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Those finding lead us to hypothesize that another FABP can compensate the deletion of FABP5 in septoclasts of its gene-mutant mice. Based on the hypothesis, the present study examined the expression levels of several other FABPs in septoclasts and their morphology in FABP5<jats:sup>\u2212\/\u2212<\/jats:sup> mouse tibiae. Processes of FABP5<jats:sup>\u2212\/\u2212<\/jats:sup> septoclasts tend to be shorter than wild septoclasts. FABP4-positive septoclasts in FABP5<jats:sup>\u2212\/\u2212<\/jats:sup> mice were more numerous than those cells in wild mice.<\/jats:p><jats:p>Peroxisome proliferator-activated receptor (PPAR) \u03b3 was expressed in FABP4-positive septoclasts of FABP5<jats:sup>\u2212\/\u2212<\/jats:sup> mice as well as mice administered with GW1929, a PPAR\u03b3 agonist, suggesting that the occurrence of PPAR\u03b3 induces an increase of FABP4-positive septoclasts. The present finding suggests that the functional exertion of FABP5 in septoclasts is supplemented by FABP4 in normal and FABP5<jats:sup>\u2212\/\u2212<\/jats:sup> mice, and that the expression of FABP4 is up-regulated in accompany with PPAR\u03b3 in FABP5<jats:sup>\u2212\/\u2212<\/jats:sup> for maintenance of resorptive activity in the GP.<\/jats:p>","DOI":"10.1007\/s00418-020-01953-y","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T13:03:43Z","timestamp":1611147823000},"page":"439-449","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Expression and enhancement of FABP4 in septoclasts of the growth plate in FABP5-deficient mouse tibiae"],"prefix":"10.1007","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4164-047X","authenticated-orcid":false,"given":"Yasuhiko","family":"Bando","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuko","family":"Tokuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudai","family":"Ogasawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go","family":"Onozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arata","family":"Nagasaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Sakiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Owada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Amano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,4]]},"reference":[{"issue":"2","key":"1953_CR1","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.bbalip.2006.02.006","volume":"1761","author":"A Adida","year":"2006","unstructured":"Adida A, Spener F (2006) Adipocyte-type fatty acid-binding protein as inter-compartmental shuttle for peroxisome proliferator activated receptor gamma agonists in cultured cell. 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