{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:29:05Z","timestamp":1773282545901,"version":"3.50.1"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2011,8,4]],"date-time":"2011-08-04T00:00:00Z","timestamp":1312416000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Histochem Cell Biol"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1007\/s00418-011-0844-9","type":"journal-article","created":{"date-parts":[[2011,8,3]],"date-time":"2011-08-03T19:46:34Z","timestamp":1312400794000},"page":"301-319","source":"Crossref","is-referenced-by-count":27,"title":["Connective tissue growth factor modulates podocyte actin cytoskeleton and extracellular matrix synthesis and is induced in podocytes upon injury"],"prefix":"10.1007","volume":"136","author":[{"given":"Rudolf","family":"Fuchshofer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Ullmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludwig F.","family":"Zeilbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Junglas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernst R.","family":"Tamm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,8,4]]},"reference":[{"key":"844_CR1","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1128\/MCB.19.4.2958","volume":"19","author":"AM Babic","year":"1999","unstructured":"Babic AM, Chen CC, Lau LF (1999) Fisp12\/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo. Mol Cell Biol 19:2958\u20132966","journal-title":"Mol Cell Biol"},{"key":"844_CR2","doi-asserted-by":"crossref","unstructured":"Bohr DC, Koch M, Kritzenberger M, Fuchshofer R, Tamm ER (2011) Increased expression of olfactomedin-1 and myocilin in podocytes during puromycin aminonucleoside nephrosis. Nephrol Dial Transplant 26(1):83\u201392","DOI":"10.1093\/ndt\/gfq366"},{"key":"844_CR3","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1097\/01.ASN.0000033611.79556.AE","volume":"13","author":"EP B\u00f6ttinger","year":"2002","unstructured":"B\u00f6ttinger EP, Bitzer M (2002) TGF-beta signaling in renal disease. J Am Soc Nephrol 13:2600\u20132610","journal-title":"J Am Soc Nephrol"},{"key":"844_CR4","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/(SICI)1096-9896(199606)179:2<188::AID-PATH551>3.0.CO;2-#","volume":"179","author":"YI Cai","year":"1996","unstructured":"Cai YI, Sich M, Beziau A, Kleppel MM, Gubler MC (1996) Collagen distribution in focal and segmental glomerulosclerosis: an immunofluorescence and ultrastructural immunogold study. J Pathol 179:188\u2013196","journal-title":"J Pathol"},{"key":"844_CR5","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1111\/j.1742-4658.2006.05360.x","volume":"273","author":"B Chaqour","year":"2006","unstructured":"Chaqour B, Goppelt-Struebe M (2006) Mechanical regulation of the Cyr61\/CCN1 and CTGF\/CCN2 proteins. Febs J 273:3639\u20133649","journal-title":"Febs J"},{"key":"844_CR6","doi-asserted-by":"crossref","first-page":"10443","DOI":"10.1074\/jbc.M008087200","volume":"276","author":"CC Chen","year":"2001","unstructured":"Chen CC, Chen N, Lau LF (2001) The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts. J Biol Chem 276:10443\u201310452","journal-title":"J Biol Chem"},{"key":"844_CR7","doi-asserted-by":"crossref","first-page":"5635","DOI":"10.1091\/mbc.E04-06-0490","volume":"15","author":"Y Chen","year":"2004","unstructured":"Chen Y, Abraham DJ, Shi-Wen X, Pearson JD, Black CM, Lyons KM, Leask A (2004) CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin. Mol Biol Cell 15:5635\u20135646","journal-title":"Mol Biol Cell"},{"key":"844_CR8","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1161\/01.ATV.0000162173.27682.7b","volume":"25","author":"I Cicha","year":"2005","unstructured":"Cicha I, Yilmaz A, Klein M, Raithel D, Brigstock DR, Daniel WG, Goppelt-Struebe M, Garlichs CD (2005) Connective tissue growth factor is overexpressed in complicated atherosclerotic plaques and induces mononuclear cell chemotaxis in vitro. Arterioscler Thromb Vasc Biol 25:1008\u20131013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"844_CR9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1159\/000079845","volume":"69","author":"FF di Mola","year":"2004","unstructured":"di Mola FF, Di Sebastiano P, Gardini A, Innocenti P, Zimmermann A, Buchler MW, Friess H (2004) Differential expression of connective tissue growth factor in inflammatory bowel disease. Digestion 69:245\u2013253","journal-title":"Digestion"},{"key":"844_CR10","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1096\/fasebj.13.13.1774","volume":"13","author":"MR Duncan","year":"1999","unstructured":"Duncan MR, Frazier KS, Abramson S, Williams S, Klapper H, Huang X, Grotendorst GR (1999) Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP. Faseb J 13:1774\u20131786","journal-title":"Faseb J"},{"key":"844_CR11","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.tcb.2007.06.006","volume":"17","author":"C Faul","year":"2007","unstructured":"Faul C, Asanuma K, Yanagida-Asanuma E, Kim K, Mundel P (2007) Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton. Trends Cell Biol 17:428\u2013437","journal-title":"Trends Cell Biol"},{"key":"844_CR12","first-page":"486","volume":"67","author":"J Floege","year":"1992","unstructured":"Floege J, Alpers CE, Sage EH, Pritzl P, Gordon K, Johnson RJ, Couser WG (1992) Markers of complement-dependent and complement-independent glomerular visceral epithelial cell injury in vivo. Expression of antiadhesive proteins and cytoskeletal changes. Lab Invest 67:486\u2013497","journal-title":"Lab Invest"},{"key":"844_CR13","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.exer.2009.01.005","volume":"88","author":"R Fuchshofer","year":"2009","unstructured":"Fuchshofer R, Tamm ER (2009) Modulation of extracellular matrix turnover in the trabecular meshwork. Exp Eye Res 88:683\u2013688","journal-title":"Exp Eye Res"},{"key":"844_CR14","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1167\/iovs.04-0649","volume":"46","author":"R Fuchshofer","year":"2005","unstructured":"Fuchshofer R, Birke M, Welge-L\u00fcssen U, Kook D, L\u00fctjen-Drecoll E (2005) Transforming growth factor-beta 2 modulated extracellular matrix component expression in cultured human optic nerve head astrocytes. Invest Ophthalmol Vis Sci 46:568\u2013578","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"844_CR15","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1167\/iovs.06-0226","volume":"48","author":"R Fuchshofer","year":"2007","unstructured":"Fuchshofer R, Yu AH, Welge-L\u00fcssen U, Tamm ER (2007) Bone morphogenetic protein-7 is an antagonist of transforming growth factor-beta2 in human trabecular meshwork cells. Invest Ophthalmol Vis Sci 48:715\u2013726","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"844_CR16","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S1359-6101(97)00010-5","volume":"8","author":"GR Grotendorst","year":"1997","unstructured":"Grotendorst GR (1997) Connective tissue growth factor: a mediator of TGF-\u03b2 action on fibroblasts. Cytokine Growth Factor Rev 8:171\u2013179","journal-title":"Cytokine Growth Factor Rev"},{"key":"844_CR17","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1096\/fj.06-6713com","volume":"21","author":"M Guha","year":"2007","unstructured":"Guha M, Xu ZG, Tung D, Lanting L, Natarajan R (2007) Specific down-regulation of connective tissue growth factor attenuates progression of nephropathy in mouse models of type 1 and type 2 diabetes. Faseb J 21:3355\u20133368","journal-title":"Faseb J"},{"key":"844_CR18","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1681\/ASN.V1291853","volume":"12","author":"J Heusinger-Ribeiro","year":"2001","unstructured":"Heusinger-Ribeiro J, Eberlein M, Wahab NA, Goppelt-Struebe M (2001) Expression of connective tissue growth factor in human renal fibroblasts: regulatory roles of RhoA and cAMP. J Am Soc Nephrol 12:1853\u20131861","journal-title":"J Am Soc Nephrol"},{"key":"844_CR19","doi-asserted-by":"crossref","first-page":"16797","DOI":"10.1074\/jbc.M010722200","volume":"276","author":"K Hishikawa","year":"2001","unstructured":"Hishikawa K, Oemar BS, Nakaki T (2001) Static pressure regulates connective tissue growth factor expression in human mesangial cells. J Biol Chem 276:16797\u201316803","journal-title":"J Biol Chem"},{"key":"844_CR20","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/1523-1747.ep12318465","volume":"105","author":"A Igarashi","year":"1995","unstructured":"Igarashi A, Nashiro K, Kikuchi K, Sato S, Ihn H, Grotendorst GR, Takehara K (1995) Significant correlation between connective tissue growth factor gene expression and skin sclerosis in tissue sections from patients with systemic sclerosis. J Invest Dermatol 105:280\u2013284","journal-title":"J Invest Dermatol"},{"key":"844_CR21","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1097\/00002281-200211000-00009","volume":"14","author":"H Ihn","year":"2002","unstructured":"Ihn H (2002) Pathogenesis of fibrosis: role of TGF-\u03b2 and CTGF. Curr Opin Rheumatol 14:681\u2013685","journal-title":"Curr Opin Rheumatol"},{"key":"844_CR22","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/j.1523-1755.1998.00820.x","volume":"53","author":"Y Ito","year":"1998","unstructured":"Ito Y, Aten J, Bende RJ, Oemar BS, Rabelink TJ, Weening JJ, Goldschmeding R (1998) Expression of connective tissue growth factor in human renal fibrosis. Kidney Int 53:853\u2013861","journal-title":"Kidney Int"},{"key":"844_CR23","first-page":"1381","volume":"141","author":"CL Jones","year":"1992","unstructured":"Jones CL, Buch S, Post M, McCulloch L, Liu E, Eddy AA (1992) Renal extracellular matrix accumulation in acute puromycin aminonucleoside nephrosis in rats. Am J Pathol 141:1381\u20131396","journal-title":"Am J Pathol"},{"key":"844_CR24","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.exer.2009.01.008","volume":"88","author":"B Junglas","year":"2009","unstructured":"Junglas B, Yu AH, Welge-Lussen U, Tamm ER, Fuchshofer R (2009) Connective tissue growth factor induces extracellular matrix deposition in human trabecular meshwork cells. Exp Eye Res 88:1065\u20131075","journal-title":"Exp Eye Res"},{"key":"844_CR25","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.yexcr.2006.12.006","volume":"313","author":"L Kennedy","year":"2007","unstructured":"Kennedy L, Liu S, Shi-Wen X, Chen Y, Eastwood M, Sabetkar M, Carter DE, Lyons KM, Black CM, Abraham DJ, Leask A (2007) CCN2 is necessary for the function of mouse embryonic fibroblasts. Exp Cell Res 313:952\u2013964","journal-title":"Exp Cell Res"},{"key":"844_CR26","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1172\/JCI200114629","volume":"108","author":"D Kerjaschki","year":"2001","unstructured":"Kerjaschki D (2001) Caught flat-footed: podocyte damage and the molecular bases of focal glomerulosclerosis. J Clin Invest 108:1583\u20131587","journal-title":"J Clin Invest"},{"key":"844_CR27","doi-asserted-by":"crossref","first-page":"36575","DOI":"10.1074\/jbc.M101602200","volume":"276","author":"D Kessler","year":"2001","unstructured":"Kessler D, Dethlefsen S, Haase I, Plomann M, Hirche F, Krieg T, Eckes B (2001) Fibroblasts in mechanically stressed collagen lattices assume a \u201csynthetic\u201d phenotype. J Biol Chem 276:36575\u201336585","journal-title":"J Biol Chem"},{"key":"844_CR28","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1152\/japplphysiol.00531.2007","volume":"103","author":"R Kivela","year":"2007","unstructured":"Kivela R, Kyrolainen H, Selanne H, Komi PV, Kainulainen H, Vihko V (2007) A single bout of exercise with high mechanical loading induces the expression of Cyr61\/CCN1 and CTGF\/CCN2 in human skeletal muscle. J Appl Physiol 103:1395\u20131401","journal-title":"J Appl Physiol"},{"key":"844_CR29","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2353\/ajpath.2008.070057","volume":"172","author":"Y Li","year":"2008","unstructured":"Li Y, Kang YS, Dai C, Kiss LP, Wen X, Liu Y (2008) Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuria. Am J Pathol 172:299\u2013308","journal-title":"Am J Pathol"},{"key":"844_CR30","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1523-1755.2004.00381.x","volume":"65","author":"LJ Ma","year":"2004","unstructured":"Ma LJ, Jha S, Ling H, Pozzi A, Ledbetter S, Fogo AB (2004) Divergent effects of low versus high dose anti-TGF-beta antibody in puromycin aminonucleoside nephropathy in rats. Kidney Int 65:106\u2013115","journal-title":"Kidney Int"},{"key":"844_CR31","doi-asserted-by":"crossref","first-page":"5646","DOI":"10.1210\/en.2004-0436","volume":"145","author":"SV McLennan","year":"2004","unstructured":"McLennan SV, Wang XY, Moreno V, Yue DK, Twigg SM (2004) Connective tissue growth factor mediates high glucose effects on matrix degradation through tissue inhibitor of matrix metalloproteinase type 1: implications for diabetic nephropathy. Endocrinology 145:5646\u20135655","journal-title":"Endocrinology"},{"key":"844_CR32","doi-asserted-by":"crossref","first-page":"C1732","DOI":"10.1152\/ajpcell.00552.2006","volume":"292","author":"S Muehlich","year":"2007","unstructured":"Muehlich S, Cicha I, Garlichs CD, Krueger B, Posern G, Goppelt-Struebe M (2007) Actin-dependent regulation of connective tissue growth factor. Am J Physiol Cell Physiol 292:C1732\u2013C1738","journal-title":"Am J Physiol Cell Physiol"},{"key":"844_CR33","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/BF00240371","volume":"192","author":"P Mundel","year":"1995","unstructured":"Mundel P, Kriz W (1995) Structure and function of podocytes: an update. Anat Embryol 192:385\u2013397","journal-title":"Anat Embryol"},{"key":"844_CR34","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1083\/jcb.139.1.193","volume":"139","author":"P Mundel","year":"1997","unstructured":"Mundel P, Heid HW, Mundel TM, Kruger M, Reiser J, Kriz W (1997) Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes. J Cell Biol 139:193\u2013204","journal-title":"J Cell Biol"},{"key":"844_CR35","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/clin.1993.1005","volume":"66","author":"T Nakamura","year":"1993","unstructured":"Nakamura T, Ebihara I, Fukui M, Osada S, Nagaoka I, Horikoshi S, Tomino Y, Koide H (1993) Messenger RNA expression for growth factors in glomeruli from focal glomerular sclerosis. Clin Immunol Immunopathol 66:33\u201342","journal-title":"Clin Immunol Immunopathol"},{"key":"844_CR36","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s12079-007-0005-z","volume":"1","author":"T Nishida","year":"2007","unstructured":"Nishida T, Kawaki H, Baxter RM, Deyoung RA, Takigawa M, Lyons KM (2007) CCN2 (connective tissue growth factor) is essential for extracellular matrix production and integrin signaling in chondrocytes. J Cell Commun Signal 1:45\u201358","journal-title":"J Cell Commun Signal"},{"key":"844_CR37","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1161\/01.CIR.95.4.831","volume":"95","author":"BS Oemar","year":"1997","unstructured":"Oemar BS, Werner A, Garnier JM, Do DD, Godoy N, Nauck M, Marz W, Rupp J, Pech M, Luscher TF (1997) Human connective tissue growth factor is expressed in advanced atherosclerotic lesions. Circulation 95:831\u2013839","journal-title":"Circulation"},{"key":"844_CR38","doi-asserted-by":"crossref","first-page":"44305","DOI":"10.1074\/jbc.M309140200","volume":"278","author":"C Ott","year":"2003","unstructured":"Ott C, Iwanciw D, Graness A, Giehl K, Goppelt-Struebe M (2003) Modulation of the expression of connective tissue growth factor by alterations of the cytoskeleton. J Biol Chem 278:44305\u201344311","journal-title":"J Biol Chem"},{"key":"844_CR39","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/hep.510300425","volume":"30","author":"V Paradis","year":"1999","unstructured":"Paradis V, Dargere D, Vidaud M, De Gouville AC, Huet S, Martinez V, Gauthier JM, Ba N, Sobesky R, Ratziu V, Bedossa P (1999) Expression of connective tissue growth factor in experimental rat and human liver fibrosis. Hepatology 30:968\u2013976","journal-title":"Hepatology"},{"key":"844_CR40","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1152\/physrev.00020.2002","volume":"83","author":"H Pavenst\u00e4dt","year":"2003","unstructured":"Pavenst\u00e4dt H, Kriz W, Kretzler M (2003) Cell biology of the glomerular podocyte. Physiol Rev 83:253\u2013307","journal-title":"Physiol Rev"},{"key":"844_CR41","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.1159\/000262316","volume":"114","author":"MK Phanish","year":"2009","unstructured":"Phanish MK, Winn SK, Dockrell ME (2009) Connective tissue growth factor-(CTGF, CCN2)\u2014a marker, mediator and therapeutic target for renal fibrosis. Nephron Exp Nephrol 114:e83\u2013e92","journal-title":"Nephron Exp Nephrol"},{"key":"844_CR42","doi-asserted-by":"crossref","first-page":"F213","DOI":"10.1152\/ajprenal.90421.2008","volume":"296","author":"JW Pippin","year":"2009","unstructured":"Pippin JW, Brinkkoetter PT, Cormack-Aboud FC, Durvasula RV, Hauser PV, Kowalewska J, Krofft RD, Logar CM, Marshall CB, Ohse T, Shankland SJ (2009) Inducible rodent models of acquired podocyte diseases. Am J Physiol Renal Physiol 296:F213\u2013F229","journal-title":"Am J Physiol Renal Physiol"},{"key":"844_CR43","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1002\/art.24620","volume":"60","author":"M Ponticos","year":"2009","unstructured":"Ponticos M, Holmes AM, Shi-Wen X, Leoni P, Khan K, Rajkumar VS, Hoyles RK, Bou-Gharios G, Black CM, Denton CP, Abraham DJ, Leask A, Lindahl GE (2009) Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen. Arthritis Rheum 60:2142\u20132155","journal-title":"Arthritis Rheum"},{"key":"844_CR44","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1111\/j.1523-1755.2005.00723.x","volume":"68","author":"RF Ransom","year":"2005","unstructured":"Ransom RF, Lam NG, Hallett MA, Atkinson SJ, Smoyer WE (2005) Glucocorticoids protect and enhance recovery of cultured murine podocytes via actin filament stabilization. Kidney Int 68:2473\u20132483","journal-title":"Kidney Int"},{"key":"844_CR45","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/ki.2009.297","volume":"76","author":"S Ren","year":"2009","unstructured":"Ren S, Babelova A, Moreth K, Xin C, Eberhardt W, Doller A, Pavenstadt H, Schaefer L, Pfeilschifter J, Huwiler A (2009) Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression. Kidney Int 76:857\u2013867","journal-title":"Kidney Int"},{"key":"844_CR46","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1681\/ASN.V11125","volume":"11","author":"BL Riser","year":"2000","unstructured":"Riser BL, Denichilo M, Cortes P, Baker C, Grondin JM, Yee J, Narins RG (2000) Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis. J Am Soc Nephrol 11:25\u201338","journal-title":"J Am Soc Nephrol"},{"key":"844_CR47","doi-asserted-by":"crossref","first-page":"F1344","DOI":"10.1152\/ajprenal.00174.2005","volume":"290","author":"P Roestenberg","year":"2006","unstructured":"Roestenberg P, van Nieuwenhoven FA, Joles JA, Trischberger C, Martens PP, Oliver N, Aten J, Hoppener JW, Goldschmeding R (2006) Temporal expression profile and distribution pattern indicate a role of connective tissue growth factor (CTGF\/CCN-2) in diabetic nephropathy in mice. Am J Physiol Renal Physiol 290:F1344\u2013F1354","journal-title":"Am J Physiol Renal Physiol"},{"key":"844_CR48","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1681\/ASN.V133630","volume":"13","author":"MA Saleem","year":"2002","unstructured":"Saleem MA, O\u2019Hare MJ, Reiser J, Coward RJ, Inward CD, Farren T, Xing CY, Ni L, Mathieson PW, Mundel P (2002) A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression. J Am Soc Nephrol 13:630\u2013638","journal-title":"J Am Soc Nephrol"},{"key":"844_CR49","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1006\/exmp.2000.2345","volume":"70","author":"V Sanwal","year":"2001","unstructured":"Sanwal V, Pandya M, Bhaskaran M, Franki N, Reddy K, Ding G, Kapasi A, Valderrama E, Singhal PC (2001) Puromycin aminonucleoside induces glomerular epithelial cell apoptosis. Exp Mol Pathol 70:54\u201364","journal-title":"Exp Mol Pathol"},{"key":"844_CR50","first-page":"149","volume":"27","author":"S Sato","year":"2000","unstructured":"Sato S, Nagaoka T, Hasegawa M, Tamatani T, Nakanishi T, Takigawa M, Takehara K (2000) Serum levels of connective tissue growth factor are elevated in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis. J Rheumatol 27:149\u2013154","journal-title":"J Rheumatol"},{"key":"844_CR51","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1006\/excr.2001.5458","volume":"274","author":"C Schild","year":"2002","unstructured":"Schild C, Trueb B (2002) Mechanical stress is required for high-level expression of connective tissue growth factor. Exp Cell Res 274:83\u201391","journal-title":"Exp Cell Res"},{"key":"844_CR52","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bbamcr.2003.12.001","volume":"1691","author":"C Schild","year":"2004","unstructured":"Schild C, Trueb B (2004) Three members of the connective tissue growth factor family CCN are differentially regulated by mechanical stress. Biochim Biophys Acta 1691:33\u201340","journal-title":"Biochim Biophys Acta"},{"key":"844_CR53","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1038\/sj.ki.5000410","volume":"69","author":"SJ Shankland","year":"2006","unstructured":"Shankland SJ (2006) The podocyte\u2019s response to injury: role in proteinuria and glomerulosclerosis. Kidney Int 69:2131\u20132147","journal-title":"Kidney Int"},{"key":"844_CR54","doi-asserted-by":"crossref","first-page":"10715","DOI":"10.1074\/jbc.M511343200","volume":"281","author":"X Shi-wen","year":"2006","unstructured":"Shi-wen X, Stanton LA, Kennedy L, Pala D, Chen Y, Howat SL, Renzoni EA, Carter DE, Bou-Gharios G, Stratton RJ, Pearson JD, Beier F, Lyons KM, Black CM, Abraham DJ, Leask A (2006) CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts. J Biol Chem 281:10715\u201310726","journal-title":"J Biol Chem"},{"key":"844_CR55","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1096\/fj.01-0681com","volume":"16","author":"WE Smoyer","year":"2002","unstructured":"Smoyer WE, Ransom RF (2002) Hsp27 regulates podocyte cytoskeletal changes in an in vitro model of podocyte process retraction. Faseb J 16:315\u2013326","journal-title":"Faseb J"},{"key":"844_CR56","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0891-5849(01)00641-4","volume":"31","author":"T Suzuki","year":"2001","unstructured":"Suzuki T, Takemura H, Noiri E, Nosaka K, Toda A, Taniguchi S, Uchida K, Fujita T, Kimura S, Nakao A (2001) Puromycin aminonucleoside induces apoptosis and increases HNE in cultured glomerular epithelial cells. Free Radic Biol Med 31:615\u2013623","journal-title":"Free Radic Biol Med"},{"key":"844_CR57","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1369\/jhc.2009.953224","volume":"57","author":"T Turk","year":"2009","unstructured":"Turk T, Leeuwis JW, Gray J, Torti SV, Lyons KM, Nguyen TQ, Goldschmeding R (2009) BMP signaling and podocyte markers are decreased in human diabetic nephropathy in association with CTGF overexpression. J Histochem Cytochem 57:623\u2013631","journal-title":"J Histochem Cytochem"},{"key":"844_CR58","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1210\/en.142.5.1760","volume":"142","author":"SM Twigg","year":"2001","unstructured":"Twigg SM, Chen MM, Joly AH, Chakrapani SD, Tsubaki J, Kim HS, Oh Y, Rosenfeld RG (2001) Advanced glycosylation end products up-regulate connective tissue growth factor (insulin-like growth factor-binding protein-related protein 2) in human fibroblasts: a potential mechanism for expansion of extracellular matrix in diabetes mellitus. Endocrinology 142:1760\u20131769","journal-title":"Endocrinology"},{"key":"844_CR59","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.1210\/en.2002-220619","volume":"143","author":"SM Twigg","year":"2002","unstructured":"Twigg SM, Cao Z, MC SV, Burns WC, Brammar G, Forbes JM, Cooper ME (2002) Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine. Endocrinology 143:4907\u20134915","journal-title":"Endocrinology"},{"key":"844_CR60","doi-asserted-by":"crossref","unstructured":"Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3:RESEARCH0034","DOI":"10.1186\/gb-2002-3-7-research0034"},{"key":"844_CR61","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1681\/ASN.2005020142","volume":"16","author":"T Wada","year":"2005","unstructured":"Wada T, Pippin JW, Marshall CB, Griffin SV, Shankland SJ (2005) Dexamethasone prevents podocyte apoptosis induced by puromycin aminonucleoside: role of p53 and Bcl-2-related family proteins. J Am Soc Nephrol 16:2615\u20132625","journal-title":"J Am Soc Nephrol"},{"key":"844_CR62","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1042\/0264-6021:3590089","volume":"359","author":"NA Wahab","year":"2001","unstructured":"Wahab NA, Brinkman H, Mason RM (2001a) Uptake and intracellular transport of the connective tissue growth factor: a potential mode of action. Biochem J 359:89\u201397","journal-title":"Biochem J"},{"key":"844_CR63","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1042\/0264-6021:3590077","volume":"359","author":"NA Wahab","year":"2001","unstructured":"Wahab NA, Yevdokimova N, Weston BS, Roberts T, Li XJ, Brinkman H, Mason RM (2001b) Role of connective tissue growth factor in the pathogenesis of diabetic nephropathy. Biochem J 359:77\u201387","journal-title":"Biochem J"},{"key":"844_CR64","doi-asserted-by":"crossref","first-page":"C1490","DOI":"10.1152\/ajpcell.00049.2009","volume":"297","author":"X Wang","year":"2009","unstructured":"Wang X, McLennan SV, Allen TJ, Tsoutsman T, Semsarian C, Twigg SM (2009) Adverse effects of high glucose and free fatty acid on cardiomyocytes are mediated by connective tissue growth factor. Am J Physiol Cell Physiol 297:C1490\u2013C1500","journal-title":"Am J Physiol Cell Physiol"},{"key":"844_CR65","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1097\/01.ASN.0000051600.53134.B9","volume":"14","author":"BS Weston","year":"2003","unstructured":"Weston BS, Wahab NA, Mason RM (2003) CTGF mediates TGF-beta-induced fibronectin matrix deposition by upregulating active alpha5beta1 integrin in human mesangial cells. J Am Soc Nephrol 14:601\u2013610","journal-title":"J Am Soc Nephrol"},{"key":"844_CR66","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1046\/j.1523-1755.1999.00590.x","volume":"56","author":"G Wolf","year":"1999","unstructured":"Wolf G, Ziyadeh FN (1999) Molecular mechanisms of diabetic renal hypertrophy. Kidney Int 56:393\u2013405","journal-title":"Kidney Int"},{"key":"844_CR67","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.2337\/diabetes.54.6.1626","volume":"54","author":"G Wolf","year":"2005","unstructured":"Wolf G, Chen S, Ziyadeh FN (2005) From the periphery of the glomerular capillary wall toward the center of disease: podocyte injury comes of age in diabetic nephropathy. Diabetes 54:1626\u20131634","journal-title":"Diabetes"},{"key":"844_CR68","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S8756-3282(03)00242-4","volume":"33","author":"M Wong","year":"2003","unstructured":"Wong M, Siegrist M, Goodwin K (2003) Cyclic tensile strain and cyclic hydrostatic pressure differentially regulate expression of hypertrophic markers in primary chondrocytes. Bone 33:685\u2013693","journal-title":"Bone"},{"key":"844_CR69","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1159\/000087015","volume":"211","author":"T Yamamoto","year":"2005","unstructured":"Yamamoto T, Sawada Y, Katayama I, Nishioka K (2005) Nodular scleroderma: increased expression of connective tissue growth factor. Dermatology 211:218\u2013223","journal-title":"Dermatology"},{"key":"844_CR70","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1177\/00220345010800021201","volume":"80","author":"T Yamashiro","year":"2001","unstructured":"Yamashiro T, Fukunaga T, Kobashi N, Kamioka H, Nakanishi T, Takigawa M, Takano-Yamamoto T (2001) Mechanical stimulation induces CTGF expression in rat osteocytes. J Dent Res 80:461\u2013465","journal-title":"J Dent Res"},{"key":"844_CR71","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1210\/jc.83.7.2593","volume":"83","author":"DH Yang","year":"1998","unstructured":"Yang DH, Kim HS, Wilson EM, Rosenfeld RG, Oh Y (1998) Identification of glycosylated 38-kDa connective tissue growth factor (IGFBP-related protein 2) and proteolytic fragments in human biological fluids, and up-regulation of IGFBP-rP2 expression by TGF-beta in Hs578T human breast cancer cells. J Clin Endocrinol Metab 83:2593\u20132596","journal-title":"J Clin Endocrinol Metab"},{"key":"844_CR72","first-page":"899","volume":"136","author":"E Yaoita","year":"1990","unstructured":"Yaoita E, Kawasaki K, Yamamoto T, Kihara I (1990) Variable expression of desmin in rat glomerular epithelial cells. Am J Pathol 136:899\u2013908","journal-title":"Am J Pathol"},{"key":"844_CR73","doi-asserted-by":"crossref","first-page":"F933","DOI":"10.1152\/ajprenal.00122.2001","volume":"282","author":"H Yokoi","year":"2002","unstructured":"Yokoi H, Mukoyama M, Sugawara A, Mori K, Nagae T, Makino H, Suganami T, Yahata K, Fujinaga Y, Tanaka I, Nakao K (2002) Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis. Am J Physiol Renal Physiol 282:F933\u2013F942","journal-title":"Am J Physiol Renal Physiol"},{"key":"844_CR74","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/sj.ki.5002722","volume":"73","author":"H Yokoi","year":"2008","unstructured":"Yokoi H, Mukoyama M, Mori K, Kasahara M, Suganami T, Sawai K, Yoshioka T, Saito Y, Ogawa Y, Kuwabara T, Sugawara A, Nakao K (2008) Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice. Kidney Int 73:446\u2013455","journal-title":"Kidney Int"},{"key":"844_CR75","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00428-005-0134-9","volume":"448","author":"J Zou","year":"2006","unstructured":"Zou J, Yaoita E, Watanabe Y, Yoshida Y, Nameta M, Li H, Qu Z, Yamamoto T (2006) Upregulation of nestin, vimentin, and desmin in rat podocytes in response to injury. Virchows Arch 448:485\u2013492","journal-title":"Virchows Arch"}],"container-title":["Histochemistry and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-011-0844-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00418-011-0844-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-011-0844-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T14:20:33Z","timestamp":1712672433000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00418-011-0844-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,4]]},"references-count":75,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["844"],"URL":"https:\/\/doi.org\/10.1007\/s00418-011-0844-9","relation":{},"ISSN":["0948-6143","1432-119X"],"issn-type":[{"value":"0948-6143","type":"print"},{"value":"1432-119X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,4]]}}}