{"key":"7534_CR25","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.2147\/CIA.S147642","volume":"12","author":"D Karagiannis","year":"2017","unstructured":"Karagiannis D, Chatziralli I, Kaprinis K, Georgalas I, Parikakis E, Mitropoulos P (2017) Location of submacular hemorrhage as a predictor of visual outcome after intravitreal ranibizumab for age-related macular degeneration. Clin Interv Aging 12:1829\u20131834. https:\/\/doi.org\/10.2147\/CIA.S147642","journal-title":"Clin Interv Aging"},{"key":"7534_CR26","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1177\/11206721231202048","volume":"34","author":"E Barayev","year":"2024","unstructured":"Barayev E, Tiosano A, Zlatkin R, Elul R, Dotan A, Hadayer A, Gal-Or O, Ehrlich R (2024) Prognostic factors for visual acuity improvement after treatment of submacular hemorrhage secondary to exudative age-related macular degeneration. Eur J Ophthalmol 34:823\u2013829. https:\/\/doi.org\/10.1177\/11206721231202048","journal-title":"Eur J Ophthalmol"},{"key":"7534_CR27","doi-asserted-by":"publisher","first-page":"3160963","DOI":"10.1155\/2021\/3160963","volume":"2021","author":"YA Said","year":"2021","unstructured":"Said YA, Dewilde E, Stalmans P (2021) Visual outcome after vitrectomy with subretinal tPA injection to treat submacular hemorrhage secondary to age-related macular degeneration or macroaneurysm. J Ophthalmol 2021:3160963. https:\/\/doi.org\/10.1155\/2021\/3160963","journal-title":"J Ophthalmol"},{"key":"7534_CR28","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1159\/000502442","volume":"243","author":"RN Hussain","year":"2020","unstructured":"Hussain RN, Stappler T, Hiscott P, Wong D (2020) Histopathological changes and clinical outcomes following intervention for sub-internal limiting membrane haemorrhage. Ophthalmologica 243:217\u2013223. https:\/\/doi.org\/10.1159\/000502442","journal-title":"Ophthalmologica"},{"key":"7534_CR29","doi-asserted-by":"publisher","first-page":"2561","DOI":"10.1167\/iovs.11-8502","volume":"53","author":"PB Henrich","year":"2012","unstructured":"Henrich PB, Monnier CA, Halfter W, Haritoglou C, Strauss RW, Lim RYH, Loparic M (2012) Nanoscale topographic and biomechanical studies of the human internal limiting membrane. Invest Ophthalmol Vis Sci 53:2561\u20132570. https:\/\/doi.org\/10.1167\/iovs.11-8502","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"7534_CR30","doi-asserted-by":"publisher","first-page":"3147","DOI":"10.1039\/C0SM01017K","volume":"7","author":"K Franze","year":"2011","unstructured":"Franze K, Francke M, G\u00fcnter K, Christ AF, K\u00f6rber N, Reichenbach A, Guck J (2011) Spatial mapping of the mechanical properties of the living retina using scanning force microscopy. Soft Matter 7:3147\u20133154. https:\/\/doi.org\/10.1039\/C0SM01017K","journal-title":"Soft Matter"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-026-07534-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-026-07534-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-026-07534-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:45:09Z","timestamp":1791528309000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-026-07534-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,9]]},"references-count":30,"alternative-id":["7534"],"URL":"https:\/\/doi.org\/10.1007\/s00417-026-07534-4","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,9]]},"assertion":[{"value":"9 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}