{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:19:13Z","timestamp":1791181153192,"version":"4.1.0"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,6,5]],"date-time":"2010-06-05T00:00:00Z","timestamp":1275696000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Histochem Cell Biol"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1007\/s00418-010-0713-y","type":"journal-article","created":{"date-parts":[[2010,6,4]],"date-time":"2010-06-04T11:39:50Z","timestamp":1275651590000},"page":"59-73","source":"Crossref","is-referenced-by-count":36,"title":["Roles of human \u03b2-defensins in innate immune defense at the ocular surface: arming and alarming corneal and conjunctival epithelial cells"],"prefix":"10.1007","volume":"134","author":[{"given":"Fabian","family":"Garreis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schlorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Worlitzsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Steven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Br\u00e4uer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"J\u00e4ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich P.","family":"Paulsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,6,5]]},"reference":[{"key":"713_CR1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1189\/jlb.72.1.167","volume":"72","author":"J Aarbiou","year":"2002","unstructured":"Aarbiou J, Ertmann M, van Wetering S, van Noort P, Rook D, Rabe KF, Litvinov SV, van Krieken JH, de Boer WI, Hiemstra PS (2002) Human neutrophil defensins induce lung epithelial cell proliferation in vitro. J Leukoc Biol 72:167\u2013174","journal-title":"J Leukoc Biol"},{"key":"713_CR2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1165\/rcmb.2002-0267OC","volume":"30","author":"J Aarbiou","year":"2004","unstructured":"Aarbiou J, Verhoosel RM, Van Wetering S, De Boer WI, Van Krieken JH, Litvinov SV, Rabe KF, Hiemstra PS (2004) Neutrophil defensins enhance lung epithelial wound closure and mucin gene expression in vitro. Am J Respir Cell Mol Biol 30:193\u2013201","journal-title":"Am J Respir Cell Mol Biol"},{"key":"713_CR3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1167\/iovs.07-0645","volume":"49","author":"A Abedin","year":"2008","unstructured":"Abedin A, Mohammed I, Hopkinson A, Dua HS (2008) A novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection. Invest Ophthalmol Vis Sci 49:28\u201333","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"713_CR4","first-page":"614","volume":"36","author":"K Araki-Sasaki","year":"1995","unstructured":"Araki-Sasaki K, Ohashi Y, Sasabe T, Hayashi K, Watanabe H, Tano Y, Handa H (1995) An SV40-immortalized human corneal epithelial cell line and its characterization. Invest Ophthalmol Vis Sci 36:614\u2013621","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"713_CR5","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1128\/IAI.66.3.1225-1232.1998","volume":"66","author":"R Bals","year":"1998","unstructured":"Bals R, Goldman MJ, Wilson JM (1998a) Mouse beta-defensin 1 is a salt-sensitive antimicrobial peptide present in epithelia of the lung and urogenital tract. Infect Immun 66:1225\u20131232","journal-title":"Infect Immun"},{"key":"713_CR6","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1172\/JCI2410","volume":"102","author":"R Bals","year":"1998","unstructured":"Bals R, Wang X, Wu Z, Freeman T, Bafna V, Zasloff M, Wilson JM (1998b) Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J Clin Invest 102:874\u2013880","journal-title":"J Clin Invest"},{"key":"713_CR7","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.2174\/138955706778560193","volume":"6","author":"G Batoni","year":"2006","unstructured":"Batoni G, Maisetta G, Esin S, Campa M (2006) Human beta-defensin-3: a promising antimicrobial peptide. Mini Rev Med Chem 6:1063\u20131073","journal-title":"Mini Rev Med Chem"},{"key":"713_CR8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2174\/1389203054065428","volume":"6","author":"C Beisswenger","year":"2005","unstructured":"Beisswenger C, Bals R (2005) Functions of antimicrobial peptides in host defense and immunity. Curr Protein Pept Sci 6:255\u2013264","journal-title":"Curr Protein Pept Sci"},{"key":"713_CR9","first-page":"27","volume":"306","author":"DM Bowdish","year":"2006","unstructured":"Bowdish DM, Davidson DJ, Hancock RE (2006) Immunomodulatory properties of defensins and cathelicidins. Curr Top Microbiol Immunol 306:27\u201366","journal-title":"Curr Top Microbiol Immunol"},{"key":"713_CR10","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/00024382-200211000-00013","volume":"18","author":"RS Burd","year":"2002","unstructured":"Burd RS, Furrer JL, Sullivan J, Smith AL (2002) Murine beta-defensin-3 is an inducible peptide with limited tissue expression and broad-spectrum antimicrobial activity. Shock 18:461\u2013464","journal-title":"Shock"},{"key":"713_CR11","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1126\/science.1147880","volume":"318","author":"SI Candille","year":"2007","unstructured":"Candille SI, Kaelin CB, Cattanach BM, Yu B, Thompson DA, Nix MA, Kerns JA, Schmutz SM, Millhauser GL, Barsh GS (2007) A -defensin mutation causes black coat color in domestic dogs. Science 318:1418\u20131423","journal-title":"Science"},{"key":"713_CR12","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.4049\/jimmunol.182.3.1247","volume":"182","author":"SK Chauhan","year":"2009","unstructured":"Chauhan SK, El Annan J, Ecoiffier T, Goyal S, Zhang Q, Saban DR, Dana R (2009) Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression. J Immunol 182:1247\u20131252","journal-title":"J Immunol"},{"key":"713_CR13","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1167\/iovs.03-0560","volume":"44","author":"Y Diebold","year":"2003","unstructured":"Diebold Y, Calonge M, Enriquez de Salamanca A, Callejo S, Corrales RM, Saez V, Siemasko KF, Stern ME (2003) Characterization of a spontaneously immortalized cell line (IOBA-NHC) from normal human conjunctiva. Invest Ophthalmol Vis Sci 44:4263\u20134274","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"713_CR14","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1172\/JCI112120","volume":"76","author":"T Ganz","year":"1985","unstructured":"Ganz T, Selsted ME, Szklarek D, Harwig SS, Daher K, Bainton DF, Lehrer RI (1985) Defensins. Natural peptide antibiotics of human neutrophils. J Clin Invest 76:1427\u20131435","journal-title":"J Clin Invest"},{"key":"713_CR15","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s004410100433","volume":"306","author":"JR Garcia","year":"2001","unstructured":"Garcia JR, Jaumann F, Schulz S, Krause A, Rodriguez-Jimenez J, Forssmann U, Adermann K, Kl\u00fcver E, Vogelmeier C, Becker D, Hedrich R, Forssmann W-G, Bals R (2001) Identification of a novel, multifunctional \u00df-defensin (human \u00df-defensin 3) with specific antimicrobial activity. Cell Tissue Res 306:257\u2013264","journal-title":"Cell Tissue Res"},{"key":"713_CR16","doi-asserted-by":"crossref","first-page":"3958","DOI":"10.4049\/jimmunol.179.6.3958","volume":"179","author":"J Grigat","year":"2007","unstructured":"Grigat J, Soruri A, Forssmann U, Riggert J, Zwirner J (2007) Chemoattraction of macrophages, T lymphocytes, and mast cells is evolutionarily conserved within the human alpha-defensin family. J Immunol 179:3958\u20133965","journal-title":"J Immunol"},{"key":"713_CR17","doi-asserted-by":"crossref","first-page":"5707","DOI":"10.1074\/jbc.M008557200","volume":"276","author":"J Harder","year":"2001","unstructured":"Harder J, Bartels J, Christophers E, Schroder JM (2001) Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic. J Biol Chem 276:5707\u20135713","journal-title":"J Biol Chem"},{"key":"713_CR18","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1128\/AAC.42.12.3332","volume":"42","author":"LO Hattenbach","year":"1998","unstructured":"Hattenbach LO, Gumbel H, Kippenberger S (1998) Identification of beta-defensins in human conjunctiva. Antimicrob Agents Chemother 42:3332","journal-title":"Antimicrob Agents Chemother"},{"key":"713_CR19","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0140-6736(05)79185-6","volume":"352","author":"RJ Haynes","year":"1998","unstructured":"Haynes RJ, Tighe PJ, Dua HS (1998) Innate defence of the eye by antimicrobial defensin peptides. Lancet 352:451\u2013452","journal-title":"Lancet"},{"key":"713_CR21","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1128\/AAC.01308-07","volume":"52","author":"K Hinrichsen","year":"2008","unstructured":"Hinrichsen K, Podschun R, Schubert S, Schroder JM, Harder J, Proksch E (2008) Mouse beta-defensin-14, an antimicrobial ortholog of human beta-defensin-3. Antimicrob Agents Chemother 52:1876\u20131879","journal-title":"Antimicrob Agents Chemother"},{"key":"713_CR22","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1167\/iovs.05-1649","volume":"47","author":"LC Huang","year":"2006","unstructured":"Huang LC, Petkova TD, Reins RY, Proske RJ, McDermott AM (2006) Multifunctional roles of human cathelicidin (LL-37) at the ocular surface. Invest Ophthalmol Vis Sci 47:2369\u20132380","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"713_CR23","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1080\/02713680701446653","volume":"32","author":"LC Huang","year":"2007","unstructured":"Huang LC, Jean D, Proske RJ, Reins RY, McDermott AM (2007) Ocular surface expression and in vitro activity of antimicrobial peptides. Curr Eye Res 32:595\u2013609","journal-title":"Curr Eye Res"},{"key":"713_CR24","doi-asserted-by":"crossref","first-page":"23216","DOI":"10.1016\/S0021-9258(18)50079-X","volume":"267","author":"DE Jones","year":"1992","unstructured":"Jones DE, Bevins CL (1992) Paneth cells of the human small intestine express an antimicrobial peptide gene. J Biol Chem 267:23216\u201323225","journal-title":"J Biol Chem"},{"key":"713_CR25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0014-5793(93)81160-2","volume":"315","author":"DE Jones","year":"1993","unstructured":"Jones DE, Bevins CL (1993) Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel. FEBS Lett 315:187\u2013192","journal-title":"FEBS Lett"},{"key":"713_CR26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0014-4835(03)00087-3","volume":"77","author":"S Kawasaki","year":"2003","unstructured":"Kawasaki S, Kawamoto S, Yokoi N, Connon C, Minesaki Y, Kinoshita S, Okubo K (2003) Up-regulated gene expression in the conjunctival epithelium of patients with Sjogren\u2019s syndrome. Exp Eye Res 77:17\u201326","journal-title":"Exp Eye Res"},{"key":"713_CR27","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1167\/iovs.04-0467","volume":"45","author":"A Kumar","year":"2004","unstructured":"Kumar A, Zhang J, Yu F-SX (2004) innate immune response of corneal epithelial cells to Staphylococcus aureus infection: role of peptidoglycan in stimulating proinflammatory cytokine secretion. Invest Ophthalmol Vis Sci 45:3513\u20133522","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"713_CR28","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.micinf.2005.07.006","volume":"8","author":"A Kumar","year":"2006","unstructured":"Kumar A, Zhang J, Yu FS (2006) Toll-like receptor 2-mediated expression of beta-defensin-2 in human corneal epithelial cells. Microbes Infect 8:380\u2013389","journal-title":"Microbes Infect"},{"key":"713_CR29","doi-asserted-by":"crossref","first-page":"4664","DOI":"10.1167\/iovs.07-0473","volume":"48","author":"A Kumar","year":"2007","unstructured":"Kumar A, Yin J, Zhang J, Yu F-SX (2007) Modulation of corneal epithelial innate immune response to Pseudomonas Infection by flagellin pretreatment. Invest Ophthalmol Vis Sci 48:4664\u20134670","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"713_CR30","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1136\/bjo.84.5.523","volume":"84","author":"OJ Lehmann","year":"2000","unstructured":"Lehmann OJ, Hussain IR, Watt PJ (2000) Investigation of beta defensin gene expression in the ocular anterior segment by semiquantitative RT-PCR. Br J Ophthalmol 84:523\u2013526","journal-title":"Br J Ophthalmol"},{"key":"713_CR31","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1167\/iovs.05-1360","volume":"47","author":"J Li","year":"2006","unstructured":"Li J, Raghunath M, Tan D, Lareu RR, Chen Z, Beuerman RW (2006) Defensins HNP1 and HBD2 stimulation of wound-associated responses in human conjunctival fibroblasts. Invest Ophthalmol Vis Sci 47:3811\u20133819","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"713_CR32","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.micpath.2007.11.006","volume":"44","author":"Q Li","year":"2008","unstructured":"Li Q, Kumar A, Gui JF, Yu FS (2008) Staphylococcus aureus lipoproteins trigger human corneal epithelial innate response through toll-like receptor-2. Microb Pathog 44:426\u2013434","journal-title":"Microb Pathog"},{"key":"713_CR33","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1167\/iovs.08-1838","volume":"50","author":"J Li","year":"2009","unstructured":"Li J, Zhu HY, Beuerman RW (2009) Stimulation of specific cytokines in human conjunctival epithelial cells by defensins HNP1, HBD2, and HBD3. Invest Ophthalmol Vis Sci 50:644\u2013653","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"713_CR34","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1002\/cbic.200700560","volume":"9","author":"S Liu","year":"2008","unstructured":"Liu S, Zhou L, Li J, Suresh A, Verma C, Foo YH, Yap EP, Tan DT, Beuerman RW (2008) Linear analogues of human beta-defensin 3: concepts for design of antimicrobial peptides with reduced cytotoxicity to mammalian cells. Chembiochem 9:964\u2013973","journal-title":"Chembiochem"},{"key":"713_CR35","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1076\/ceyr.22.1.64.6978","volume":"22","author":"AM McDermott","year":"2001","unstructured":"McDermott AM (2001) Human beta-defensin 2 is up-regulated during re-epithelialization of the cornea. Curr Eye Res 22:64\u201367","journal-title":"Curr Eye Res"},{"key":"713_CR36","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S1542-0124(12)70111-8","volume":"2","author":"AM McDermott","year":"2004","unstructured":"McDermott AM (2004) Defensins and other antimicrobial peptides at the ocular surface. Ocul Surf 2:229\u2013247","journal-title":"Ocul Surf"},{"key":"713_CR37","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1159\/000187622","volume":"41","author":"AM McDermott","year":"2008","unstructured":"McDermott AM (2008) The role of antimicrobial peptides at the ocular surface. Ophthalmic Res 41:60\u201375","journal-title":"Ophthalmic Res"},{"key":"713_CR38","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1167\/iovs.02-0787","volume":"44","author":"AM McDermott","year":"2003","unstructured":"McDermott AM, Redfern RL, Zhang B, Pei Y, Huang L, Proske RJ (2003) Defensin expression by the cornea: multiple signalling pathways mediate IL-1beta stimulation of hBD-2 expression by human corneal epithelial cells. Invest Ophthalmol Vis Sci 44:1859\u20131865","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"713_CR39","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1167\/iovs.04-0607","volume":"46","author":"RS McIntosh","year":"2005","unstructured":"McIntosh RS, Cade JE, Al-Abed M, Shanmuganathan V, Gupta R, Bhan A, Tighe PJ, Dua HS (2005) The spectrum of antimicrobial peptide expression at the ocular surface. Invest Ophthalmol Vis Sci 46:1379\u20131385","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"713_CR40","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1006\/exer.1999.0722","volume":"69","author":"N McNamara","year":"1999","unstructured":"McNamara N, Van R, Tuchin OS, Fleiszig SM (1999) Ocular surface epithelia express mRNA for human beta defensin-2. Exp Eye Res 69:483\u2013490","journal-title":"Exp Eye Res"},{"key":"713_CR41","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/jcp.1041550223","volume":"155","author":"CJ Murphy","year":"1993","unstructured":"Murphy CJ, Foster BA, Mannis MJ, Selsted ME, Reid TW (1993) Defensins are mitogenic for epithelial cells and fibroblasts. J Cell Physiol 155:408\u2013413","journal-title":"J Cell Physiol"},{"key":"713_CR42","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1167\/iovs.02-1301","volume":"44","author":"S Narayanan","year":"2003","unstructured":"Narayanan S, Miller WL, McDermott AM (2003) Expression of human beta-defensins in conjunctival epithelium: relevance to dry eye disease. Invest Ophthalmol Vis Sci 44:3795\u20133801","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"713_CR43","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/j.peptides.2003.07.023","volume":"24","author":"TX Nguyen","year":"2003","unstructured":"Nguyen TX, Cole AM, Lehrer RI (2003) Evolution of primate theta-defensins: a serpentine path to a sweet tooth. Peptides 24:1647\u20131654","journal-title":"Peptides"},{"key":"713_CR44","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.0019-2805.2004.01816.x","volume":"111","author":"F Niyonsaba","year":"2004","unstructured":"Niyonsaba F, Ogawa H, Nagaoka I (2004) Human beta-defensin-2 functions as a chemotactic agent for tumour necrosis factor-alpha-treated human neutrophils. Immunology 111:273\u2013281","journal-title":"Immunology"},{"key":"713_CR45","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/sj.jid.5700599","volume":"127","author":"F Niyonsaba","year":"2007","unstructured":"Niyonsaba F, Ushio H, Nakano N, Ng W, Sayama K, Hashimoto K, Nagaoka I, Okumura K, Ogawa H (2007) Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines. J Invest Dermatol 127:594\u2013604","journal-title":"J Invest Dermatol"},{"key":"713_CR46","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.4049\/jimmunol.171.6.3262","volume":"171","author":"I Nomura","year":"2003","unstructured":"Nomura I, Goleva E, Howell MD, Hamid QA, Ong PY, Hall CF, Darst MA, Gao B, Boguniewicz M, Travers JB, Leung DY (2003) Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes. J Immunol 171:3262\u20133269","journal-title":"J Immunol"},{"key":"713_CR47","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00403-002-0310-6","volume":"294","author":"T Oono","year":"2002","unstructured":"Oono T, Shirafuji Y, Huh WK, Akiyama H, Iwatsuki K (2002) Effects of human neutrophil peptide-1 on the expression of interstitial collagenase and type I collagen in human dermal fibroblasts. Arch Dermatol Res 294:185\u2013189","journal-title":"Arch Dermatol Res"},{"key":"713_CR48","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0014-4800(02)00023-0","volume":"74","author":"A Oren","year":"2003","unstructured":"Oren A, Ganz T, Liu L, Meerloo T (2003) In human epidermis, beta-defensin 2 is packaged in lamellar bodies. Exp Mol Pathol 74:180\u2013182","journal-title":"Exp Mol Pathol"},{"key":"713_CR49","first-page":"2157","volume":"42","author":"FP Paulsen","year":"2001","unstructured":"Paulsen FP, Pufe T, Schaudig U, Held-Feindt J, Lehmann J, Schroder JM, Tillmann BN (2001) Detection of natural peptide antibiotics in human nasolacrimal ducts. Invest Ophthalmol Vis Sci 42:2157\u20132163","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"713_CR50","first-page":"97","volume-title":"Immunology of lacrimal gland and tear film","author":"F Paulsen","year":"2005","unstructured":"Paulsen F, Varoga D, Steven P, Pufe T (2005) Antimicrobial peptides at the ocular surface. In: Zierhut M, Stern ME, Sullivan DA (eds) Immunology of lacrimal gland and tear film. Taylor & Francis, London, pp 97\u2013104"},{"key":"713_CR51","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","volume":"29","author":"MW Pfaffl","year":"2001","unstructured":"Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:e45","journal-title":"Nucleic Acids Res"},{"key":"713_CR52","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1128\/IAI.66.6.2791-2797.1998","volume":"66","author":"XD Qu","year":"1998","unstructured":"Qu XD, Lehrer RI (1998) Secretory phospholipase A2 is the principal bactericide for staphylococci and other gram-positive bacteria in human tears. Infect Immun 66:2791\u20132797","journal-title":"Infect Immun"},{"key":"713_CR53","first-page":"1247","volume":"152","author":"AJ Quayle","year":"1998","unstructured":"Quayle AJ, Porter EM, Nussbaum AA, Wang YM, Brabec C, Yip KP, Mok SC (1998) Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract. Am J Pathol 152:1247\u20131258","journal-title":"Am J Pathol"},{"key":"713_CR54","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00109-005-0657-1","volume":"83","author":"JJ Schneider","year":"2005","unstructured":"Schneider JJ, Unholzer A, Schaller M, Schafer-Korting M, Korting HC (2005) Human defensins. J Mol Med 83:587\u2013595","journal-title":"J Mol Med"},{"key":"713_CR55","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1073\/pnas.042692699","volume":"99","author":"BC Schutte","year":"2002","unstructured":"Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (2002) Discovery of five conserved beta -defensin gene clusters using a computational search strategy. Proc Natl Acad Sci USA 99:2129\u20132133","journal-title":"Proc Natl Acad Sci USA"},{"key":"713_CR56","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s11030-006-9031-7","volume":"10","author":"CA Semple","year":"2006","unstructured":"Semple CA, Gautier P, Taylor K, Dorin JR (2006) The changing of the guard: molecular diversity and rapid evolution of beta-defensins. Mol Divers 10:575\u2013584","journal-title":"Mol Divers"},{"key":"713_CR57","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/emm.2004.28","volume":"36","author":"JS Shin","year":"2004","unstructured":"Shin JS, Kim CW, Kwon YS, Kim JC (2004) Human beta-defensin 2 is induced by interleukin-1 beta in the corneal epithelial cells. Exp Mol Med 36:204\u2013210","journal-title":"Exp Mol Med"},{"key":"713_CR58","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.1002\/art.20605","volume":"50","author":"D Varoga","year":"2004","unstructured":"Varoga D, Pufe T, Harder J, Meyer-Hoffert U, Mentlein R, Schroder JM, Petersen WJ, Tillmann BN, Proksch E, Goldring MB, Paulsen FP (2004) Production of endogenous antibiotics in articular cartilage. Arthritis Rheum 50:3526\u20133534","journal-title":"Arthritis Rheum"},{"key":"713_CR59","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.aanat.2005.03.004","volume":"187","author":"D Varoga","year":"2005","unstructured":"Varoga D, Pufe T, Mentlein R, Kohrs S, Grohmann S, Tillmann B, Hassenpflug J, Paulsen F (2005) Expression and regulation of antimicrobial peptides in articular joints. Ann Anat 187:499\u2013508","journal-title":"Ann Anat"},{"key":"713_CR60","doi-asserted-by":"crossref","first-page":"11200","DOI":"10.1016\/S0021-9258(18)60449-1","volume":"264","author":"CG Wilde","year":"1989","unstructured":"Wilde CG, Griffith JE, Marra MN, Snable JL, Scott RW (1989) Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family. J Biol Chem 264:11200\u201311203","journal-title":"J Biol Chem"},{"key":"713_CR61","doi-asserted-by":"crossref","first-page":"8054","DOI":"10.4049\/jimmunol.0902140","volume":"183","author":"M Wu","year":"2009","unstructured":"Wu M, McClellan SA, Barrett RP, Zhang Y, Hazlett LD (2009) Beta-defensins 2 and 3 together promote resistance to Pseudomonas aeruginosa keratitis. J Immunol 183:8054\u20138060","journal-title":"J Immunol"},{"key":"713_CR222","doi-asserted-by":"crossref","unstructured":"Yamaguchi Y, Nagase T, Makita R, Fukuhara S, Tomita T, Tominaga T, Kurihara H, Ouchi Y (2002) Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice. J Immunol 169:2516\u20132523","DOI":"10.4049\/jimmunol.169.5.2516"},{"key":"713_CR62","doi-asserted-by":"crossref","first-page":"C2141","DOI":"10.1152\/ajpcell.00295.2006","volume":"292","author":"Y Yamaguchi","year":"2007","unstructured":"Yamaguchi Y, Nagase T, Tomita T, Nakamura K, Fukuhara S, Amano T, Yamamoto H, Ide Y, Suzuki M, Teramoto S, Asano T, Kangawa K, Nakagata N, Ouchi Y, Kurihara H (2007) Beta-defensin overexpression induces progressive muscle degeneration in mice. Am J Physiol Cell Physiol 292:C2141\u2013C2149","journal-title":"Am J Physiol Cell Physiol"},{"key":"713_CR63","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/1465-9921-6-130","volume":"6","author":"S Yanagi","year":"2005","unstructured":"Yanagi S, Ashitani J, Ishimoto H, Date Y, Mukae H, Chino N, Nakazato M (2005) Isolation of human beta- defensin-4 in lung tissue and its increase in lower respiratory tract infection. Respir Res 6:130","journal-title":"Respir Res"},{"key":"713_CR65","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1189\/jlb.68.1.9","volume":"68","author":"D Yang","year":"2000","unstructured":"Yang D, Chen Q, Chertov O, Oppenheim JJ (2000) Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells. J Leukoc Biol 68:9\u201314","journal-title":"J Leukoc Biol"},{"key":"713_CR66","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00109-006-0143-4","volume":"85","author":"M Zaiou","year":"2007","unstructured":"Zaiou M (2007) Multifunctional antimicrobial peptides: therapeutic targets in several human diseases. J Mol Med 85:317\u2013329","journal-title":"J Mol Med"},{"key":"713_CR67","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1021\/pr034065n","volume":"3","author":"L Zhou","year":"2004","unstructured":"Zhou L, Huang LQ, Beuerman RW, Grigg ME, Li SF, Chew FT, Ang L, Stern ME, Tan D (2004) Proteomic analysis of human tears: defensin expression after ocular surface surgery. J Proteome Res 3:410\u2013416","journal-title":"J Proteome Res"},{"key":"713_CR68","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1002\/pmic.200700137","volume":"7","author":"L Zhou","year":"2007","unstructured":"Zhou L, Beuerman RW, Huang L, Barathi A, Foo YH, Li SF, Chew FT, Tan D (2007) Proteomic analysis of rabbit tear fluid: defensin levels after an experimental corneal wound are correlated to wound closure. Proteomics 7:3194\u20133206","journal-title":"Proteomics"}],"container-title":["Histochemistry and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-010-0713-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00418-010-0713-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-010-0713-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T12:21:29Z","timestamp":1685622089000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00418-010-0713-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,5]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["713"],"URL":"https:\/\/doi.org\/10.1007\/s00418-010-0713-y","relation":{},"ISSN":["0948-6143","1432-119X"],"issn-type":[{"value":"0948-6143","type":"print"},{"value":"1432-119X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,5]]}}}