{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:41:41Z","timestamp":1793108501265,"version":"4.5.0"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T00:00:00Z","timestamp":1535155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Histochem Cell Biol"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s00418-018-1711-8","type":"journal-article","created":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T11:53:20Z","timestamp":1535198000000},"page":"711-719","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Dietary phosphate toxicity: an emerging global health concern"],"prefix":"10.1007","volume":"150","author":[{"given":"Sarah","family":"Erem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed S.","family":"Razzaque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,25]]},"reference":[{"issue":"2","key":"1711_CR1","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1681\/asn.2008040349","volume":"20","author":"KL Adeney","year":"2009","unstructured":"Adeney KL, Siscovick DS, Ix JH, Seliger SL, Shlipak MG, Jenny NS, Kestenbaum BR (2009) Association of serum phosphate with vascular and valvular calcification in moderate CKD. J Am Soc Nephrol 20(2):381\u2013387. \n                    https:\/\/doi.org\/10.1681\/asn.2008040349","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"1711_CR2","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1093\/jn\/107.1.42","volume":"107","author":"RR Bell","year":"1977","unstructured":"Bell RR, Draper HH, Tzeng DY, Shin HK, Schmidt GR (1977) Physiological responses of human adults to foods containing phosphate additives. J Nutr 107(1):42\u201350","journal-title":"J Nutr"},{"issue":"4","key":"1711_CR3","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1053\/ajkd.1998.v31.pm9531176","volume":"31","author":"GA Block","year":"1998","unstructured":"Block GA, Hulbert-Shearon TE, Levin NW, Port FK (1998) Association of serum phosphorus and calcium \u00d7 phosphate product with mortality risk in chronic hemodialysis patients: a national study. Am J Kidney Dis 31(4):607\u2013617","journal-title":"Am J Kidney Dis"},{"key":"1711_CR4","doi-asserted-by":"publisher","first-page":"41233","DOI":"10.1038\/srep41233","volume":"7","author":"AA Bobko","year":"2017","unstructured":"Bobko AA, Eubank TD, Driesschaert B, Dhimitruka I, Evans J, Mohammad R, Tchekneva EE, Dikov MM, Khramtsov VV (2017) Interstitial inorganic phosphate as a tumor microenvironment marker for tumor progression. Sci Rep 7:41233. \n                    https:\/\/doi.org\/10.1038\/srep41233","journal-title":"Sci Rep"},{"key":"1711_CR5","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1038\/bonekey.2015.74","volume":"4","author":"RB Brown","year":"2015","unstructured":"Brown RB, Razzaque MS (2015) Dysregulation of phosphate metabolism and conditions associated with phosphate toxicity. Bonekey Rep 4:705. \n                    https:\/\/doi.org\/10.1038\/bonekey.2015.74","journal-title":"Bonekey Rep"},{"issue":"1","key":"1711_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00795-015-0122-3","volume":"49","author":"RB Brown","year":"2016","unstructured":"Brown RB, Razzaque MS (2016) Phosphate toxicity: a stealth biochemical stress factor? Med Mol Morphol 49(1):1\u20134. \n                    https:\/\/doi.org\/10.1007\/s00795-015-0122-3","journal-title":"Med Mol Morphol"},{"issue":"2","key":"1711_CR7","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.bbcan.2018.04.007","volume":"1869","author":"RB Brown","year":"2018","unstructured":"Brown RB, Razzaque MS (2018) Phosphate toxicity and tumorigenesis. Biochim Biophys Acta 1869(2):303\u2013309. \n                    https:\/\/doi.org\/10.1016\/j.bbcan.2018.04.007","journal-title":"Biochim Biophys Acta"},{"issue":"12","key":"1711_CR8","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1139\/cjpp-2015-0083","volume":"93","author":"RB Brown","year":"2015","unstructured":"Brown RB, Haq A, Stanford CF, Razzaque MS (2015) Vitamin D, phosphate, and vasculotoxicity. Can J Physiol Pharmacol 93(12):1077\u20131082. \n                    https:\/\/doi.org\/10.1139\/cjpp-2015-0083","journal-title":"Can J Physiol Pharmacol"},{"issue":"7\u20138","key":"1711_CR9","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/S0899-9007(00)00313-0","volume":"16","author":"MS Calvo","year":"2000","unstructured":"Calvo MS (2000) Dietary considerations to prevent loss of bone and renal function. Nutrition 16(7\u20138):564\u2013566","journal-title":"Nutrition"},{"issue":"5","key":"1711_CR10","doi-asserted-by":"publisher","first-page":"e36883","DOI":"10.1371\/journal.pone.0036883","volume":"7","author":"AL Cancela","year":"2012","unstructured":"Cancela AL, Santos RD, Titan SM, Goldenstein PT, Rochitte CE, Lemos PA, dos Reis LM, Graciolli FG, Jorgetti V, Moyses RM (2012) Phosphorus is associated with coronary artery disease in patients with preserved renal function. PLoS One 7(5):e36883. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0036883","journal-title":"PLoS One"},{"issue":"2","key":"1711_CR11","first-page":"164","volume":"20","author":"J Chudek","year":"2007","unstructured":"Chudek J, Nagy A, Kokot F, Podwinski A, Wiecek A, Ritz E, Kovacs G (2007) Phosphatemia is related to chromosomal aberrations of parathyroid glands in patients with hyperparathyroidism. J Nephrol 20(2):164\u2013172","journal-title":"J Nephrol"},{"issue":"4","key":"1711_CR12","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1093\/ndt\/gfl718","volume":"22","author":"L Craver","year":"2007","unstructured":"Craver L, Marco MP, Martinez I, Rue M, Borras M, Martin ML, Sarro F, Valdivielso JM, Fernandez E (2007) Mineral metabolism parameters throughout chronic kidney disease stages 1\u20135\u2013achievement of K\/DOQI target ranges. Nephrol Dial Transplant 22(4):1171\u20131176. \n                    https:\/\/doi.org\/10.1093\/ndt\/gfl718","journal-title":"Nephrol Dial Transplant"},{"issue":"3","key":"1711_CR13","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1002\/path.2409","volume":"216","author":"S DeLuca","year":"2008","unstructured":"DeLuca S, Sitara D, Kang K, Marsell R, Jonsson K, Taguchi T, Erben RG, Razzaque MS, Lanske B (2008) Amelioration of the premature ageing-like features of Fgf-23 knockout mice by genetically restoring the systemic actions of FGF-23. J Pathol 216(3):345\u2013355. \n                    https:\/\/doi.org\/10.1002\/path.2409","journal-title":"J Pathol"},{"issue":"9","key":"1711_CR14","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1001\/archinte.167.9.879","volume":"167","author":"R Dhingra","year":"2007","unstructured":"Dhingra R, Sullivan LM, Fox CS, Wang TJ, D\u2019Agostino RB, Gaziano JM, Vasan RS (2007) Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community. Arch Intern Med 167(9):879\u2013885. \n                    https:\/\/doi.org\/10.1001\/archinte.167.9.879","journal-title":"Arch Intern Med"},{"issue":"4","key":"1711_CR15","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1681\/asn.2012090894","volume":"24","author":"JR Dominguez","year":"2013","unstructured":"Dominguez JR, Shlipak MG, Whooley MA, Ix JH (2013) Fractional excretion of phosphorus modifies the association between fibroblast growth factor-23 and outcomes. J Am Soc Nephrol 24(4):647\u2013654. \n                    https:\/\/doi.org\/10.1681\/asn.2012090894","journal-title":"J Am Soc Nephrol"},{"issue":"12","key":"1711_CR16","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1038\/ki.2009.83","volume":"75","author":"MM El-Abbadi","year":"2009","unstructured":"El-Abbadi MM, Pai AS, Leaf EM, Yang HY, Bartley BA, Quan KK, Ingalls CM, Liao HW, Giachelli CM (2009) Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin. Kidney Int 75(12):1297\u20131307. \n                    https:\/\/doi.org\/10.1038\/ki.2009.83","journal-title":"Kidney Int"},{"issue":"11","key":"1711_CR17","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1038\/ng1905","volume":"38","author":"JQ Feng","year":"2006","unstructured":"Feng JQ, Ward LM, Liu S, Lu Y, Xie Y, Yuan B, Yu X, Rauch F, Davis SI, Zhang S, Rios H, Drezner MK, Quarles LD, Bonewald LF, White KE (2006) Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat Genet 38(11):1310\u20131315. \n                    https:\/\/doi.org\/10.1038\/ng1905","journal-title":"Nat Genet"},{"issue":"2","key":"1711_CR18","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1681\/asn.2008020141","volume":"20","author":"RN Foley","year":"2009","unstructured":"Foley RN, Collins AJ, Herzog CA, Ishani A, Kalra PA (2009) Serum phosphorus levels associate with coronary atherosclerosis in young adults. J Am Soc Nephrol 20(2):397\u2013404. \n                    https:\/\/doi.org\/10.1681\/asn.2008020141","journal-title":"J Am Soc Nephrol"},{"issue":"11","key":"1711_CR19","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1681\/asn.2010020221","volume":"21","author":"OM Gutierrez","year":"2010","unstructured":"Gutierrez OM, Anderson C, Isakova T, Scialla J, Negrea L, Anderson AH, Bellovich K, Chen J, Robinson N, Ojo A, Lash J, Feldman HI, Wolf M (2010) Low socioeconomic status associates with higher serum phosphate irrespective of race. J Am Soc Nephrol 21(11):1953\u20131960. \n                    https:\/\/doi.org\/10.1681\/asn.2010020221","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"1711_CR20","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/ki.1980.85","volume":"17","author":"LL Haut","year":"1980","unstructured":"Haut LL, Alfrey AC, Guggenheim S, Buddington B, Schrier N (1980) Renal toxicity of phosphate in rats. Kidney Int 17(6):722\u2013731","journal-title":"Kidney Int"},{"issue":"3","key":"1711_CR21","doi-asserted-by":"publisher","first-page":"519","DOI":"10.2215\/cjn.06080809","volume":"5","author":"K Kalantar-Zadeh","year":"2010","unstructured":"Kalantar-Zadeh K, Gutekunst L, Mehrotra R, Kovesdy CP, Bross R, Shinaberger CS, Noori N, Hirschberg R, Benner D, Nissenson AR, Kopple JD (2010) Understanding sources of dietary phosphorus in the treatment of patients with chronic kidney disease. Clin J Am Soc Nephrol 5(3):519\u2013530. \n                    https:\/\/doi.org\/10.2215\/cjn.06080809","journal-title":"Clin J Am Soc Nephrol"},{"issue":"10","key":"1711_CR22","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1038\/ng.232","volume":"40","author":"WH Kao","year":"2008","unstructured":"Kao WH, Klag MJ, Meoni LA, Reich D, Berthier-Schaad Y, Li M, Coresh J, Patterson N, Tandon A, Powe NR, Fink NE, Sadler JH, Weir MR, Abboud HE, Adler SG, Divers J, Iyengar SK, Freedman BI, Kimmel PL, Knowler WC, Kohn OF, Kramp K, Leehey DJ, Nicholas SB, Pahl MV, Schelling JR, Sedor JR, Thornley-Brown D, Winkler CA, Smith MW, Parekh RS (2008) MYH9 is associated with nondiabetic end-stage renal disease in African Americans. Nat Genet 40(10):1185\u20131192. \n                    https:\/\/doi.org\/10.1038\/ng.232","journal-title":"Nat Genet"},{"issue":"3","key":"1711_CR23","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1007\/s00394-012-0406-5","volume":"52","author":"HJ Karp","year":"2013","unstructured":"Karp HJ, Kemi VE, Lamberg-Allardt CJ, Karkkainen MU (2013) Mono- and polyphosphates have similar effects on calcium and phosphorus metabolism in healthy young women. Eur J Nutr 52(3):991\u2013996. \n                    https:\/\/doi.org\/10.1007\/s00394-012-0406-5","journal-title":"Eur J Nutr"},{"key":"1711_CR24","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jsbmb.2018.01.010","volume":"180","author":"Anne Marie Uwitonze","year":"2018","unstructured":"Komolprasert V, Turowski P (2015) Food Additives and Packaging (ACS Symposium Series). American Chemical Society ISBN: 9780841230248. \n                    https:\/\/doi.org\/10.1016\/j.jsbmb.2018.01.010","journal-title":"The Journal of Steroid Biochemistry and Molecular Biology"},{"issue":"2","key":"1711_CR25","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1053\/j.ackd.2006.01.005","volume":"13","author":"CP Kovesdy","year":"2006","unstructured":"Kovesdy CP, Trivedi BK, Anderson JE (2006) Association of kidney function with mortality in patients with chronic kidney disease not yet on dialysis: a historical prospective cohort study. Adv Chronic Kidney Dis 13(2):183\u2013188. \n                    https:\/\/doi.org\/10.1053\/j.ackd.2006.01.005","journal-title":"Adv Chronic Kidney Dis"},{"issue":"11","key":"1711_CR26","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1038\/ki.2008.64","volume":"73","author":"CP Kovesdy","year":"2008","unstructured":"Kovesdy CP, Ahmadzadeh S, Anderson JE, Kalantar-Zadeh K (2008) Secondary hyperparathyroidism is associated with higher mortality in men with moderate to severe chronic kidney disease. Kidney Int 73(11):1296\u20131302. \n                    https:\/\/doi.org\/10.1038\/ki.2008.64","journal-title":"Kidney Int"},{"issue":"5","key":"1711_CR27","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1053\/j.ajkd.2010.06.011","volume":"56","author":"CP Kovesdy","year":"2010","unstructured":"Kovesdy CP, Kuchmak O, Lu JL, Kalantar-Zadeh K (2010) Outcomes associated with phosphorus binders in men with non-dialysis-dependent CKD. Am J Kidney Dis 56(5):842\u2013851. \n                    https:\/\/doi.org\/10.1053\/j.ajkd.2010.06.011","journal-title":"Am J Kidney Dis"},{"issue":"9","key":"1711_CR28","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1002\/mc.22153","volume":"54","author":"Y Lin","year":"2015","unstructured":"Lin Y, McKinnon KE, Ha SW, Beck GR Jr (2015) Inorganic phosphate induces cancer cell mediated angiogenesis dependent on forkhead box protein C2 (FOXC2) regulated osteopontin expression. Mol Carcinog 54(9):926\u2013934. \n                    https:\/\/doi.org\/10.1002\/mc.22153","journal-title":"Mol Carcinog"},{"key":"1711_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2017.07.025","author":"FR Mancini","year":"2017","unstructured":"Mancini FR, Affret A, Dow C, Balkau B, Clavel-Chapelon F, Bonnet F, Boutron-Ruault MC, Fagherazzi G (2017) High dietary phosphorus intake is associated with an increased risk of type 2 diabetes in the large prospective E3N cohort study. Clin Nutr. \n                    https:\/\/doi.org\/10.1016\/j.clnu.2017.07.025","journal-title":"Clin Nutr"},{"issue":"4","key":"1711_CR30","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1097\/MNH.0b013e3283621310","volume":"22","author":"J Marks","year":"2013","unstructured":"Marks J, Debnam ES, Unwin RJ (2013) The role of the gastrointestinal tract in phosphate homeostasis in health and chronic kidney disease. Curr Opin Nephrol Hypertens 22(4):481\u2013487. \n                    https:\/\/doi.org\/10.1097\/MNH.0b013e3283621310","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"7","key":"1711_CR31","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1681\/asn.2007070747","volume":"19","author":"R Mehrotra","year":"2008","unstructured":"Mehrotra R, Kermah D, Fried L, Adler S, Norris K (2008) Racial differences in mortality among those with CKD. J Am Soc Nephrol 19(7):1403\u20131410. \n                    https:\/\/doi.org\/10.1681\/asn.2007070747","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"1711_CR32","first-page":"443","volume":"32","author":"L Murphy-Gutekunst","year":"2005","unstructured":"Murphy-Gutekunst L (2005) Hidden phosphorus in popular beverages. Nephrol Nurs J 32(4):443\u2013445","journal-title":"Nephrol Nurs J"},{"issue":"4","key":"1711_CR33","doi-asserted-by":"publisher","first-page":"e31","DOI":"10.1053\/j.jrn.2007.04.005","volume":"17","author":"L Murphy-Gutekunst","year":"2007","unstructured":"Murphy-Gutekunst L (2007) Hidden phosphorus: where do we go from here? J Ren Nutr 17(4):e31\u2013e36","journal-title":"J Ren Nutr"},{"issue":"11","key":"1711_CR34","doi-asserted-by":"publisher","first-page":"3702","DOI":"10.1096\/fj.08-123992","volume":"23","author":"T Nakatani","year":"2009","unstructured":"Nakatani T, Ohnishi M, Razzaque MS (2009a) Inactivation of Klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model. FASEB J 23(11):3702\u20133711. \n                    https:\/\/doi.org\/10.1096\/fj.08-123992","journal-title":"FASEB J"},{"issue":"2","key":"1711_CR35","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1096\/fj.08-114397","volume":"23","author":"T Nakatani","year":"2009","unstructured":"Nakatani T, Sarraj B, Ohnishi M, Densmore MJ, Taguchi T, Goetz R, Mohammadi M, Lanske B, Razzaque MS (2009b) In vivo genetic evidence for Klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis. FASEB J 23(2):433\u2013441. \n                    https:\/\/doi.org\/10.1096\/fj.08-114397","journal-title":"FASEB J"},{"issue":"4","key":"1711_CR36","doi-asserted-by":"publisher","first-page":"683","DOI":"10.2215\/CJN.08601209","volume":"5","author":"N Noori","year":"2010","unstructured":"Noori N, Kalantar-Zadeh K, Kovesdy CP, Bross R, Benner D, Kopple JD (2010) Association of dietary phosphorus intake and phosphorus to protein ratio with mortality in hemodialysis patients. Clin J Am Soc Nephrol 5(4):683\u2013692. \n                    https:\/\/doi.org\/10.2215\/CJN.08601209","journal-title":"Clin J Am Soc Nephrol"},{"issue":"9","key":"1711_CR37","doi-asserted-by":"publisher","first-page":"3562","DOI":"10.1096\/fj.09-152488","volume":"24","author":"M Ohnishi","year":"2010","unstructured":"Ohnishi M, Razzaque MS (2010) Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging. Faseb j 24(9):3562\u20133571. \n                    https:\/\/doi.org\/10.1096\/fj.09-152488","journal-title":"Faseb j"},{"issue":"6","key":"1711_CR38","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1161\/CIRCGENETICS.108.847814","volume":"2","author":"M Ohnishi","year":"2009","unstructured":"Ohnishi M, Nakatani T, Lanske B, Razzaque MS (2009a) In vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin d levels. Circ Cardiovasc Genet 2(6):583\u2013590. \n                    https:\/\/doi.org\/10.1161\/CIRCGENETICS.108.847814","journal-title":"Circ Cardiovasc Genet"},{"issue":"11","key":"1711_CR39","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1038\/ki.2009.24","volume":"75","author":"M Ohnishi","year":"2009","unstructured":"Ohnishi M, Nakatani T, Lanske B, Razzaque MS (2009b) Reversal of mineral ion homeostasis and soft-tissue calcification of Klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase. Kidney Int 75(11):1166\u20131172. \n                    https:\/\/doi.org\/10.1038\/ki.2009.24","journal-title":"Kidney Int"},{"issue":"3","key":"1711_CR40","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.bbrc.2011.10.076","volume":"415","author":"M Ohnishi","year":"2011","unstructured":"Ohnishi M, Kato S, Razzaque MS (2011) Genetic induction of phosphate toxicity significantly reduces the survival of hypercholesterolemic obese mice. Biochem Biophys Res Commun 415(3):434\u2013438. \n                    https:\/\/doi.org\/10.1016\/j.bbrc.2011.10.076","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"1711_CR41","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s00774-011-0343-z","volume":"30","author":"S Osuka","year":"2012","unstructured":"Osuka S, Razzaque MS (2012) Can features of phosphate toxicity appear in normophosphatemia? J Bone Miner Metab 30(1):10\u201318. \n                    https:\/\/doi.org\/10.1007\/s00774-011-0343-z","journal-title":"J Bone Miner Metab"},{"issue":"1","key":"1711_CR42","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1093\/ndt\/gfn620","volume":"24","author":"MS Razzaque","year":"2009","unstructured":"Razzaque MS (2009a) Does FGF23 toxicity influence the outcome of chronic kidney disease? Nephrol Dial Transplant 24(1):4\u20137. \n                    https:\/\/doi.org\/10.1093\/ndt\/gfn620","journal-title":"Nephrol Dial Transplant"},{"issue":"11","key":"1711_CR43","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/nrendo.2009.196","volume":"5","author":"MS Razzaque","year":"2009","unstructured":"Razzaque MS (2009b) The FGF23-Klotho axis: endocrine regulation of phosphate homeostasis. Nat Rev Endocrinol 5(11):611\u2013619. \n                    https:\/\/doi.org\/10.1038\/nrendo.2009.196","journal-title":"Nat Rev Endocrinol"},{"issue":"3","key":"1711_CR44","doi-asserted-by":"publisher","first-page":"F470","DOI":"10.1152\/ajprenal.90538.2008","volume":"296","author":"MS Razzaque","year":"2009","unstructured":"Razzaque MS (2009c) FGF23-mediated regulation of systemic phosphate homeostasis: is Klotho an essential player? Am J Physiol Renal Physiol 296(3):F470\u2013F476. \n                    https:\/\/doi.org\/10.1152\/ajprenal.90538.2008","journal-title":"Am J Physiol Renal Physiol"},{"issue":"4","key":"1711_CR45","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1002\/iub.437","volume":"63","author":"MS Razzaque","year":"2011","unstructured":"Razzaque MS (2011a) Osteo-renal regulation of systemic phosphate metabolism. IUBMB Life 63(4):240\u2013247. \n                    https:\/\/doi.org\/10.1002\/iub.437","journal-title":"IUBMB Life"},{"issue":"3","key":"1711_CR46","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1042\/cs20100377","volume":"120","author":"MS Razzaque","year":"2011","unstructured":"Razzaque MS (2011b) Phosphate toxicity: new insights into an old problem. Clin Sci (Lond) 120(3):91\u201397. \n                    https:\/\/doi.org\/10.1042\/cs20100377","journal-title":"Clin Sci (Lond)"},{"key":"1711_CR47","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1159\/000346784","volume":"180","author":"MS Razzaque","year":"2013","unstructured":"Razzaque MS (2013) Phosphate toxicity and vascular mineralization. Contrib Nephrol 180:74\u201385. \n                    https:\/\/doi.org\/10.1159\/000346784","journal-title":"Contrib Nephrol"},{"key":"1711_CR48","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.abb.2014.06.031","volume":"561","author":"MS Razzaque","year":"2014","unstructured":"Razzaque MS (2014) Bone-kidney axis in systemic phosphate turnover. Arch Biochem Biophys 561:154\u2013158. \n                    https:\/\/doi.org\/10.1016\/j.abb.2014.06.031","journal-title":"Arch Biochem Biophys"},{"issue":"7","key":"1711_CR49","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.molmed.2006.05.002","volume":"12","author":"MS Razzaque","year":"2006","unstructured":"Razzaque MS, Lanske B (2006) Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice. Trends Mol Med 12(7):298\u2013305. \n                    https:\/\/doi.org\/10.1016\/j.molmed.2006.05.002","journal-title":"Trends Mol Med"},{"issue":"10","key":"1711_CR50","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1093\/ndt\/gfh991","volume":"20","author":"MS Razzaque","year":"2005","unstructured":"Razzaque MS, St-Arnaud R, Taguchi T, Lanske B (2005) FGF-23, vitamin D and calcification: the unholy triad. Nephrol Dial Transplant 20(10):2032\u20132035. \n                    https:\/\/doi.org\/10.1093\/ndt\/gfh991","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"1711_CR51","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1074\/jbc.M408903200","volume":"280","author":"H Saito","year":"2005","unstructured":"Saito H, Maeda A, Ohtomo S, Hirata M, Kusano K, Kato S, Ogata E, Segawa H, Miyamoto K, Fukushima N (2005) Circulating FGF-23 is regulated by 1alpha,25-dihydroxyvitamin D3 and phosphorus in vivo. J Biol Chem 280(4):2543\u20132549. \n                    https:\/\/doi.org\/10.1074\/jbc.M408903200","journal-title":"J Biol Chem"},{"issue":"5 Suppl","key":"1711_CR52","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S0272-6386(03)00372-X","volume":"41","author":"MJ Sarnak","year":"2003","unstructured":"Sarnak MJ (2003) Cardiovascular complications in chronic kidney disease. Am J Kidney Dis 41(5 Suppl):11\u201317","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"1711_CR53","doi-asserted-by":"publisher","first-page":"825","DOI":"10.2215\/cjn.02101205","volume":"1","author":"S Schwarz","year":"2006","unstructured":"Schwarz S, Trivedi BK, Kalantar-Zadeh K, Kovesdy CP (2006) Association of disorders in mineral metabolism with progression of chronic kidney disease. Clin J Am Soc Nephrol 1(4):825\u2013831. \n                    https:\/\/doi.org\/10.2215\/cjn.02101205","journal-title":"Clin J Am Soc Nephrol"},{"issue":"1","key":"1711_CR54","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1053\/j.ajkd.2009.01.269","volume":"54","author":"RA Sherman","year":"2009","unstructured":"Sherman RA, Mehta O (2009) Dietary phosphorus restriction in dialysis patients: potential impact of processed meat, poultry, and fish products as protein sources. Am J Kidney Dis 54(1):18\u201323. \n                    https:\/\/doi.org\/10.1053\/j.ajkd.2009.01.269","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"1711_CR55","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1172\/jci19081","volume":"113","author":"T Shimada","year":"2004","unstructured":"Shimada T, Kakitani M, Yamazaki Y, Hasegawa H, Takeuchi Y, Fujita T, Fukumoto S, Tomizuka K, Yamashita T (2004) Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest 113(4):561\u2013568. \n                    https:\/\/doi.org\/10.1172\/jci19081","journal-title":"J Clin Invest"},{"issue":"12","key":"1711_CR56","doi-asserted-by":"publisher","first-page":"e29105","DOI":"10.1371\/journal.pone.0029105","volume":"6","author":"Y Shutto","year":"2011","unstructured":"Shutto Y, Shimada M, Kitajima M, Yamabe H, Razzaque MS (2011) Lack of awareness among future medical professionals about the risk of consuming hidden phosphate-containing processed food and drinks. PLoS One 6(12):e29105. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0029105","journal-title":"PLoS One"},{"issue":"11","key":"1711_CR57","doi-asserted-by":"publisher","first-page":"e78660","DOI":"10.1371\/journal.pone.0078660","volume":"8","author":"Y Shutto","year":"2013","unstructured":"Shutto Y, Shimada M, Kitajima M, Yamabe H, Saitoh Y, Saitoh H, Razzaque MS (2013) Inadequate awareness among chronic kidney disease patients regarding food and drinks containing artificially added phosphate. PLoS One 8(11):e78660. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0078660","journal-title":"PLoS One"},{"issue":"8","key":"1711_CR58","doi-asserted-by":"publisher","first-page":"e1000154","DOI":"10.1371\/journal.pgen.1000154","volume":"4","author":"D Sitara","year":"2008","unstructured":"Sitara D, Kim S, Razzaque MS, Bergwitz C, Taguchi T, Schuler C, Erben RG, Lanske B (2008) Genetic evidence of serum phosphate-independent functions of FGF-23 on bone. PLoS Genet 4(8):e1000154. \n                    https:\/\/doi.org\/10.1371\/journal.pgen.1000154","journal-title":"PLoS Genet"},{"issue":"5","key":"1711_CR59","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1053\/j.jrn.2007.05.008","volume":"17","author":"CM Sullivan","year":"2007","unstructured":"Sullivan CM, Leon JB, Sehgal AR (2007) Phosphorus-containing food additives and the accuracy of nutrient databases: implications for renal patients. J Ren Nutr 17(5):350\u2013354. \n                    https:\/\/doi.org\/10.1053\/j.jrn.2007.05.008","journal-title":"J Ren Nutr"},{"issue":"6","key":"1711_CR60","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1753-4887.2012.00473.x","volume":"70","author":"E Takeda","year":"2012","unstructured":"Takeda E, Yamamoto H, Yamanaka-Okumura H, Taketani Y (2012) Dietary phosphorus in bone health and quality of life. Nutr Rev 70(6):311\u2013321. \n                    https:\/\/doi.org\/10.1111\/j.1753-4887.2012.00473.x","journal-title":"Nutr Rev"},{"issue":"17","key":"1711_CR61","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1161\/circulationaha.105.553198","volume":"112","author":"M Tonelli","year":"2005","unstructured":"Tonelli M, Sacks F, Pfeffer M, Gao Z, Curhan G (2005) Relation between serum phosphate level and cardiovascular event rate in people with coronary disease. Circulation 112(17):2627\u20132633. \n                    https:\/\/doi.org\/10.1161\/circulationaha.105.553198","journal-title":"Circulation"},{"issue":"8","key":"1711_CR62","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.2215\/cjn.03950609","volume":"4","author":"J Uribarri","year":"2009","unstructured":"Uribarri J (2009) Phosphorus additives in food and their effect in dialysis patients. Clin J Am Soc Nephrol 4(8):1290\u20131292. \n                    https:\/\/doi.org\/10.2215\/cjn.03950609","journal-title":"Clin J Am Soc Nephrol"},{"issue":"3","key":"1711_CR63","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1046\/j.1525-139X.2003.16037.x","volume":"16","author":"J Uribarri","year":"2003","unstructured":"Uribarri J, Calvo MS (2003) Hidden sources of phosphorus in the typical American diet: does it matter in nephrology? Semin Dial 16(3):186\u2013188","journal-title":"Semin Dial"},{"issue":"5","key":"1711_CR64","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.ahj.2013.02.014","volume":"165","author":"AJ Ballegooijen van","year":"2013","unstructured":"van Ballegooijen AJ, Reinders I, Visser M, Brouwer IA (2013) Parathyroid hormone and cardiovascular disease events: A systematic review and meta-analysis of prospective studies. Am Heart J 165(5):655\u2013664. \n                    https:\/\/doi.org\/10.1016\/j.ahj.2013.02.014\n                    \n                   664.e651\u2013655.","journal-title":"Am Heart J"},{"issue":"7","key":"1711_CR65","first-page":"456","volume":"15","author":"DN Ward","year":"1955","unstructured":"Ward DN, Griffin AC (1955) Phosphorus incorporation into nucleic acids and proteins of liver nuclei of normal and azo dye-fed rats. Cancer Res 15(7):456\u2013461","journal-title":"Cancer Res"},{"issue":"5","key":"1711_CR66","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1097\/01.ASN.0000123691.46138.E2","volume":"15","author":"DE Weiner","year":"2004","unstructured":"Weiner DE, Tighiouart H, Amin MG, Stark PC, MacLeod B, Griffith JL, Salem DN, Levey AS, Sarnak MJ (2004) Chronic kidney disease as a risk factor for cardiovascular disease and all-cause mortality: a pooled analysis of community-based studies. J Am Soc Nephrol 15(5):1307\u20131315","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"1711_CR67","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3164\/jcbn.17-20","volume":"62","author":"R Yoshikawa","year":"2018","unstructured":"Yoshikawa R, Yamamoto H, Nakahashi O, Kagawa T, Tajiri M, Nakao M, Fukuda S, Arai H, Masuda M, Iwano M, Takeda E, Taketani Y (2018) The age-related changes of dietary phosphate responsiveness in plasma 1,25-dihydroxyvitamin D levels and renal Cyp27b1 and Cyp24a1 gene expression is associated with renal alpha-Klotho gene expression in mice. J Clin Biochem Nutr 62(1):68\u201374. \n                    https:\/\/doi.org\/10.3164\/jcbn.17-20","journal-title":"J Clin Biochem Nutr"},{"issue":"1","key":"1711_CR68","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12882-018-0836-2","volume":"19","author":"YY Zhang","year":"2018","unstructured":"Zhang YY, Yang M, Bao JF, Gu LJ, Yu HL, Yuan WJ (2018) Phosphate stimulates myotube atrophy through autophagy activation: evidence of hyperphosphatemia contributing to skeletal muscle wasting in chronic kidney disease. BMC Nephrol 19(1):45. \n                    https:\/\/doi.org\/10.1186\/s12882-018-0836-2","journal-title":"BMC Nephrol"}],"container-title":["Histochemistry and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00418-018-1711-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-018-1711-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-018-1711-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T23:25:45Z","timestamp":1566689145000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00418-018-1711-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,25]]},"references-count":68,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1711"],"URL":"https:\/\/doi.org\/10.1007\/s00418-018-1711-8","relation":{},"ISSN":["0948-6143","1432-119X"],"issn-type":[{"value":"0948-6143","type":"print"},{"value":"1432-119X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,25]]},"assertion":[{"value":"17 August 2018","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2018","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}