{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:45:02Z","timestamp":1788295502521,"version":"build-2803163510"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Histochem Cell Biol"],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1007\/s00418-005-0785-2","type":"journal-article","created":{"date-parts":[[2005,6,14]],"date-time":"2005-06-14T14:01:17Z","timestamp":1118757677000},"page":"585-593","source":"Crossref","is-referenced-by-count":37,"title":["Immunohistochemical distribution of activated nuclear factor \u03baB and peroxisome proliferator-activated receptors in carbon tetrachloride-induced chronic liver injury in rats"],"prefix":"10.1007","volume":"123","author":[{"given":"Claudine","family":"Orfila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Lepert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Alric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Carrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryse","family":"B\u00e9raud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Pipy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"785_CR1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/hep.510230329","volume":"23","author":"L Alric","year":"1996","unstructured":"Alric L, Pinelli E, Carrera G, Vinel J, Beraud M, Duffaut M, Pascal JP, Pipy B (1996) Involvement of calcium in macrophage leukotriene release during experimental cirrhosis. Hepatology 23:614\u2013622","journal-title":"Hepatology"},{"key":"785_CR2","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1007\/s000110050649","volume":"49","author":"L Alric","year":"2000","unstructured":"Alric L, Orfila C, Carrere N, Beraud M, Carrera G, Lepert JC, Duffaut M, Pipy B, Vinel JP (2000) Reactive oxygen intermediates and eicosanoid production by Kupffer cells and infiltrated macrophages in acute and chronic liver injury induced in rats by CCl4. Inflamm Res 49:700\u2013707","journal-title":"Inflamm Res"},{"key":"785_CR3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF00570285","volume":"88","author":"S Angermuller","year":"1988","unstructured":"Angermuller S, Fahimi HD (1988) Heterogenous staining of d-amino acid oxidase in peroxisomes of rat liver and kidney. A light and electron microscopic study. Histochemistry 88:277\u2013285","journal-title":"Histochemistry"},{"key":"785_CR4","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/hep.1840140523","volume":"14","author":"J Armendariz-Borunda","year":"1991","unstructured":"Armendariz-Borunda J, Seyer JM, Postlethwaite AE, Kang AH (1991) Kupffer cells from carbon tetrachloride-injured rat livers produce chemotactic factors for fibroblasts and monocytes: the role of tumor necrosis factor-\u03b1. Hepatology 14:895\u2013900","journal-title":"Hepatology"},{"key":"785_CR5","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.2337\/diab.46.8.1319","volume":"46","author":"D Auboeuf","year":"1997","unstructured":"Auboeuf D, Rieusset J, Fajas L, Vallier P, Frering V, Riou JP, Staels B, Auwerx J, Laville M, Vidal H (1997) Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-\u03b1 in humans. Diabetes 46:1319\u20131327","journal-title":"Diabetes"},{"key":"785_CR6","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/BF00210629","volume":"74","author":"J Auwerx","year":"1996","unstructured":"Auwerx J, Martin G, Guerre-Milo M, Staels B (1996) Transcription adipocyte differentiation and obesity. J Molec Med 74:347\u2013352","journal-title":"J Molec Med"},{"key":"785_CR7","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0014-5793(97)00805-3","volume":"412","author":"K Beier","year":"1997","unstructured":"Beier K, Volki A, Fahimi HD (1997) TNF-alpha downregulates the peroxisome proliferator activated receptor-alpha and the mRNAs encoding peroxisomal proteins in rat liver. FEBS Lett 412:385\u2013387","journal-title":"FEBS Lett"},{"key":"785_CR8","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1210\/endo.137.1.8536636","volume":"137","author":"O Braissant","year":"1996","unstructured":"Braissant O, Foufelle F, Scotto C, Dau\u00e7a M, Wahli W (1996) Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-\u03b1, -\u03b2, -\u03b3 in the adult rat. Endocrinology 137:354\u2013366","journal-title":"Endocrinology"},{"key":"785_CR9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/path.1711700115","volume":"170","author":"AW Burr","year":"1993","unstructured":"Burr AW, Carpenter MR, Hines JE, Gullick WJ, Burt AD (1993) Intrahepatic distribution of transforming growth factor-alpha (TGF alpha) during liver regeneration following carbon tetrachloride-induced necrosis. J Pathol 170:95\u2013100","journal-title":"J Pathol"},{"key":"785_CR10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/83348","volume":"7","author":"G Chinetti","year":"2001","unstructured":"Chinetti G, Lestavel S, Bocher V, Remaley AT, Neve B, Torra IP, Teissier E, Minnich A, Jaye M, Duverger N, Bewer HB, Fruchart JC, Clavey V, Staels B (2001) PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat Med 7:53\u201358","journal-title":"Nat Med"},{"key":"785_CR11","first-page":"32861","volume":"276","author":"SW Chung","year":"2000","unstructured":"Chung SW, Kang BY, Kim SH, Kim YM, Cho D, Trinchieri G, Kim TS (2000) Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between PPAR\u03b3 and NF-\u03baB. J Biol Chem 276:32861\u201332867","journal-title":"J Biol Chem"},{"key":"785_CR12","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1006\/mcbr.2000.0176","volume":"2","author":"GF Davies","year":"1999","unstructured":"Davies GF, Khandelwal RL, Roesler WJ (1999) Troglitazone induces expression of PPAR\u03b3 in liver. Mol Cell Biol Res Commun 2:202\u2013208","journal-title":"Mol Cell Biol Res Commun"},{"key":"785_CR13","doi-asserted-by":"crossref","first-page":"32048","DOI":"10.1074\/jbc.274.45.32048","volume":"274","author":"P Delerive","year":"1999","unstructured":"Delerive P, De Bosscher K, Besnard S, Vanden Berghe W, Peters JM, Gonzalez FJ, Fruchart JC, Tedgui A, Haegeman G, Staels B (1999) Peroxisome proliferator-activated receptor \u03b1 negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-\u03baB and AP-1. J Biol Chem 274:32048\u201332054","journal-title":"J Biol Chem"},{"key":"785_CR14","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1006\/taap.1993.1070","volume":"119","author":"AE ElSisi","year":"1993","unstructured":"ElSisi AE, Hall P, Sim WL, Earnest DL, Sipes IG (1993) Characterization of vitamin A potentiation of carbon tetrachloride-induced liver injury. Toxicol Appl Pharmacol 119:280\u2013288","journal-title":"Toxicol Appl Pharmacol"},{"key":"785_CR15","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1034\/j.1600-0676.2000.020003191.x","volume":"20","author":"L Everett","year":"2000","unstructured":"Everett L, Galli A, Crabb D (2000) The role of hepatic peroxisome proliferator-activated receptors (PPARs) in health and disease. Liver 20:191\u2013199","journal-title":"Liver"},{"key":"785_CR16","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.4049\/jimmunol.156.4.1540","volume":"156","author":"S Gossart","year":"1996","unstructured":"Gossart S, Cambon C, Orfila C, Segu\u00e9las MH, Lepert JC, Rami J, Carr\u00e9 P, Pipy B (1996) Reactive oxygen intermediates as regulators of TNF-\u03b1 production in rat lung inflammation induced by silica. J Immunol 156:1540\u20131548","journal-title":"J Immunol"},{"key":"785_CR17","doi-asserted-by":"crossref","first-page":"9856","DOI":"10.1073\/pnas.92.21.9856","volume":"92","author":"E Hu","year":"1995","unstructured":"Hu E, Tontonoz P, Spiegelman BM (1995) Transdifferentiation of myoblasts by the adipocyte transcription factors PPAR gamma and C\/EBP alpha. Proc Natl Acad Sci 92:9856\u20139860","journal-title":"Proc Natl Acad Sci"},{"key":"785_CR18","first-page":"307","volume":"6","author":"Q Huang","year":"1995","unstructured":"Huang Q, Yeldandi AV, Alvares K, Ide H, Reddy JK, Rao MS (1995) Localization of peroxisome proliferator-activated receptor in mouse and rat tissues and demonstration of its nuclear translocation in transfected CV-1 cells. Int J Oncol 6:307\u2013312","journal-title":"Int J Oncol"},{"key":"785_CR19","doi-asserted-by":"crossref","first-page":"G1186","DOI":"10.1152\/ajpgi.1997.272.5.G1186","volume":"272","author":"Y Imuro","year":"1997","unstructured":"Imuro Y, Frankenberg MV, Arteel GE, Bradford BU, Wall CA, Thurman RG (1997) Female rats exhibit greater susceptibility to early alcohol-induced injury than males. Am J Physiol Gastrointest Liver Physiol 272:G1186\u2013G1194","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"785_CR20","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1002\/hep.20170","volume":"39","author":"E Ip","year":"2004","unstructured":"Ip E, Farrell G, Robertson G, Leclercq I (2004) Administration of the potent PPARalpha agonist, WY-14,643, reverses nutritional fibrosis and steatohepatitis in mice. Hepatology 39:1286\u20131296","journal-title":"Hepatology"},{"key":"785_CR21","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/34184","volume":"391","author":"C Jiang","year":"1998","unstructured":"Jiang C, Ting AT, Seed B (1998) PPAR-\u03b3 agonists inhibit production of monocyte inflammatory cytokines. Nature 391:82\u201386","journal-title":"Nature"},{"key":"785_CR22","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/path.1711660406","volume":"166","author":"SJ Johnson","year":"1992","unstructured":"Johnson SJ, Hines JE, Burt AD (1992) Macrophage and perisinusoidal cell kinetics in acute liver injury. J Pathol 166:351\u2013358","journal-title":"J Pathol"},{"key":"785_CR23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1006\/bbrc.2002.6385","volume":"15","author":"K Kon","year":"2002","unstructured":"Kon K, Ikejima K, Hirose M, Yoshikawa M, Enomoto N, Kitamura T, Takei Y, Sato N (2002) Pioglitazone prevents early-phase hepatic fibrogenesis caused by carbon tetrachloride. Biochem Biophys Res Commun 15:55\u201361","journal-title":"Biochem Biophys Res Commun"},{"key":"785_CR24","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1749-6632.1996.tb18619.x","volume":"804","author":"T Lemberger","year":"1996","unstructured":"Lemberger T, Braissant O, Juge-Aubry C, Keller H, Saladin R, Staels B, Auwerx J, Burger AG, Meier CA, Wahli W (1996) PPAR tissue distribution and interactions with other hormone-signaling pathways. Ann N Y Acad Sci 804:231\u2013251","journal-title":"Ann N Y Acad Sci"},{"key":"785_CR25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1083\/jcb.37.1.27","volume":"37","author":"AV Loud","year":"1968","unstructured":"Loud AV (1968) A quantitative stereological description of the ultrastructure of normal rat liver parenchymal cells. J Cell Biol 37:27\u201346","journal-title":"J Cell Biol"},{"key":"785_CR26","first-page":"62","volume":"13","author":"M Malapel","year":"2004","unstructured":"Malapel M, Dharancy S, Roskams T, Auwerx J, Mathurin P, Desreumaux P (2004) Anti-inflammatory effects of peroxysome proliferator-activated receptor gamma in CCl4-induces hepatitis. Mediators Inflamm 13:62","journal-title":"Mediators Inflamm"},{"key":"785_CR27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0002-9440(10)65540-X","volume":"153","author":"N Marx","year":"1998","unstructured":"Marx N, Sukhova G, Murphy C, Libby P, Plutzky J (1998) Macrophages in human atheroma contain PPAR\u03b3. Am J Pathol 153:17\u201323","journal-title":"Am J Pathol"},{"issue":"Suppl 3","key":"785_CR28","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1038\/sj.ijo.0802494","volume":"27","author":"DE Moller","year":"2003","unstructured":"Moller DE, Berger JP (2003) Role of PPARs in the regulation of obesity-related insulin sensitivity and inflammation. Int J Obes Relat Metab Disord 27(Suppl 3):S17\u201321","journal-title":"Int J Obes Relat Metab Disord"},{"key":"785_CR29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0960-0760(94)90089-2","volume":"51","author":"R Mukherjee","year":"1994","unstructured":"Mukherjee R, Jow L, Noonan D, McDonnell D (1994) Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. J Steroid Biochem Mol Biol 51:157\u2013166","journal-title":"J Steroid Biochem Mol Biol"},{"key":"785_CR30","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0006-2952(00)00430-5","volume":"60","author":"BP Neve","year":"2000","unstructured":"Neve BP, Fruchart J, Staels B (2000) Role of the peroxisome proliferator-activated receptors (PPAR) in atheroscleosis. Biochem Pharmacol 60:1245\u20131250","journal-title":"Biochem Pharmacol"},{"key":"785_CR31","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1023\/A:1003485312164","volume":"30","author":"C Orfila","year":"1998","unstructured":"Orfila C, Lepert JC, Gossart S, Frisach MF, Cambon C, Pipy B (1998) Immunocytochemical characterization of lung macrophage surface phenotypes and expression of cytokines in acute experimental silicosis in mice. Histochem J 30:857\u2013867","journal-title":"Histochem J"},{"key":"785_CR32","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1023\/A:1003851821487","volume":"31","author":"C Orfila","year":"1999","unstructured":"Orfila C, Lepert JC, Alric L, Carrera G, Beraud M, Vinel JP, Pipy B (1999) Expression of TNF-alpha and immunohistochemical distribution of hepatic macrophage surface markers in carbon tetrachloride-induced chronic liver injury in rats. Histochem J 31:677\u2013685","journal-title":"Histochem J"},{"key":"785_CR33","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1093\/carcin\/21.4.823","volume":"21","author":"JM Peters","year":"2000","unstructured":"Peters JM, Rusyn I, Rose ML, Gonzalez FJ, Thurman G (2000) Peroxisome proliferator-activated receptor \u03b1 is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis. Carcinogenesis 21:823\u2013826","journal-title":"Carcinogenesis"},{"key":"785_CR34","doi-asserted-by":"crossref","first-page":"32833","DOI":"10.1074\/jbc.273.49.32833","volume":"49","author":"ME Poynter","year":"1998","unstructured":"Poynter ME, Daynes RA (1998) Peroxisome proliferator-activated receptor \u03b1 activation modulates cellular redox status, represses nuclear factor-\u03baB signaling, and reduces inflammatory cytokine production in aging. J Biol Chem 49:32833\u201332841","journal-title":"J Biol Chem"},{"key":"785_CR35","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/S0016-5085(82)80126-1","volume":"83","author":"E Proctor","year":"1982","unstructured":"Proctor E, Chatamra K (1982) High yield micronodular cirrhosis in the rat. Gastroenterology 83:1183\u20131190","journal-title":"Gastroenterology"},{"key":"785_CR36","first-page":"145","volume":"16","author":"MS Rao","year":"2002","unstructured":"Rao MS, Papreddy K, Musunuri S, Okonkwo A (2002) Preventional\/reversal of choline deficiency-induced steatohepatitis by a peroxisome proliferator-activated receptor alpha ligand in rats. In vivo 16:145\u2013152","journal-title":"In vivo"},{"key":"785_CR37","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/34178","volume":"391","author":"M Ricote","year":"1998","unstructured":"Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK (1998) The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 391:79\u201382","journal-title":"Nature"},{"key":"785_CR38","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1089\/15230860050192350","volume":"2","author":"I Rusyn","year":"2000","unstructured":"Rusyn I, Rose ML, Bojes HK, Thurman RG (2000) Novel role of oxidants in the molecular mechanism of action of peroxisome proliferators. Antiox Redox Signal 2:607\u2013621","journal-title":"Antiox Redox Signal"},{"key":"785_CR39","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3109\/10715769209079515","volume":"17","author":"R Schreck","year":"1992","unstructured":"Schreck R, Albermann KAJ, Baeurle PA (1992) Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukariotic cells (a review). Free Radic Res Commun 17:221\u2013237","journal-title":"Free Radic Res Commun"},{"key":"785_CR40","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0083-6729(08)60924-3","volume":"54","author":"HN Sorensen","year":"1998","unstructured":"Sorensen HN, Treuter E, Gustafsson JA (1998) Regulation of peroxisome proliferator-activated receptors. Vitam Horm 54:121\u2013126","journal-title":"Vitam Horm"},{"key":"785_CR41","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1093\/intimm\/9.10.1581","volume":"9","author":"NF Spencer","year":"1997","unstructured":"Spencer NF, Poynter ME, Im SY, Daynes RA (1997) Constitutive activation of NF-kappa B in an animal model of aging. Int Immunol 9:1581\u20131588","journal-title":"Int Immunol"}],"container-title":["Histochemistry and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-005-0785-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00418-005-0785-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-005-0785-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T11:18:06Z","timestamp":1683112686000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00418-005-0785-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["785"],"URL":"https:\/\/doi.org\/10.1007\/s00418-005-0785-2","relation":{},"ISSN":["0948-6143","1432-119X"],"issn-type":[{"value":"0948-6143","type":"print"},{"value":"1432-119X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}