{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T21:40:20Z","timestamp":1768772420173,"version":"3.49.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T00:00:00Z","timestamp":1583712000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T00:00:00Z","timestamp":1583712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Histochem Cell Biol"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1007\/s00418-020-01862-0","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T02:25:21Z","timestamp":1593483921000},"page":"385-396","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["CX3CL1\/CX3CR1-signalling in the CD9\/S100\u03b2\/SOX2-positive adult pituitary stem\/progenitor cells modulates differentiation into endothelial cells"],"prefix":"10.1007","volume":"153","author":[{"given":"Kotaro","family":"Horiguchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saishu","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Tsukada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumi","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Takigami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunji","family":"Ohsako","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yashiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takako","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,3,9]]},"reference":[{"key":"1862_CR1","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/33340","volume":"392","author":"M Baggiolini","year":"1998","unstructured":"Baggiolini M (1998) Chemokines and leukocyte traffic. Nature 392:565\u2013568","journal-title":"Nature"},{"key":"1862_CR2","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/0304-3835(94)90214-3","volume":"87","author":"SK Banerjee","year":"1994","unstructured":"Banerjee SK, De A, Sarkar DK (1994) Colocalization of prolactin and proliferating cell nuclear antigen in the anterior pituitary during estrogen-induced pituitary tumors. Cancer Lett 87:139\u2013144","journal-title":"Cancer Lett"},{"key":"1862_CR3","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/385640a0","volume":"385","author":"JF Bazan","year":"1997","unstructured":"Bazan JF, Bacon KB, Hardiman G, Wang W, Soo K, Rossi D, Greaves DR, Zlotnik A, Schall TJ (1997) A new class of membrane-bound chemokine with a CX3C motif. Nature 385:640\u2013644","journal-title":"Nature"},{"key":"1862_CR4","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1046\/j.1365-2249.2002.01906.x","volume":"129","author":"SJ Chakravorty","year":"2002","unstructured":"Chakravorty SJ, Cockwell P, Girdlestone J, Brooks CJ, Savage CO (2002) Fractalkine expression on human renal tubular epithelial cells: potential role in mononuclear cell adhesion. Clin Exp Immunol 129:150\u2013159","journal-title":"Clin Exp Immunol"},{"key":"1862_CR5","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1002\/sctm.18-0178","volume":"8","author":"GM Fernandes-Cunha","year":"2019","unstructured":"Fernandes-Cunha GM, Na KS, Putra I, Lee HJ, Hull S, Cheng YC, Blanco IJ, Eslani M, Djalilian AR, Myung D (2019) Corneal wound healing effects of mesenchymal stem cell secretome delivered within a viscoelastic gel carrier. Stem Cells Transl Med 8:478\u2013489","journal-title":"Stem Cells Transl Med"},{"key":"1862_CR6","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s00441-010-1078-1","volume":"342","author":"K Fujiwara","year":"2010","unstructured":"Fujiwara K, Jindatip D, Kikuchi M, Yashiro T (2010) In situ hybridization reveals that type I and III collagens are produced by pericytes in the anterior pituitary gland of rats. Cell Tissue Res 342:491\u2013495","journal-title":"Cell Tissue Res"},{"key":"1862_CR7","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s00441-016-2564-x","volume":"368","author":"K Fujiwara","year":"2017","unstructured":"Fujiwara K, Yatabe M, Tofrizal A, Jindatip D, Yashiro T, Nagai R (2017) Identification of M2 macrophages in anterior pituitary glands of normal rats and rats with estrogen-induced prolactinoma. Cell Tissue Res 368:371\u2013378","journal-title":"Cell Tissue Res"},{"key":"1862_CR8","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1002\/jlb.66.6.937","volume":"66","author":"JK Harrison","year":"1999","unstructured":"Harrison JK, Jiang Y, Wees EA, Salafranca MN, Liang HX, Feng L, Belardinelli L (1999) Inflammatory agents regulate in vivo expression of fractalkine in endothelial cells of the rat heart. J Leukoc Biol 66:937\u2013944","journal-title":"J Leukoc Biol"},{"key":"1862_CR10","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1111\/j.1447-073X.2008.00239.x","volume":"83","author":"K Horiguchi","year":"2008","unstructured":"Horiguchi K, Fujiwara K, Kouki T, Kikuchi M, Yashiro T (2008) Immunohistochemistry of connexin 43 throughout anterior pituitary gland in a transgenic rat with green fluorescent protein-expressing folliculo-stellate cells. Anat Sci Int 83:256\u2013260","journal-title":"Anat Sci Int"},{"key":"1862_CR12","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1210\/en.2011-1937","volume":"153","author":"K Horiguchi","year":"2012","unstructured":"Horiguchi K, Ilmiawati C, Fujiwara K, Tsukada T, Kikuchi M, Yashiro T (2012) Expression of chemokine CXCL12 and its receptor CXCR4 in folliculostellate (FS) cells of the rat anterior pituitary gland: the CXCL12\/CXCR4 axis induces interconnection of FS cells. Endocrinology 153:1717\u20131724","journal-title":"Endocrinology"},{"key":"1862_CR9","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1007\/s00441-014-1864-2","volume":"357","author":"K Horiguchi","year":"2014","unstructured":"Horiguchi K, Fujiwara K, Higuchi M, Yoshida S, Tsukada T, Ueharu H, Chen M, Hasegawa R, Takigami S, Ohsako S, Yashiro T, Kato T, Kato Y (2014) Expression of chemokine CXCL10 in dendritic-cell-like S100beta-positive cells in rat anterior pituitary gland. Cell Tissue Res 357:757\u2013765","journal-title":"Cell Tissue Res"},{"key":"1862_CR13","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.bbrc.2016.10.049","volume":"480","author":"K Horiguchi","year":"2016","unstructured":"Horiguchi K, Nakakura T, Yoshida S, Tsukada T, Kanno N, Hasegawa R, Takigami S, Ohsako S, Kato T, Kato Y (2016) Identification of THY1 as a novel thyrotrope marker and THY1 antibody-mediated thyrotrope isolation in the rat anterior pituitary gland. Biochem Biophys Res Commun 480:273\u2013279","journal-title":"Biochem Biophys Res Commun"},{"key":"1862_CR11","doi-asserted-by":"publisher","first-page":"5533","DOI":"10.1038\/s41598-018-23923-0","volume":"8","author":"K Horiguchi","year":"2018","unstructured":"Horiguchi K, Fujiwara K, Yoshida S, Nakakura T, Arae K, Tsukada T, Hasegawa R, Takigami S, Ohsako S, Yashiro T, Kato T, Kato Y (2018) Isolation and characterisation of CD9-positive pituitary adult stem\/progenitor cells in rats. Sci Rep 8:5533","journal-title":"Sci Rep"},{"key":"1862_CR14","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1006\/bbrc.2001.5589","volume":"287","author":"BM Hosking","year":"2001","unstructured":"Hosking BM, Wang SC, Chen SL, Penning S, Koopman P, Muscat GE (2001) SOX18 directly interacts with MEF2C in endothelial cells. Biochem Biophys Res Commun 287:493\u2013500","journal-title":"Biochem Biophys Res Commun"},{"key":"1862_CR15","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S0092-8674(00)80438-9","volume":"91","author":"T Imai","year":"1997","unstructured":"Imai T, Hieshima K, Haskell C, Baba M, Nagira M, Nishimura M, Kakizaki M, Takagi S, Nomiyama H, Schall TJ, Yoshie O (1997) Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 91:521\u2013530","journal-title":"Cell"},{"key":"1862_CR16","doi-asserted-by":"publisher","first-page":"15","DOI":"10.5551\/jat.11.15","volume":"11","author":"T Imaizumi","year":"2004","unstructured":"Imaizumi T, Yoshida H, Satoh K (2004) Regulation of CX3CL1\/fractalkine expression in endothelial cells. J Atheroscler Thromb 11:15\u201321","journal-title":"J Atheroscler Thromb"},{"key":"1862_CR17","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1679\/aohc.62.205","volume":"62","author":"K Inoue","year":"1999","unstructured":"Inoue K, Couch EF, Takano K, Ogawa S (1999) The structure and function of folliculo-stellate cells in the anterior pituitary gland. Arch Histol Cytol 62:205\u2013218","journal-title":"Arch Histol Cytol"},{"key":"1862_CR18","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1016\/j.jacc.2005.02.047","volume":"45","author":"H Koga","year":"2005","unstructured":"Koga H, Sugiyama S, Kugiyama K, Watanabe K, Fukushima H, Tanaka T, Sakamoto T, Yoshimura M, Jinnouchi H, Ogawa H (2005) Elevated levels of VE-cadherin-positive endothelial microparticles in patients with type 2 diabetes mellitus and coronary artery disease. J Am Coll Cardiol 45:1622\u20131630","journal-title":"J Am Coll Cardiol"},{"key":"1862_CR19","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1038\/onc.2011.338","volume":"31","author":"O Leis","year":"2012","unstructured":"Leis O, Eguiara A, Lopez-Arribillaga E, Alberdi MJ, Hernandez-Garcia S, Elorriaga K, Pandiella A, Rezola R, Martin AG (2012) Sox2 expression in breast tumours and activation in breast cancer stem cells. Oncogene 31:1354\u20131365","journal-title":"Oncogene"},{"key":"1862_CR20","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.4049\/jimmunol.163.3.1628","volume":"163","author":"D Maciejewski-Lenoir","year":"1999","unstructured":"Maciejewski-Lenoir D, Chen S, Feng L, Maki R, Bacon KB (1999) Characterization of fractalkine in rat brain cells: migratory and activation signals for CX3CR-1-expressing microglia. J Immunol (Baltimore, Md: 1950) 163:1628\u20131635","journal-title":"J Immunol (Baltimore, Md: 1950)"},{"key":"1862_CR21","doi-asserted-by":"publisher","first-page":"2551","DOI":"10.1002\/(SICI)1521-4141(199908)29:08<2551::AID-IMMU2551>3.0.CO;2-T","volume":"29","author":"EJ Papadopoulos","year":"1999","unstructured":"Papadopoulos EJ, Sassetti C, Saeki H, Yamada N, Kawamura T, Fitzhugh DJ, Saraf MA, Schall T, Blauvelt A, Rosen SD, Hwang ST (1999) Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up-regulated upon dendritic cell maturation. Eur J Immunol 29:2551\u20132559","journal-title":"Eur J Immunol"},{"key":"1862_CR22","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/nrd3024","volume":"9","author":"S Rajagopal","year":"2010","unstructured":"Rajagopal S, Rajagopal K, Lefkowitz RJ (2010) Teaching old receptors new tricks: biasing seven-transmembrane receptors. Nat Rev Drug Discov 9:373\u2013386","journal-title":"Nat Rev Drug Discov"},{"key":"1862_CR23","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.ejca.2006.01.006","volume":"42","author":"RM Strieter","year":"2006","unstructured":"Strieter RM, Burdick MD, Mestas J, Gomperts B, Keane MP, Belperio JA (2006) Cancer CXC chemokine networks and tumour angiogenesis. Eur J Cancer (Oxford, England: 1990) 42:768\u2013778","journal-title":"Eur J Cancer (Oxford, England: 1990)"},{"key":"1862_CR24","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1093\/ajcp\/85.2.160","volume":"85","author":"MJ Vanstapel","year":"1986","unstructured":"Vanstapel MJ, Gatter KC, de Wolf-Peeters C, Mason DY, Desmet VD (1986) New sites of human S-100 immunoreactivity detected with monoclonal antibodies. Am J Clin Pathol 85:160\u2013168","journal-title":"Am J Clin Pathol"},{"key":"1862_CR25","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s00395-010-0142-z","volume":"106","author":"KL Walenta","year":"2011","unstructured":"Walenta KL, Bettink S, Bohm M, Friedrich EB (2011) Differential chemokine receptor expression regulates functional specialization of endothelial progenitor cell subpopulations. Basic Res Cardiol 106:299\u2013305","journal-title":"Basic Res Cardiol"},{"key":"1862_CR26","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1006\/abio.1999.4085","volume":"270","author":"J Winer","year":"1999","unstructured":"Winer J, Jung CK, Shackel I, Williams PM (1999) Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro. Anal Biochem 270:41\u201349","journal-title":"Anal Biochem"},{"key":"1862_CR27","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S1074-7613(00)80165-X","volume":"12","author":"A Zlotnik","year":"2000","unstructured":"Zlotnik A, Yoshie O (2000) Chemokines: a new classification system and their role in immunity. Immunity 12:121\u2013127","journal-title":"Immunity"}],"container-title":["Histochemistry and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-020-01862-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00418-020-01862-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-020-01862-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T04:02:50Z","timestamp":1696305770000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00418-020-01862-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,9]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["1862"],"URL":"https:\/\/doi.org\/10.1007\/s00418-020-01862-0","relation":{},"ISSN":["0948-6143","1432-119X"],"issn-type":[{"value":"0948-6143","type":"print"},{"value":"1432-119X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,9]]},"assertion":[{"value":"26 February 2020","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2020","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors have no conflicts of interest that might affect the impartiality of this research.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The current study was approved by the Committee on Animal Experiments of the School of Agriculture, Meiji University, and Kyorin University based on the NIH Guidelines for the Care and Use of Laboratory Animals. This article does not contain any studies with human participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}