{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T07:11:52Z","timestamp":1781248312547,"version":"3.54.1"},"reference-count":111,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T00:00:00Z","timestamp":1481673600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Histochem Cell Biol"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s00418-016-1515-7","type":"journal-article","created":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T10:07:21Z","timestamp":1481710041000},"page":"415-438","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Golgi apparatus dis- and reorganizations studied with the aid of 2-deoxy-d-glucose and visualized by 3D-electron tomography"],"prefix":"10.1007","volume":"147","author":[{"given":"Carmen","family":"Ranftler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Meisslitzer-Ruppitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Neum\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolf","family":"Ellinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"Pavelka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,12,14]]},"reference":[{"key":"1515_CR1","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/282615a0","volume":"282","author":"DP Aden","year":"1979","unstructured":"Aden DP, Fogel A, Plotkin S, Damjanov I, Knowles BB (1979) Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line. Nature 282:615\u2013616. doi: 10.1038\/282615a0","journal-title":"Nature"},{"key":"1515_CR2","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/sj.bjc.6600547","volume":"87","author":"RL Aft","year":"2002","unstructured":"Aft RL, Zhang FW, Gius D (2002) Evaluation of 2-deoxy-d-glucose as a chemotherapeutic agent: mechanism of cell death. Br J Cancer 87:805\u2013812. doi: 10.1038\/sj.bjc.6600547","journal-title":"Br J Cancer"},{"key":"1515_CR3","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1002\/iub.1364","volume":"67","author":"A Ahadova","year":"2015","unstructured":"Ahadova A, Gebert J, von Knebel Doeberitz M, Kopitz J, Kloor M (2015) Dose-dependent effect of 2-deoxy-d-glucose on glycoprotein mannosylation in cancer cells. IUBMB Life 67:218\u2013226. doi: 10.1002\/iub.1364","journal-title":"IUBMB Life"},{"key":"1515_CR4","doi-asserted-by":"publisher","unstructured":"Berger EG (1997) The Golgi apparatus: from discovery to contemporary studies. In: Berger EG, Roth J (eds) The Golgi apparatus. Birkh\u00e4user Verlag, Basel, pp 1\u201335. doi: 10.1007\/978-3-0348-8876-9_1","DOI":"10.1007\/978-3-0348-8876-9_1"},{"key":"1515_CR5","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1002\/cber.19220550122","volume":"55","author":"M Bergmann","year":"1922","unstructured":"Bergmann M, Schotte H, Lechinsky W (1922) \u00dcber die unges\u00e4ttigten Reduktionsprodukte der Zuckerarten und ihre Umwandlungen, III.: \u00dcber 2-desoxyglucose (Glucodesose). Ber Dtsch Chem Ges 55:158\u2013172. doi: 10.1002\/cber.19220550122","journal-title":"Ber Dtsch Chem Ges"},{"key":"1515_CR6","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1002\/cber.19230560511","volume":"56","author":"M Bergmann","year":"1923","unstructured":"Bergmann M, Schotte H, Lechinsky W (1923) \u00dcber die unges\u00e4ttigten Reduktionsprodukte der Zuckerarten und ihre Umwandlungen, V.: \u00dcber 2-desoxyglucose (Glucodesose) (II.). Ber Dtsch Chem Ges 56:1052\u20131059. doi: 10.1002\/cber.19230560511","journal-title":"Ber Dtsch Chem Ges"},{"key":"1515_CR7","doi-asserted-by":"publisher","first-page":"e02009","DOI":"10.7554\/eLife.02009","volume":"3","author":"GV Beznoussenko","year":"2014","unstructured":"Beznoussenko GV, Parashuraman S, Rizzo R, Polishchuk R, Martella O, Di Giandomenico D, Fusella A, Spaar A, Sallese M, Capestrano MG, Pavelka M, Vos MR, Rikers YG, Helms V, Mironov AA, Luini A (2014) Transport of soluble proteins through the Golgi occurs by diffusion via continuities across cisternae. eLife 3:e02009. doi: 10.7554\/eLife.02009","journal-title":"eLife"},{"key":"1515_CR8","doi-asserted-by":"publisher","first-page":"5299","DOI":"10.3390\/ijms16035299","volume":"16","author":"GV Beznoussenko","year":"2015","unstructured":"Beznoussenko GV, Pilyugin SS, Geerts WJ, Kozlov MM, Burger KN, Luini A, Derganc J, Mironov AA (2015) Trans-membrane area asymmetry controls the shape of cellular organelles. Int J Mol Sci 16:5299\u20135333. doi: 10.3390\/ijms16035299","journal-title":"Int J Mol Sci"},{"key":"1515_CR9","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-016-1483-y","author":"GV Beznoussenko","year":"2016","unstructured":"Beznoussenko GV, Ragnini-Wilson A, Wilson C, Mironov AA (2016) Three-dimensional and immune electron microscopic analysis of the secretory pathway in Saccharomyces cerevisiae. Histochem Cell Biol. doi: 10.1007\/s00418-016-1483-y","journal-title":"Histochem Cell Biol"},{"key":"1515_CR10","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.devcel.2014.06.018","volume":"30","author":"J Cancino","year":"2014","unstructured":"Cancino J, Capalbo A, Di Campli A, Giannotta M, Rizzo R, Jung JE, Di Martino R, Persico M, Heinklein P, Sallese M, Luini A (2014) Control systems of membrane transport at the interface between the endoplasmic reticulum and the Golgi. Dev Cell 30:280\u2013294. doi: 10.1016\/j.devcel.2014.06.018","journal-title":"Dev Cell"},{"key":"1515_CR11","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3389\/fcell.2016.00018","volume":"4","author":"PY Cheung","year":"2016","unstructured":"Cheung PY, Pfeffer SR (2016) Transport vesicle tethering at the trans Golgi network: Coiled coil proteins in action. Front Cell Dev Biol 4:18. doi: 10.3389\/fcell.2016.00018","journal-title":"Front Cell Dev Biol"},{"key":"1515_CR12","doi-asserted-by":"publisher","first-page":"e12790","DOI":"10.7554\/eLife.12790","volume":"4","author":"PY Cheung","year":"2015","unstructured":"Cheung PY, Limouse C, Mabuchi H, Pfeffer SR (2015) Protein flexibility is required for vesicle tethering at the Golgi. eLife 4:e12790. doi: 10.7554\/eLife.12790","journal-title":"eLife"},{"key":"1515_CR13","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0021-9258(18)84849-9","volume":"65","author":"CF Cori","year":"1925","unstructured":"Cori CF, Cori GT (1925) The carbohydrate metabolism of tumors: II. Changes in the sugar, lactic acid, and CO2-combining power of blood passing through a tumor. J Biol Chem 65:397\u2013405","journal-title":"J Biol Chem"},{"key":"1515_CR14","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1002\/1873-3468.12210","volume":"590","author":"J Dancourt","year":"2016","unstructured":"Dancourt J, Zheng H, Bottanelli F, Allgeyer ES, Bewersdorf J, Graham M, Liu X, Rothman JE, Lavieu G (2016) Small cargoes pass through synthetically glued Golgi stacks. FEBS Lett 590:1675\u20131686. doi: 10.1002\/1873-3468.12210","journal-title":"FEBS Lett"},{"key":"1515_CR15","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s00418-013-1128-3","volume":"140","author":"KJ Day","year":"2013","unstructured":"Day KJ, Staehelin LA, Glick BS (2013) A three-stage model of Golgi structure and function. Histochem Cell Biol 140:239\u2013249. doi: 10.1007\/s00418-013-1128-3","journal-title":"Histochem Cell Biol"},{"key":"1515_CR16","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.1242\/jcs.112.22.4017","volume":"112","author":"M Valle del","year":"1999","unstructured":"del Valle M, Robledo Y, Sandoval IV (1999) Membrane flow through the Golgi apparatus: specific disassembly of the cis-Golgi network by ATP depletion. J Cell Sci 112:4017\u20134029 (PMID: 10547362)","journal-title":"J Cell Sci"},{"key":"1515_CR17","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.bbabio.2010.08.010","volume":"1807","author":"R Diaz-Ruiz","year":"2011","unstructured":"Diaz-Ruiz R, Rigoulet M, Devin A (2011) The Warburg and Crabtree effects: on the origin of cancer cell energy metabolism and of yeast glucose repression. Biochim Biophys Acta 1807:568\u2013576. doi: 10.1016\/j.bbabio.2010.08.010","journal-title":"Biochim Biophys Acta"},{"key":"1515_CR18","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s004180050256","volume":"109","author":"A Dinter","year":"1998","unstructured":"Dinter A, Berger EG (1998) Golgi-disturbing agents. Histochem Cell Biol 109:571\u2013590. doi: 10.1007\/s004180050256","journal-title":"Histochem Cell Biol"},{"key":"1515_CR19","doi-asserted-by":"publisher","first-page":"633","DOI":"10.3892\/mmr_00000149","volume":"2","author":"CS Djuzenova","year":"2009","unstructured":"Djuzenova CS, Krasnyanska J, Kiesel M, Stingl L, Zimmermann U, Flentje M, Sukhorukov VL (2009) Intracellular delivery of 2-deoxy-d-glucose into tumor cells by long-term cultivation and through swelling-activated pathways: implications for radiation treatment. Mol Med Report 2:633\u2013640. doi: 10.3892\/mmr_00000149","journal-title":"Mol Med Report"},{"key":"1515_CR20","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s00418-013-1146-1","volume":"141","author":"Z Dong","year":"2014","unstructured":"Dong Z, Zuber C, Pierce M, Stanley P, Roth J (2014) Reduction in Golgi apparatus dimension in the absence of a residential protein, N-acetylglucosaminyltransferase V. Histochem Cell Biol 141:153\u2013164. doi: 10.1007\/s00418-013-1146-1","journal-title":"Histochem Cell Biol"},{"key":"1515_CR21","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.4103\/0973-1482.55137","volume":"5","author":"BS Dwarakanath","year":"2009","unstructured":"Dwarakanath BS (2009) Cytoxicity, radiosensitization, and chemosensitization of tumor cells by 2-deoxy-d-glucose in vitro. J Cancer Res Ther 5:S27\u2013S31. doi: 10.4103\/0973-1482.55137","journal-title":"J Cancer Res Ther"},{"key":"1515_CR22","doi-asserted-by":"publisher","first-page":"11264","DOI":"10.1073\/pnas.1515337112","volume":"112","author":"BD Engel","year":"2015","unstructured":"Engel BD, Schaffer M, Albert S, Asano S, Plitzko JM, Baumeister W (2015) In situ structural analysis of Golgi intracisternal protein arrays. Proc Natl Acad Sci USA 112:11264\u201311269. doi: 10.1073\/pnas.1515337112","journal-title":"Proc Natl Acad Sci USA"},{"key":"1515_CR23","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1016\/j.bcp.2012.09.022","volume":"84","author":"MC Esta\u00f1","year":"2012","unstructured":"Esta\u00f1 MC, Calvi\u00f1o E, de Blas E, Boyano-Ad\u00e1nez Mdel C, Mena ML, G\u00f3mez-G\u00f3mez M, Rial E, Aller P (2012) 2-Deoxy-d-glucose cooperates with arsenic trioxide to induce apoptosis in leukemia cells: involvement of IGF-1R-regulated Akt\/mTOR, MEK\/ERK and LKB-1\/AMPK signaling pathways. Biochem Pharmacol 84:1604\u20131616. doi: 10.1016\/j.bcp.2012.09.022","journal-title":"Biochem Pharmacol"},{"key":"1515_CR24","doi-asserted-by":"publisher","first-page":"77s","DOI":"10.1083\/jcb.91.3.77s","volume":"91","author":"MG Farquhar","year":"1981","unstructured":"Farquhar MG, Palade GE (1981) The Golgi apparatus (complex)-(1954-1981)-from artifact to center stage. J Cell Biol 91:77s\u2013103s. doi: 10.1083\/jcb.91.3.77s","journal-title":"J Cell Biol"},{"key":"1515_CR25","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/S0962-8924(97)01187-2","volume":"8","author":"MG Farquhar","year":"1998","unstructured":"Farquhar MG, Palade GE (1998) The Golgi apparatus: 100\u00a0years of progress and controversy. Trends Cell Biol 8:2\u201310. doi: 10.1016\/S0962-8924(97)01187-2","journal-title":"Trends Cell Biol"},{"key":"1515_CR26","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.yexmp.2010.08.006","volume":"89","author":"LM Ferreira","year":"2010","unstructured":"Ferreira LM (2010) Cancer metabolism: the Warburg effect today. Exp Mol Pathol 89:372\u2013380. doi: 10.1016\/j.yexmp.2010.08.006","journal-title":"Exp Mol Pathol"},{"key":"1515_CR27","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1038\/nn1791","volume":"9","author":"M Garriga-Canut","year":"2006","unstructured":"Garriga-Canut M, Schoenike B, Qazi R, Bergendahl K, Daley TJ, Pfender RM, Morrison JF, Ockuly J, Stafstrom C, Sutula T, Roopra A (2006) 2-Deoxy-d-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure. Nat Neurosci 9:1382\u20131387. doi: 10.1038\/nn1791","journal-title":"Nat Neurosci"},{"key":"1515_CR28","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1146\/annurev.cellbio.24.110707.175421","volume":"25","author":"BS Glick","year":"2009","unstructured":"Glick BS, Nakano A (2009) Membrane traffic within the Golgi apparatus. Annu Rev Cell Dev Biol 25:113\u2013132. doi: 10.1146\/annurev.cellbio.24.110707.175421","journal-title":"Annu Rev Cell Dev Biol"},{"key":"1515_CR29","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/nmeth806","volume":"2","author":"M Grabenbauer","year":"2005","unstructured":"Grabenbauer M, Geerts WJC, Fernandez-Rodriguez J, Hoenger A, Koster AJ, Nilsson T (2005) Correlative microscopy and electron tomography of GFP through photooxidation. Nat Methods 2:857\u2013862. doi: 10.1038\/nmeth806","journal-title":"Nat Methods"},{"key":"1515_CR30","doi-asserted-by":"crossref","first-page":"491","DOI":"10.55782\/ane-2004-1533","volume":"64","author":"P Grieb","year":"2004","unstructured":"Grieb P, Gordon-Krajcer W, Frontczak-Baniewicz M, Walski M, Ryba MS, Kryczka T, Fiedorowicz M, Kulinowski P, Su\u0142ek Z, Majcher K, Jasi\u0144ski A (2004) 2-deoxyglucose induces beta-APP overexpression, tau hyperphosphorylation and expansion of the trans-part of the Golgi complex in rat cerebral cortex. Acta Neurobiol Exp (Wars) 64:491\u2013502 (PMID: 15586666)","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"1515_CR31","doi-asserted-by":"publisher","first-page":"448","DOI":"10.3389\/fnins.2015.00448","volume":"9","author":"G Haase","year":"2015","unstructured":"Haase G, Rabouille C (2015) Golgi fragmentation in ALS motor neurons New mechanisms targeting microtubules, tethers, and transport vesicles. Front Neurosci 9:448. doi: 10.3389\/fnins.2015.00448","journal-title":"Front Neurosci"},{"key":"1515_CR32","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1038\/onc.2015.264","volume":"35","author":"J Hagenbuchner","year":"2015","unstructured":"Hagenbuchner J, Kiechl-Kohlendorfer U, Obexer P, Ausserlechner MJ (2015) BIRC5\/Survivin as a target for glycolysis inhibition in high-stage neuroblastoma. Oncogene 35:2052\u20132061. doi: 10.1038\/onc.2015.264","journal-title":"Oncogene"},{"key":"1515_CR33","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s00418-013-1136-3","volume":"140","author":"HM Han","year":"2013","unstructured":"Han HM, Bouchet-Marquis C, Huebinger J, Grabenbauer M (2013) Golgi apparatus analyzed by cryo-electron microscopy. Histochem Cell Biol 140:369\u2013381. doi: 10.1007\/s00418-013-1136-3","journal-title":"Histochem Cell Biol"},{"key":"1515_CR34","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.bbrc.2015.08.097","volume":"465","author":"SY Hong","year":"2015","unstructured":"Hong SY, Hagen T (2015) 2-Deoxyglucose induces the expression of thioredoxin interacting protein (TXNIP) by increasing O-GlcNAcylation\u2014implications for targeting the Warburg effect in cancer cells. Biochem Biophys Res Commun 465:838\u2013844. doi: 10.1016\/j.bbrc.2015.08.097","journal-title":"Biochem Biophys Res Commun"},{"key":"1515_CR35","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.ejphar.2013.02.005","volume":"705","author":"YY Huang","year":"2013","unstructured":"Huang YY, Liu H, Li Y, Pu LJ, Jiang CC, Xu JC, Jiang ZW (2013) Down-regulation of RIP1 by 2-deoxy-d-glucose sensitizes breast cancer cells to TRAIL-induced apoptosis. Eur J Pharmacol 705:26\u201334. doi: 10.1016\/j.ejphar.2013.02.005","journal-title":"Eur J Pharmacol"},{"key":"1515_CR36","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1242\/dmm.021667","volume":"8","author":"CC Huang","year":"2015","unstructured":"Huang CC, Wang SY, Lin LL, Wang PW, Chen TY, Hsu WM, Lin TK, Liou CW, Chuang JH (2015) Glycolytic inhibitor 2-deoxyglucose simultaneously targets cancer and endothelial cells to suppress neuroblastoma growth in mice. Dis Model Mech 8:1247\u20131254. doi: 10.1242\/dmm.021667","journal-title":"Dis Model Mech"},{"key":"1515_CR37","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.arr.2014.11.005","volume":"20","author":"DK Ingram","year":"2015","unstructured":"Ingram DK, Roth GS (2015) Calorie restriction mimetics: can you have your cake and eat it, too? Ageing Res Rev 20:46\u201362. doi: 10.1016\/j.arr.2014.11.005","journal-title":"Ageing Res Rev"},{"key":"1515_CR38","doi-asserted-by":"publisher","first-page":"10134","DOI":"10.18632\/oncotarget.3548","volume":"6","author":"JR Jangamreddy","year":"2015","unstructured":"Jangamreddy JR, Jain MV, Hallbeck AL, Roberg K, Lotfi K, \u0141os MJ (2015) Glucose starvation-mediated inhibition of salinomycin induced autophagy amplifies cancer cell specific cell death. Oncotarget 6:10134\u201310145. doi: 10.18632\/oncotarget.3548","journal-title":"Oncotarget"},{"key":"1515_CR39","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1186\/s12885-015-1640-z","volume":"15","author":"JY Jeon","year":"2015","unstructured":"Jeon JY, Kim SW, Park KC, Yun M (2015) The bifunctional autophagic flux by 2-deoxyglucose to control survival or growth of prostate cancer cells. BMC Cancer 15:623. doi: 10.1186\/s12885-015-1640-z","journal-title":"BMC Cancer"},{"key":"1515_CR40","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1007\/s12035-015-9126-1","volume":"53","author":"Y Kaneko","year":"2016","unstructured":"Kaneko Y, Sullivan R, Dailey T, Vale FL, Tajiri N, Borlongan CV (2016) Kainic acid-induced Golgi complex fragmentation\/dispersal shifts the proteolysis of reelin in primary rat neuronal cells: an in vitro model of early stage epilepsy. Mol Neurobiol 53:1874\u20131883. doi: 10.1007\/s12035-015-9126-1","journal-title":"Mol Neurobiol"},{"key":"1515_CR41","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1016\/j.lfs.2005.07.001","volume":"78","author":"HT Kang","year":"2006","unstructured":"Kang HT, Hwang ES (2006) 2-Deoxyglucose: an anticancer and antiviral therapeutic, but not any more a low glucose mimetic. Life Sci 78:1392\u20131399. doi: 10.1016\/j.lfs.2005.07.001","journal-title":"Life Sci"},{"key":"1515_CR42","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1042\/BJ20141562","volume":"470","author":"S Kavaliauskiene","year":"2015","unstructured":"Kavaliauskiene S, Skotland T, Sylv\u00e4nne T, Simolin H, Klokk TI, Torgensen ML, Lingelem ABD, Simm R, Ekroos K, Sandvig K (2015) Novel actions of 2-deoxy-d-glucose: protection against Shiga toxins and changes in cellular lipids. Biochem J 470:23\u201337. doi: 10.1042\/BJ20141562","journal-title":"Biochem J"},{"key":"1515_CR43","first-page":"433","volume":"24","author":"J Keenan","year":"2004","unstructured":"Keenan J, Liang Y, Clynes M (2004) Two-deoxyglucose as an anti-metabolite in human carcinoma cell line RPMI-2650 and drug-resistant variants. Anticancer Res 24:433\u2013440 (PMID: 15152941)","journal-title":"Anticancer Res"},{"key":"1515_CR44","doi-asserted-by":"publisher","first-page":"a005181","DOI":"10.1101\/cshperspect.a005181","volume":"3","author":"J Klumperman","year":"2011","unstructured":"Klumperman J (2011) Architecture of the mammalian Golgi. Cold Spring Harbor Perspect Biol 3:a005181. doi: 10.1101\/cshperspect.a005181","journal-title":"Cold Spring Harbor Perspect Biol"},{"key":"1515_CR45","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1126\/science.6248960","volume":"209","author":"BB Knowles","year":"1980","unstructured":"Knowles BB, Howe CC, Aden DP (1980) Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science 209:497\u2013499. doi: 10.1126\/science.6248960","journal-title":"Science"},{"key":"1515_CR46","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.bbrc.2015.09.106","volume":"467","author":"H Kobayashi","year":"2015","unstructured":"Kobayashi H, Nishimura H, Matsumoto K, Yoshida M (2015) Identification of the determinants of 2-deoxyglucose sensitivity in cancer cells by shRNA library screening. Biochem Biophys Res Commun 467:121\u2013127. doi: 10.1016\/j.bbrc.2015.09.106","journal-title":"Biochem Biophys Res Commun"},{"key":"1515_CR47","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1111\/jmi.12379","volume":"263","author":"D Koga","year":"2016","unstructured":"Koga D, Bochimoto H, Watanabe T, Ushiki T (2016) Backscattered electron image of osmium-impregnated\/macerated tissues as a novel technique for identifying the cis-face of the Golgi apparatus by high-resolution scanning electron microscopy. J Microsc 263:87\u201396. doi: 10.1111\/jmi.12379","journal-title":"J Microsc"},{"key":"1515_CR48","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1006\/jsbi.1996.0013","volume":"116","author":"JR Kremer","year":"1996","unstructured":"Kremer JR, Mastronarde DN, McIntosh JR (1996) Computer visualization of three-dimensional image data using IMOD. J Struct Biol 116:71\u201376. doi: 10.1006\/jsbi.1996.0013","journal-title":"J Struct Biol"},{"key":"1515_CR49","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1083\/jcb.144.6.1135","volume":"144","author":"MS Ladinski","year":"1999","unstructured":"Ladinski MS, Mastronarde DN, McIntosh JR, Howell KE, Staehelin LA (1999) Structure of the Golgi in three dimensions: functional insights from the normal rat kidney. J Cell Biol 144:1135\u20131149. doi: 10.1083\/jcb.144.6.1135","journal-title":"J Cell Biol"},{"key":"1515_CR50","doi-asserted-by":"publisher","first-page":"e00558","DOI":"10.7554\/eLife.00558","volume":"2","author":"G Lavieu","year":"2013","unstructured":"Lavieu G, Zheng H, Rothman JE (2013) Stapled Golgi cisternae remain in place as cargo passes through the stack. eLife 2:e00558. doi: 10.7554\/eLife.00558","journal-title":"eLife"},{"key":"1515_CR51","doi-asserted-by":"publisher","first-page":"3028","DOI":"10.1091\/mbc.E14-04-0931","volume":"25","author":"G Lavieu","year":"2014","unstructured":"Lavieu G, Dunlop MH, Lerich A, Zheng H, Bottanelli F, Rothman JE (2014) The Golgi ribbon structure facilitates anterograde transport of large cargoes. Mol Biol Cell 25:3028\u20133036. doi: 10.1091\/mbc.E14-04-0931","journal-title":"Mol Biol Cell"},{"key":"1515_CR52","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1073\/pnas.1323895111","volume":"111","author":"I Lee","year":"2014","unstructured":"Lee I, Tiwari N, Dunlop MH, Graham M, Liu X, Rothman JE (2014) Membrane adhesion dictates Golgi stacking and cisternal morphology. Proc Natl Acad Sci USA 111:1849\u20131854. doi: 10.1073\/pnas.1323895111","journal-title":"Proc Natl Acad Sci USA"},{"key":"1515_CR53","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ceb.2016.02.011","volume":"39","author":"TP Levine","year":"2016","unstructured":"Levine TP, Patel S (2016) Signalling at membrane contact sites: two membranes come together to handle second messengers. Curr Opin Cell Biol 39:77\u201383. doi: 10.1016\/j.ceb.2016.02.011","journal-title":"Curr Opin Cell Biol"},{"key":"1515_CR54","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.redox.2014.12.001","volume":"4","author":"L Li","year":"2015","unstructured":"Li L, Fath MA, Scarbrough PM, Watson WH, Spitz DR (2015) Combined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancer. Redox Biol 4:127\u2013135. doi: 10.1016\/j.redox.2014.12.001","journal-title":"Redox Biol"},{"key":"1515_CR55","first-page":"3413","volume":"63","author":"X Lin","year":"2003","unstructured":"Lin X, Zhang F, Bradbury CM, Kaushal A, Li L, Spitz DR, Aft RL, Gius D (2003) 2-Deoxy-d-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism. Cancer Res 63:3413\u20133417","journal-title":"Cancer Res"},{"key":"1515_CR56","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/S0962-8924(97)01199-9","volume":"8","author":"J Lippincott-Schwartz","year":"1998","unstructured":"Lippincott-Schwartz J, Cole N, Presley J (1998) Unravelling Golgi membrane traffic with green fluorescent protein chimeras. Trends Cell Biol 8:16\u201320. doi: 10.1016\/S0962-8924(97)01199-9","journal-title":"Trends Cell Biol"},{"key":"1515_CR57","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1016\/j.humpath.2009.07.003","volume":"40","author":"D L\u00f3pez-Terrada","year":"2009","unstructured":"L\u00f3pez-Terrada D, Cheung SW, Finegold MJ, Knowles BB (2009) Hep G2 is a hepatoblastoma-derived cell line. Hum Pathol 40:1512\u20131515. doi: 10.1016\/j.humpath.2009.07.003","journal-title":"Hum Pathol"},{"key":"1515_CR58","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.ceb.2010.10.004","volume":"23","author":"M Lowe","year":"2011","unstructured":"Lowe M (2011) Structural organization of the Golgi apparatus. Curr Opin Cell Biol 23:85\u201393. doi: 10.1016\/j.ceb.2010.10.004","journal-title":"Curr Opin Cell Biol"},{"key":"1515_CR59","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.ceb.2016.01.014","volume":"39","author":"A Luini","year":"2016","unstructured":"Luini A, Parashuraman S (2016) Signaling at the Golgi: sensing and controlling the membrane fluxes. Curr Opin Cell Biol 39:37\u201342. doi: 10.1016\/j.ceb.2016.01.014","journal-title":"Curr Opin Cell Biol"},{"key":"1515_CR60","doi-asserted-by":"publisher","first-page":"421","DOI":"10.3389\/fnins.2015.00421","volume":"9","author":"CE Machamer","year":"2015","unstructured":"Machamer CE (2015) The Golgi complex in stress and death. Front Neurosci 9:421. doi: 10.3389\/fnins.2015.00421","journal-title":"Front Neurosci"},{"key":"1515_CR61","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1002\/(SICI)1097-0215(19980529)76:5<639::AID-IJC5>3.0.CO;2-R","volume":"76","author":"T Maehama","year":"1998","unstructured":"Maehama T, Patzelt A, Lengert M, Hutter KJ, Kanazawa K, Hausen H, R\u00f6sl F (1998) Selective down-regulation of human papillomavirus transcription by 2-deoxyglucose. Int J Cancer 76:639\u2013646. doi: 10.1002\/(SICI)1097-0215(19980529)76:5<639:AID-IJC5>3.0.CO;2-R","journal-title":"Int J Cancer"},{"key":"1515_CR62","doi-asserted-by":"publisher","first-page":"e16988","DOI":"10.7554\/eLife.16988","volume":"5","author":"M Magdeleine","year":"2016","unstructured":"Magdeleine M, Gautier R, Gounon P, Barelli H, Vanni S, Antonny B (2016) A filter at the entrance of the Golgi that selects vesicles according to size and bulk lipid composition. eLife 5:e16988. doi: 10.7554\/eLife.16988","journal-title":"eLife"},{"key":"1515_CR63","doi-asserted-by":"publisher","unstructured":"Marsh B, Pavelka M (2013) Viewing Golgi structure and function from a different perspective\u2014insights from electron tomography. In: Perez F, Stephens DJ (eds) Methods for analysis of Golgi complex function. Methods in Cell Biology, vol 118. Elsevier, Amsterdam, pp 259\u2013279. doi: 10.1016\/B978-0-12-417164-0.00016-1","DOI":"10.1016\/B978-0-12-417164-0.00016-1"},{"key":"1515_CR64","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1743-7075-5-33","volume":"5","author":"J Marsh","year":"2008","unstructured":"Marsh J, Mukherjee P, Seyfried TN (2008) Drug\/diet synergy for managing malignant astrocytoma in mice: 2-deoxy-d-glucose and the restricted ketogenic diet. Nutr Metab (Lond) 5:33. doi: 10.1186\/1743-7075-5-33","journal-title":"Nutr Metab (Lond)"},{"key":"1515_CR65","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s00418-010-0773-z","volume":"135","author":"C Meisslitzer-Ruppitsch","year":"2011","unstructured":"Meisslitzer-Ruppitsch C, R\u00f6hrl C, Ranftler C, Neum\u00fcller J, Vetterlein M, Ellinger A, Pavelka M (2011) The ceramide-enriched trans-Golgi compartments reorganize together with other parts of the Golgi apparatus in response to ATP-depletion. Histochem Cell Biol 135:159\u2013171. doi: 10.1007\/s00418-010-0773-z","journal-title":"Histochem Cell Biol"},{"key":"1515_CR66","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1078\/0171-9335-00377","volume":"83","author":"AA Mironov","year":"2004","unstructured":"Mironov AA, Colanzi A, Polishchuk RS, Beznoussenko GV, Mironov AA Jr, Fusella A, Di Tullio G, Silletta MG, Corda D, De Matteis MA, Luini A (2004) Dicumarol, an inhibitor of ADP-ribosylation of CtBP3\/BARS, fragments Golgi non-compact tubular zones and inhibits intra-Golgi transport. Eur J Cell Biol 83:263\u2013279. doi: 10.1078\/0171-9335-00377","journal-title":"Eur J Cell Biol"},{"key":"1515_CR67","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s00418-013-1141-6","volume":"140","author":"AA Mironov","year":"2013","unstructured":"Mironov AA, Sesorova IV, Beznoussenko GV (2013) Golgi\u2019s way: a long path toward the new paradigm of the intra-Golgi transport. Histochem Cell Biol 140:383\u2013393. doi: 10.1007\/s00418-013-1141-6","journal-title":"Histochem Cell Biol"},{"key":"1515_CR68","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/jemt.1060170103","volume":"17","author":"HH Mollenhauer","year":"1991","unstructured":"Mollenhauer HH, Morr\u00e9 DJ (1991) Perspectives on Golgi apparatus form and function. J Electron Microsc Tech 17:2\u201314. doi: 10.1002\/jemt.1060170103","journal-title":"J Electron Microsc Tech"},{"key":"1515_CR69","doi-asserted-by":"publisher","first-page":"e0120531","DOI":"10.1371\/journal.pone.0120531","volume":"10","author":"T M\u00fchlenberg","year":"2015","unstructured":"M\u00fchlenberg T, Grunewald S, Treckmann J, Podleska L, Schuler M, Fletcher JA, Bauer S (2015) Inhibition of KIT-glycosylation by 2-deoxyglucose abrogates KIT-signaling and combination with ABT-263 synergistically induces apoptosis in gastrointestinal stromal tumor. PLoS ONE 10:e0120531. doi: 10.1371\/journal.pone.0120531","journal-title":"PLoS ONE"},{"key":"1515_CR70","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1080\/01635581.2015.1002626","volume":"67","author":"P Muley","year":"2015","unstructured":"Muley P, Olinger A, Tummala H (2015) 2-Deoxyglucose induces cell cycle arrest and apoptosis in colorectal cancer cells independent of its glycolysis inhibition. Nutr Cancer 67:514\u2013522. doi: 10.1080\/01635581.2015.1002626","journal-title":"Nutr Cancer"},{"key":"1515_CR71","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.7314\/APJCP.2015.16.8.3213","volume":"16","author":"EH Mustafa","year":"2015","unstructured":"Mustafa EH, Mahmoud HT, Al-Hudhud MY, Ahmad IM, Yasin SR, Elkarmi AZ, Tahtamouni LH (2015) 2-deoxy-d-glucose synergizes with doxorubicin or l-buthionine sulfoximine to reduce adhesion and migration of breast cancer cells. Asian Pac J Cancer Prev 16:3213\u20133222 (PMID: 25921122)","journal-title":"Asian Pac J Cancer Prev"},{"key":"1515_CR72","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.ceb.2012.05.009","volume":"24","author":"N Nakamura","year":"2012","unstructured":"Nakamura N, Wei JH, Seemann J (2012) Modular organization of the mammalian Golgi apparatus. Curr Opin Cell Biol 24:467\u2013474. doi: 10.1016\/j.ceb.2012.05.009","journal-title":"Curr Opin Cell Biol"},{"key":"1515_CR73","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/nature14521","volume":"521","author":"A Nakano","year":"2015","unstructured":"Nakano A (2015) Cell biology: polarized transport in the Golgi apparatus. Nature 521:427\u2013428. doi: 10.1038\/nature14521","journal-title":"Nature"},{"key":"1515_CR74","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.eplepsyres.2012.04.012","volume":"101","author":"JC Ockuly","year":"2012","unstructured":"Ockuly JC, Gielissen JM, Levenick CV, Zeal C, Groble K, Munsey K, Sutula TP, Stafstrom CE (2012) Behavioral, cognitive, and safety profile of 2-deoxy-2-glucose (2DG) in adult rats. Epilepsy Res 101:246\u2013252. doi: 10.1016\/j.eplepsyres.2012.04.012","journal-title":"Epilepsy Res"},{"key":"1515_CR75","doi-asserted-by":"crossref","first-page":"5471","DOI":"10.7314\/APJCP.2015.16.13.5471","volume":"16","author":"M Oladghaffari","year":"2015","unstructured":"Oladghaffari M, Islamian JP, Baradaran B, Monfared AS, Farajollahi A, Shanehbandi D, Mohammadi M (2015) High efficiency apoptosis induction in breast cancer cell lines by MLN4924\/2DG co-treatment. Asian Pac J Cancer Prev 16:5471\u20135476 (PMID: 26225696)","journal-title":"Asian Pac J Cancer Prev"},{"key":"1515_CR76","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.ceb.2014.04.010","volume":"29","author":"E Papanikou","year":"2014","unstructured":"Papanikou E, Glick BS (2014) Golgi compartmentation and identity. Curr Opin Cell Biol 29:74\u201381. doi: 10.1016\/j.ceb.2014.04.010","journal-title":"Curr Opin Cell Biol"},{"key":"1515_CR77","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s00418-013-1126-5","volume":"140","author":"M Pavelka","year":"2013","unstructured":"Pavelka M, Roth J (2013) In focus in Bad Ischl: Golgi apparatus 2013. Histochem Cell Biol 140:233\u2013234. doi: 10.1007\/s00418-013-1126-5","journal-title":"Histochem Cell Biol"},{"key":"1515_CR78","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s00418-008-0383-1","volume":"129","author":"M Pavelka","year":"2008","unstructured":"Pavelka M, Neum\u00fcller J, Ellinger A (2008) Retrograde traffic in the biosynthetic-secretory route. Histochem Cell Biol 129:277\u2013288. doi: 10.1007\/s00418-008-0383-1","journal-title":"Histochem Cell Biol"},{"key":"1515_CR79","doi-asserted-by":"publisher","first-page":"e01296","DOI":"10.7554\/eLife.01296","volume":"2","author":"PA Pellett","year":"2013","unstructured":"Pellett PA, Dietrich F, Bewersdorf J, Rothman JE, Lavieu G (2013) Inter-Golgi transport mediated by COPI-containing vesicles carrying small cargoes. eLife 2:e01296. doi: 10.7554\/eLife.01296","journal-title":"eLife"},{"key":"1515_CR80","doi-asserted-by":"publisher","first-page":"e00903","DOI":"10.7554\/eLife.00903","volume":"2","author":"SR Pfeffer","year":"2013","unstructured":"Pfeffer SR (2013) Hopping rim to rim through the Golgi. eLife 2:e00903. doi: 10.7554\/eLife.00903","journal-title":"eLife"},{"key":"1515_CR81","doi-asserted-by":"publisher","first-page":"489","DOI":"10.3389\/fnins.2015.00489","volume":"9","author":"C Rabouille","year":"2016","unstructured":"Rabouille C, Haase G (2016) Editorial: Golgi pathology in neurodegenerative diseases. Front Neurosci 9:489. doi: 10.3389\/fnins.2015.00489","journal-title":"Front Neurosci"},{"key":"1515_CR82","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fcell.2016.00001","volume":"4","author":"C Rabouille","year":"2016","unstructured":"Rabouille C, Linstedt AD (2016) GRASP: a multitasking tether. Front Cell Dev Biol 4:1. doi: 10.3389\/fcell.2016.00001","journal-title":"Front Cell Dev Biol"},{"key":"1515_CR83","doi-asserted-by":"publisher","unstructured":"Rabouille C, Warren G (1997) Changes of the architecture of the Golgi apparatus during mitosis. In: Berger EG, Roth J (eds) The Golgi apparatus. Birkh\u00e4user Verlag, Basel, pp 195\u2013217. doi: 10.1007\/978-3-0348-8876-9","DOI":"10.1007\/978-3-0348-8876-9"},{"key":"1515_CR84","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s00280-012-2045-1","volume":"71","author":"LE Raez","year":"2013","unstructured":"Raez LE, Papadopoulos K, Ricart AD, Chiorean EG, Dipaola RS, Stein MN, Rocha Lima CM, Schlesselman JJ, Tolba K, Langmuir VK, Kroll S, Jung DT, Kurtoglu M, Rosenblatt J, Lampidis TJ (2013) A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors. Cancer Chemother Pharmacol 71:523\u2013530. doi: 10.1007\/s00280-012-2045-1","journal-title":"Cancer Chemother Pharmacol"},{"key":"1515_CR85","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/978-1-62703-056-4_22","volume":"931","author":"C Ranftler","year":"2013","unstructured":"Ranftler C, Auinger P, Meisslitzer-Ruppitsch C, Ellinger A, Neum\u00fcller J, Pavelka M (2013) Electron microscopy of endocytic pathways. Methods Mol Biol 931:437\u2013447. doi: 10.1007\/978-1-62703-056-4_22","journal-title":"Methods Mol Biol"},{"key":"1515_CR86","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s00418-014-1297-8","volume":"143","author":"C Ranftler","year":"2015","unstructured":"Ranftler C, Meisslitzer-Ruppitsch C, Stangl H, R\u00f6hrl C, Fruhw\u00fcrth S, Neum\u00fcller J, Pavelka M, Ellinger A (2015) 2-Deoxy-d-glucose treatment changes the Golgi apparatus architecture without blocking synthesis of complex lipids. Histochem Cell Biol 143:369\u2013380. doi: 10.1007\/s00418-014-1297-8","journal-title":"Histochem Cell Biol"},{"key":"1515_CR87","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1083\/jcb.201211147","volume":"201","author":"R Rizzo","year":"2013","unstructured":"Rizzo R, Parashuraman S, Mirabelli P, Puri C, Lucocq J, Luini A (2013) The dynamics of engineered resident proteins in the mammalian Golgi complex relies on cisternal maturation. J Cell Biol 201:1027\u20131036. doi: 10.1083\/jcb.201211147","journal-title":"J Cell Biol"},{"key":"1515_CR88","doi-asserted-by":"publisher","unstructured":"Roth J (1997) Topology of glycosylation in the Golgi apparatus. In: Berger EG, Roth J (eds) The Golgi apparatus. Birkh\u00e4user Verlag, Basel, pp 131\u2013166. doi: 10.1007\/978-3-0348-8876-9_4","DOI":"10.1007\/978-3-0348-8876-9_4"},{"key":"1515_CR89","doi-asserted-by":"publisher","first-page":"12676","DOI":"10.1002\/anie.201402380","volume":"53","author":"JE Rothman","year":"2014","unstructured":"Rothman JE (2014) The principle of membrane fusion in the cell (Nobel lecture). Angew Chem Int Ed Engl 53:12676\u201312694. doi: 10.1002\/anie.201402380","journal-title":"Angew Chem Int Ed Engl"},{"key":"1515_CR90","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1242\/jcs.154443","volume":"128","author":"CE Schuberth","year":"2015","unstructured":"Schuberth CE, T\u00e4ngemo C, Coneva C, Tischer C, Pepperkok R (2015) Self-organization of core Golgi material is independent of COPII-mediated endoplasmic reticulum export. J Cell Sci 128:1279\u20131293. doi: 10.1242\/jcs.154443","journal-title":"J Cell Sci"},{"key":"1515_CR91","doi-asserted-by":"crossref","first-page":"8878","DOI":"10.1016\/S0021-9258(19)52477-2","volume":"256","author":"AL Schwartz","year":"1981","unstructured":"Schwartz AL, Fridovich SE, Knowles BB, Lodish HF (1981) Characterization of the asialoglycoprotein receptor in a continuous hepatoma line. J Biol Chem 256:8878\u20138881 (PMID: 6267054)","journal-title":"J Biol Chem"},{"key":"1515_CR92","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1002\/ana.21603","volume":"65","author":"CE Stafstrom","year":"2009","unstructured":"Stafstrom CE, Ockuly JC, Murphree L, Valley MT, Roopra A, Sutula TP (2009) Anticonvulsant and antiepileptic actions of 2-deoxy-d-glucose in epilepsy models. Ann Neurol 65:435\u2013447. doi: 10.1002\/ana.21603","journal-title":"Ann Neurol"},{"key":"1515_CR93","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/ncb1180","volume":"6","author":"A Trucco","year":"2004","unstructured":"Trucco A, Polishchuk RS, Martella O, Di Pentima A, Fusella A, Di Giandomenico D, San Pietro E, Beznoussenko GV, Polishchuk EV, Baldassarre M, Buccione R, Geerts WJ, Koster AJ, Burger KN, Mironov AA, Luini A (2004) Secretory traffic triggers the formation of tubular continuities across Golgi sub-compartments. Nat Cell Biol 6:1071\u20131081. doi: 10.1038\/ncb1180","journal-title":"Nat Cell Biol"},{"key":"1515_CR94","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s00418-001-0371-1","volume":"117","author":"M Vetterlein","year":"2002","unstructured":"Vetterlein M, Ellinger A, Neum\u00fcller J, Pavelka M (2002) Golgi apparatus and TGN during endocytosis. Histochem Cell Biol 117:143\u2013150. doi: 10.1007\/s00418-001-0371-1","journal-title":"Histochem Cell Biol"},{"key":"1515_CR95","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s00418-003-0552-1","volume":"120","author":"M Vetterlein","year":"2003","unstructured":"Vetterlein M, Niapir M, Ellinger A, Neum\u00fcller J, Pavelka M (2003) Brefeldin A-regulated retrograde transport into the endoplasmic reticulum of internalised wheat germ agglutinin. Histochem Cell Biol 120:121\u2013128. doi: 10.1007\/s00418-003-0552-1","journal-title":"Histochem Cell Biol"},{"key":"1515_CR96","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/emboj.2012.329","volume":"32","author":"J Villeneuve","year":"2013","unstructured":"Villeneuve J, Scarpa M, Ortega-Bellido M, Malhotra V (2013) MEK1 inactivates Myt1 to regulate Golgi membrane fragmentation and mitotic entry in mammalian cells. EMBO J 32:72\u201385. doi: 10.1038\/emboj.2012.329","journal-title":"EMBO J"},{"key":"1515_CR97","doi-asserted-by":"publisher","first-page":"a005330","DOI":"10.1101\/cshperspect.a005330","volume":"3","author":"Y Wang","year":"2011","unstructured":"Wang Y, Seemann J (2011) Golgi biogenesis. Cold Spring Harb Perspect Biol 3:a005330. doi: 10.1101\/cshperspect.a005330","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"1515_CR98","doi-asserted-by":"publisher","first-page":"e17234","DOI":"10.1371\/journal.pone.0017234","volume":"6","author":"Q Wang","year":"2011","unstructured":"Wang Q, Liang B, Shirwany NA, Zou MH (2011) 2-Deoxy-d-glucose treatment of endothelial cells induces autophagy by reactive oxygen species-mediated activation of the AMP-activated protein kinase. PLoS ONE 6:e17234. doi: 10.1371\/journal.pone.0017234","journal-title":"PLoS ONE"},{"key":"1515_CR99","volume-title":"The metabolism of tumors","author":"O Warburg","year":"1930","unstructured":"Warburg O (1930) The metabolism of tumors. Arnold Constable and Co., London"},{"key":"1515_CR100","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1126\/science.123.3191.309","volume":"123","author":"O Warburg","year":"1956","unstructured":"Warburg O (1956a) On the origin of cancer cells. Science 123:309\u2013314. doi: 10.1126\/science.123.3191.309","journal-title":"Science"},{"key":"1515_CR101","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1126\/science.124.3215.267","volume":"124","author":"O Warburg","year":"1956","unstructured":"Warburg O (1956b) On respiratory impairment in cancer cells. Science 124:269\u2013270. doi: 10.1126\/science.124.3215.267","journal-title":"Science"},{"key":"1515_CR102","doi-asserted-by":"publisher","first-page":"C125","DOI":"10.1152\/ajpcell.00247.2006","volume":"292","author":"M Wu","year":"2007","unstructured":"Wu M, Neilson A, Swift AL, Moran R, Tamagnine J, Parslow D, Armistead S, Lemire K, Orrell J, Teich J, Chomicz S, Ferrick DA (2007) Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am J Physiol Cell Physiol 292:C125\u2013C136. doi: 10.1152\/ajpcell.00247.2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"1515_CR103","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1158\/0008-5472.CAN-08-2872","volume":"69","author":"H Wu","year":"2009","unstructured":"Wu H, Zhu H, Liu DX, Niu TK, Ren X, Patel R, Hait WN, Yang JM (2009) Silencing of elongation factor-2 kinase potentiates the effect of 2-deoxy-d-glucose against human glioma cells through blunting of autophagy. Cancer Res 69:2453\u20132460. doi: 10.1158\/0008-5472.CAN-08-2872","journal-title":"Cancer Res"},{"key":"1515_CR104","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1007\/s00280-010-1391-0","volume":"67","author":"H Xi","year":"2011","unstructured":"Xi H, Kurtoglu M, Liu H, Wangpaichitr M, You M, Liu X, Savaraj N, Lampidis TJ (2011) 2-Deoxy-d-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion. Cancer Chemother Pharmacol 67:899\u2013910. doi: 10.1007\/s00280-010-1391-0","journal-title":"Cancer Chemother Pharmacol"},{"key":"1515_CR105","doi-asserted-by":"publisher","first-page":"e21788","DOI":"10.1371\/journal.pone.0021788","volume":"6","author":"J Yao","year":"2011","unstructured":"Yao J, Chen S, Mao Z, Cadenas E, Brinton RD (2011) 2-Deoxy-d-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer\u2019s disease. PLoS ONE 6:e21788. doi: 10.1371\/journal.pone.0021788","journal-title":"PLoS ONE"},{"key":"1515_CR106","doi-asserted-by":"publisher","first-page":"274ra18","DOI":"10.1126\/scitranslmed.aaa0835","volume":"7","author":"Y Yin","year":"2015","unstructured":"Yin Y, Choi SC, Xu Z, Perry DJ, Seay H, Croker BP, Sobel ES, Brusko TM, Morel L (2015) Normalization of CD4\u00a0+\u00a0T cell metabolism reverses lupus. Sci Transl Med 7:274ra18. doi: 10.1126\/scitranslmed.aaa0835","journal-title":"Sci Transl Med"},{"key":"1515_CR107","doi-asserted-by":"publisher","first-page":"7089","DOI":"10.1021\/bi00528a006","volume":"20","author":"VI Zannis","year":"1981","unstructured":"Zannis VI, Breslow JL, SanGiacomo TR, Aden DP, Knowles BB (1981) Characterization of the major apolipoproteins secreted by two human hepatoma cell lines. Biochemistry 20:7089\u20137096. doi: 10.1021\/bi00528a006","journal-title":"Biochemistry"},{"key":"1515_CR108","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3389\/fcell.2015.00084","volume":"3","author":"X Zhang","year":"2016","unstructured":"Zhang X, Wang Y (2016) GRASPs in Golgi structure and function. Front Cell Dev Biol 3:84. doi: 10.3389\/fcell.2015.00084","journal-title":"Front Cell Dev Biol"},{"key":"1515_CR109","first-page":"3561","volume":"26","author":"XD Zhang","year":"2006","unstructured":"Zhang XD, Deslandes E, Villedieu M, Poulain L, Duval M, Gauduchon P, Schwartz L, Icard P (2006) Effect of 2-deoxy-d-glucose on various malignant cell lines in vitro. Anticancer Res 26:3561\u20133566 (PMID: 17094483)","journal-title":"Anticancer Res"},{"key":"1515_CR110","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.canlet.2014.09.003","volume":"355","author":"D Zhang","year":"2014","unstructured":"Zhang D, Li J, Wang F, Hu J, Wang S, Sun Y (2014) 2-Deoxy-d-glucose targeting of glucose metabolism in cancer cells as a potential therapy. Cancer Lett 355:176\u2013183. doi: 10.1016\/j.canlet.2014.09.003","journal-title":"Cancer Lett"},{"key":"1515_CR111","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1002\/jbt.21730","volume":"29","author":"L Zhang","year":"2015","unstructured":"Zhang L, Su J, Xie Q, Zeng L, Wang Y, Yi D, Yu Y, Liu S, Li S, Xu Y (2015) 2-Deoxy-d-glucose sensitizes human ovarian cancer cells to cisplatin by increasing ER stress and decreasing ATP stores in acidic vesicles. J Biochem Molec Toxicol 29:572\u2013578. doi: 10.1002\/jbt.21730","journal-title":"J Biochem Molec Toxicol"}],"container-title":["Histochemistry and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-016-1515-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00418-016-1515-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-016-1515-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T05:17:17Z","timestamp":1718947037000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00418-016-1515-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,14]]},"references-count":111,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["1515"],"URL":"https:\/\/doi.org\/10.1007\/s00418-016-1515-7","relation":{},"ISSN":["0948-6143","1432-119X"],"issn-type":[{"value":"0948-6143","type":"print"},{"value":"1432-119X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,14]]}}}