{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:30:07Z","timestamp":1780090207612,"version":"3.54.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T00:00:00Z","timestamp":1410912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Histochem Cell Biol"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1007\/s00418-014-1271-5","type":"journal-article","created":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T21:19:16Z","timestamp":1414185556000},"page":"185-194","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The monocarboxylate transporters exist in the cattle endocrine pancreas"],"prefix":"10.1007","volume":"143","author":[{"given":"Doaa","family":"Kirat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiyu","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,9,17]]},"reference":[{"key":"1271_CR1","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1071\/BI9721277","volume":"25","author":"JM Bassett","year":"1972","unstructured":"Bassett JM (1972) Plasma glucagon concentrations in sheep: their regulation and relation to concentrations of insulin and growth hormone. Aust J Biol Sci 25:1277\u20131287","journal-title":"Aust J Biol Sci"},{"key":"1271_CR2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1071\/BI9740157","volume":"27","author":"JM Bassett","year":"1974","unstructured":"Bassett JM (1974) Early changes in plasma insulin and growth hormone levels after feeding in lambs and adult sheep. Aust J Biol Sci 27:157\u2013166","journal-title":"Aust J Biol Sci"},{"key":"1271_CR3","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1152\/physrev.1990.70.2.567","volume":"70","author":"EN Bergman","year":"1990","unstructured":"Bergman EN (1990) Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Physiol Rev 70:567\u2013590","journal-title":"Physiol Rev"},{"key":"1271_CR4","first-page":"55","volume":"19","author":"RP Brockman","year":"1978","unstructured":"Brockman RP (1978) Roles of glucagon and insulin in the regulation of metabolism in ruminants. A Rev Can Vet J 19:55\u201362","journal-title":"A Rev Can Vet J"},{"key":"1271_CR5","doi-asserted-by":"crossref","first-page":"11312","DOI":"10.1074\/jbc.M211609200","volume":"278","author":"AJ Brown","year":"2003","unstructured":"Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D, Muir AI, Wigglesworth MJ, Kinghorn I, Fraser NJ, Pike NB, Strum JC, Steplewski KM, Murdock PR, Holder JC, Marshall FH, Szekeres PG, Wilson S, Ignar DM, Foord SM, Wise A, Dowell SJ (2003) The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem 278:11312\u201311319","journal-title":"J Biol Chem"},{"key":"1271_CR6","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/jn\/122.1.191","volume":"122","author":"WJ Croom Jr","year":"1992","unstructured":"Croom WJ Jr, Bull LS, Taylor IL (1992) Regulation of pancreatic exocrine secretion in ruminants: a review. J Nutr 122:191\u2013202","journal-title":"J Nutr"},{"key":"1271_CR7","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1113\/jphysiol.2001.014241","volume":"539","author":"MA Cuff","year":"2002","unstructured":"Cuff MA, Lambert DW, Shirazi-Beechey SP (2002) Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1. J Physiol 539:361\u2013371","journal-title":"J Physiol"},{"key":"1271_CR8","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1677\/joe.0.0920357","volume":"92","author":"A Jong De","year":"1982","unstructured":"De Jong A (1982) Patterns of plasma concentrations of insulin and glucagon after intravascular and intraruminal administration of volatile fatty acids in the goat. J Endocrinol 92:357\u2013370","journal-title":"J Endocrinol"},{"key":"1271_CR9","doi-asserted-by":"crossref","first-page":"16245","DOI":"10.1073\/pnas.0504419102","volume":"102","author":"AA Deora","year":"2005","unstructured":"Deora AA, Philp N, Hu J, Bok D, Rodriguez-Boulan E (2005) Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia. Proc Natl Acad Sci USA 102:16245\u201316250","journal-title":"Proc Natl Acad Sci USA"},{"key":"1271_CR10","doi-asserted-by":"crossref","first-page":"C846","DOI":"10.1152\/ajpcell.00112.2005","volume":"289","author":"RK Gill","year":"2005","unstructured":"Gill RK, Saksena S, Sarwar Z, Alrefai WA, Goldstein JL, Carroll RE, Ramaswamy K, Dudeja PK (2005) Expression and membrane localization of MCT isoforms along the length of the human intestine. Am J Physiol Cell Physiol 289:C846\u2013C852","journal-title":"Am J Physiol Cell Physiol"},{"key":"1271_CR11","doi-asserted-by":"crossref","first-page":"G775","DOI":"10.1152\/ajpgi.2000.279.4.G775","volume":"279","author":"C Hadjiagapiou","year":"2000","unstructured":"Hadjiagapiou C, Schmidt L, Dudeja PK, Layden TJ, Ramaswamy K (2000) Mechanism(s) of butyrate transport in Caco-2 cells: role of monocarboxylate transporter1. Am J Physiol Gastro intest Liver Physiol 279:G775\u2013G780","journal-title":"Am J Physiol Gastro intest Liver Physiol"},{"issue":"1","key":"1271_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/iub.573","volume":"64","author":"AP Halestrap","year":"2012","unstructured":"Halestrap AP (2012) The monocarboxylate transporter family\u2013Structure and functional characterization. IUBMB Life 64(1):1\u20139","journal-title":"IUBMB Life"},{"key":"1271_CR13","first-page":"284","volume":"244","author":"E Harada","year":"1983","unstructured":"Harada E, Kato S (1983) Effect of short-chain fatty acids on the secretory response of the ovine exocrine pancreas. Am J Physiol 244:284\u2013290","journal-title":"Am J Physiol"},{"key":"1271_CR14","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.2527\/1992.7041290x","volume":"70","author":"DL Harmon","year":"1992","unstructured":"Harmon DL (1992) Impact of nutrition on pancreatic exocrine and endocrine secretion in ruminants: a review. J Anim Sci 70:1290\u20131301","journal-title":"J Anim Sci"},{"key":"1271_CR15","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1124\/dmd.107.014902","volume":"35","author":"C Hilgendorf","year":"2007","unstructured":"Hilgendorf C, Ahlin G, Seithel A, Artursson P, Ungell AL, Karlsson J (2007) Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines. Drug Metab Dispos 35:1333\u20131340","journal-title":"Drug Metab Dispos"},{"key":"1271_CR16","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1113\/jphysiol.2006.115931","volume":"576","author":"D Kirat","year":"2006","unstructured":"Kirat D, Masuoka J, Hayashi H, Iwano H, Yokota H, Taniyama H, Kato S (2006) Monocarboxylate transporter 1 (MCT1) plays a direct role in short-chain fatty acids absorption in caprine rumen. J Physiol 576:635\u2013647","journal-title":"J Physiol"},{"key":"1271_CR17","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.gene.2006.12.020","volume":"391","author":"D Kirat","year":"2007","unstructured":"Kirat D, Matsuda Y, Yamashiki N, Hayashi H, Kato S (2007) Expression, cellular localization, and functional role of monocarboxylate transporter 4 (MCT4) in the gastrointestinal tract of ruminants. Gene 391:140\u2013149","journal-title":"Gene"},{"key":"1271_CR18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.mce.2008.09.040","volume":"298","author":"D Kirat","year":"2009","unstructured":"Kirat D, Sallam K, Hayashi H, Miyasho T, Kato S (2009) Presence of ten isoforms of monocarboxylate transporter (MCT) family in the bovine adrenal gland. Mol Cell Endocrinol 298:89\u2013100","journal-title":"Mol Cell Endocrinol"},{"key":"1271_CR19","author":"D Kirat","year":"2013","unstructured":"Kirat D, Sallam KI, Kato S (2013) Expression and cellular localization of monocarboxylate transporters (MCT2, MCT7, and MCT8) along the cattle gastrointestinal tract. Cell Tissue Res. doi: 10.1007\/s00441-013-1570-5","journal-title":"Cell Tissue Res"},{"key":"1271_CR20","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1093\/emboj\/19.15.3896","volume":"19","author":"P Kirk","year":"2000","unstructured":"Kirk P, Wilson MC, Heddle C, Brown MH, Barclay AN, Halestrap AP (2000) CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. EMBO J 19:3896\u20133904","journal-title":"EMBO J"},{"key":"1271_CR21","doi-asserted-by":"crossref","first-page":"25481","DOI":"10.1074\/jbc.M301403200","volume":"278","author":"E Poul Le","year":"2003","unstructured":"Le Poul E, Loison C, Struyf S, Springael JY, Lannoy V, Decobecq ME, Brezillon S, Dupriez V, Vassart G, Van Damme J, Parmentier M, Detheux M (2003) Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem 278:25481\u201325489","journal-title":"J Biol Chem"},{"key":"1271_CR22","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1152\/ajplegacy.1967.212.4.747","volume":"212","author":"JG Manns","year":"1967","unstructured":"Manns JG, Boda JM (1967) Insulin release by acetate, propionate, butyrate, and glucose in lambs and adult sheep. Am J Physiol 212:747\u2013755","journal-title":"Am J Physiol"},{"key":"1271_CR23","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1152\/ajplegacy.1967.212.4.756","volume":"212","author":"JG Manns","year":"1967","unstructured":"Manns JG, Boda JM, Willes RF (1967) Probable role of propionate and butyrate in control of insulin secretion in sheep. Am J Physiol 212:756\u2013764","journal-title":"Am J Physiol"},{"key":"1271_CR24","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0300-9629(90)90241-J","volume":"95","author":"H Mineo","year":"1990","unstructured":"Mineo H, Kanai M, Kato S, Ushijima JI (1990) Effects of intravenous injection of butyrate, valerate and their isomers on endocrine pancreatic responses in conscious sheep (Ovisaries). Comp Biochem Physiol A 95:411\u2013416","journal-title":"Comp Biochem Physiol A"},{"key":"1271_CR25","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S0006-291X(03)00488-1","volume":"303","author":"NE Nilsson","year":"2003","unstructured":"Nilsson NE, Kotarsky K, Owman C, Olde B (2003) Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. Biochem Biophys Res Commun 303:1047\u20131052","journal-title":"Biochem Biophys Res Commun"},{"key":"1271_CR26","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1086\/520960","volume":"81","author":"T Otonkoski","year":"2007","unstructured":"Otonkoski T, Jiao H, Kaminen-Ahola N, Tapia-Paez I, Ullah MS, Parton LE, Schuit F, Quintens R, Sipil\u00e4 I, Mayatepek E, Meissner T, Halestrap AP, Rutter GA, Kere J (2007) Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells. Am J Hum Genet 81:467\u2013474","journal-title":"Am J Hum Genet"},{"key":"1271_CR27","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1007\/s11064-012-0847-5","volume":"37","author":"C Rae","year":"2012","unstructured":"Rae C, Fekete AD, Kashem MA, Nasrallah FA, Br\u00f6er S (2012) Metabolism, compartmentation, transport and production of acetate in the cortical brain tissue slice. Neurochem Res 37:2541\u20132553","journal-title":"Neurochem Res"},{"key":"1271_CR28","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1469-7793.1998.719ba.x","volume":"513","author":"A Ritzhaupt","year":"1998","unstructured":"Ritzhaupt A, Wood IS, Ellis A, Hosie KB, Shirazi-Beechey SP (1998) Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport L-lactate as well as butyrate. J Physiol 513:719\u2013732","journal-title":"J Physiol"},{"key":"1271_CR29","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1093\/jn\/103.4.488","volume":"103","author":"JP Ross","year":"1973","unstructured":"Ross JP, Kitts WD (1973) Relationship between postprandial plasma volatile fatty acids, glucose and insulin levels in sheep fed different feeds. J Nutr 103:488\u2013493","journal-title":"J Nutr"},{"key":"1271_CR30","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.2527\/1995.73103038x","volume":"73","author":"H Sano","year":"1995","unstructured":"Sano H, Tano S, Takahashi H, Terashima Y (1995) Dose response of plasma insulin and glucagon to intravenous n-butyrate infusion in sheep. J Anim Sci 73:3038\u20133043","journal-title":"J Anim Sci"},{"key":"1271_CR31","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1053\/j.gastro.2010.01.053","volume":"138","author":"R Soret","year":"2010","unstructured":"Soret R, Chevalier J, De Coppet P, Poupeau G, Derkinderen P, Segain JP, Neunlist M (2010) Short-chain fatty acids regulate the enteric neurons and control gastrointestinal motility in rats. Gastroenterology 138:1772\u20131782","journal-title":"Gastroenterology"},{"key":"1271_CR32","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1211\/0022357991776804","volume":"51","author":"I Tamai","year":"1999","unstructured":"Tamai I, Sai Y, Ono A, Kido Y, Yabuchi H, Takanaga H, Satoh E, Ogihara T, Amano O, Izeki S, Tsuji A (1999) Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1. J Pharm Pharmacol 51:1113\u20131121","journal-title":"J Pharm Pharmacol"},{"key":"1271_CR33","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.3168\/jds.2009-2037","volume":"92","author":"A Wang","year":"2009","unstructured":"Wang A, GuZ HeidB, Akers RM, Jiang H (2009) Identification and characterization of the bovine G protein-coupled receptor GPR41 and GPR43 genes. J Dairy Sci 92:2696\u20132705","journal-title":"J Dairy Sci"},{"key":"1271_CR34","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.3168\/jds.2011-4886","volume":"95","author":"A Wang","year":"2012","unstructured":"Wang A, Akers RM, Jiang H (2012) Short communication: presence of G protein-coupled receptor 43 in rumen epithelium but not in the islets of Langerhans in cattle. J Dairy Sci 95:1371\u20131375","journal-title":"J Dairy Sci"},{"key":"1271_CR35","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2337\/diabetes.50.2.361","volume":"50","author":"C Zhao","year":"2001","unstructured":"Zhao C, Wilson MC, Schuit F, Halestrap AP, Rutter GA (2001) Expression and distribution of lactate\/monocarboxylate transporter isoforms in pancreatic islets and the exocrine pancreas. Diabetes 50:361\u2013366","journal-title":"Diabetes"}],"container-title":["Histochemistry and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-014-1271-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00418-014-1271-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-014-1271-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T12:36:39Z","timestamp":1565958999000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00418-014-1271-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,17]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["1271"],"URL":"https:\/\/doi.org\/10.1007\/s00418-014-1271-5","relation":{},"ISSN":["0948-6143","1432-119X"],"issn-type":[{"value":"0948-6143","type":"print"},{"value":"1432-119X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,17]]}}}