{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:10:23Z","timestamp":1789067423240,"version":"build-2803163510"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,11,23]],"date-time":"2014-11-23T00:00:00Z","timestamp":1416700800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Histochem Cell Biol"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1007\/s00418-014-1296-9","type":"journal-article","created":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T17:25:14Z","timestamp":1417541114000},"page":"517-529","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Conditioned deletion of ephrinB1 and\/or ephrinB2 in either thymocytes or thymic epithelial cells alters the organization of thymic medulla and favors the appearance of thymic epithelial cysts"],"prefix":"10.1007","volume":"143","author":[{"given":"Teresa","family":"Cejalvo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"Munoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Tobajas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Alfaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Garc\u00eda-Ceca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn","family":"Zapata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,11,23]]},"reference":[{"key":"1296_CR1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.immuni.2008.06.015","volume":"29","author":"T Akiyama","year":"2008","unstructured":"Akiyama T, Shimo Y, Yanai H, Qin J, Ohshima D, Maruyama Y, Asaumi Y, Kitazawa J, Takayanagi H, Penninger JM, Matsumoto M, Nitta T, Takahama Y, Inoue J (2008) The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity 29:423\u2013437","journal-title":"Immunity"},{"key":"1296_CR2","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3389\/fimmu.2012.00278","volume":"3","author":"T Akiyama","year":"2012","unstructured":"Akiyama T, Shinzawa M, Akiyama N (2012) TNF receptor family signaling in the development and functions of medullary thymic epithelial cells. Front Immunol 3:278","journal-title":"Front Immunol"},{"key":"1296_CR3","doi-asserted-by":"crossref","unstructured":"Alfaro D, Munoz JJ, Garcia-Ceca J, Cejalvo T, Jimenez E, Zapata AG (2011) The Eph\/ephrinB signal balance determines the pattern of T-cell maturation in the thymus. Immunol Cell Biol 89:844\u2013852","DOI":"10.1038\/icb.2010.172"},{"key":"1296_CR4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/eji.201344110","volume":"44","author":"NL Alves","year":"2014","unstructured":"Alves NL, Takahama Y, Ohigashi I, Ribeiro AR, Baik S, Anderson G, Jenkinson WE (2014) Serial progression of cortical and medullary thymic epithelial microenvironments. Eur J Immunol 44:16\u201322","journal-title":"Eur J Immunol"},{"key":"1296_CR5","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.it.2012.03.005","volume":"33","author":"G Anderson","year":"2012","unstructured":"Anderson G, Takahama Y (2012) Thymic epithelial cells: working class heroes for T cell development and repertoire selection. Trends Immunol 33:256\u2013263","journal-title":"Trends Immunol"},{"key":"1296_CR6","first-page":"19","volume":"373","author":"G Anderson","year":"2014","unstructured":"Anderson G, Baik S, Cowan JE, Holland AM, McCarthy NI, Nakamura K, Parnell SM, White AJ, Lane PJ, Jenkinson EJ, Jenkinson WE (2014) Mechanisms of thymus medulla development and function. Curr Top Microbiol Immunol 373:19\u201347","journal-title":"Curr Top Microbiol Immunol"},{"key":"1296_CR7","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/eji.201243209","volume":"43","author":"S Baik","year":"2013","unstructured":"Baik S, Jenkinson EJ, Lane PJ, Anderson G, Jenkinson WE (2013) Generation of both cortical and Aire(+) medullary thymic epithelial compartments from CD205(+) progenitors. Eur J Immunol 43:589\u2013594","journal-title":"Eur J Immunol"},{"key":"1296_CR8","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.1002\/eji.200425248","volume":"34","author":"C Benz","year":"2004","unstructured":"Benz C, Heinzel K, Bleul CC (2004) Homing of immature thymocytes to the subcapsular microenvironment within the thymus is not an absolute requirement for T cell development. Eur J Immunol 34:3652\u20133663","journal-title":"Eur J Immunol"},{"key":"1296_CR9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cell.2012.01.049","volume":"149","author":"L Calderon","year":"2012","unstructured":"Calderon L, Boehm T (2012) Synergistic, context-dependent, and hierarchical functions of epithelial components in thymic microenvironments. Cell 149:159\u2013172","journal-title":"Cell"},{"key":"1296_CR10","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.4049\/jimmunol.1201931","volume":"190","author":"T Cejalvo","year":"2013","unstructured":"Cejalvo T, Munoz JJ, Tobajas E, Fanlo L, Alfaro D, Garcia-Ceca J, Zapata A (2013) Ephrin-B-dependent thymic epithelial cell-thymocyte interactions are necessary for correct T cell differentiation and thymus histology organization: relevance for thymic cortex development. J Immunol 190:2670\u20132681","journal-title":"J Immunol"},{"key":"1296_CR11","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1084\/jem.20112061","volume":"210","author":"JM Coquet","year":"2013","unstructured":"Coquet JM, Ribot JC, Babala N, Middendorp S, van der Horst G, Xiao Y, Neves JF, Fonseca-Pereira D, Jacobs H, Pennington DJ, Silva-Santos B, Borst J (2013) Epithelial and dendritic cells in the thymic medulla promote CD4\u00a0+\u00a0Foxp3\u00a0+\u00a0regulatory T cell development via the CD27-CD70 pathway. J Exp Med 210:715\u2013728","journal-title":"J Exp Med"},{"key":"1296_CR12","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1101\/gad.1171704","volume":"18","author":"A Davy","year":"2004","unstructured":"Davy A, Aubin J, Soriano P (2004) Ephrin-B1 forward and reverse signaling are required during mouse development. Genes Dev 18:572\u2013583","journal-title":"Genes Dev"},{"key":"1296_CR13","doi-asserted-by":"crossref","first-page":"5519","DOI":"10.4049\/jimmunol.1201815","volume":"189","author":"GE Desanti","year":"2012","unstructured":"Desanti GE, Cowan JE, Baik S, Parnell SM, White AJ, Penninger JM, Lane PJ, Jenkinson EJ, Jenkinson WE, Anderson G (2012) Developmentally regulated availability of RANKL and CD40 ligand reveals distinct mechanisms of fetal and adult cross-talk in the thymus medulla. J Immunol 189:5519\u20135526","journal-title":"J Immunol"},{"key":"1296_CR14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1034\/j.1600-065X.2002.18903.x","volume":"189","author":"AG Farr","year":"2002","unstructured":"Farr AG, Dooley JL, Erickson M (2002) Organization of thymic medullary epithelial heterogeneity: implications for mechanisms of epithelial differentiation. Immunol Rev 189:20\u201327","journal-title":"Immunol Rev"},{"key":"1296_CR15","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1365-2818.2005.01466.x","volume":"218","author":"JC Fiala","year":"2005","unstructured":"Fiala JC (2005) Reconstruct: a free editor for serial section microscopy. J Microsc 218:52\u201361","journal-title":"J Microsc"},{"key":"1296_CR16","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1387\/ijdb.082702jg","volume":"53","author":"J Garcia-Ceca","year":"2009","unstructured":"Garcia-Ceca J, Jimenez E, Alfaro D, Cejalvo T, Chumley MJ, Henkemeyer M, Munoz JJ, Zapata AG (2009a) On the role of Eph signalling in thymus histogenesis; EphB2\/B3 and the organizing of the thymic epithelial network. Int J Dev Biol 53:971\u2013982","journal-title":"Int J Dev Biol"},{"key":"1296_CR17","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1002\/eji.200939437","volume":"39","author":"J Garcia-Ceca","year":"2009","unstructured":"Garcia-Ceca J, Jimenez E, Alfaro D, Cejalvo T, Munoz JJ, Zapata AG (2009b) Cell-autonomous role of EphB2 and EphB3 receptors in the thymic epithelial cell organization. Eur J Immunol 39:2916\u20132924","journal-title":"Eur J Immunol"},{"key":"1296_CR18","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1177\/002215540305100913","volume":"51","author":"WT Germeraad","year":"2003","unstructured":"Germeraad WT, Kawamoto H, Itoi M, Jiang Y, Amagai T, Katsura Y, van Ewijk W (2003) Development of thymic microenvironments in vitro is oxygen-dependent and requires permanent presence of T-cell progenitors. J Histochem Cytochem 51:1225\u20131235","journal-title":"J Histochem Cytochem"},{"key":"1296_CR19","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1182\/blood-2006-02-004531","volume":"108","author":"DH Gray","year":"2006","unstructured":"Gray DH, Seach N, Ueno T, Milton MK, Liston A, Lew AM, Goodnow CC, Boyd RL (2006) Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood 108:3777\u20133785","journal-title":"Blood"},{"issue":"3","key":"1296_CR20","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00109-010-0700-8","volume":"89","author":"J Guo","year":"2011","unstructured":"Guo J, Rahman M, Cheng L, Zhang S, Tvinnereim A, Su DM (2011) Morphogenesis and maintenance of the 3D thymic medulla and prevention of nude skin phenotype require FoxN1 in pre- and post-natal K14 epithelium. J Mol Med 89(3):263\u2013277","journal-title":"J Mol Med"},{"key":"1296_CR21","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/ni1438","volume":"8","author":"Y Hamazaki","year":"2007","unstructured":"Hamazaki Y, Fujita H, Kobayashi T, Choi Y, Scott HS, Matsumoto M, Minato N (2007) Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin. Nat Immunol 8:304\u2013311","journal-title":"Nat Immunol"},{"key":"1296_CR22","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.immuni.2008.06.018","volume":"29","author":"Y Hikosaka","year":"2008","unstructured":"Hikosaka Y, Nitta T, Ohigashi I, Yano K, Ishimaru N, Hayashi Y, Matsumoto M, Matsuo K, Penninger JM, Takayanagi H, Yokota Y, Yamada H, Yoshikai Y, Inoue J, Akiyama T, Takahama Y (2008) The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity 29:438\u2013450","journal-title":"Immunity"},{"key":"1296_CR23","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.immuni.2008.08.007","volume":"29","author":"M Irla","year":"2008","unstructured":"Irla M, Hugues S, Gill J, Nitta T, Hikosaka Y, Williams IR, Hubert FX, Scott HS, Takahama Y, Hollander GA, Reith W (2008) Autoantigen-specific interactions with CD4\u00a0+\u00a0thymocytes control mature medullary thymic epithelial cell cellularity. Immunity 29:451\u2013463","journal-title":"Immunity"},{"key":"1296_CR24","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1471-2172-12-68","volume":"12","author":"W Jin","year":"2011","unstructured":"Jin W, Qi S, Luo H (2011) The effect of conditional EFNB1 deletion in the T cell compartment on T cell development and function. BMC Immunol 12:68","journal-title":"BMC Immunol"},{"key":"1296_CR25","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.molimm.2012.05.008","volume":"52","author":"W Jin","year":"2012","unstructured":"Jin W, Qi S, Luo H (2012) T cell-specific deletion of EFNB2 minimally affects T cell development and function. Mol Immunol 52:141\u2013147","journal-title":"Mol Immunol"},{"key":"1296_CR26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molimm.2013.10.008","volume":"58","author":"W Jin","year":"2014","unstructured":"Jin W, Luo H, Wu J (2014) Effect of reduced EPHB4 expression in thymic epithelial cells on thymocyte development and peripheral T cell function. Mol Immunol 58:1\u20139","journal-title":"Mol Immunol"},{"key":"1296_CR27","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.4049\/jimmunol.169.6.2842","volume":"169","author":"DB Klug","year":"2002","unstructured":"Klug DB, Carter C, Gimenez-Conti IB, Richie ER (2002) Cutting edge: thymocyte-independent and thymocyte-dependent phases of epithelial patterning in the fetal thymus. J Immunol 169:2842\u20132845","journal-title":"J Immunol"},{"key":"1296_CR28","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1172\/JCI21846","volume":"114","author":"H Luo","year":"2004","unstructured":"Luo H, Yu G, Tremblay J, Wu J (2004) EphB6-null mutation results in compromised T cell function. J Clin Invest 114:1762\u20131773","journal-title":"J Clin Invest"},{"key":"1296_CR29","doi-asserted-by":"crossref","first-page":"44976","DOI":"10.1074\/jbc.M111.316414","volume":"286","author":"H Luo","year":"2011","unstructured":"Luo H, Wu Z, Qi S, Jin W, Han B, Wu J (2011) Ephrinb1 and Ephrinb2 are associated with interleukin-7 receptor alpha and retard its internalization from the cell surface. J Biol Chem 286:44976\u201344987","journal-title":"J Biol Chem"},{"key":"1296_CR30","doi-asserted-by":"crossref","first-page":"804","DOI":"10.4049\/jimmunol.177.2.804","volume":"177","author":"JJ Munoz","year":"2006","unstructured":"Munoz JJ, Alfaro D, Garcia-Ceca J, Alonso CL, Jimenez E, Zapata A (2006) Thymic alterations in EphA4-deficient mice. J Immunol 177:804\u2013813","journal-title":"J Immunol"},{"key":"1296_CR31","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1159\/000329490","volume":"18","author":"JJ Munoz","year":"2011","unstructured":"Munoz JJ, Cejalvo T, Alonso-Colmenar LM, Alfaro D, Garcia-Ceca J, Zapata A (2011) Eph\/Ephrin-mediated interactions in the thymus. Neuroimmunomodulation 18:271\u2013280","journal-title":"Neuroimmunomodulation"},{"key":"1296_CR32","doi-asserted-by":"crossref","first-page":"9885","DOI":"10.1073\/pnas.1301799110","volume":"110","author":"I Ohigashi","year":"2013","unstructured":"Ohigashi I, Zuklys S, Sakata M, Mayer CE, Zhanybekova S, Murata S, Tanaka K, Hollander GA, Takahama Y (2013) Aire-expressing thymic medullary epithelial cells originate from beta5t-expressing progenitor cells. Proc Natl Acad Sci USA 110:9885\u20139890","journal-title":"Proc Natl Acad Sci USA"},{"key":"1296_CR33","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/17402520600935097","volume":"13","author":"M Osada","year":"2006","unstructured":"Osada M, Ito E, Fermin HA, Vazquez-Cintron E, Venkatesh T, Friedel RH, Pezzano M (2006) The Wnt signaling antagonist Kremen1 is required for development of thymic architecture. Clin Dev Immunol 13:299\u2013319","journal-title":"Clin Dev Immunol"},{"key":"1296_CR34","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1155\/1993\/56290","volume":"3","author":"DB Palmer","year":"1993","unstructured":"Palmer DB, Viney JL, Ritter MA, Hayday AC, Owen MJ (1993) Expression of the alpha beta T-cell receptor is necessary for the generation of the thymic medulla. Dev Immunol 3:175\u2013179","journal-title":"Dev Immunol"},{"key":"1296_CR35","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/nrm1662","volume":"6","author":"EB Pasquale","year":"2005","unstructured":"Pasquale EB (2005) Eph receptor signalling casts a wide net on cell behaviour. Nat Rev Mol Cell Biol 6:462\u2013475","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1296_CR36","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.devcel.2004.09.006","volume":"7","author":"A Poliakov","year":"2004","unstructured":"Poliakov A, Cotrina M, Wilkinson DG (2004) Diverse roles of eph receptors and ephrins in the regulation of cell migration and tissue assembly. Dev Cell 7:465\u2013480","journal-title":"Dev Cell"},{"key":"1296_CR37","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.4049\/jimmunol.167.4.1954","volume":"167","author":"JM Revest","year":"2001","unstructured":"Revest JM, Suniara RK, Kerr K, Owen JJ, Dickson C (2001) Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIb. J Immunol 167:1954\u20131961","journal-title":"J Immunol"},{"key":"1296_CR38","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.4049\/jimmunol.1203042","volume":"191","author":"AR Ribeiro","year":"2014","unstructured":"Ribeiro AR, Rodrigues PM, Meireles C, Di Santo JP, Alves NL (2014) Thymocyte selection regulates the homeostasis of IL-7-expressing thymic cortical epithelial cells in vivo. J Immunol 191:1200\u20131209","journal-title":"J Immunol"},{"key":"1296_CR39","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1002\/eji.200737275","volume":"37","author":"SW Rossi","year":"2007","unstructured":"Rossi SW, Chidgey AP, Parnell SM, Jenkinson WE, Scott HS, Boyd RL, Jenkinson EJ, Anderson G (2007) Redefining epithelial progenitor potential in the developing thymus. Eur J Immunol 37:2411\u20132418","journal-title":"Eur J Immunol"},{"key":"1296_CR40","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S1074-7613(01)00180-7","volume":"15","author":"S Sano","year":"2001","unstructured":"Sano S, Takahama Y, Sugawara T, Kosaka H, Itami S, Yoshikawa K, Miyazaki J, van Ewijk W, Takeda J (2001) Stat3 in thymic epithelial cells is essential for postnatal maintenance of thymic architecture and thymocyte survival. Immunity 15:261\u2013273","journal-title":"Immunity"},{"key":"1296_CR41","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/intimm\/13.1.105","volume":"13","author":"C Shimizu","year":"2001","unstructured":"Shimizu C, Kawamoto H, Yamashita M, Kimura M, Kondou E, Kaneko Y, Okada S, Tokuhisa T, Yokoyama M, Taniguchi M, Katsura Y, Nakayama T (2001) Progression of T cell lineage restriction in the earliest subpopulation of murine adult thymus visualized by the expression of lck proximal promoter activity. Int Immunol 13:105\u2013117","journal-title":"Int Immunol"},{"key":"1296_CR42","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1093\/intimm\/6.9.1393","volume":"6","author":"EW Shores","year":"1994","unstructured":"Shores EW, Van Ewijk W, Singer A (1994) Maturation of medullary thymic epithelium requires thymocytes expressing fully assembled CD3-TCR complexes. Int Immunol 6:1393\u20131402","journal-title":"Int Immunol"},{"key":"1296_CR43","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1006\/smim.1998.0158","volume":"11","author":"W Ewijk van","year":"1999","unstructured":"van Ewijk W, Wang B, Hollander G, Kawamoto H, Spanopoulou E, Itoi M, Amagai T, Jiang YF, Germeraad WT, Chen WF, Katsura Y (1999) Thymic microenvironments, 3-D versus 2-D? Semin Immunol 11:57\u201364","journal-title":"Semin Immunol"},{"key":"1296_CR44","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.molimm.2009.10.034","volume":"47","author":"E Vroegindeweij","year":"2010","unstructured":"Vroegindeweij E, Crobach S, Itoi M, Satoh R, Zuklys S, Happe C, Germeraad WT, Cornelissen JJ, Cupedo T, Hollander GA, Kawamoto H, van Ewijk W (2010) Thymic cysts originate from Foxn1 positive thymic medullary epithelium. Mol Immunol 47:1106\u20131113","journal-title":"Mol Immunol"},{"key":"1296_CR45","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.4049\/jimmunol.1002151","volume":"185","author":"AJ White","year":"2010","unstructured":"White AJ, Nakamura K, Jenkinson WE, Saini M, Sinclair C, Seddon B, Narendran P, Pfeffer K, Nitta T, Takahama Y, Caamano JH, Lane PJ, Jenkinson EJ, Anderson G (2010) Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells. J Immunol 185:4769\u20134776","journal-title":"J Immunol"}],"container-title":["Histochemistry and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-014-1296-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00418-014-1296-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-014-1296-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T19:49:01Z","timestamp":1559072941000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00418-014-1296-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,23]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["1296"],"URL":"https:\/\/doi.org\/10.1007\/s00418-014-1296-9","relation":{},"ISSN":["0948-6143","1432-119X"],"issn-type":[{"value":"0948-6143","type":"print"},{"value":"1432-119X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,23]]}}}