{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:49:16Z","timestamp":1791517756955,"version":"4.3.4"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"DOI":"10.1007\/s00417-026-07550-4","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:58:09Z","timestamp":1791514689000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Corneal clarity and biomechanical stability after mitomycin C\u2013assisted photorefractive keratectomy in low, moderate, and high myopia"],"prefix":"10.1007","author":[{"given":"Betul Seher","family":"Uysal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve","family":"Oral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcu","family":"Atay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130layda","family":"Aydin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Cuneyt","family":"Ozmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Bilgihan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"issue":"3","key":"7550_CR1","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1136\/bjo-2024-325427","volume":"109","author":"J Liang","year":"2025","unstructured":"Liang J, Pu Y, Chen J, Liu M, Ouyang B, Jin Z et al (2025) Global prevalence, trend and projection of myopia in children and adolescents from 1990 to 2050: a comprehensive systematic review and meta-analysis. Br J Ophthalmol 109(3):362\u2013371","journal-title":"Br J Ophthalmol"},{"issue":"5","key":"7550_CR2","doi-asserted-by":"publisher","first-page":"e344","DOI":"10.3928\/1081597X-20240322-01","volume":"40","author":"Z Qu","year":"2024","unstructured":"Qu Z, Li X, Yuan Y, Wang P, Li Y, Lin S et al (2024) In Vivo Corneal Biomechanical Response to Three Different Laser Corneal Refractive Surgeries. J Refract Surg 40(5):e344\u2013e52","journal-title":"J Refract Surg"},{"issue":"7","key":"7550_CR3","doi-asserted-by":"publisher","first-page":"454","DOI":"10.3928\/1081597X-20130617-03","volume":"29","author":"DZ Reinstein","year":"2013","unstructured":"Reinstein DZ, Archer TJ, Randleman JB (2013) Mathematical model to compare the relative tensile strength of the cornea after PRK, LASIK, and small incision lenticule extraction. J Refract Surg 29(7):454\u2013460","journal-title":"J Refract Surg"},{"issue":"1","key":"7550_CR4","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S0161-6420(94)31371-6","volume":"101","author":"T Seiler","year":"1994","unstructured":"Seiler T, Holschbach A, Derse M, Jean B, Genth U (1994) Complications of myopic photorefractive keratectomy with the excimer laser. Ophthalmology 101(1):153\u2013160","journal-title":"Ophthalmology"},{"key":"7550_CR5","doi-asserted-by":"publisher","first-page":"4775","DOI":"10.2147\/OPTH.S346992","volume":"15","author":"N Tananuvat","year":"2021","unstructured":"Tananuvat N, Winaikosol P, Niparugs M, Chaidaroon W, Tangmonkongvoragul C, Ausayakhun S (2021) Twelve-Month Outcomes of the Wavefront-Optimized Photorefractive Keratectomy for High Myopic Correction Compared with Low-to-Moderate Myopia. Clin Ophthalmol 15:4775\u20134785","journal-title":"Clin Ophthalmol"},{"issue":"1","key":"7550_CR6","doi-asserted-by":"publisher","first-page":"25327","DOI":"10.1038\/s41598-025-10445-9","volume":"15","author":"Z Shi","year":"2025","unstructured":"Shi Z, Gao M, Liu C, Zhang S, Zhao Q (2025) TransPRK in the treatment of low to moderate and high myopia: a comparative study of the clinical outcomes. Sci Rep 15(1):25327","journal-title":"Sci Rep"},{"issue":"1","key":"7550_CR7","doi-asserted-by":"publisher","first-page":"48","DOI":"10.4103\/IJO.IJO_519_25","volume":"74","author":"SR Kumar","year":"2026","unstructured":"Kumar SR, Dhabarde K, Joshi RS (2026) The outcome of photorefractive keratectomy in low, moderate, and high myopia: A prospective observational study in a tertiary care center of Central India. Indian J Ophthalmol 74(1):48\u201352","journal-title":"Indian J Ophthalmol"},{"key":"7550_CR8","doi-asserted-by":"crossref","unstructured":"Fantes FE, Hanna KD, Waring GO 3rd, Pouliquen Y, Thompson KP, Savoldelli M (1990) Wound healing after excimer laser keratomileusis (photorefractive keratectomy) in monkeys. Arch Ophthalmol 108(5):665\u2013675","DOI":"10.1001\/archopht.1990.01070070051034"},{"issue":"12","key":"7550_CR9","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1038\/eye.2017.107","volume":"31","author":"F Poyales","year":"2017","unstructured":"Poyales F, Garz\u00f3n N, Mendicute J, Illarramendi I, Caro P, J\u00e1\u00f1ez O et al (2017) Corneal densitometry after photorefractive keratectomy, laser-assisted in situ keratomileusis, and small-incision lenticule extraction. Eye (Lond) 31(12):1647\u20131654","journal-title":"Eye (Lond)"},{"issue":"2","key":"7550_CR10","doi-asserted-by":"publisher","first-page":"82","DOI":"10.4103\/tjo.tjo_92_17","volume":"7","author":"YL Liu","year":"2017","unstructured":"Liu YL, Tseng CC, Lin CP (2017) Visual performance after excimer laser photorefractive keratectomy for high myopia. Taiwan J Ophthalmol 7(2):82\u201388","journal-title":"Taiwan J Ophthalmol"},{"issue":"9","key":"7550_CR11","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1097\/j.jcrs.0000000000000611","volume":"47","author":"F D\u2019Oria","year":"2021","unstructured":"D\u2019Oria F, Fern\u00e1ndez-Buenaga R, Casanova L, Garc\u00eda-Corral MJ, Vega A, Alio JL (2021) Surface ablation outcomes in high myopia with different epithelium removal techniques. J Cataract Refract Surg 47(9):1175\u20131182","journal-title":"J Cataract Refract Surg"},{"issue":"12","key":"7550_CR12","doi-asserted-by":"publisher","first-page":"3421","DOI":"10.4103\/ijo.IJO_3768_20","volume":"69","author":"Y Ouerdane","year":"2021","unstructured":"Ouerdane Y, Zaazouee MS, Mohamed MEA, Hasan MT, Hamdy M, Ghoneim AM et al (2021) Mitomycin C application after photorefractive keratectomy in high, moderate, or low myopia: Systematic review and meta-analysis. Indian J Ophthalmol 69(12):3421\u20133431","journal-title":"Indian J Ophthalmol"},{"key":"7550_CR13","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.2147\/OPTH.S164110","volume":"12","author":"MD Mifflin","year":"2018","unstructured":"Mifflin MD, Betts BS, Nguyen J, Pouly S (2018) High myopic photorefractive keratectomy outcomes with the Alcon Wavelight(\u00ae) EX500 excimer laser. Clin Ophthalmol 12:1041\u20131048","journal-title":"Clin Ophthalmol"},{"issue":"1","key":"7550_CR14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.51329\/mehdiophthal1465","volume":"12","author":"S Ramin","year":"2023","unstructured":"Ramin S, Moallemi Rad L, Abbasi A, Rafatifard A, Rahimi Y, Ghorbani S et al (2023) Myopic regression after photorefractive keratectomy: a retrospective cohort study. Med Hypothesis Discov Innov Ophthalmol 12(1):9\u201317","journal-title":"Med Hypothesis Discov Innov Ophthalmol"},{"issue":"3","key":"7550_CR15","doi-asserted-by":"publisher","first-page":"318","DOI":"10.3928\/1081-597X-19980501-16","volume":"14","author":"CS Matta","year":"1998","unstructured":"Matta CS, Piebenga LW, Deitz MR, Tauber J, Garner LP (1998) Five and three year follow-up of photorefractive keratectomy for myopia of -1 to -6 diopters. J Refract Surg 14(3):318\u2013324","journal-title":"J Refract Surg"},{"key":"7550_CR16","doi-asserted-by":"crossref","unstructured":"Hersh PS, Stulting RD, Steinert RF, Waring GO 3rd, Thompson KP, O\u2019Connell M et al (1997) Results of phase III excimer laser photorefractive keratectomy for myopia. The Summit PRK Study Group. Ophthalmology 104(10):1535\u20131553","DOI":"10.1016\/S0161-6420(97)30073-6"},{"issue":"8","key":"7550_CR17","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1016\/j.jcrs.2011.03.037","volume":"37","author":"G Cennamo","year":"2011","unstructured":"Cennamo G, Forte R, Aufiero B, La Rana A (2011) Computerized Scheimpflug densitometry as a measure of corneal optical density after excimer laser refractive surgery in myopic eyes. J Cataract Refract Surg 37(8):1502\u20131506","journal-title":"J Cataract Refract Surg"},{"issue":"2","key":"7550_CR18","doi-asserted-by":"publisher","first-page":"142","DOI":"10.3341\/kjo.2020.0105","volume":"35","author":"HM Gharieb","year":"2021","unstructured":"Gharieb HM, Awad-Allah MAA, Ahmed AA, Othman IS (2021) Transepithelial Laser versus Alcohol Assisted Photorefractive Keratectomy Safety and Efficacy: 1-Year Follow-up of a Contralateral Eye Study. Korean J Ophthalmol 35(2):142\u2013152","journal-title":"Korean J Ophthalmol"},{"issue":"1","key":"7550_CR19","doi-asserted-by":"publisher","first-page":"8","DOI":"10.4103\/1319-4534.301295","volume":"34","author":"A Khattak","year":"2020","unstructured":"Khattak A, An-Nakhli F (2020) Incidence and quantification of corneal haze by Pentacam Scheimpflug densitometry following photorefractive keratectomy for myopia in virgin and post corneal transplant eyes with dark irides. Saudi J Ophthalmol 34(1):8\u201312","journal-title":"Saudi J Ophthalmol"},{"issue":"1","key":"7550_CR20","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s12938-019-0636-3","volume":"18","author":"M J\u0119dzierowska","year":"2019","unstructured":"J\u0119dzierowska M, Koprowski R (2019) Novel dynamic corneal response parameters in a practice use: a critical review. Biomed Eng Online 18(1):17","journal-title":"Biomed Eng Online"},{"issue":"7","key":"7550_CR21","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1097\/ICO.0000000000002888","volume":"41","author":"S Zarei-Ghanavati","year":"2022","unstructured":"Zarei-Ghanavati S, Jafarpour S, Hassanzadeh S, Bakhtiari E, Daraee G, Monadi SD et al (2022) Changes in Corneal Biomechanical Properties After Small-Incision Lenticule Extraction and Photorefractive Keratectomy, Using a Noncontact Tonometer. Cornea 41(7):886\u2013893","journal-title":"Cornea"},{"issue":"1","key":"7550_CR22","doi-asserted-by":"publisher","first-page":"128","DOI":"10.4103\/IJO.IJO_1250_24","volume":"73","author":"S Joshi","year":"2025","unstructured":"Joshi S, Bari A, Shakkarwal C, Agarwal T, Dada T, Sinha R et al (2025) The visual outcomes and corneal biomechanical properties after PRK and SMILE in low to moderate myopia. Indian J Ophthalmol 73(1):128\u2013133","journal-title":"Indian J Ophthalmol"},{"issue":"4","key":"7550_CR23","doi-asserted-by":"publisher","first-page":"310","DOI":"10.4103\/tmj.tmj_24_24","volume":"52","author":"HG Shady","year":"2024","unstructured":"Shady HG, Elseht RM, Hasby HA, Abdel-Halim TI (2024) Evaluation of corneal biomechanical changes in moderate myopia after different techniques of corneal refractive surgeries. Tanta Med J 52(4):310\u2013317","journal-title":"Tanta Med J"},{"issue":"10","key":"7550_CR24","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1097\/j.jcrs.0000000000000629","volume":"47","author":"R Vinciguerra","year":"2021","unstructured":"Vinciguerra R, Ambr\u00f3sio R Jr., Elsheikh A, Hafezi F, Yong Kang DS, Kermani O et al (2021) Detection of postlaser vision correction ectasia with a new combined biomechanical index. J Cataract Refract Surg 47(10):1314\u20131318","journal-title":"J Cataract Refract Surg"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-026-07550-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-026-07550-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-026-07550-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:58:11Z","timestamp":1791514691000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-026-07550-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,9]]},"references-count":24,"alternative-id":["7550"],"URL":"https:\/\/doi.org\/10.1007\/s00417-026-07550-4","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,9]]},"assertion":[{"value":"2 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee (Gazi University Ethical Committee) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from all participants included in the study.","order":2,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":3,"name":"Ethics","label":"Financial Disclosures","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"not applicable.","order":4,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no competing interests to declare that are relevant to the content of this article.","order":6,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}