{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:43:02Z","timestamp":1790037782862,"version":"4.0.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T00:00:00Z","timestamp":1494374400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004381","name":"Western University","doi-asserted-by":"publisher","award":["R5193A01"],"award-info":[{"award-number":["R5193A01"]}],"id":[{"id":"10.13039\/501100004381","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008958","name":"Lawson Health Research Institute","doi-asserted-by":"publisher","award":["LHR F0565"],"award-info":[{"award-number":["LHR F0565"]}],"id":[{"id":"10.13039\/100008958","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Histochem Cell Biol"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1007\/s00418-017-1580-6","type":"journal-article","created":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T01:07:36Z","timestamp":1494378456000},"page":"345-357","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Characterization of OATP1B3 and OATP2B1 transporter expression in the islet of the adult human pancreas"],"prefix":"10.1007","volume":"148","author":[{"given":"Michelle","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perri","family":"Deacon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rommel G.","family":"Tirona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Pin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henriette E.","family":"Meyer zu Schwabedissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rennian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute I.","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,5,10]]},"reference":[{"issue":"3","key":"1580_CR1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.2133\/dmpk.25.274","volume":"25","author":"M Abe","year":"2010","unstructured":"Abe M, Toyohara T, Ishii A, Suzuki T, Noguchi N, Akiyama Y, Shiwaku HO, Nakagomi-Hagihara R, Zheng G, Shibata E, Souma T, Shindo T, Shima H, Takeuchi Y, Mishima E, Tanemoto M, Terasaki T, Onogawa T, Unno M, Ito S, Takasawa S, Abe T (2010) The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides. Drug Metab Pharmacokinet 25(3):274\u2013282. pii:JST.JSTAGE\/dmpk\/25.274","journal-title":"Drug Metab Pharmacokinet"},{"issue":"3","key":"1580_CR2","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1210\/jcem.85.3.6431","volume":"85","author":"B Ahren","year":"2000","unstructured":"Ahren B, Holst JJ, Efendic S (2000) Antidiabetogenic action of cholecystokinin-8 in type 2 diabetes. J Clin Endocrinol Metab 85(3):1043\u20131048. doi:\n                        10.1210\/jcem.85.3.6431","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"1580_CR3","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.cmet.2016.04.002","volume":"23","author":"HE Arda","year":"2016","unstructured":"Arda HE, Li L, Tsai J, Torre EA, Rosli Y, Peiris H, Spitale RC, Dai C, Gu X, Qu K, Wang P, Wang J, Grompe M, Scharfmann R, Snyder MS, Bottino R, Powers AC, Chang HY, Kim SK (2016) Age-dependent pancreatic gene regulation reveals mechanisms governing human beta cell function. Cell Metab 23(5):909\u2013920. doi:\n                        10.1016\/j.cmet.2016.04.002","journal-title":"Cell Metab"},{"issue":"4","key":"1580_CR4","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1124\/dmd.114.062034","volume":"43","author":"J Badee","year":"2015","unstructured":"Badee J, Achour B, Rostami-Hodjegan A, Galetin A (2015) Meta-analysis of expression of hepatic organic anion-transporting polypeptide (OATP) transporters in cellular systems relative to human liver tissue. Drug Metab Dispos 43(4):424\u2013432. doi:\n                        10.1124\/dmd.114.062034","journal-title":"Drug Metab Dispos"},{"issue":"5","key":"1580_CR5","doi-asserted-by":"publisher","first-page":"G808","DOI":"10.1152\/ajpgi.00333.200200333.2002","volume":"284","author":"L Bai","year":"2003","unstructured":"Bai L, Zhang X, Ghishan FK (2003) Characterization of vesicular glutamate transporter in pancreatic alpha-and beta-cells and its regulation by glucose. Am J Physiol Gastrointest Liver Physiol 284(5):G808\u2013G814. doi:\n                        10.1152\/ajpgi.00333.200200333.2002","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"12","key":"1580_CR6","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.2174\/156802607780960492","volume":"7","author":"GS Baldwin","year":"2007","unstructured":"Baldwin GS, Shulkes A (2007) CCK receptors and cancer. Curr Top Med Chem 7(12):1232\u20131238","journal-title":"Curr Top Med Chem"},{"issue":"1","key":"1580_CR7","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1096\/fj.11-186841","volume":"26","author":"E Blanchet","year":"2012","unstructured":"Blanchet E, Bertrand C, Annicotte JS, Schlernitzauer A, Pessemesse L, Levin J, Fouret G, Feillet-Coudray C, Bonafos B, Fajas L, Cabello G, Wrutniak-Cabello C, Casas F (2012) Mitochondrial T3 receptor p43 regulates insulin secretion and glucose homeostasis. FASEB J 26(1):40\u201350. doi:\n                        10.1096\/fj.11-186841","journal-title":"FASEB J"},{"issue":"1","key":"1580_CR8","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2337\/diabetes.52.1.102","volume":"52","author":"AE Butler","year":"2003","unstructured":"Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC (2003) Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52(1):102\u2013110","journal-title":"Diabetes"},{"issue":"6","key":"1580_CR9","doi-asserted-by":"crossref","first-page":"699","DOI":"10.2337\/diab.44.6.699","volume":"44","author":"MM Byrne","year":"1995","unstructured":"Byrne MM, Sturis J, Fajans SS, Ortiz FJ, Stoltz A, Stoffel M, Smith MJ, Bell GI, Halter JB, Polonsky KS (1995) Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20. Diabetes 44(6):699\u2013704","journal-title":"Diabetes"},{"key":"1580_CR10","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1146\/annurev-pharmtox-010611-134529","volume":"52","author":"MK DeGorter","year":"2012","unstructured":"DeGorter MK, Xia CQ, Yang JJ, Kim RB (2012) Drug transporters in drug efficacy and toxicity. Annu Rev Pharmacol Toxicol 52:249\u2013273. doi:\n                        10.1146\/annurev-pharmtox-010611-134529","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"1","key":"1580_CR11","doi-asserted-by":"publisher","first-page":"e1024405","DOI":"10.1080\/19382014.2015.1024405","volume":"7","author":"J Dolensek","year":"2015","unstructured":"Dolensek J, Rupnik MS, Stozer A (2015) Structural similarities and differences between the human and the mouse pancreas. Islets 7(1):e1024405. doi:\n                        10.1080\/19382014.2015.1024405","journal-title":"Islets"},{"key":"1580_CR12","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.drup.2016.06.005","volume":"27","author":"S Durmus","year":"2016","unstructured":"Durmus S, van Hoppe S, Schinkel AH (2016) The impact of organic anion-transporting polypeptides (OATPs) on disposition and toxicity of antitumor drugs: insights from knockout and humanized mice. Drug Resist Updates 27:72\u201388. doi:\n                        10.1016\/j.drup.2016.06.005","journal-title":"Drug Resist Updates"},{"issue":"2","key":"1580_CR13","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1210\/en.2012-1818","volume":"154","author":"JC Geisler","year":"2013","unstructured":"Geisler JC, Corbin KL, Li Q, Feranchak AP, Nunemaker CS, Li C (2013) Vesicular nucleotide transporter-mediated ATP release regulates insulin secretion. Endocrinology 154(2):675\u2013684. doi:\n                        10.1210\/en.2012-1818","journal-title":"Endocrinology"},{"issue":"3","key":"1580_CR14","doi-asserted-by":"crossref","first-page":"767","DOI":"10.2337\/diabetes.52.3.767","volume":"52","author":"X Geng","year":"2003","unstructured":"Geng X, Li L, Watkins S, Robbins PD, Drain P (2003) The insulin secretory granule is the major site of K(ATP) channels of the endocrine pancreas. Diabetes 52(3):767\u2013776","journal-title":"Diabetes"},{"issue":"3","key":"1580_CR15","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/sj.clpt.6100056","volume":"81","author":"H Glaeser","year":"2007","unstructured":"Glaeser H, Bailey DG, Dresser GK, Gregor JC, Schwarz UI, McGrath JS, Jolicoeur E, Lee W, Leake BF, Tirona RG, Kim RB (2007) Intestinal drug transporter expression and the impact of grapefruit juice in humans. Clin Pharmacol Ther 81(3):362\u2013370. doi:\n                        10.1038\/sj.clpt.6100056","journal-title":"Clin Pharmacol Ther"},{"issue":"5","key":"1580_CR16","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1007\/s00424-003-1168-y","volume":"447","author":"B Hagenbuch","year":"2004","unstructured":"Hagenbuch B, Meier PJ (2004) Organic anion-transporting polypeptides of the OATP\/SLC21 family: phylogenetic classification as OATP\/SLCO superfamily, new nomenclature and molecular\/functional properties. Pflugers Arch 447(5):653\u2013665. doi:\n                        10.1007\/s00424-003-1168-y","journal-title":"Pflugers Arch"},{"issue":"2\u20133","key":"1580_CR17","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.mam.2012.10.009","volume":"34","author":"B Hagenbuch","year":"2013","unstructured":"Hagenbuch B, Stieger B (2013) The SLCO (former SLC21) superfamily of transporters. Mol Aspects Med 34(2\u20133):396\u2013412. doi:\n                        10.1016\/j.mam.2012.10.009","journal-title":"Mol Aspects Med"},{"issue":"11","key":"1580_CR18","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1023\/A:1011973015634","volume":"15","author":"A Hajri","year":"1998","unstructured":"Hajri A, Damge C (1998) Effects of cholecystokinin octapeptide on a pancreatic acinar carcinoma in the rat. Pharm Res 15(11):1767\u20131774","journal-title":"Pharm Res"},{"issue":"11","key":"1580_CR19","doi-asserted-by":"publisher","first-page":"e7855","DOI":"10.1371\/journal.pone.0007855","volume":"4","author":"LW Harries","year":"2009","unstructured":"Harries LW, Brown JE, Gloyn AL (2009) Species-specific differences in the expression of the HNF1A, HNF1B and HNF4A genes. PLoS One 4(11):e7855. doi:\n                        10.1371\/journal.pone.0007855","journal-title":"PLoS One"},{"issue":"4","key":"1580_CR20","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1128\/MCB.21.4.1393-1403.2001","volume":"21","author":"GP Hayhurst","year":"2001","unstructured":"Hayhurst GP, Lee YH, Lambert G, Ward JM, Gonzalez FJ (2001) Hepatocyte nuclear factor 4 alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol 21(4):1393\u20131403. doi:\n                        10.1128\/MCB.21.4.1393-1403.2001","journal-title":"Mol Cell Biol"},{"issue":"9","key":"1580_CR21","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.1007\/s11095-012-0962-7","volume":"30","author":"A Hays","year":"2013","unstructured":"Hays A, Apte U, Hagenbuch B (2013) Organic anion-transporting polypeptides expressed in pancreatic cancer may serve as potential diagnostic markers and therapeutic targets for early stage adenocarcinomas. Pharm Res 30(9):2260\u20132269. doi:\n                        10.1007\/s11095-012-0962-7","journal-title":"Pharm Res"},{"issue":"6","key":"1580_CR22","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1053\/j.gastro.2006.02.034","volume":"130","author":"RH Ho","year":"2006","unstructured":"Ho RH, Tirona RG, Leake BF, Glaeser H, Lee W, Lemke CJ, Wang Y, Kim RB (2006) Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Gastroenterology 130(6):1793\u20131806. doi:\n                        10.1053\/j.gastro.2006.02.034","journal-title":"Gastroenterology"},{"issue":"8","key":"1580_CR23","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1039\/b926588k","volume":"6","author":"AG Ianculescu","year":"2010","unstructured":"Ianculescu AG, Friesema EC, Visser TJ, Giacomini KM, Scanlan TS (2010) Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine. Mol BioSyst 6(8):1403\u20131410. doi:\n                        10.1039\/b926588k","journal-title":"Mol BioSyst"},{"issue":"3","key":"1580_CR24","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/j.bbrc.2005.02.072","volume":"329","author":"A Ihara","year":"2005","unstructured":"Ihara A, Yamagata K, Nammo T, Miura A, Yuan M, Tanaka T, Sladek FM, Matsuzawa Y, Miyagawa J, Shimomura I (2005) Functional characterization of the HNF4alpha isoform (HNF4alpha8) expressed in pancreatic beta-cells. Biochem Biophys Res Commun 329(3):984\u2013990. doi:\n                        10.1016\/j.bbrc.2005.02.072","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"1580_CR25","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.tips.2011.10.005","volume":"33","author":"D Iusuf","year":"2012","unstructured":"Iusuf D, van de Steeg E, Schinkel AH (2012) Functions of OATP1A and 1B transporters in vivo: insights from mouse models. Trends Pharmacol Sci 33(2):100\u2013108. doi:\n                        10.1016\/j.tips.2011.10.005","journal-title":"Trends Pharmacol Sci"},{"issue":"10","key":"1580_CR26","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1111\/tri.12617","volume":"28","author":"K Kloster-Jensen","year":"2015","unstructured":"Kloster-Jensen K, Vethe NT, Bremer S, Abadpour S, Korsgren O, Foss A, Bergan S, Scholz H (2015) Intracellular sirolimus concentration is reduced by tacrolimus in human pancreatic islets in vitro. Transpl Int 28(10):1152\u20131161. doi:\n                        10.1111\/tri.12617","journal-title":"Transpl Int"},{"issue":"2","key":"1580_CR27","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1161\/CIRCRESAHA.109.203596","volume":"106","author":"MJ Knauer","year":"2010","unstructured":"Knauer MJ, Urquhart BL, Meyer zu Schwabedissen HE, Schwarz UI, Lemke CJ, Leake BF, Kim RB, Tirona RG (2010) Human skeletal muscle drug transporters determine local exposure and toxicity of statins. Circ Res 106(2):297\u2013306. doi:\n                        10.1161\/CIRCRESAHA.109.203596","journal-title":"Circ Res"},{"issue":"6","key":"1580_CR28","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1124\/mol.112.083618","volume":"83","author":"MJ Knauer","year":"2013","unstructured":"Knauer MJ, Girdwood AJ, Kim RB, Tirona RG (2013) Transport function and transcriptional regulation of a liver-enriched human organic anion transporting polypeptide 2B1 transcriptional start site variant. Mol Pharmacol 83(6):1218\u20131228. doi:\n                        10.1124\/mol.112.083618","journal-title":"Mol Pharmacol"},{"issue":"1","key":"1580_CR29","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.jss.2006.10.015","volume":"140","author":"S Konduri","year":"2007","unstructured":"Konduri S, Schwarz RE (2007) Estrogen receptor beta\/alpha ratio predicts response of pancreatic cancer cells to estrogens and phytoestrogens. J Surg Res 140(1):55\u201366. doi:\n                        10.1016\/j.jss.2006.10.015","journal-title":"J Surg Res"},{"key":"1580_CR30","doi-asserted-by":"publisher","first-page":"27","DOI":"10.2147\/OTT.S16706","volume":"4","author":"V Kounnis","year":"2011","unstructured":"Kounnis V, Ioachim E, Svoboda M, Tzakos A, Sainis I, Thalhammer T, Steiner G, Briasoulis E (2011) Expression of organic anion-transporting polypeptides 1B3, 1B1, and 1A2 in human pancreatic cancer reveals a new class of potential therapeutic targets. Onco Targets Ther 4:27\u201332. doi:\n                        10.2147\/OTT.S16706","journal-title":"Onco Targets Ther"},{"issue":"2","key":"1580_CR31","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1210\/en.2010-0877","volume":"152","author":"M Krishnamurthy","year":"2011","unstructured":"Krishnamurthy M, Li J, Fellows GF, Rosenberg L, Goodyer CG, Wang R (2011) Integrin {alpha}3, but not {beta}1, regulates islet cell survival and function via PI3\u00a0K\/Akt signaling pathways. Endocrinology 152(2):424\u2013435. doi:\n                        10.1210\/en.2010-0877","journal-title":"Endocrinology"},{"issue":"2","key":"1580_CR32","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1053\/gast.2001.21176","volume":"120","author":"GA Kullak-Ublick","year":"2001","unstructured":"Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B (2001) Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology 120(2):525\u2013533","journal-title":"Gastroenterology"},{"issue":"6","key":"1580_CR33","first-page":"464","volume":"5","author":"E Kuntz","year":"2004","unstructured":"Kuntz E, Pinget M, Damge P (2004) Cholecystokinin octapeptide: a potential growth factor for pancreatic beta cells in diabetic rats. JOP 5(6):464\u2013475","journal-title":"JOP"},{"issue":"8","key":"1580_CR34","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1158\/1535-7163.MCT-12-0926","volume":"12","author":"CS Lancaster","year":"2013","unstructured":"Lancaster CS, Sprowl JA, Walker AL, Hu S, Gibson AA, Sparreboom A (2013) Modulation of OATP1B-type transporter function alters cellular uptake and disposition of platinum chemotherapeutics. Mol Cancer Ther 12(8):1537\u20131544. doi:\n                        10.1158\/1535-7163.MCT-12-0926","journal-title":"Mol Cancer Ther"},{"issue":"10","key":"1580_CR35","doi-asserted-by":"publisher","first-page":"9610","DOI":"10.1074\/jbc.M411092200","volume":"280","author":"W Lee","year":"2005","unstructured":"Lee W, Glaeser H, Smith LH, Roberts RL, Moeckel GW, Gervasini G, Leake BF, Kim RB (2005) Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry. J Biol Chem 280(10):9610\u20139617. doi:\n                        10.1074\/jbc.M411092200","journal-title":"J Biol Chem"},{"issue":"8","key":"1580_CR36","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/nrd4626","volume":"14","author":"L Lin","year":"2015","unstructured":"Lin L, Yee SW, Kim RB, Giacomini KM (2015) SLC transporters as therapeutic targets: emerging opportunities. Nat Rev Drug Discov 14(8):543\u2013560. doi:\n                        10.1038\/nrd4626","journal-title":"Nat Rev Drug Discov"},{"issue":"Suppl 1","key":"1580_CR37","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1111\/jdi.12465JDI12465","volume":"7","author":"AK Linnemann","year":"2016","unstructured":"Linnemann AK, Davis DB (2016) Glucagon-like peptide-1 and cholecystokinin production and signaling in the pancreatic islet as an adaptive response to obesity. J Diabetes Investig 7(Suppl 1):44\u201349. doi:\n                        10.1111\/jdi.12465JDI12465","journal-title":"J Diabetes Investig"},{"issue":"2","key":"1580_CR38","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1093\/toxsci\/kfq280","volume":"118","author":"H Lu","year":"2010","unstructured":"Lu H, Gonzalez FJ, Klaassen C (2010) Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha. Toxicol Sci 118(2):380\u2013390. doi:\n                        10.1093\/toxsci\/kfq280","journal-title":"Toxicol Sci"},{"key":"1580_CR39","unstructured":"Mastracci TL, Evans-Molina C (2014) Pancreatic and Islet Development and Function: The Role of Thyroid Hormone. J Endocrinol Diabetes Obes 2(3):1044"},{"issue":"2","key":"1580_CR40","doi-asserted-by":"publisher","first-page":"775","DOI":"10.2337\/db13-1005","volume":"63","author":"HE Meyer zu Schwabedissen","year":"2014","unstructured":"Meyer zu Schwabedissen HE, Boettcher K, Steiner T, Schwarz UI, Keiser M, Kroemer HK, Siegmund W (2014) OATP1B3 is expressed in pancreatic beta-islet cells and enhances the insulinotropic effect of the sulfonylurea derivative glibenclamide. Diabetes 63(2):775\u2013784. doi:\n                        10.2337\/db13-1005","journal-title":"Diabetes"},{"issue":"8","key":"1580_CR41","doi-asserted-by":"publisher","first-page":"5246","DOI":"10.1074\/jbc.M507496200","volume":"281","author":"A Miura","year":"2006","unstructured":"Miura A, Yamagata K, Kakei M, Hatakeyama H, Takahashi N, Fukui K, Nammo T, Yoneda K, Inoue Y, Sladek FM, Magnuson MA, Kasai H, Miyagawa J, Gonzalez FJ, Shimomura I (2006) Hepatocyte nuclear factor-4 alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells. J Biol Chem 281(8):5246\u20135257. doi:\n                        10.1074\/jbc.M507496200","journal-title":"J Biol Chem"},{"key":"1580_CR42","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1146\/annurev-pharmtox-010510-100556","volume":"52","author":"A Obaidat","year":"2012","unstructured":"Obaidat A, Roth M, Hagenbuch B (2012) The expression and function of organic anion transporting polypeptides in normal tissues and in cancer. Annu Rev Pharmacol Toxicol 52:135\u2013151. doi:\n                        10.1146\/annurev-pharmtox-010510-100556","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"4","key":"1580_CR43","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.cmet.2014.03.008","volume":"19","author":"KJ Prentice","year":"2014","unstructured":"Prentice KJ, Luu L, Allister EM, Liu Y, Jun LS, Sloop KW, Hardy AB, Wei L, Jia W, Fantus IG, Sweet DH, Sweeney G, Retnakaran R, Dai FF, Wheeler MB (2014) The furan fatty acid metabolite CMPF is elevated in diabetes and induces beta cell dysfunction. Cell Metab 19(4):653\u2013666. doi:\n                        10.1016\/j.cmet.2014.03.008","journal-title":"Cell Metab"},{"issue":"5","key":"1580_CR44","doi-asserted-by":"publisher","first-page":"e20372","DOI":"10.1371\/journal.pone.0020372","volume":"6","author":"H Pressler","year":"2011","unstructured":"Pressler H, Sissung TM, Venzon D, Price DK, Figg WD (2011) Expression of OATP family members in hormone-related cancers: potential markers of progression. PLoS One 6(5):e20372. doi:\n                        10.1371\/journal.pone.0020372","journal-title":"PLoS One"},{"issue":"1","key":"1580_CR45","doi-asserted-by":"publisher","first-page":"111","DOI":"10.2337\/dc12-0421","volume":"36","author":"Y Saisho","year":"2013","unstructured":"Saisho Y, Butler AE, Manesso E, Elashoff D, Rizza RA, Butler PC (2013) Beta-cell mass and turnover in humans: effects of obesity and aging. Diabetes Care 36(1):111\u2013117. doi:\n                        10.2337\/dc12-0421","journal-title":"Diabetes Care"},{"key":"1580_CR46","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/978-1-60327-040-3_7","volume":"429","author":"TD Schmittgen","year":"2008","unstructured":"Schmittgen TD, Lee EJ, Jiang J (2008) High-throughput real-time PCR. Methods Mol Biol 429:89\u201398. doi:\n                        10.1007\/978-1-60327-040-3_7","journal-title":"Methods Mol Biol"},{"issue":"3","key":"1580_CR47","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1097\/FPC.0b013e328342f5b1","volume":"21","author":"UI Schwarz","year":"2011","unstructured":"Schwarz UI, Meyer zu Schwabedissen HE, Tirona RG, Suzuki A, Leake BF, Mokrab Y, Mizuguchi K, Ho RH, Kim RB (2011) Identification of novel functional organic anion-transporting polypeptide 1B3 polymorphisms and assessment of substrate specificity. Pharmacogenet Genomics 21(3):103\u2013114. doi:\n                        10.1097\/FPC.0b013e328342f5b1","journal-title":"Pharmacogenet Genomics"},{"key":"1580_CR48","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1471-2164-11-17","volume":"11","author":"S Sreedharan","year":"2010","unstructured":"Sreedharan S, Shaik JH, Olszewski PK, Levine AS, Schioth HB, Fredriksson R (2010) Glutamate, aspartate and nucleotide transporters in the SLC17 family form four main phylogenetic clusters: evolution and tissue expression. BMC Genomics 11:17. doi:\n                        10.1186\/1471-2164-11-17","journal-title":"BMC Genomics"},{"issue":"1","key":"1580_CR49","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1021\/mp3005353","volume":"10","author":"N Thakkar","year":"2013","unstructured":"Thakkar N, Kim K, Jang ER, Han S, Kim D, Merchant N, Lockhart AC, Lee W (2013) A cancer-specific variant of the SLCO1B3 gene encodes a novel human organic anion transporting polypeptide 1B3 (OATP1B3) localized mainly in the cytoplasm of colon and pancreatic cancer cells. Mol Pharm 10(1):406\u2013416. doi:\n                        10.1021\/mp3005353","journal-title":"Mol Pharm"},{"issue":"3","key":"1580_CR50","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1534\/genetics.115.179432","volume":"201","author":"J Tian","year":"2015","unstructured":"Tian J, Keller MP, Oler AT, Rabaglia ME, Schueler KL, Stapleton DS, Broman AT, Zhao W, Kendziorski C, Yandell BS, Hagenbuch B, Broman KW, Attie AD (2015) Identification of the bile acid transporter Slco1a6 as a candidate gene that broadly affects gene expression in mouse pancreatic islets. Genetics 201(3):1253\u20131262. doi:\n                        10.1534\/genetics.115.179432","journal-title":"Genetics"},{"issue":"2","key":"1580_CR51","doi-asserted-by":"publisher","first-page":"173","DOI":"10.4161\/isl.19747","volume":"4","author":"J Tiano","year":"2012","unstructured":"Tiano J, Mauvais-Jarvis F (2012a) Selective estrogen receptor modulation in pancreatic beta-cells and the prevention of type 2 diabetes. Islets 4(2):173\u2013176. doi:\n                        10.4161\/isl.19747","journal-title":"Islets"},{"issue":"6","key":"1580_CR52","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/nrendo.2011.242","volume":"8","author":"JP Tiano","year":"2012","unstructured":"Tiano JP, Mauvais-Jarvis F (2012b) Importance of oestrogen receptors to preserve functional beta-cell mass in diabetes. Nat Rev Endocrinol 8(6):342\u2013351. doi:\n                        10.1038\/nrendo.2011.242","journal-title":"Nat Rev Endocrinol"}],"container-title":["Histochemistry and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00418-017-1580-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-017-1580-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-017-1580-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T00:37:53Z","timestamp":1505435873000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00418-017-1580-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,10]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["1580"],"URL":"https:\/\/doi.org\/10.1007\/s00418-017-1580-6","relation":{},"ISSN":["0948-6143","1432-119X"],"issn-type":[{"value":"0948-6143","type":"print"},{"value":"1432-119X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,10]]}}}