{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:00:13Z","timestamp":1778274013631,"version":"3.51.4"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2012,2,7]],"date-time":"2012-02-07T00:00:00Z","timestamp":1328572800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Histochem Cell Biol"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1007\/s00418-012-0927-2","type":"journal-article","created":{"date-parts":[[2012,2,6]],"date-time":"2012-02-06T11:29:09Z","timestamp":1328527749000},"page":"589-597","source":"Crossref","is-referenced-by-count":8,"title":["Guanylin and functional coupling proteins in the hepatobiliary system of rat and guinea pig"],"prefix":"10.1007","volume":"137","author":[{"given":"Karen","family":"Schwabe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yalcin","family":"Cetin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,2,7]]},"reference":[{"issue":"1","key":"927_CR1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1203\/PDR.0b013e3181ff61ba","volume":"69","author":"V Buccigrossi","year":"2011","unstructured":"Buccigrossi V, Armellino C, Ruberto E, Barone MV, Marco GD, Esposito C, Guarino A (2011) Polar effects on ion transport and cell proliferation induced by gc-c ligands in intestinal epithelial cells. Pediatr Res 69(1):17\u201322","journal-title":"Pediatr Res"},{"key":"927_CR2","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1073\/pnas.89.7.2912","volume":"89","author":"Y Cetin","year":"1992","unstructured":"Cetin Y, Bargsten G, Grube D (1992) Mutual relationships between chromogranins A and B and gastrin in individual gastrin cells. Proc NatI Acad Sci USA 89:2912\u20132916","journal-title":"Proc NatI Acad Sci USA"},{"key":"927_CR3","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1073\/pnas.90.6.2360","volume":"90","author":"Y Cetin","year":"1993","unstructured":"Cetin Y, Aunis D, Bader MF, Galindo E, J\u00f6rns A, Bargsten G, Grube D (1993) Chromostatin, a chromogranin A-derived bioactive peptide, is present in human pancreatic insulin (beta) cells. Proc NatI Acad Sci USA 90:2360\u20132364","journal-title":"Proc NatI Acad Sci USA"},{"key":"927_CR4","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1073\/pnas.91.8.2935","volume":"91","author":"Y Cetin","year":"1994","unstructured":"Cetin Y, Kuhn M, Kulaksiz H, Adermann K, Bargsten G, Grube D, Forssmann WG (1994) Enterchromaffin cells of the digestive system: celluluar source of guanylin, a guanylate cyclase-activating peptide. Proc NatI Acad Sci USA 91:2935\u20132939","journal-title":"Proc NatI Acad Sci USA"},{"key":"927_CR5","doi-asserted-by":"crossref","first-page":"5929","DOI":"10.1073\/pnas.92.13.5925","volume":"92","author":"Y Cetin","year":"1995","unstructured":"Cetin Y, Kulaksiz H, Redecker P, Bargsten G, Adermann K, Grube D, Forssmann WG (1995) Bronchiolar nonciliated secretory (Clara) cells: source of guanylin in the mammalian lung. Proc NatI Acad Sci USA 92:5929\u201359925","journal-title":"Proc NatI Acad Sci USA"},{"key":"927_CR6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1476-5381.1994.tb13024.x","volume":"122","author":"AW Cuthbert","year":"1994","unstructured":"Cuthbert AW, Hickman ME, MacVinish LJ, Evans MJ, Colledge WH, Ratcliff R, Seale PW, Humphrey PPA (1994) Chloride secretion in response to guanylin in colonic epithelia from normal and transgenic cysic fibrosis mice. Br J Pharmacol 122:31\u201336","journal-title":"Br J Pharmacol"},{"key":"927_CR8","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1152\/jappl.1986.60.2.646","volume":"60","author":"SJ Dodgson","year":"1986","unstructured":"Dodgson SJ, Foster RE 2nd (1986) Carbonic anhydrase: inhibition results in decreased urea production by hepatocytes. J Appl Physiol 60:646\u2013652","journal-title":"J Appl Physiol"},{"issue":"8","key":"927_CR9","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1139\/y11-050","volume":"89","author":"MC Fonteles","year":"2011","unstructured":"Fonteles MC, do Nascimento NR (2011) Guanylin peptide family: history, interactions with ANP, and new pharmacological perspectives. Can J Physiol Pharmacol 89(8):575\u2013585","journal-title":"Can J Physiol Pharmacol"},{"key":"927_CR10","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1172\/JCI116476","volume":"91","author":"LR Forte","year":"1993","unstructured":"Forte LR, Eber SL, Turner JT, Freeman RH, Fok KF, Currie MG (1993) Guanylin stimulation of Cl\u2013secretion in human intestinal T84 cells via cyclic guanosine monophosphate. J Clin Invest 91:2423\u20132428","journal-title":"J Clin Invest"},{"key":"927_CR11","doi-asserted-by":"crossref","first-page":"C267","DOI":"10.1152\/ajpcell.1992.263.2.C267","volume":"263","author":"CM Fuller","year":"1992","unstructured":"Fuller CM, Benos DJ (1992) CFTR! Am J Physiol 263:C267\u2013C286","journal-title":"Am J Physiol"},{"key":"927_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0092-8674(92)90259-F","volume":"71","author":"DL Garbers","year":"1992","unstructured":"Garbers DL (1992) Guanylyl cyclase receptors and their endocrine, paracrine, and autocrine ligands. Cell 71:1\u20134","journal-title":"Cell"},{"key":"927_CR13","first-page":"2","volume":"945","author":"JJ Garcia-Marin","year":"1988","unstructured":"Garcia-Marin JJ, Peez-Barriocanal F, Garcia A, Serrano MA, Requeiro P, Esteller A (1988) Evidence for the presence of carbonic anhydrase in the plasma membrane of the rat hepatocytes. Biochim Biophys Acta 945:2\u201317","journal-title":"Biochim Biophys Acta"},{"key":"927_CR14","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/S0016-5085(96)70018-5","volume":"111","author":"M Guba","year":"1996","unstructured":"Guba M, Kuhn M, Forssmann WG, Classen M, Gregor M, Seidler U (1996) Guanylin strongly stimulates rat duodenal HCO3 \u2212 secretion: proposed mechanism and comparison with other secretagogues. Gastroenterology 111:1558\u20131568","journal-title":"Gastroenterology"},{"key":"927_CR15","doi-asserted-by":"crossref","first-page":"10464","DOI":"10.1073\/pnas.90.22.10464","volume":"90","author":"FK Hamra","year":"1993","unstructured":"Hamra FK, Forte LR, Eber SL, Pidhorodeckyj NV, Krause WJ, Freeman RH, Chin DT, Tompkins JA, Fok KF, Smith CE et al (1993) Uroguanylin: structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase. Proc NatI Acad Sci USA 90:10464\u201310468","journal-title":"Proc NatI Acad Sci USA"},{"key":"927_CR16","first-page":"G708","volume":"270","author":"FK Hamra","year":"1996","unstructured":"Hamra FK, Krause WJ, Eber SL, Freeman RH, Smith CE, Currie MG, Forte LR (1996) Opossum colonic mucosa contains uroguanylin and guanylin peptides. Am J Physio 270:G708\u2013G716","journal-title":"Am J Physio"},{"key":"927_CR17","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1073\/pnas.94.6.2705","volume":"94","author":"FK Hamra","year":"1997","unstructured":"Hamra FK, Eber SL, Chin DT, Currie MG, Forte LR (1997) Regulation of intestinal uroguanylin\/guanylin receptor-mediated responses by mucosal acidity. Proc NatI Acad Sci USA 94:2705\u20132710","journal-title":"Proc NatI Acad Sci USA"},{"key":"927_CR18","doi-asserted-by":"crossref","first-page":"G633","DOI":"10.1152\/ajpcell.1998.274.3.C633","volume":"274","author":"NS Joo","year":"1998","unstructured":"Joo NS, London RM, Kim HD, Forte LR, Clarke LL (1998) Regulation of intestinal Cl\u2212 and HCO3 \u2212 secretion by uroguanylin. Am J Physiol 274:G633\u2013G644","journal-title":"Am J Physiol"},{"key":"927_CR19","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1677\/joe.0.1700267","volume":"170","author":"H Kulaksiz","year":"2001","unstructured":"Kulaksiz H, Cetin Y (2001) Uroguanylin and guanylate cyclase C in the human pancreas: expression and mutuality of ligand\/receptor localization as indicators of intercellular paracrine signaling pathways. J Endocrinol 170:267\u2013275","journal-title":"J Endocrinol"},{"key":"927_CR20","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s004180000244","volume":"115","author":"H Kulaksiz","year":"2001","unstructured":"Kulaksiz H, Rausch U, Vaccaro R, Renda TG, Cetin Y (2001a) Guanylin and uroguanylin in the parotid and submandibular glands: potential intrinsic regulators of electrolyte secretion in salivary glands. Histochem Cell Biol 115:527\u2013533","journal-title":"Histochem Cell Biol"},{"key":"927_CR21","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s004180000244","volume":"115","author":"H Kulaksiz","year":"2001","unstructured":"Kulaksiz H, Schmid A, H\u00f6nscheid M, Eissele R, Klempnauer J, Cetin Y (2001b) Guanylin in the human pancreas: a novel luminocrine regulatory pathway of electrolyte secretion via cGMP and CFTR in the ductal system. Histochem Cell Biol 115:131\u2013145","journal-title":"Histochem Cell Biol"},{"key":"927_CR22","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0002-9440(10)64221-6","volume":"161","author":"H Kulaksiz","year":"2002","unstructured":"Kulaksiz H, Rehberg E, Stremmel W, Cetin Y (2002a) Guanylin and functional coupling proteins in the human salivary glands and gland tumors. Am J Pathol 161:655\u2013664","journal-title":"Am J Pathol"},{"key":"927_CR23","doi-asserted-by":"crossref","first-page":"6796","DOI":"10.1073\/pnas.102171199","volume":"99","author":"H Kulaksiz","year":"2002","unstructured":"Kulaksiz H, Schmid A, H\u00f6nscheid M, Ramaswamy A, Cetin Y (2002b) Clara cell impact in air-side activation of CFTR in small pulmonary airways. Proc NatI Acad Sci USA 99:6796\u20136801","journal-title":"Proc NatI Acad Sci USA"},{"key":"927_CR24","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1053\/j.gastro.2003.11.053","volume":"126","author":"H Kulaksiz","year":"2004","unstructured":"Kulaksiz H, Schlenker T, Rost D, Stiehl A, Volkmann M, Lehnert T, Cetin Y, Stremmel W (2004) Guanylin regulates chloride secretion in the human gallbladder via the bile fluid. Gastroenterology 126:732\u2013740","journal-title":"Gastroenterology"},{"key":"927_CR25","doi-asserted-by":"crossref","first-page":"14670","DOI":"10.1074\/jbc.274.21.14670","volume":"274","author":"MG Lee","year":"1999","unstructured":"Lee MG, Choi JY, Luo X, Strickland E, Thomas PJ, Muallem S (1999a) Cystic fibrosis transmembrane conductance regulator regulates luminal Cl-\/HCO3\u2013exchange in mouse submandibular and pancreatic ducts. J Biol Chem 274:14670\u201314677","journal-title":"J Biol Chem"},{"key":"927_CR26","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1074\/jbc.274.6.3414","volume":"274","author":"MG Lee","year":"1999","unstructured":"Lee MG, WIgley WC, Zeng W, Noel LE, Marino CR, Thomas PJ, Muallem S (1999b) Regulation of Cl-\/HCO3\u2013exchange by cystic fibrosis transmembrane conductance regulator expressed in NIH 3T3 and HEK 293 cells. J Biol Chem 274:3414\u20133421","journal-title":"J Biol Chem"},{"key":"927_CR27","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1006\/bbrc.1993.2285","volume":"196","author":"LG Lewis","year":"1993","unstructured":"Lewis LG, Witte DP, Laney DW, Currie MG, Cohen MB (1993) Guanylin mRNA is expressed in villous enterocytes of the rat small intestine and superficial epithelia of the rat colon. Biochem Biophys Res Commun 196:553\u2013560","journal-title":"Biochem Biophys Res Commun"},{"key":"927_CR28","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1016\/0016-5085(95)90753-X","volume":"109","author":"Z Li","year":"1995","unstructured":"Li Z, Taylor-Blake B, Light AR, Goy MF (1995) Guanylin, an endogenous ligand for C-type guanylate cyclase is produced by goblet cells in the rat intestine. Gastroenterology 109:1863\u20131875","journal-title":"Gastroenterology"},{"key":"927_CR29","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1152\/jappl.1988.65.6.2736","volume":"65","author":"B Lipsen","year":"1988","unstructured":"Lipsen B, Effros RM (1988) CO2 and bicarbonate exchange in the rat liver. J Appl Physiol 65:2736\u20132743","journal-title":"J Appl Physiol"},{"key":"927_CR30","first-page":"G93","volume":"273","author":"RM London","year":"1997","unstructured":"London RM, Krause WJ, Fan X, Eber SL, Forte LR (1997) Signal transduction pathways via guanylin and uroguanylin in stomach and intestine. Am J Physiol 273:G93\u2013G105","journal-title":"Am J Physiol"},{"key":"927_CR31","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0014-5793(96)01235-5","volume":"398","author":"M Miyazato","year":"1996","unstructured":"Miyazato M, Nakazato M, Matsukura S, Kangawa K, Matsuo H (1996) Uroguanylin gene expression in the alimentary tract and extra-gastrointestinal tissues. FEBS Lett 398:170\u2013174","journal-title":"FEBS Lett"},{"key":"927_CR32","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1002\/hep.510240521","volume":"24","author":"S Parkkila","year":"1996","unstructured":"Parkkila S, Parkkila AK, Juvonen T, Waheed A, Sly WS, Saarnio J, Kaunisto K, Kellokumpu S, Rajaniemi H (1996) Membrane-bound carbonic anhydrase IV is expressed in the luminal plasma membrane of the human gallbladder epithelium. Hepatology 24:1104\u20131108","journal-title":"Hepatology"},{"key":"927_CR33","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1126\/science.274.5295.2082","volume":"274","author":"A Pfeiffer","year":"1996","unstructured":"Pfeiffer A, Aszodi A, Seidler U, Ruth P, Hofmann F, F\u00e4ssler R (1996) Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II. Science 274:2082\u20132086","journal-title":"Science"},{"key":"927_CR34","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1152\/physrev.1999.79.1.S3","volume":"79","author":"PM Quinton","year":"1999","unstructured":"Quinton PM (1999) Physiological basis of cystic fibrosis: a historical perspective. Physiol Rev 79:S3\u2013S22","journal-title":"Physiol Rev"},{"key":"927_CR36","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/S0016-5085(98)70592-X","volume":"114","author":"MV St. Pierre","year":"1998","unstructured":"St. Pierre MV, Schlenker T, Dufour JF, Jefferson DM, Fitz JG, Arias IM (1998) Stimulation of cyclic guanosine monophosphate production by natriuretic peptide in human biliary cells. Gastroenterology 114:782\u2013790","journal-title":"Gastroenterology"},{"key":"927_CR37","first-page":"165","volume":"2","author":"D Sterling","year":"2001","unstructured":"Sterling D, Reithmeier RA, Casey JR (2001) Carbonic anhydrase: in the driver\u2019s seat for bicarbonate transport. JOP 2:165\u2013170","journal-title":"JOP"},{"key":"927_CR38","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1023\/A:1014231722696","volume":"230","author":"AB Vaandrager","year":"2002","unstructured":"Vaandrager AB (2002) Structure and function of the heat-stable enterotoxin receptor\/guanylyl cyclase C. Mol Cell Biochem 230:73\u201383","journal-title":"Mol Cell Biochem"},{"key":"927_CR39","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1073\/pnas.95.4.1466","volume":"95","author":"AB Vaandrager","year":"1998","unstructured":"Vaandrager AB, Smolenski A, Tilly BC, Houtsmuller AB, Ehlert EME, Bot AGM, Edixhoven M, Boomaars WEM, Lohmann SM, de Jonge HR (1998) Membrane targeting of cGMP-dependent protein kinase is required for cystic fibrosis transmembrane conductance regulator Cl\u2212 channel activation. Proc NatI Acad Sci USA 95:1466\u20131471","journal-title":"Proc NatI Acad Sci USA"},{"key":"927_CR40","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00429-003-0375-9","volume":"208","author":"R Vaccaro","year":"2004","unstructured":"Vaccaro R, Cetin Y, Renda TG (2004) Ontogeny of guanylin-immunoreactive cells in rat salivary glands. Anat Embryol (Berl) 208:65\u201373","journal-title":"Anat Embryol (Berl)"},{"key":"927_CR41","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1177\/002215549804600410","volume":"46","author":"B Wilhelm","year":"1998","unstructured":"Wilhelm B, Keppler C, Hoffbauer G, Lottspeich F, Linder D, Meinhardt A, Aum\u00fcller G, Seitz J (1998) Cytoplasmic carbonic anhydrase II of rat coagulating gland is secreted via the apocrine export mode. J Histochem Cytochem 46:505\u2013511","journal-title":"J Histochem Cytochem"}],"container-title":["Histochemistry and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-012-0927-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00418-012-0927-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-012-0927-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,23]],"date-time":"2019-06-23T07:14:47Z","timestamp":1561274087000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00418-012-0927-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,7]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["927"],"URL":"https:\/\/doi.org\/10.1007\/s00418-012-0927-2","relation":{},"ISSN":["0948-6143","1432-119X"],"issn-type":[{"value":"0948-6143","type":"print"},{"value":"1432-119X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,7]]}}}