{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:38:50Z","timestamp":1764995930648},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T00:00:00Z","timestamp":1353456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Histochem Cell Biol"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1007\/s00418-012-1054-9","type":"journal-article","created":{"date-parts":[[2012,11,22]],"date-time":"2012-11-22T12:58:23Z","timestamp":1353589103000},"page":"595-603","source":"Crossref","is-referenced-by-count":15,"title":["Placental hCG immunohistochemistry and serum free-Beta-hCG at 11\u201313\u00a0weeks\u2019 gestation in intrauterine fetal demise"],"prefix":"10.1007","volume":"139","author":[{"given":"Ambrogio P.","family":"Londero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Orsaria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Grassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Calcagno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Marzinotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Ceraudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arrigo","family":"Fruscalzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenza","family":"Driul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Mariuzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,11,21]]},"reference":[{"key":"1054_CR1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.preghy.2011.01.005","volume":"1","author":"S Bertozzi","year":"2011","unstructured":"Bertozzi S, Londero AP, Salvador S, Grassi T, Fruscalzo A, Driul L, Marchesoni D (2011) Influence of the couple on hypertensive disorders during pregnancy: a retrospective cohort study. Pregnancy Hypertens Intern J Women\u2019s Cardiovasc Health 1:156\u2013163. doi: 10.1016\/j.preghy.2011.01.005","journal-title":"Pregnancy Hypertens Intern J Women\u2019s Cardiovasc Health"},{"key":"1054_CR2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1477-7827-8-102","volume":"8","author":"LA Cole","year":"2010","unstructured":"Cole LA (2010) Biological functions of hcg and hcg-related molecules. Reprod Biol Endocrinol 8:102. doi: 10.1186\/1477-7827-8-102","journal-title":"Reprod Biol Endocrinol"},{"key":"1054_CR3","first-page":"213","volume":"3","author":"A Fabro Del","year":"2011","unstructured":"Del Fabro A, Driul L, Anis O, Londero AP, Bertozzi S, Bortotto L, Marchesoni D (2011) Fetal gender ratio in recurrent miscarriages. Int J Womens Health 3:213\u2013217. doi: 10.2147\/IJWH.S20557","journal-title":"Int J Womens Health"},{"key":"1054_CR4","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.ajog.2004.06.052","volume":"191","author":"L Dugoff","year":"2004","unstructured":"Dugoff L, Hobbins JC, Malone FD, Porter TF, Luthy D, Comstock CH, Hankins G, Berkowitz RL, Merkatz I, Craigo SD, Timor-Tritsch IE, Carr SR, Wolfe HM, Vidaver J, D\u2019Alton ME (2004) First-trimester maternal serum papp-a and free-beta subunit human chorionic gonadotropin concentrations and nuchal translucency are associated with obstetric complications: a population-based screening study (the faster trial). Am J Obstet Gynecol 191:1446\u20131451. doi: 10.1016\/j.ajog.2004.06.052","journal-title":"Am J Obstet Gynecol"},{"key":"1054_CR5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1471-2393-9-24","volume":"9","author":"V Flenady","year":"2009","unstructured":"Flenady V, Fr\u00f8en JF, Pinar H, Torabi R, Saastad E, Guyon G, Russell L, Charles A, Harrison C, Chauke L, Pattinson R, Koshy R, Bahrin S, Gardener G, Day K, Petersson K, Gordon A, Gilshenan K (2009) An evaluation of classification systems for stillbirth. BMC Pregnancy Childbirth 9:24. doi: 10.1186\/1471-2393-9-24","journal-title":"BMC Pregnancy Childbirth"},{"key":"1054_CR6","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/S0140-6736(10)62233-7","volume":"377","author":"V Flenady","year":"2011","unstructured":"Flenady V, Koopmans L, Middleton P, Fr\u00f8en JF, Smith GC, Gibbons K, Coory M, Gordon A, Ellwood D, McIntyre HD, Fretts R, Ezzati M (2011a) Major risk factors for stillbirth in high-income countries: a systematic review and meta-analysis. Lancet 377:1331\u20131340. doi: 10.1016\/S0140-6736(10)62233-7","journal-title":"Lancet"},{"key":"1054_CR7","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/S0140-6736(11)60064-0","volume":"377","author":"V Flenady","year":"2011","unstructured":"Flenady V, Middleton P, Smith GC, Duke W, Erwich JJ, Khong TY, Neilson J, Ezzati M, Koopmans L, Ellwood D, Fretts R, Fr\u00f8en JF, LSSsc (2011b) Stillbirths: the way forward in high-income countries. Lancet 377:1703\u20131717. doi: 10.1016\/S0140-6736(11)60064-0","journal-title":"Lancet"},{"key":"1054_CR8","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/S0140-6736(10)62232-5","volume":"377","author":"JF Fr\u00f8en","year":"2011","unstructured":"Fr\u00f8en JF, Cacciatore J, McClure EM, Kuti O, Jokhio AH, Islam M, Shiffman J, LSSsc (2011) Stillbirths: why they matter. Lancet 377:1353\u20131366. doi: 10.1016\/S0140-6736(10)62232-5","journal-title":"Lancet"},{"key":"1054_CR9","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/01.AOG.0000129969.78308.4f","volume":"104","author":"L Goetzl","year":"2004","unstructured":"Goetzl L, Krantz D, Simpson JL, Silver RK, Zachary JM, Pergament E, Platt LD, Mahoney MJ, Wapner RJ (2004) Pregnancy-associated plasma protein a, free beta-hcg, nuchal translucency, and risk of pregnancy loss. Obstet Gynecol 104:30\u201336. doi: 10.1097\/01.AOG.0000129969.78308.4f","journal-title":"Obstet Gynecol"},{"key":"1054_CR10","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.1210\/en.2007-0286","volume":"148","author":"K Handschuh","year":"2007","unstructured":"Handschuh K, Guibourdenche J, Tsatsaris V, Guesnon M, Laurendeau I, Evain-Brion D, Fournier T (2007) Human chorionic gonadotropin produced by the invasive trophoblast but not the villous trophoblast promotes cell invasion and is down-regulated by peroxisome proliferator-activated receptor-gamma. Endocrinology 148:5011\u20135019. doi: 10.1210\/en.2007-0286","journal-title":"Endocrinology"},{"key":"1054_CR11","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1210\/jcem-67-6-1322","volume":"67","author":"DL Hay","year":"1988","unstructured":"Hay DL, Lopata A (1988) Chorionic gonadotropin secretion by human embryos in vitro. J Clin Endocrinol Metab 67:1322\u20131324","journal-title":"J Clin Endocrinol Metab"},{"key":"1054_CR12","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1210\/jcem-29-9-1281","volume":"29","author":"RB Jaffe","year":"1969","unstructured":"Jaffe RB, Lee PA, Midgley A Jr (1969) Serum gonadotropins before, at the inception of, and following human pregnancy. J Clin Endocrinol Metab 29:1281\u20131283","journal-title":"J Clin Endocrinol Metab"},{"key":"1054_CR13","first-page":"203","volume":"14","author":"JL Jameson","year":"1993","unstructured":"Jameson JL, Hollenberg AN (1993) Regulation of chorionic gonadotropin gene expression. Endocr Rev 14:203\u2013221","journal-title":"Endocr Rev"},{"key":"1054_CR14","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1677\/joe.0.1720497","volume":"172","author":"G Kovalevskaya","year":"2002","unstructured":"Kovalevskaya G, Birken S, Kakuma T, Ozaki N, Sauer M, Lindheim S, Cohen M, Kelly A, Schlatterer J, O\u2019Connor JF (2002) Differential expression of human chorionic gonadotropin (hcg) glycosylation isoforms in failing and continuing pregnancies: preliminary characterization of the hyperglycosylated hcg epitope. J Endocrinol 172:497\u2013506","journal-title":"J Endocrinol"},{"key":"1054_CR15","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.ajog.2004.05.068","volume":"191","author":"D Krantz","year":"2004","unstructured":"Krantz D, Goetzl L, Simpson JL, Thom E, Zachary J, Hallahan TW, Silver R, Pergament E, Platt LD, Filkins K, Johnson A, Mahoney M, Hogge WA, Wilson RD, Mohide P, Hershey D, Wapner R, FTMSB, Group FNTSBS (2004) Association of extreme first-trimester free human chorionic gonadotropin-beta, pregnancy-associated plasma protein a, and nuchal translucency with intrauterine growth restriction and other adverse pregnancy outcomes. Am J Obstet Gynecol 191:1452\u20131458","journal-title":"Am J Obstet Gynecol"},{"key":"1054_CR16","doi-asserted-by":"crossref","unstructured":"Lawn JE, Lee ACC, Kinney M, Sibley L, Carlo WA, Paul VK, Pattinson R, Darmstadt GL (2009) Two million intrapartum-related stillbirths and neonatal deaths: where, why, and what can be done? Int J Gynaecol Obstet 107 Suppl 1:S5\u2013S18, S19. doi: 10.1016\/j.ijgo.2009.07.016","DOI":"10.1016\/j.ijgo.2009.07.016"},{"key":"1054_CR17","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/S0140-6736(10)62187-3","volume":"377","author":"JE Lawn","year":"2011","unstructured":"Lawn JE, Blencowe H, Pattinson R, Cousens S, Kumar R, Ibiebele I, Gardosi J, Day LT, Stanton C, LSSsc (2011) Stillbirths: where? when? why? how to make the data count? Lancet 377:1448\u20131463. doi: 10.1016\/S0140-6736(10)62187-3","journal-title":"Lancet"},{"key":"1054_CR18","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/(SICI)1097-0223(199802)18:2<147::AID-PD231>3.0.CO;2-W","volume":"18","author":"LP Morssink","year":"1998","unstructured":"Morssink LP, Kornman LH, Hallahan TW, Kloosterman MD, Beekhuis JR, de Wolf BT, Mantingh A (1998) Maternal serum levels of free beta-hcg and papp-a in the first trimester of pregnancy are not associated with subsequent fetal growth retardation or preterm delivery. Prenat Diagn 18:147\u2013152","journal-title":"Prenat Diagn"},{"key":"1054_CR19","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/uog.1860","volume":"25","author":"KH Nicolaides","year":"2005","unstructured":"Nicolaides KH, Spencer K, Avgidou K, Faiola S, Falcon O (2005) Multicenter study of first-trimester screening for trisomy 21 in 75 821 pregnancies: results and estimation of the potential impact of individual risk-orientated two-stage first-trimester screening. Ultrasound Obstet Gynecol 25:221\u2013226. doi: 10.1002\/uog.1860","journal-title":"Ultrasound Obstet Gynecol"},{"key":"1054_CR20","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1111\/j.1471-0528.2000.tb11618.x","volume":"107","author":"CY Ong","year":"2000","unstructured":"Ong CY, Liao AW, Spencer K, Munim S, Nicolaides KH (2000) First trimester maternal serum free beta human chorionic gonadotrophin and pregnancy associated plasma protein a as predictors of pregnancy complications. BJOG 107:1265\u20131270","journal-title":"BJOG"},{"key":"1054_CR21","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/S0140-6736(10)62306-9","volume":"377","author":"R Pattinson","year":"2011","unstructured":"Pattinson R, Kerber K, Buchmann E, Friberg IK, Belizan M, Lansky S, Weissman E, Mathai M, Rudan I, Walker N, Lawn JE, LSSsc (2011) Stillbirths: how can health systems deliver for mothers and babies? Lancet 377:1610\u20131623. doi: 10.1016\/S0140-6736(10)62306-9","journal-title":"Lancet"},{"key":"1054_CR22","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.fertnstert.2007.03.010","volume":"89","author":"Y Sasaki","year":"2008","unstructured":"Sasaki Y, Ladner DG, Cole LA (2008) Hyperglycosylated human chorionic gonadotropin and the source of pregnancy failures. Fertil Steril 89:1781\u20131786. doi: 10.1016\/j.fertnstert.2007.03.010","journal-title":"Fertil Steril"},{"key":"1054_CR23","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1210\/jc.87.4.1762","volume":"87","author":"GCS Smith","year":"2002","unstructured":"Smith GCS, Stenhouse EJ, Crossley JA, Aitken DA, Cameron AD, Connor JM (2002) Early pregnancy levels of pregnancy-associated plasma protein a and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirth. J Clin Endocrinol Metab 87:1762\u20131767","journal-title":"J Clin Endocrinol Metab"},{"key":"1054_CR24","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1001\/jama.292.18.2249","volume":"292","author":"GCS Smith","year":"2004","unstructured":"Smith GCS, Crossley JA, Aitken DA, Pell JP, Cameron AD, Connor JM, Dobbie R (2004) First-trimester placentation and the risk of antepartum stillbirth. JAMA 292:2249\u20132254. doi: 10.1001\/jama.292.18.2249","journal-title":"JAMA"},{"key":"1054_CR25","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/uog.3809","volume":"28","author":"K Spencer","year":"2006","unstructured":"Spencer K, Cowans NJ, Avgidou K, Nicolaides KH (2006) First-trimester ultrasound and biochemical markers of aneuploidy and the prediction of impending fetal death. Ultrasound Obstet Gynecol 28:637\u2013643. doi: 10.1002\/uog.3809","journal-title":"Ultrasound Obstet Gynecol"},{"key":"1054_CR26","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1002\/pd.735","volume":"23","author":"N Tul","year":"2003","unstructured":"Tul N, Pusenjak S, Osredkar J, Spencer K, Novak-Antolic Z (2003) Predicting complications of pregnancy with first-trimester maternal serum free-beta hcg, papp-a and inhibin-a. Prenat Diagn 23:990\u2013996. doi: 10.1002\/pd.735","journal-title":"Prenat Diagn"},{"key":"1054_CR27","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/pd.2610","volume":"31","author":"R Ravenswaaij van","year":"2011","unstructured":"van Ravenswaaij R, van der Goot MT, de Wolf S, van Leeuwen-Spruijt M, Visser GHA, Schielen PCJI (2011) First-trimester serum papp-a and fbeta-hcg concentrations and other maternal characteristics to establish logistic regression-based predictive rules for adverse pregnancy outcome. Prenat Diagn 31:50\u201357. doi: 10.1002\/pd.2610","journal-title":"Prenat Diagn"},{"issue":"Suppl","key":"1054_CR28","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1016\/j.placenta.2011.11.003","volume":"33","author":"MS Weedon-Fekj\u00e6r","year":"2012","unstructured":"Weedon-Fekj\u00e6r MS, Task\u00e9n K (2012) Review: spatiotemporal dynamics of hcg\/camp signaling and regulation of placental function. Placenta 33(Suppl):S87\u2013S91. doi: 10.1016\/j.placenta.2011.11.003","journal-title":"Placenta"},{"key":"1054_CR29","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1210\/en.2002-220922","volume":"144","author":"M Yang","year":"2003","unstructured":"Yang M, Lei ZM, Rao CV (2003) The central role of human chorionic gonadotropin in the formation of human placental syncytium. Endocrinology 144:1108\u20131120","journal-title":"Endocrinology"}],"container-title":["Histochemistry and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-012-1054-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00418-012-1054-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-012-1054-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T15:48:53Z","timestamp":1559058533000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00418-012-1054-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,21]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["1054"],"URL":"https:\/\/doi.org\/10.1007\/s00418-012-1054-9","relation":{},"ISSN":["0948-6143","1432-119X"],"issn-type":[{"value":"0948-6143","type":"print"},{"value":"1432-119X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,21]]}}}