{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T05:36:36Z","timestamp":1770960996046,"version":"3.50.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2006,4,11]],"date-time":"2006-04-11T00:00:00Z","timestamp":1144713600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Histochem Cell Biol"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1007\/s00418-006-0178-1","type":"journal-article","created":{"date-parts":[[2006,4,10]],"date-time":"2006-04-10T10:00:28Z","timestamp":1144663228000},"page":"437-444","source":"Crossref","is-referenced-by-count":53,"title":["Binding of galectin-1 (gal-1) to the Thomsen\u2013Friedenreich (TF) antigen on trophoblast cells and inhibition of proliferation of trophoblast tumor cells in vitro by gal-1 or an anti-TF antibody"],"prefix":"10.1007","volume":"126","author":[{"given":"Udo","family":"Jeschke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Karsten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irmi","family":"Wiest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Schulze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Friese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann","family":"Walzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,4,11]]},"reference":[{"key":"178_CR1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0167-4889(96)00031-6","volume":"1312","author":"L Adams","year":"1996","unstructured":"Adams L, Scott GK, Weinberg CS (1996) Biphasic modulation of cell growth by recombinant human galectin-1. Biochim Biophys Acta 1312:137\u2013144","journal-title":"Biochim Biophys Acta"},{"key":"178_CR2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0092-8674(94)90498-7","volume":"76","author":"SH Barondes","year":"1994a","unstructured":"Barondes SH, Castronovo V, Cooper DN, Cummings RD, Drickamer K, Feizi T, Gitt MA, Hirabayashi J, Hughes C, Kasai K, et al. (1994a) Galectins: a family of animal beta-galactoside-binding lectins. Cell 76:597\u2013598","journal-title":"Cell"},{"key":"178_CR3","doi-asserted-by":"crossref","first-page":"20807","DOI":"10.1016\/S0021-9258(17)31891-4","volume":"269","author":"SH Barondes","year":"1994b","unstructured":"Barondes SH, Cooper DN, Gitt MA, Leffler H (1994b) Galectins. Structure and function of a large family of animal lectins. J Biol Chem 269:20807\u201320810","journal-title":"J Biol Chem"},{"key":"178_CR4","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1002\/1097-0142(19890815)64:4<834::AID-CNCR2820640413>3.0.CO;2-A","volume":"64","author":"N Barr","year":"1989","unstructured":"Barr N, Taylor CR, Young T, Springer GF (1989) Are pancarcinoma T and Tn differentiation antigens? Cancer 64:834\u2013841","journal-title":"Cancer"},{"key":"178_CR46","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/BF00482959","volume":"84","author":"DM Boorsma","year":"1986","unstructured":"Boorsma DM, Van Bommel J, Vanden Heuvel J (1986) Avidin-HRP conjugates in biotin-avidin immunoenzyme cytochemistry. Histochemistry 84:333\u2013337","journal-title":"Histochemistry"},{"key":"178_CR5","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/01.LAB.0000059949.01480.40","volume":"83","author":"F Brule van den","year":"2003","unstructured":"van den Brule F, Califice S, Garnier F, Fernandez PL, Berchuck A, Castronovo V (2003) Galectin-1 accumulation in the ovary carcinoma peritumoral stroma is induced by ovary carcinoma cells and affects both cancer cell proliferation and adhesion to laminin-1 and fibronectin. Lab Invest 83:377\u2013386","journal-title":"Lab Invest"},{"key":"178_CR6","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1023\/B:GLYC.0000014083.48508.6a","volume":"19","author":"F Brule van den","year":"2004","unstructured":"van den Brule F, Califice S, Castronovo V (2004) Expression of galectins in cancer: a critical review. Glycoconj J 19:537\u2013542","journal-title":"Glycoconj J"},{"key":"178_CR7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1159\/000064026","volume":"23","author":"G Butschak","year":"2002","unstructured":"Butschak G, Karsten U (2002) Isolation and characterization of thomsen\u2013friedenreich-specific antibodies from human serum. Tumour Biol 23:113\u2013122","journal-title":"Tumour Biol"},{"key":"178_CR8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF02484401","volume":"106","author":"Y Cao","year":"1996","unstructured":"Cao Y, Stosiek P, Springer GF, Karsten U (1996) Thomsen\u2013Friedenreich-related carbohydrate antigens in normal adult human tissues: a systematic and comparative study. Histochem Cell Biol 106:197\u2013207","journal-title":"Histochem Cell Biol"},{"key":"178_CR9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s004280050083","volume":"431","author":"Y Cao","year":"1997","unstructured":"Cao Y, Schlag PM, Karsten U (1997) Immunodetection of epithelial mucin (MUC1, MUC3) and mucin-associated glycotopes (TF, Tn, and sialosyl-Tn) in benign and malignant lesions of colonic epithelium: apolar localization corresponds to malignant transformation. Virchows Arch 431:159\u2013166","journal-title":"Virchows Arch"},{"key":"178_CR10","first-page":"2584","volume":"60","author":"VV Glinsky","year":"2000","unstructured":"Glinsky VV, Huflejt ME, Glinsky GV, Deutscher SL, Quinn TP (2000) Effects of Thomsen\u2013Friedenreich antigen-specific peptide P-30 on beta-galactoside-mediated homotypic aggregation and adhesion to the endothelium of MDA-MB-435 human breast carcinoma cells. Cancer Res 60:2584\u20132588","journal-title":"Cancer Res"},{"key":"178_CR11","first-page":"4851","volume":"61","author":"VV Glinsky","year":"2001","unstructured":"Glinsky VV, Glinsky GV, Rittenhouse-Olson K, Huflejt ME, Glinskii OV, Deutscher SL, Quinn TP (2001) The role of Thomsen\u2013Friedenreich antigen in adhesion of human breast and prostate cancer cells to the endothelium. Cancer Res 61:4851\u20134857","journal-title":"Cancer Res"},{"key":"178_CR12","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/978-1-4615-0065-0_10","volume":"535","author":"S Goletz","year":"2003","unstructured":"Goletz S, Cao Y, Danielczyk A, Ravn P, Schoeber U, Karsten U (2003) Thomsen\u2013Friedenreich antigen: the \u201chidden\u201d tumor antigen. Adv Exp Med Biol 535:147\u2013162","journal-title":"Adv Exp Med Biol"},{"key":"178_CR13","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0143-4004(94)90008-6","volume":"15","author":"R Grummer","year":"1994","unstructured":"Grummer R, Hohn HP, Mareel MM, Denker HW (1994) Adhesion and invasion of three human choriocarcinoma cell lines into human endometrium in a three-dimensional organ culture system. Placenta 15:411\u2013429","journal-title":"Placenta"},{"key":"178_CR14","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/BF00731447","volume":"13","author":"C Hafer-Macko","year":"1996","unstructured":"Hafer-Macko C, Pang M, Seilhamer JJ, Baum LG (1996) Galectin-1 is expressed by thymic epithelial cells in myasthenia gravis. Glycoconj J 13:591\u2013597","journal-title":"Glycoconj J"},{"key":"178_CR15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1600-0897.1999.tb00471.x","volume":"42","author":"A Hammer","year":"1999","unstructured":"Hammer A, Dohr G (1999) Apoptotic nuclei within the uterine decidua of first trimester pregnancy arise from CD45 positive leukocytes. Am J Reprod Immunol 42:88\u201394","journal-title":"Am J Reprod Immunol"},{"key":"178_CR16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1600-0897.1999.tb00074.x","volume":"41","author":"A Hammer","year":"1999","unstructured":"Hammer A, Blaschitz A, Daxbock C, Walcher W, Dohr G (1999) Fas and Fas-ligand are expressed in the uteroplacental unit of first-trimester pregnancy. Am J Reprod Immunol 41:41\u201351","journal-title":"Am J Reprod Immunol"},{"key":"178_CR17","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/0006-291X(84)91181-1","volume":"122","author":"J Hirabayashi","year":"1984","unstructured":"Hirabayashi J, Kasai K (1984) Human placenta beta-galactoside-binding lectin. Purification and some properties. Biochem Biophys Res Commun 122:938\u2013944","journal-title":"Biochem Biophys Res Commun"},{"key":"178_CR18","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/glycob\/3.4.297","volume":"3","author":"J Hirabayashi","year":"1993","unstructured":"Hirabayashi J, Kasai K (1993) The family of metazoan metal-independent beta-galactoside-binding lectins: structure, function and molecular evolution. Glycobiology 3:297\u2013304","journal-title":"Glycobiology"},{"key":"178_CR19","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0300-9084(01)01289-5","volume":"83","author":"RC Hughes","year":"2001","unstructured":"Hughes RC (2001) Galectins as modulators of cell adhesion. Biochimie 83:667\u2013676","journal-title":"Biochimie"},{"key":"178_CR20","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/oxfordjournals.jbchem.a002959","volume":"130","author":"FJ Irazoqui","year":"2001","unstructured":"Irazoqui FJ, Jansson B, Lopez PH, Nores GA (2001) Correlative fine specificity of several Thomsen\u2013Friedenreich disaccharide-binding proteins with an effect on tumor cell proliferation (Tokyo). J Biochem 130:33\u201337","journal-title":"J Biochem"},{"key":"178_CR21","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1432-1033.1989.tb14850.x","volume":"182","author":"C Jeppesen","year":"1989","unstructured":"Jeppesen C, Nielsen PE (1989) Photofootprinting of drug-binding sites on DNA using diazo- and azido-9-aminoacridine derivatives. Eur J Biochem 182:437\u2013444","journal-title":"Eur J Biochem"},{"key":"178_CR22","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00418-004-0660-6","volume":"121","author":"U Jeschke","year":"2004","unstructured":"Jeschke U, Reimer T, Bergemann C, Wiest I, Schulze S, Friese K, Walzel H (2004) Binding of galectin-1 (gal-1) on trophoblast cells and inhibition of hormone production of trophoblast tumor cells in vitro by gal-1. Histochem Cell Biol 121:501\u2013508","journal-title":"Histochem Cell Biol"},{"key":"178_CR23","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00418-002-0383-5","volume":"117","author":"U Jeschke","year":"2002","unstructured":"Jeschke U, Richter DU, Hammer A, Briese V, Friese K, Karsten U (2002) Expression of the Thomsen\u2013Friedenreich antigen and of its putative carrier protein mucin 1 in the human placenta and in trophoblast cells in vitro. Histochem Cell Biol 117:219\u2013226","journal-title":"Histochem Cell Biol"},{"key":"178_CR24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1089\/hyb.1995.14.37","volume":"14","author":"U Karsten","year":"1995","unstructured":"Karsten U, Butschak G, Cao Y, Goletz S, Hanisch FG (1995) A new monoclonal antibody (A78-G\/A7) to the Thomsen\u2013Friedenreich pan-tumor antigen. Hybridoma 14:37\u201344","journal-title":"Hybridoma"},{"key":"178_CR25","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1074\/jbc.M209590200","volume":"278","author":"SK Khaldoyanidi","year":"2003","unstructured":"Khaldoyanidi SK, Glinsky VV, Sikora L, Glinskii AB, Mossine VV, Quinn TP, Glinsky GV, Sriramarao P (2003) MDA-MB-435 human breast carcinoma cell homo- and heterotypic adhesion under flow conditions is mediated in part by Thomsen\u2013Friedenreich antigen-galectin-3 interactions. J Biol Chem 278:4127\u20134134","journal-title":"J Biol Chem"},{"key":"178_CR26","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/jnci\/90.2.118","volume":"90","author":"JE Lehr","year":"1998","unstructured":"Lehr JE, Pienta KJ (1998) Preferential adhesion of prostate cancer cells to a human bone marrow endothelial cell line. J Natl Cancer Inst 90:118\u2013123","journal-title":"J Natl Cancer Inst"},{"key":"178_CR27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0165-5728(90)90032-I","volume":"28","author":"H Offner","year":"1990","unstructured":"Offner H, Celnik B, Bringman TS, Casentini-Borocz D, Nedwin GE, Vandenbark AA (1990) Recombinant human beta-galactoside binding lectin suppresses clinical and histological signs of experimental autoimmune encephalomyelitis. J Neuroimmunol 28:177\u2013184","journal-title":"J Neuroimmunol"},{"key":"178_CR28","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.4049\/jimmunol.165.5.2331","volume":"165","author":"KE Pace","year":"2000","unstructured":"Pace KE, Hahn HP, Pang M, Nguyen JT, Baum LG (2000) CD7 delivers a pro-apoptotic signal during galectin-1-induced T cell death. J Immunol 165:2331\u20132334","journal-title":"J Immunol"},{"key":"178_CR29","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/378736a0","volume":"378","author":"NL Perillo","year":"1995","unstructured":"Perillo NL, Pace KE, Seilhamer JJ, Baum LG (1995) Apoptosis of T cells mediated by galectin-1. Nature 378:736\u2013739","journal-title":"Nature"},{"key":"178_CR30","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1242\/dev.115.1.143","volume":"115","author":"F Poirier","year":"1992","unstructured":"Poirier F, Timmons PM, Chan CT, Guenet JL, Rigby PW (1992) Expression of the L14 lectin during mouse embryogenesis suggests multiple roles during pre- and post-implantation development. Development 115:143\u2013155","journal-title":"Development"},{"key":"178_CR31","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00262-001-0238-2","volume":"50","author":"GA Rabinovich","year":"2002","unstructured":"Rabinovich GA, Rubinstein N, Matar P, Rozados V, Gervasoni S, Scharovsky GO (2002) The antimetastatic effect of a single low dose of cyclophosphamide involves modulation of galectin-1 and Bcl-2 expression. Cancer Immunol Immunother 50:597\u2013603","journal-title":"Cancer Immunol Immunother"},{"key":"178_CR32","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/BF00144274","volume":"6","author":"A Raz","year":"1987","unstructured":"Raz A, Lotan R (1987) Endogenous galactoside-binding lectins: a new class of functional tumor cell surface molecules related to metastasis. Cancer Metastasis Rev 6:433\u2013452","journal-title":"Cancer Metastasis Rev"},{"key":"178_CR33","first-page":"5129","volume":"20","author":"DU Richter","year":"2000","unstructured":"Richter DU, Jeschke U, Makovitzky J, Goletz S, Karsten U, Briese V, Friese K (2000) Expression of the Thomsen\u2013Friedenreich (TF) antigen in the human placenta. Anticancer Res 20:5129\u20135133","journal-title":"Anticancer Res"},{"key":"178_CR34","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1093\/glycob\/8.11.1053","volume":"8","author":"JJ Rooijen van","year":"1998","unstructured":"van Rooijen JJ, Jeschke U, Kamerling JP, Vliegenthart JF (1998) Expression of N-linked sialyl Le(x) determinants and O-glycans in the carbohydrate moiety of human amniotic fluid transferrin during pregnancy. Glycobiology 8:1053\u20131064","journal-title":"Glycobiology"},{"key":"178_CR35","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1126\/science.6729450","volume":"224","author":"GF Springer","year":"1984","unstructured":"Springer GF (1984) T and Tn, general carcinoma autoantigens. Science 224:1198\u20131206","journal-title":"Science"},{"key":"178_CR36","doi-asserted-by":"crossref","first-page":"778","DOI":"10.4049\/jimmunol.176.2.778","volume":"176","author":"BN Stillman","year":"2006","unstructured":"Stillman BN, Hsu DK, Pang M, Brewer CF, Johnson P, Liu FT, Baum LG (2006) Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death. J Immunol 176:778\u2013789","journal-title":"J Immunol"},{"key":"178_CR37","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/1097-0215(200002)9999:9999<::AID-IJC1022>3.3.CO;2-Q","volume":"91","author":"N Tinari","year":"2001","unstructured":"Tinari N, Kuwabara I, Huflejt ME, Shen PF, Iacobelli S, Liu FT (2001) Glycoprotein 90K\/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation. Int J Cancer 91:167\u2013172","journal-title":"Int J Cancer"},{"key":"178_CR38","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1093\/humrep\/13.3.730","volume":"13","author":"L Vicovac","year":"1998","unstructured":"Vicovac L, Jankovic M, Cuperlovic M (1998) Galectin-1 and -3 in cells of the first trimester placental bed. Hum Reprod 13:730\u2013735","journal-title":"Hum Reprod"},{"key":"178_CR39","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0065-1281(11)80204-7","volume":"97","author":"H Walzel","year":"1995","unstructured":"Walzel H, Neels P, Bremer H, Kohler H, Raab N, Barten M, Brock J (1995) Immunohistochemical and glycohistochemical localization of the beta-galactoside-binding S-type lectin in human placenta. Acta Histochem 97:33\u201342","journal-title":"Acta Histochem"},{"key":"178_CR40","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0165-2478(99)00012-7","volume":"67","author":"H Walzel","year":"1999","unstructured":"Walzel H, Schulz U, Neels P, Brock J (1999) Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45. Immunol Lett 67:193\u2013202","journal-title":"Immunol Lett"},{"key":"178_CR41","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/glycob\/10.2.131","volume":"10","author":"H Walzel","year":"2000","unstructured":"Walzel H, Blach M, Hirabayashi J, Kasai KI, Brock J (2000) Involvement of CD2 and CD3 in galectin-1 induced signaling in human Jurkat T-cells. Glycobiology 10:131\u2013140","journal-title":"Glycobiology"},{"key":"178_CR42","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0092-8674(91)90211-G","volume":"64","author":"V Wells","year":"1991","unstructured":"Wells V, Mallucci L (1991) Identification of an autocrine negative growth factor: mouse beta-galactoside-binding protein is a cytostatic factor and cell growth regulator. Cell 64:91\u201397","journal-title":"Cell"},{"key":"178_CR43","first-page":"1575","volume":"25","author":"I Wiest","year":"2005","unstructured":"Wiest I, Seliger C, Walzel H, Friese K, Jeschke U (2005) Induction of apoptosis in human breast cancer and trophoblast tumor cells by galectin-1. Anticancer Res 25:1575\u20131580","journal-title":"Anticancer Res"},{"key":"178_CR44","doi-asserted-by":"crossref","unstructured":"Yeaman GR, Collins JE, Lang GA (2002) Autoantibody responses to carbohydrate epitopes in endometriosis. Ann N Y Acad Sci 955:174\u2013182; discussion 199\u2013200, 396\u2013406","DOI":"10.1111\/j.1749-6632.2002.tb02778.x"},{"key":"178_CR45","doi-asserted-by":"crossref","unstructured":"Yu LG, Jansson B, Fernig DG, Milton JD, Smith JA, Gerasimenko OV, Jones M, Rhodes JM (1997) Stimulation of proliferation in human colon cancer cells by human monoclonal antibodies against the TF antigen (galactose beta1-3 N-acetyl-galactosamine). Int J Cancer 73:424\u2013431","DOI":"10.1002\/(SICI)1097-0215(19971104)73:3<424::AID-IJC18>3.0.CO;2-C"}],"container-title":["Histochemistry and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-006-0178-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00418-006-0178-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-006-0178-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T18:11:43Z","timestamp":1706983903000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00418-006-0178-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,11]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["178"],"URL":"https:\/\/doi.org\/10.1007\/s00418-006-0178-1","relation":{},"ISSN":["0948-6143","1432-119X"],"issn-type":[{"value":"0948-6143","type":"print"},{"value":"1432-119X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,11]]}}}